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Food Allergy

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3. Assessment of food allergies and sensitivities

Assessment of food allergies and sensitivities Assessment of food allergies and sensitivities - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of food allergies and sensitivities Last reviewed: February 2019 Last updated: June 2018 Summary Food allergy is defined as an adverse immunological response to a food protein. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin Immunol. 2006 Feb;117(2 Suppl (...) Mini-Primer):S470-5. http://www.ncbi.nlm.nih.gov/pubmed/16455349?tool=bestpractice.com Although approximately 20% of people alter their diet due to a perceived adverse reaction to food, only 6% of young children and 3.7% of adults in the US have a true food allergy. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S470-5. http://www.ncbi.nlm.nih.gov/pubmed/16455349?tool=bestpractice.com People who believe they have a food allergy may suffer from

2018 BMJ Best Practice

4. Food allergy

Food allergy Food allergy - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Food allergy Last reviewed: February 2019 Last updated: May 2018 Summary Most reactions are from peanut, tree nuts, milk, egg, fish, shellfish, wheat, and soya. Symptoms usually appear within 20 minutes of ingestion and nearly always within 2 hours. Symptoms and signs may vary from pruritus and mild cutaneous eruption to severe anaphylactic (...) an epinephrine (adrenaline) auto-injector, and know how to activate emergency response services. Definition Food allergy is an adverse immune response to food proteins. Reactions may be either IgE-mediated, non-IgE-mediated, or mixed IgE-mediated/non-IgE-mediated reactions. IgE-mediated reactions to food are primarily considered here. History and exam presence of risk factors milk, egg, nut, fish, shellfish, wheat, or soya ingestion reproducible symptoms flushing, urticaria, or angio-oedema of the skin

2018 BMJ Best Practice

5. WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. (PubMed)

WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants.To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human (...) August 2016).We searched for randomised and quasi-randomised trials that compared use of a hydrolysed formula versus human milk or CMF. Trials with ≥ 80% follow-up of participants were eligible for inclusion.We independently assessed eligibility of studies for inclusion, methodological quality and data extraction. Primary outcomes included clinical allergy, specific allergy and food allergy. We conducted meta-analysis using a fixed-effect (FE) model.Two studies assessed the effect of three to four

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2017 Cochrane

6. Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. (PubMed)

Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants.To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human breast milk (...) searched for randomised and quasi-randomised trials that compared use of a hydrolysed formula versus human milk or CMF. Trials with ≥ 80% follow-up of participants were eligible for inclusion.We independently assessed eligibility of studies for inclusion, methodological quality and data extraction. Primary outcomes included clinical allergy, specific allergy and food allergy. We conducted meta-analysis using a fixed-effect (FE) model.Two studies assessed the effect of three to four days' infant

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2017 Cochrane

7. Impact of Food Allergy on Food Insecurity and Health Literacy in a Tertiary Care Pediatric Allergy Population. (PubMed)

Impact of Food Allergy on Food Insecurity and Health Literacy in a Tertiary Care Pediatric Allergy Population. Food insecurity (FI), limited availability of or access to nutritional foods, is linked to poor child/caregiver health. We examined FI in food-allergic and non-food-allergic children to determine whether dietary limitations associated with food allergy increases risk of FI.Food-allergic and non-food-allergic children (1-17 years) were recruited from Arkansas Children's Hospital allergy (...) /asthma clinics. The USDA Food Security Survey, the Newest Vital Sign Health Literacy (HL) questionnaire, and the Food Allergy Impact Scale QOL survey were administered. Logistic regression and analysis of covariance models were utilized for data analysis.Subjects (n = 650) included 325 food-allergic and 325 non-food-allergic children. Overall rate of FI was 21.5% (food allergic 22.2% and non-food allergic 20.9%) with no significant difference in the prevalence of FI between groups (OR = 1.30; 95% CI

2019 Pediatric Allergy and Immunology

8. Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologic (PubMed)

Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologic Naturally occurring botulism is rare, but a large number of cases could result from unintentional or intentional contamination of a commercial food. Despeciated, equine-derived, heptavalent botulinum antitoxin (HBAT) is licensed in the United (...) States. Timely treatment reduces morbidity and mortality, but concerns that botulinum antitoxin can induce anaphylaxis exist. We sought to quantify the allergy risk of botulinum antitoxin treatment and the usefulness of skin testing to assess this risk.We conducted a systematic review of (1) allergic reactions to botulinum antitoxin and (2) the predictive value of skin testing (ST) before botulinum antitoxin administration. We searched 5 scientific literature databases, reviewed articles' references

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2017 Clinical Infectious Diseases

9. Infant diets that include egg or peanut products appear to reduce food allergies

Infant diets that include egg or peanut products appear to reduce food allergies Infant diets that include egg or peanut products appear to reduce food allergies Discover Portal Discover Portal Infant diets that include egg or peanut products appear to reduce food allergies Published on 29 November 2016 doi: Certain allergenic foods introduced to an infant’s diet while weaning appear to reduce the chance of developing food allergies. This high quality review, including studies published (...) this year, suggests that historical recommendations to delay the introduction of peanut and other allergenic foods to infant child’s diet in the first year of life may have been mistaken. The methodological limitations in some studies included in this review, reduce our certainty in the degree of benefit, but as more high quality studies are undertaken the benefits and practicalities of how to introduce these foods are likely to become clearer. The causes of food allergies are not fully understood

2019 NIHR Dissemination Centre

10. Randomised controlled trial: Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants

Randomised controlled trial: Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You (...) cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Article Text Therapeutics/Prevention Randomised controlled trial Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Matthew Greenhawt 1 , Carina Venter 2 Statistics from Altmetric.com Commentary on : Perkin MR , Logan K

2017 Evidence-Based Medicine (Requires free registration)

11. Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study. (PubMed)

Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study. 29969633 2018 10 08 1097-6825 142 4 2018 Oct The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Evaluation of food allergy candidate loci in the Genetics of Food Allergy study. 1368-1370.e2 S0091-6749(18)30929-1 10.1016/j.jaci.2018.06.019 Marenholz Ingo I Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental and Clinical Research Center (...) of MDC and Charité Universitätsmedizin Berlin, Berlin, Germany. Grosche Sarah S Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental and Clinical Research Center of MDC and Charité Universitätsmedizin Berlin, Berlin, Germany. Rüschendorf Franz F Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany. Kalb Birgit B Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental

2018 Journal of Allergy and Clinical Immunology

12. Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children. (PubMed)

Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children. Atopic diseases, including food allergy, have become a predominant cause of chronic illness among children in developed countries. In Australia, a rise in hospitalisations among infants coded as anaphylaxis to foods coincided with the replacement of whole-cell pertussis (wP) vaccine (...) in IgE-mediated food allergy among Australian infants.This is a retrospective individually matched case-control study among a cohort of Australian children born from 1997 to 1999, the period of transition from wP to aP vaccines; we include in the cohort children listed on Australia's comprehensive population-based immunisation register as having received a first dose of either pertussis vaccine by 16 weeks old. 500 cohort children diagnosed as having IgE-mediated food allergy at specialist allergy

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2018 BMJ open

13. Food Allergy Training for Schools and Restaurants (The Food Allergy Community Program): Protocol to Evaluate the Effectiveness of a Web-Based Program (PubMed)

Food Allergy Training for Schools and Restaurants (The Food Allergy Community Program): Protocol to Evaluate the Effectiveness of a Web-Based Program Food allergy is a growing public health concern. The literature suggests that a significant number of reactions occur in community services, such as schools and restaurants. Therefore, suitable training and education for education and catering professionals using viable and practical tools is needed.The objective of this study is to evaluate (...) the effectiveness of a Web-based food allergy training program for professionals working in schools and restaurants, designed to improve knowledge and good practices in the community.Free learning programs which contain educational animated videos about food allergy were developed for professionals working at schools and restaurants. The learning programs comprise of nine 5-minute videos, developed in video animation format using GoAnimate, with a total course length of 45-60 minutes. The courses

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2018 JMIR Research Protocols

14. Rural and Urban Food Allergy Prevalence from the South African Food Allergy Study (Saffa). (PubMed)

Rural and Urban Food Allergy Prevalence from the South African Food Allergy Study (Saffa). Food sensitization and challenge-proved food allergy (FA) have not been compared in urban and rural settings.We sought to determine and compare the prevalence of food sensitization and challenge-proved IgE-mediated FA in urban and rural South African toddlers aged 12 to 36 months.This cross-sectional study of unselected children included 1185 participants in urban Cape Town and 398 in the rural Eastern (...) response ≥1 mm) to any food was 11.4% (95% CI, 9.6% to 13.3%) and 9.0% (95% CI, 7.5% to 10.8%) at an SPT response of 3 mm or greater. Sensitization in rural cohorts was significantly lower than in the urban cohort (1-mm SPT response, 4.5% [95% CI, 2.5% to 6.6%]; 3-mm SPT response, 2.8% [95% CI, 1.4% to 4.9%]; P < .01). In the rural black African cohort 0.5% (95% CI, 0.1% to 1.8%) of children had food allergy, all to egg. This is significantly lower than the prevalence of the urban cohort overall (2.5

2018 Journal of Allergy and Clinical Immunology

15. Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy. (PubMed)

Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy. Processed foods are part of daily life. Almost all processed foods contain food additives such as sweeteners, preservatives and colourants. From childhood, it is difficult to avoid consuming food additives. It is thought that oral tolerance for food antigens is acquired during early life. If tolerance fails, adverse immune responses to food (...) proteins may occur.We hypothesized that food additives prevent acquisition of oral tolerance and aimed to verify the safety of food additives.We induced experimental oral tolerance in mice for ovalbumin (OVA), a food antigen, by previous oral treatment with OVA before sensitization with OVA injections. Food additives were administered at the induction of oral tolerance, and food allergy was induced by repeated administration of OVA. Symptoms of food allergy were defined as a change in body temperature

2017 Clinical and Experimental Allergy

16. Age at introduction to complementary solid food and food allergy and sensitization: a systematic review and meta-analysis. (PubMed)

Age at introduction to complementary solid food and food allergy and sensitization: a systematic review and meta-analysis. An infant's age at introduction of complementary solids may contribute to food allergy. We aimed to synthesize the literature on the association between age at introduction of complementary solids, excluding milk products, and food allergy and sensitization.We searched the electronic databases PubMed and EMBASE (January 1946-February 2017) using solid food, allergy (...) and sensitization terms.Two authors selected papers according to inclusion criteria, identifying 16 cohort studies, 1 case-control study and 8 randomized controlled trials (RCTs). Pooled effects across studies were estimated using random-effects meta-analysis.Cohort studies - Introducing complementary solids at age ≥4 months versus <4 months was not associated with food allergy (OR 1.22; 95%CI, 0.76-1.96) but was associated with food sensitization (OR 1.93; 95%CI 1.57-2.38). First exposure from age 4-6 months

2019 Clinical and Experimental Allergy

17. Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. (PubMed)

Precision Medicine in Allergic Disease - Food Allergy, Drug Allergy, and Anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. This consensus document summarizes the current knowledge on the potential for precision medicine in food allergy, drug allergy, and anaphylaxis under the auspices of the PRACTALL collaboration platform. PRACTALL is a joint effort of the European Academy of Allergy and Clinical (...) Immunology and the American Academy of Allergy, Asthma and Immunology, which aims to synchronize the European and American approaches to allergy care. Precision medicine is an emerging approach for disease treatment based on disease endotypes, which are phenotypic subclasses associated with specific mechanisms underlying the disease. Although significant progress has been made in defining endotypes for asthma, definitions of endotypes for food and drug allergy or for anaphylaxis lag behind. Progress has

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2017 Allergy

18. Eating out with a food allergy in the UK: Change in the eating out practices of consumers with food allergy following introduction of allergen information legislation. (PubMed)

Eating out with a food allergy in the UK: Change in the eating out practices of consumers with food allergy following introduction of allergen information legislation. Strict allergen avoidance is important in day-to-day management of food allergy and avoidance when eating outside the home can present particular difficulties. EU legislation (EU FIC) introduced in December 2014 aimed to improve food allergen information provision for customers by requiring retailers of non-prepacked foods (...) to provide information related to the content of one or more of 14 specified food allergens within their foods.To investigate the impact of EU FIC on the behaviours, experiences and attitudes of consumers with food allergy when eating out.As part of longitudinal research, participants with food allergy from across the UK took part in either (A) pre and post legislation in-depth interviews, or (B) pre and post legislation surveys. In-depth interviews were carried out with 28 participants pre and post

2017 Clinical and Experimental Allergy

19. Prevention of food allergy development and suppression of established food allergy by neutralization of TSLP, IL-25 and IL-33. (PubMed)

Prevention of food allergy development and suppression of established food allergy by neutralization of TSLP, IL-25 and IL-33. Food allergy (FA) is an increasing problem that has no approved treatment. The pro-TH2 cytokines IL-25, IL-33, and thymic stromal lymphopoietin (TSLP) are associated with FA, and mAbs to these cytokines are reported to suppress murine FA development.We sought to determine whether anti-pro-TH2 cytokine mAbs can block both FA maintenance and induction.IgE-mediated FA (...) model of FA, whereas any pro-TH2 cytokine can maintain established FA. Pro-TH2 cytokines prevent oral tolerance. Combined treatment with antagonists to all 3 pro-TH2 cytokines or with an inhibitor of pro-TH2 cytokine production might be able to suppress established human FA.Copyright © 2017 American Academy of Allergy, Asthma & Immunology. All rights reserved.

2017 Journal of Allergy and Clinical Immunology

20. The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology (PubMed)

The diagnosis and management of food allergies. Position paper of the Food Allergy Section the Polish Society of Allergology The paper concerns the current position of the Polish Society of Allergology Food Allergy Section on the diagnosis and management of food allergies. The aim of this position is to provide evidence-based recommendations on the diagnosis and management of patients with allergic hypersensitivity to foods. This position statement includes a systematic review of studies (...) in three areas, namely, the epidemiology, diagnosis and management of food allergies. While taking into account the specific Polish setting, in this publication we also used the current European Academy of Allergy and Clinical Immunology (EAACI) position paper and other current position statements, including those of the United States National Institute of Allergy and Infectious Diseases (NIAID).

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2017 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

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