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Food Allergy

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1. Oral Immunotherapy for Food Oral Immunotherapy Protocols for Food Allergy in Infants and Children: Comparative Clinical Effectiveness

Oral Immunotherapy for Food Oral Immunotherapy Protocols for Food Allergy in Infants and Children: Comparative Clinical Effectiveness Oral Immunotherapy for Food Oral Immunotherapy Protocols for Food Allergy in Infants and Children: Comparative Clinical Effectiveness | CADTH.ca Find the information you need Oral Immunotherapy for Food Oral Immunotherapy Protocols for Food Allergy in Infants and Children: Comparative Clinical Effectiveness Oral Immunotherapy for Food Oral Immunotherapy Protocols (...) for Food Allergy in Infants and Children: Comparative Clinical Effectiveness Last updated: November 2, 2018 Project Number: RB1272-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of oral immunotherapy (OIT) for food allergy in children? Key Message Six randomized controlled trials and two non-randomized studies were identified regarding the clinical effectiveness of oral immunotherapy (OIT) for food

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

4. Assessment of food allergies and sensitivities

Assessment of food allergies and sensitivities Assessment of food allergies and sensitivities - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of food allergies and sensitivities Last reviewed: February 2019 Last updated: June 2018 Summary Food allergy is defined as an adverse immunological response to a food protein. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin Immunol. 2006 Feb;117(2 Suppl (...) Mini-Primer):S470-5. http://www.ncbi.nlm.nih.gov/pubmed/16455349?tool=bestpractice.com Although approximately 20% of people alter their diet due to a perceived adverse reaction to food, only 6% of young children and 3.7% of adults in the US have a true food allergy. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin Immunol. 2006 Feb;117(2 Suppl Mini-Primer):S470-5. http://www.ncbi.nlm.nih.gov/pubmed/16455349?tool=bestpractice.com People who believe they have a food allergy may suffer from

2018 BMJ Best Practice

5. Food allergy

Food allergy Food allergy - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Food allergy Last reviewed: February 2019 Last updated: May 2018 Summary Most reactions are from peanut, tree nuts, milk, egg, fish, shellfish, wheat, and soya. Symptoms usually appear within 20 minutes of ingestion and nearly always within 2 hours. Symptoms and signs may vary from pruritus and mild cutaneous eruption to severe anaphylactic (...) an epinephrine (adrenaline) auto-injector, and know how to activate emergency response services. Definition Food allergy is an adverse immune response to food proteins. Reactions may be either IgE-mediated, non-IgE-mediated, or mixed IgE-mediated/non-IgE-mediated reactions. IgE-mediated reactions to food are primarily considered here. History and exam presence of risk factors milk, egg, nut, fish, shellfish, wheat, or soya ingestion reproducible symptoms flushing, urticaria, or angio-oedema of the skin

2018 BMJ Best Practice

6. ASCIA Information on how to introduce solid foods to babies for allergy prevention

ASCIA Information on how to introduce solid foods to babies for allergy prevention ASCIA INFORMATION FOR PATIENTS, CONSUMERS AND CARERS 1 Parent Information: Frequently Asked Questions (FAQ) How to Introduce Solid Foods For Allergy Prevention This information aims to provide practical advice on how to introduce solid foods to your baby, and is based on current evidence for food allergy prevention. This advice is relevant for all babies, particularly those with severe eczema, or existing food (...) allergy, or a family member (parent or sibling) with allergies. Key Points • Start to introduce solid foods around six months of age (not before four months), and when your baby is ready. If possible, continue to breastfeed your baby while you are introducing solid foods. • When introducing solid foods to your baby, include common allergy causing foods by 12 months in an age appropriate form, such as well cooked egg and smooth peanut butter/paste. These foods include egg, peanut, cow’s milk (dairy

2019 Australasian Society of Clinical Immunology and Allergy

7. Oral Immunotherapy for Food Allergy in Infants and Children: Clinical Effectiveness, Cost-Effectiveness and Guidelines

Oral Immunotherapy for Food Allergy in Infants and Children: Clinical Effectiveness, Cost-Effectiveness and Guidelines Oral Immunotherapy for Food Allergy in Infants and Children: Clinical Effectiveness, Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Oral Immunotherapy for Food Allergy in Infants and Children: Clinical Effectiveness, Cost-Effectiveness and Guidelines Oral Immunotherapy for Food Allergy in Infants and Children: Clinical Effectiveness, Cost (...) -Effectiveness and Guidelines Last updated: October 4, 2018 Project Number: RB1264-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report Question What is the clinical effectiveness of oral immunotherapy for food allergy in children? What is the cost-effectiveness of oral immunotherapy for food allergy in children? Key Message Three systematic reviews with meta-analyses, thirteen randomized-controlled studies, one economic evaluation, and three evidence

2018 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. (PubMed)

WITHDRAWN: Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants.To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human (...) August 2016).We searched for randomised and quasi-randomised trials that compared use of a hydrolysed formula versus human milk or CMF. Trials with ≥ 80% follow-up of participants were eligible for inclusion.We independently assessed eligibility of studies for inclusion, methodological quality and data extraction. Primary outcomes included clinical allergy, specific allergy and food allergy. We conducted meta-analysis using a fixed-effect (FE) model.Two studies assessed the effect of three to four

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2017 Cochrane

9. Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. (PubMed)

Infant formulas containing hydrolysed protein for prevention of allergic disease and food allergy. Allergy is common and may be associated with foods, including cow's milk formula (CMF). Formulas containing hydrolysed proteins have been used to treat infants with allergy. However, it is unclear whether hydrolysed formulas can be advocated for prevention of allergy in infants.To compare effects on allergy and food allergy when infants are fed a hydrolysed formula versus CMF or human breast milk (...) searched for randomised and quasi-randomised trials that compared use of a hydrolysed formula versus human milk or CMF. Trials with ≥ 80% follow-up of participants were eligible for inclusion.We independently assessed eligibility of studies for inclusion, methodological quality and data extraction. Primary outcomes included clinical allergy, specific allergy and food allergy. We conducted meta-analysis using a fixed-effect (FE) model.Two studies assessed the effect of three to four days' infant

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2017 Cochrane

10. Impact of Food Allergy on Food Insecurity and Health Literacy in a Tertiary Care Pediatric Allergy Population. (PubMed)

Impact of Food Allergy on Food Insecurity and Health Literacy in a Tertiary Care Pediatric Allergy Population. Food insecurity (FI), limited availability of or access to nutritional foods, is linked to poor child/caregiver health. We examined FI in food-allergic and non-food-allergic children to determine whether dietary limitations associated with food allergy increases risk of FI.Food-allergic and non-food-allergic children (1-17 years) were recruited from Arkansas Children's Hospital allergy (...) /asthma clinics. The USDA Food Security Survey, the Newest Vital Sign Health Literacy (HL) questionnaire, and the Food Allergy Impact Scale QOL survey were administered. Logistic regression and analysis of covariance models were utilized for data analysis.Subjects (n = 650) included 325 food-allergic and 325 non-food-allergic children. Overall rate of FI was 21.5% (food allergic 22.2% and non-food allergic 20.9%) with no significant difference in the prevalence of FI between groups (OR = 1.30; 95% CI

2019 Pediatric Allergy and Immunology

11. Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model. (PubMed)

Nitrated food proteins induce a regulatory immune response associated with allergy prevention after oral exposure in a Balb/c mouse food allergy model. Food allergy is associated with a high personal health and economic burden. For immunomodulation toward tolerance, food compounds could be chemically modified, for example, by posttranslational protein nitration, which also occurs via diet-derived nitrating agents in the gastrointestinal tract.We sought to analyze the effect of pretreatment (...) with nitrated food proteins on the immune response in a mouse food allergy model and on human monocyte-derived dendritic cells (moDCs) and PBMCs.The model allergen ovalbumin (OVA) was nitrated in different nitration degrees, and the secondary structures of proteins were determined by circular dichroism (CD). Allergy-preventive treatment with OVA, nitrated OVA (nOVA), and maximally nitrated OVA (nOVAmax) were performed before mice were immunized with or without gastric acid-suppression medication. Antibody

2019 Allergy

12. Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologic (PubMed)

Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologic Naturally occurring botulism is rare, but a large number of cases could result from unintentional or intentional contamination of a commercial food. Despeciated, equine-derived, heptavalent botulinum antitoxin (HBAT) is licensed in the United (...) States. Timely treatment reduces morbidity and mortality, but concerns that botulinum antitoxin can induce anaphylaxis exist. We sought to quantify the allergy risk of botulinum antitoxin treatment and the usefulness of skin testing to assess this risk.We conducted a systematic review of (1) allergic reactions to botulinum antitoxin and (2) the predictive value of skin testing (ST) before botulinum antitoxin administration. We searched 5 scientific literature databases, reviewed articles' references

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2017 Clinical Infectious Diseases

13. Infant diets that include egg or peanut products appear to reduce food allergies

Infant diets that include egg or peanut products appear to reduce food allergies Infant diets that include egg or peanut products appear to reduce food allergies Discover Portal Discover Portal Infant diets that include egg or peanut products appear to reduce food allergies Published on 29 November 2016 doi: Certain allergenic foods introduced to an infant’s diet while weaning appear to reduce the chance of developing food allergies. This high quality review, including studies published (...) this year, suggests that historical recommendations to delay the introduction of peanut and other allergenic foods to infant child’s diet in the first year of life may have been mistaken. The methodological limitations in some studies included in this review, reduce our certainty in the degree of benefit, but as more high quality studies are undertaken the benefits and practicalities of how to introduce these foods are likely to become clearer. The causes of food allergies are not fully understood

2019 NIHR Dissemination Centre

14. Randomised controlled trial: Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants

Randomised controlled trial: Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants | BMJ Evidence-Based Medicine We use cookies to improve our service and to tailor our content and advertising to you. You (...) cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Article Text Therapeutics/Prevention Randomised controlled trial Having your cake and EATing it too: early timing of multiple allergen introduction does not increase the risk of developing food allergy in standard risk, breastfed infants Matthew Greenhawt 1 , Carina Venter 2 Statistics from Altmetric.com Commentary on : Perkin MR , Logan K

2017 Evidence-Based Medicine (Requires free registration)

15. ASCIA Guide for introduction of peanut to infants with severe eczema and/or food allergy

ASCIA Guide for introduction of peanut to infants with severe eczema and/or food allergy 1 Guide for introduction of peanut to infants with severe eczema and/or food allergy This guide provides options and information for health professionals about introducing peanut to infants with severe eczema and/or existing food allergy. These infants are considered to have an increased risk of developing peanut allergy. Why should this guide be followed? Recently published studies (1,2) have shown (...) that the introduction of peanut to infants with severe eczema and/or egg allergy before 12 months can reduce the risk of these infants developing peanut allergy by around 80%. For all infants, including those with severe eczema and/or existing food allergy, peanut and other solid foods should be introduced around 6 months (not before 4 months) and in the first 12 months, when developmentally ready, as recommended in the ASCIA guidelines for infant feeding and allergy prevention. If possible, it is preferable

2017 Australasian Society of Clinical Immunology and Allergy

16. Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study. (PubMed)

Evaluation of food allergy candidate loci in the Genetics of Food Allergy Study. 29969633 2018 10 08 1097-6825 142 4 2018 Oct The Journal of allergy and clinical immunology J. Allergy Clin. Immunol. Evaluation of food allergy candidate loci in the Genetics of Food Allergy study. 1368-1370.e2 S0091-6749(18)30929-1 10.1016/j.jaci.2018.06.019 Marenholz Ingo I Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental and Clinical Research Center (...) of MDC and Charité Universitätsmedizin Berlin, Berlin, Germany. Grosche Sarah S Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental and Clinical Research Center of MDC and Charité Universitätsmedizin Berlin, Berlin, Germany. Rüschendorf Franz F Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany. Kalb Birgit B Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany; Clinic for Pediatric Allergy, Experimental

2018 Journal of Allergy and Clinical Immunology

17. Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children. (PubMed)

Protocol for Pertussis Immunisation and Food Allergy (PIFA): a case-control study of the association between pertussis vaccination in infancy and the risk of IgE-mediated food allergy among Australian children. Atopic diseases, including food allergy, have become a predominant cause of chronic illness among children in developed countries. In Australia, a rise in hospitalisations among infants coded as anaphylaxis to foods coincided with the replacement of whole-cell pertussis (wP) vaccine (...) in IgE-mediated food allergy among Australian infants.This is a retrospective individually matched case-control study among a cohort of Australian children born from 1997 to 1999, the period of transition from wP to aP vaccines; we include in the cohort children listed on Australia's comprehensive population-based immunisation register as having received a first dose of either pertussis vaccine by 16 weeks old. 500 cohort children diagnosed as having IgE-mediated food allergy at specialist allergy

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2018 BMJ open

18. Food Allergy Training for Schools and Restaurants (The Food Allergy Community Program): Protocol to Evaluate the Effectiveness of a Web-Based Program (PubMed)

Food Allergy Training for Schools and Restaurants (The Food Allergy Community Program): Protocol to Evaluate the Effectiveness of a Web-Based Program Food allergy is a growing public health concern. The literature suggests that a significant number of reactions occur in community services, such as schools and restaurants. Therefore, suitable training and education for education and catering professionals using viable and practical tools is needed.The objective of this study is to evaluate (...) the effectiveness of a Web-based food allergy training program for professionals working in schools and restaurants, designed to improve knowledge and good practices in the community.Free learning programs which contain educational animated videos about food allergy were developed for professionals working at schools and restaurants. The learning programs comprise of nine 5-minute videos, developed in video animation format using GoAnimate, with a total course length of 45-60 minutes. The courses

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2018 JMIR Research Protocols

19. Rural and Urban Food Allergy Prevalence from the South African Food Allergy Study (Saffa). (PubMed)

Rural and Urban Food Allergy Prevalence from the South African Food Allergy Study (Saffa). Food sensitization and challenge-proved food allergy (FA) have not been compared in urban and rural settings.We sought to determine and compare the prevalence of food sensitization and challenge-proved IgE-mediated FA in urban and rural South African toddlers aged 12 to 36 months.This cross-sectional study of unselected children included 1185 participants in urban Cape Town and 398 in the rural Eastern (...) response ≥1 mm) to any food was 11.4% (95% CI, 9.6% to 13.3%) and 9.0% (95% CI, 7.5% to 10.8%) at an SPT response of 3 mm or greater. Sensitization in rural cohorts was significantly lower than in the urban cohort (1-mm SPT response, 4.5% [95% CI, 2.5% to 6.6%]; 3-mm SPT response, 2.8% [95% CI, 1.4% to 4.9%]; P < .01). In the rural black African cohort 0.5% (95% CI, 0.1% to 1.8%) of children had food allergy, all to egg. This is significantly lower than the prevalence of the urban cohort overall (2.5

2018 Journal of Allergy and Clinical Immunology

20. Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy. (PubMed)

Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy. Processed foods are part of daily life. Almost all processed foods contain food additives such as sweeteners, preservatives and colourants. From childhood, it is difficult to avoid consuming food additives. It is thought that oral tolerance for food antigens is acquired during early life. If tolerance fails, adverse immune responses to food (...) proteins may occur.We hypothesized that food additives prevent acquisition of oral tolerance and aimed to verify the safety of food additives.We induced experimental oral tolerance in mice for ovalbumin (OVA), a food antigen, by previous oral treatment with OVA before sensitization with OVA injections. Food additives were administered at the induction of oral tolerance, and food allergy was induced by repeated administration of OVA. Symptoms of food allergy were defined as a change in body temperature

2017 Clinical and Experimental Allergy

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