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61. Chronic Pelvic Pain

: guidance for study inclusion criteria, outcome measurement and clinical practice. Aliment Pharmacol Ther, 2010. 32: 1192. 274. Slieker-ten Hove, M.C., et al. Face validity and reliability of the first digital assessment scheme of pelvic floor muscle function conform the new standardized terminology of the International Continence Society. Neurourol Urodyn, 2009. 28: 295. 275. Wyndaele, J.J., et al. Reproducibility of digital testing of the pelvic floor muscles in men. Arch Phys Med Rehabil, 1996. 77

2018 European Association of Urology

62. Best Practices across the Continuum of Care for the Treatment of Opioid Use Disorder

and nasal forms of naloxone as open benefits for First Nations and Inuit people under the non-insured health benefits program. Correctional Services of Canada has developed a national project to provide individuals being released from incarceration with access to a take-home naloxone kit. Across Canada, naloxone can be obtained at pharmacies without a prescription (without a fee in some areas) for anyone concerned about the risk of overdose for themselves or others. The Honourable Ginette Petitpas (...) ? Detoxification should be avoided; methadone and buprenorphine are safe for treatment during pregnancy. 7,22 Pharmacological Interventions Youth ? Bup/nal should be the first-line opioid therapy for youth, and only opioid therapy for youth that live or frequently travel to communities where methadone is not available. 87,88 ? Buprenorphine, methadone and naltrexone can be considered for youth. 7 Women who are pregnant ? Opioid agonist therapy should be initiated or maintained during pregnancy, 7,16,87 labour

2018 Canadian Centre on Substance Abuse

63. WHO recommendations: intrapartum care for a positive childbirth experience

Integration of recommendations from published WHO guidelines 13 2.8 Focus and approach 13 2.9 Evidence identification and retrieval 13 2.10 Quality assessment and grading of the evidence 14 2.11 Formulation of the recommendations 15 2.12 Decision-making during the GDG meetings 16 2.13 Declaration of interests by external contributors 17 2.14 Document preparation and peer review 17 2.15 Presentation of guideline content 17 3. Evidence and recommendations 19 3.1 Care throughout labour and birth 19 3.2 First (...) of providing a comprehensive document for end-users. Recommendations The WHO technical consultations led to 56 recommendations on intrapartum care: 26 of these are newly developed recommendations and 30 are recommendations integrated from existing WHO guidelines. Recommendations are presented according to the intrapartum care context to which they are relevant, namely, care throughout labour and birth, care during the first stage of labour, care during the second stage of labour, care during the third

2018 World Health Organisation Guidelines

64. Management of Strongyloidiasis

and malabsorption may be present in chronic infection. The diagnosis was traditionally established by identifying larvae in feces (using the Baermann funnel technique), but this has been progressively replaced by commercially available serodiagnostic kits. The treatment of choice is single-dose ivermectin 200 µg/kg. An alternative is albendazole, but this is significantly less effective and is not recommended. Infection can be prevented by avoiding skin contact with soil that contains larvae. 1.2 WGO cascades (...) Strongyloides is endemic. Poverty, poor housing, poor sanitation; walking barefoot, living in an environment in which open defecation occurs Prisoners of war Refugee status—refugees from countries in which strongyloidiasis is endemic Travelers to and from endemic areas Some studies have reported male sex, advanced age, animal–human transmission, and humid, wet climates in the tropics and subtropics as risk factors [ ] 2.5 Risk factors and special groups at risk for disseminated infection Immunosuppressive

2018 World Gastroenterology Organisation

65. HIV and infant feeding in emergencies: operational guidance

Rescue Committee), Kirrily De Polnay (MSF), Caty Fall (Global Fund to Fight AIDs, Tuberculosis and Malaria), Alice Fay (Office of the United Nations High Commissioner for Refugees [UNHCR]), Rebekka Frick (GOAL), Diane Holland (UNICEF), Josephine Ippe (Global Nutrition Cluster), Sarah Karmin (UNICEF), Pe Thet Khin (Ministry of Health, Myanmar), David Lai (Global Health Cluster), Marie McGrath (ENN), Isabelle Modigell (Office of US Foreign Disaster Assistance), Ohnmar Mon (Yangon, Myanmar), Manaan (...) States Office of Foreign Disaster Assistance, as part of a body of work to produce the updated publication, Infant and young child feeding in emergencies. Operational guidance for emergency relief staff and programme managers , version 3, 2017 (OG-IFE); the HIV and infant feeding content of this publication is based on this guidance. ENN’s role was also supported by Irish Aid. WHO, UNICEF and ENN are grateful to all the individuals and institutions that contributed time and made other in-kind

2018 World Health Organisation Guidelines

66. Circulating Tumor DNA Analysis in Patients With Cancer: An ASCO/CAP Joint Review

first proposed by the Evaluation of Genomic Applications in Practice and Prevention initiative of the Centers for Disease Control with regard to genetic testing and later adopted and refined by a panel of the Institute of Medicine. The three terms are analytical validity, clinical validity, and clinical utility. Analytical validity refers to the ability of a test to accurately and reliably detect the variant(s) of interest and includes measures of accuracy, sensitivity, specificity, and robustness (...) tubes, without compromise of ctDNA detection or quantification. , , , - However, a head-to-head performance comparison of all tube types used for blood collection for ctDNA analysis has not been reported. Once peripheral blood is collected, it is typically processed through filtration or a sequential pair of centrifugations at low speed and high speed. - The significant excess of white cells compared with ctDNA in peripheral blood underscores the importance that either filtration or the first, low

2018 American Society of Clinical Oncology Guidelines

67. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology Full Text available with Trip Pro

, the pediatric needs of specimen management are also emphasized. There is intentional redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a guidance for physicians in choosing tests that will aid them to quickly and accurately diagnose infectious diseases in their patients. , , , , Contents Introduction and Executive Summary I. Bloodstream Infections and Infections of the Cardiovascular System II. Central Nervous System Infections III (...) is extremely low. e Legionella bacteremia occurs infrequently and rarely is the organism recovered from blood even when optimum culture techniques are employed. f The optimum urine specimen is the first voided specimen of the day. g Since yeast are highly aerobic, when fungemia due to yeast is suspected, it might be prudent within a series of blood cultures to inoculate at least 1 blood specimen into 2 aerobic vials rather than the customary aerobic and anaerobic vial pair. Alternatively, a broth medium

2018 Infectious Diseases Society of America

68. Improving Quality of Life: Substance Use and Aging

). In absolute terms, this is equivalent to a $30.9-billion increase in healthcare expenditures, or $905 per Canadian. As older adults represent a fast-growing, economically significant population, determining strategies for promoting successful aging will be essential to ensuring positive aging outcomes and controlling healthcare costs (see Chapter 2 for more discussion on that topic). Before reviewing the research on successful aging, it is first necessary to describe how the typical aging process unfolds (...) functioning; and social and productive engagement. This model was then incorporated into the MacArthur Foundation Research Network on Successful Aging study, which followed 1,000 older adults and was the first large-scale longitudinal study of successful aging. Despite the influence of Rowe and Kahn’s definition, there is currently no consensus on how to define successful aging. Depp and Jeste (2006) reviewed 28 studies on successful aging and identified 29 distinct definitions. Consistent with Rowe

2018 Canadian Centre on Substance Abuse

69. Australian Airborne Pollen and Spore Monitoring Network Interim Standard and Protocols

facilities (road safety, first aid kit, water, toilet etc.); ? Access policy and regulations (steps required to visit or work on the site and site rules if applicable and defined); ? Working alone policies o Carry mobile phone at all times; o Report to nominated contact person upon safe return to the working place from the field sampling within the scheduled time; ? Fire and emergency procedures; ? Medical emergency plans. Relevant examples of common pollen and spore monitoring risks and control measures (...) of quality data on exposure to allergenic pollen and fungal spores that can be used to enhance the quality of life of individuals with allergic diseases, assist with clinical diagnosis and management of patients and inform public health policy and practices. This Standard and Protocols document is designed to improve the consistency of processes between sites and to enhance reliability of data enabling better comparability of data derived from different locations across the continent. This is the first

2018 Australasian Society of Clinical Immunology and Allergy

70. Implementing Supervised Injection Services

are identified in two ways. First, stakeholders are recruited through a public call issued on the RNAO website (RNAO.ca/bpg/get-involved/stakeholder). Second, individuals and organizations with expertise in the guideline topic area are identified by the RNAO Best Practice Guideline Development Team and the expert panel, and are directly invited to participate in the review. Stakeholder reviewers are individuals with subject matter expertise in the guideline topic or those who may be affected (...) People Who Inject Drugs and Their Root Causes Health Complications Associated with Injection Drug Use Injection drug use is associated with high mortality compared to that of the general population. Major causes of death for people who inject drugs are related to drug overdose and AIDS-related mortality (16). Other health-related harms associated with injection drug use include high prevalence of hepatitis C (17–19), injection site infections and injuries (such as bacterial skin and soft tissue

2018 Registered Nurses' Association of Ontario

71. HTA of extending the HPV vaccination to boys

types and 9-valent vaccine that protects against nine HPV types. Ireland has a nationally funded, school-based, girls-only HPV immunisation programme (through the National Schools Immunisation Programme), based on the 4-valent vaccine. The aim of this assessment is to ascertain the clinical and cost- effectiveness of providing the HPV vaccine to boys in their first year as well. Organisational and ethical issues were also considered. Work on the assessment was undertaken by an Evaluation Team from (...) to undertake the HTA following a formal request from the Department of Health. The HTA aimed to establish the clinical and cost-effectiveness of extending the current immunisation programme, which offers the 4-valent HPV vaccine to all girls in their first year of second-level education (12 to 13 year olds), to a programme that includes boys. The HTA also examined the organisational, societal and ethical implications of the proposed change. HIQA’s advice to the National Immunisation Office (NIO

2018 Health Information and Quality Authority

72. LATITUDE NXT Patient Management System for monitoring cardiac devices at home

indications and settings. LATITUDE NXT Patient Management System for monitoring cardiac devices at home (MIB67) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 4 of 23About the technology CE marking CE marking The LATITUDE NXT Patient Management System (including the LATITUDE Communicator and the Communicator accessory and literature kit) is a class III device. Boston Scientific was first awarded a CE mark in March 2012 (...) in the UK have heart failure, commonly caused by coronary artery disease and previous heart attack (NICE guideline on chronic heart failure in adults). Both arrhythmia and heart failure can significantly affect a person's quality of life as well as putting them at risk of sudden cardiac death. The first-line treatment for arrhythmia and heart failure focuses on pharmacological therapy but when this is no longer effective or can no longer be used, one of the following implantable cardiac devices may

2016 National Institute for Health and Clinical Excellence - Advice

73. AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis

accuracy. AdenoPlus point-of-care test for diagnosing adenoviral conjunctivitis (MIB46) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 2 of 23T T echnical and patient factors echnical and patient factors AdenoPlus is a single-use diagnostic test. Each test kit comprises a sample collector, a test cassette and a buffer vial; the test result is available in around 10 minutes. The AdenoPlus test is intended to be used (...) the front of the eye. It may be caused by infection, allergy or an external irritant. People with infectious conjunctivitis usually present with symptoms including an irritated red eye with a watery or purulent discharge. Symptoms often appear in one eye at first and then spread to the other eye. Most people with conjunctivitis are first treated by GPs rather than eye care specialists (Azari and Barney 2013). In England, there were 4.5 million GP consultations concerning the eye in 2011–12 (Health

2015 National Institute for Health and Clinical Excellence - Advice

74. Social prescribing evidence map: technical report

949 records after duplicates removed. Titles screened 799 records excluded at title screening 57 records identified from other sources 62 sources included in evidence map 2 sources (protocols) not included in map 2 protocols excluded 10 Based on the problems they targeted these six types were considered to fall into two main types of non-clinical intervention. The first type predominantly targeted psychosocial need. These constituted link worker programmes; community arts programmes (...) score post-intervention was reported, but this was for only six of 73 people referred 15 . Of 36 individuals prescribed anti- depressants at the point of signposting, 14 were no longer prescribed afterwards, but the number of these who actually accessed a social prescribing intervention was not ascertained 15 . 5.1.5 Intervention design and implementation lessons The authors of the scoping review of studies on linking schemes identified involvement of health professionals in aiding the referral

2017 Public Health Wales Observatory Evidence Service

75. A literature review on community and institutional preparedness synergies

these meetings, such as lack of childcare or travel provision, must be addressed where possible to make sure those who want to play a role are able to [7]. EXAMPLE: In one Californian city, the police noticed a high level of violent crime. They first engaged with the community to obtain information on the frequency and nature of local crime and at the next community meeting, the police brought together a number of government departments including fire, housing authorities and public works. Community and city (...) preparedness synergies TECHNICAL REPORT iv Glossary Catastrophe An event is a catastrophe when the impact is regional, with most daily routines of individuals, families, businesses and governments completely disrupted. Most or all of the community area is heavily impacted and there are often many deaths. A key difference to a disaster is that, in a catastrophe, multiple regions are affected; thereby preventing help from communities close by, so national and international aid is required. However, this aid

2017 European Centre for Disease Prevention and Control - Literature Reviews

76. British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017.

Past or current comorbid conditions (e.g., inflammatory bowel disease, cardiovascular disease) Conception plans Body weight The person's views and any stated preference on administration route or frequency Adherence. Recommendation 15 . Be aware that the recommended first-line choice of biologic therapy will not be appropriate for every individual; use the decision aid and reference to Recommendation 14 to inform the choice of alternative licensed biologic therapies. ( Strong recommendation (...) of an intervention ) Recommendation 18 . Consider secukinumab as a first-line biologic agent in adults with psoriasis, with or without psoriatic arthritis. ( Weak recommendation for the use of an intervention ) Choice of Biologic Therapy in Adults: Second Line Recommendation 19 . Offer any of the currently licensed biologic therapies when psoriasis has not responded to a first biologic therapy. Use the decision aid (see the "Availability of Companion Documents" field) and take into account all factors detailed

2017 National Guideline Clearinghouse (partial archive)

77. Clinical indications, image acquisition and data interpretation for white blood cells and anti-granulocyte monoclonal antibody scintigraphy

devices for WBC labelling (Leukokit® and WBC Marker kit®) [9], functioning as disposable mini-isola- tors, has enormously facilitated the labelling procedure that, however, remains time consuming and requires with- drawing 30–40 ml of blood from patient. Once injected i.v. in the patient, radiolabelled WBC migrate rapidly to the lungs and, if not damaged, proceed to liver, spleen and the reticulo-endothelial system, including bone marrow. Approximately 1 h after injection, labeled cells further (...) Morethanamillionhipreplacementsareperformedeachyear worldwide,andthenumberofotherartificialjoints(shoulder, elbow,hip,knee)insertedisalsorising.Withincreasingnum- bers of implantations, mechanical and infected loosening of theprostheseshavebecomemorecommon.Theriskofinfec- tion is highest during the first two years after implantation. Differentiating infection from aseptic loosening is difficult because the clinical presentation and the histopathological changes in both entities can be similar, but at the same time is extremely important because

2018 European Association of Nuclear Medicine

78. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

. Gadberry AL. A survey of the use of aided augmentative and alternative communication during music therapy sessions with persons with autism spectrum disorders. J Music Ther. 2011 Spring;48(1):74-89. PMID: 21866714.X-1 628. Gale CM, Eikeseth S, Rudrud E. Functional assessment and behavioural intervention for eating difficulties in children with autism: a study conducted in the natural environment using parents and ABA tutors as therapists. J Autism Dev Disord. 2011 Oct;41(10):1383-96. doi: 10.1007 (...) -2788.2011.01455.x. PMID: 21806693.X-1 635. Gerdts J, Bernier R. The broader autism phenotype and its implications on the etiology and treatment of autism spectrum disorders. Autism Res Treat. 2011;2011:545901. doi: 10.1155/2011/545901. PMID: 22937250.X- 1 636. Ghanizadeh A. c-Kit+ cells transplantation as a new treatment for autism, a novel hypothesis with important research and clinical implication. J Autism Dev Disord. 2011 Nov;41(11):1591-2. doi: 10.1007/s10803-010-1174-9. PMID: 21225454. X-2 637

2017 Effective Health Care Program (AHRQ)

79. HPV Testing for Primary Cervical Cancer Screening — Project Protocol

undergo screening. Therefore, screening improves survival from cervical cancer. 19 The evaluation of screening procedures can be considered using six criteria: validity, reliability, yield, cost, acceptance, and the availability of follow-up services. 20 The first three criteria are related to the performance of the screening test. Validity refers to the ability of the screening test to separate those with and without the condition of interest. Diagnostic test accuracy outcomes, such as sensitivity (...) reported that in the first screening round, significantly higher numbers of CIN2, CIN2+, and CIN3+ were detected in women who were screened with HPV testing compared with those who had cytology. In the second round, lower numbers of CIN2+ and CIN3+ were detected in the women who underwent HPV testing at first screening. An interpretation of these results proposes that HPV testing performs better than cytology as a tool for early detection of clinically significant CIN, allowing prompt follow-up

2017 CADTH - Optimal Use

80. Screening for Hepatitis C Virus: A Systematic Review

of effect of HCV screening relative to a comparator. GRADE was likewise not used to assess confidence in findings for cost-effectiveness, as the methods for the assessment of evidence derived from cost-effectiveness analysis studies have not yet been established. A total of five main findings related to participant preferences and values related to HCV screening were evaluated with CERQual. The level of confidence was graded as moderate for the three main findings pertaining to the first descriptive (...) important considerations for the implementation of screening programs for these groups. A large range was observed for the proportion of patients who tested positive on both an Ab or Ag test and a PCR test. Based on results reported by studies conducted in a general population with a large sample size (n > 1,000), Ab tests may be acceptable as a first step in a screening pathway. These tests are sufficiently able to identify individuals with active HCV infection, indicated by the presence of viral RNA

2017 CADTH - Health Technology Assessment

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