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41. Best Practices on Periodicity of Examination, Preventive Dental Services, Anticipatory Guidance/Counseling, and Oral Treatment for Infants, Children, and Adolescents

as the first primary teeth erupt and be reassessed periodically by dental and medical providers. 6,25 Its goal is to prevent disease by (1) identifying children at high risk for caries, (2) developing individualized preventive measures and caries management, as well as (3) aiding the practitioner in determining appropriate periodicity of services. 25,52,53 Given that the etiology of dental caries is multifactorial and complex, current caries-risk assessment models entail a combination of factors including (...) injuries could have improved outcomes not only if the public were aware of first-aid measures and the need to seek immediate treatment, but also if the injured child had access to emergency care at all times. Caregivers report that, even though their children had a dental home, they have experienced barriers to care when referred outside of the dental home for emergency services. 112 Barriers faced by caregivers include availability of providers and clinics for delivery of emergency care

2018 American Academy of Pediatric Dentistry

42. WHO recommendations: intrapartum care for a positive childbirth experience

Integration of recommendations from published WHO guidelines 13 2.8 Focus and approach 13 2.9 Evidence identification and retrieval 13 2.10 Quality assessment and grading of the evidence 14 2.11 Formulation of the recommendations 15 2.12 Decision-making during the GDG meetings 16 2.13 Declaration of interests by external contributors 17 2.14 Document preparation and peer review 17 2.15 Presentation of guideline content 17 3. Evidence and recommendations 19 3.1 Care throughout labour and birth 19 3.2 First (...) of providing a comprehensive document for end-users. Recommendations The WHO technical consultations led to 56 recommendations on intrapartum care: 26 of these are newly developed recommendations and 30 are recommendations integrated from existing WHO guidelines. Recommendations are presented according to the intrapartum care context to which they are relevant, namely, care throughout labour and birth, care during the first stage of labour, care during the second stage of labour, care during the third

2018 World Health Organisation Guidelines

43. Circulating Tumor DNA Analysis in Patients With Cancer: An ASCO/CAP Joint Review

first proposed by the Evaluation of Genomic Applications in Practice and Prevention initiative of the Centers for Disease Control with regard to genetic testing and later adopted and refined by a panel of the Institute of Medicine. The three terms are analytical validity, clinical validity, and clinical utility. Analytical validity refers to the ability of a test to accurately and reliably detect the variant(s) of interest and includes measures of accuracy, sensitivity, specificity, and robustness (...) tubes, without compromise of ctDNA detection or quantification. , , , - However, a head-to-head performance comparison of all tube types used for blood collection for ctDNA analysis has not been reported. Once peripheral blood is collected, it is typically processed through filtration or a sequential pair of centrifugations at low speed and high speed. - The significant excess of white cells compared with ctDNA in peripheral blood underscores the importance that either filtration or the first, low

2018 American Society of Clinical Oncology Guidelines

44. Management of Strongyloidiasis

and malabsorption may be present in chronic infection. The diagnosis was traditionally established by identifying larvae in feces (using the Baermann funnel technique), but this has been progressively replaced by commercially available serodiagnostic kits. The treatment of choice is single-dose ivermectin 200 µg/kg. An alternative is albendazole, but this is significantly less effective and is not recommended. Infection can be prevented by avoiding skin contact with soil that contains larvae. 1.2 WGO cascades (...) Strongyloides is endemic. Poverty, poor housing, poor sanitation; walking barefoot, living in an environment in which open defecation occurs Prisoners of war Refugee status—refugees from countries in which strongyloidiasis is endemic Travelers to and from endemic areas Some studies have reported male sex, advanced age, animal–human transmission, and humid, wet climates in the tropics and subtropics as risk factors [ ] 2.5 Risk factors and special groups at risk for disseminated infection Immunosuppressive

2018 World Gastroenterology Organisation

45. HIV and infant feeding in emergencies: operational guidance

Rescue Committee), Kirrily De Polnay (MSF), Caty Fall (Global Fund to Fight AIDs, Tuberculosis and Malaria), Alice Fay (Office of the United Nations High Commissioner for Refugees [UNHCR]), Rebekka Frick (GOAL), Diane Holland (UNICEF), Josephine Ippe (Global Nutrition Cluster), Sarah Karmin (UNICEF), Pe Thet Khin (Ministry of Health, Myanmar), David Lai (Global Health Cluster), Marie McGrath (ENN), Isabelle Modigell (Office of US Foreign Disaster Assistance), Ohnmar Mon (Yangon, Myanmar), Manaan (...) States Office of Foreign Disaster Assistance, as part of a body of work to produce the updated publication, Infant and young child feeding in emergencies. Operational guidance for emergency relief staff and programme managers , version 3, 2017 (OG-IFE); the HIV and infant feeding content of this publication is based on this guidance. ENN’s role was also supported by Irish Aid. WHO, UNICEF and ENN are grateful to all the individuals and institutions that contributed time and made other in-kind

2018 World Health Organisation Guidelines

46. AASLD Guidelines for Treatment of Chronic Hepatitis B

Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY Ochsner Medical Center, New Orleans, LA Division of Clinical Decision Making, Tufts Medical Center, Tufts University School of Medicine, Boston, MA First published: 05 February 2018 Cited by: Potential conflict of interest: Dr. Hwang received grants from Merck and Gilead. Dr. Chang advises Arbutus. Dr. Lok received grants from Gilead and Bristol‐Myers Squibb. Dr. Jonas consults for Gilead and received grants from (...) Entecavir dose is 1 mg daily if the patient is lamivudine experienced or if they have decompensated cirrhosis. Abbreviation: TSH, thyroid stimulating hormone. Table 2. Efficacy of Approved First‐Line Antiviral Therapies in Adults with Treatment‐Naïve Chronic Hepatitis B and Immune‐Active Disease (Not Head‐to‐Head Comparisons) HBeAg Positive Peg‐IFN a Assessed 6 months after completion of 12 months of therapy. Entecavir b Assessed after 3 years of continuous therapy. Tenofovir Disoproxil Fumarate b

2018 American Association for the Study of Liver Diseases

47. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology

, the pediatric needs of specimen management are also emphasized. There is intentional redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a guidance for physicians in choosing tests that will aid them to quickly and accurately diagnose infectious diseases in their patients. , , , , Contents Introduction and Executive Summary I. Bloodstream Infections and Infections of the Cardiovascular System II. Central Nervous System Infections III (...) is extremely low. e Legionella bacteremia occurs infrequently and rarely is the organism recovered from blood even when optimum culture techniques are employed. f The optimum urine specimen is the first voided specimen of the day. g Since yeast are highly aerobic, when fungemia due to yeast is suspected, it might be prudent within a series of blood cultures to inoculate at least 1 blood specimen into 2 aerobic vials rather than the customary aerobic and anaerobic vial pair. Alternatively, a broth medium

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2018 Infectious Diseases Society of America

48. Best Practices across the Continuum of Care for the Treatment of Opioid Use Disorder

and nasal forms of naloxone as open benefits for First Nations and Inuit people under the non-insured health benefits program. Correctional Services of Canada has developed a national project to provide individuals being released from incarceration with access to a take-home naloxone kit. Across Canada, naloxone can be obtained at pharmacies without a prescription (without a fee in some areas) for anyone concerned about the risk of overdose for themselves or others. The Honourable Ginette Petitpas (...) ? Detoxification should be avoided; methadone and buprenorphine are safe for treatment during pregnancy. 7,22 Pharmacological Interventions Youth ? Bup/nal should be the first-line opioid therapy for youth, and only opioid therapy for youth that live or frequently travel to communities where methadone is not available. 87,88 ? Buprenorphine, methadone and naltrexone can be considered for youth. 7 Women who are pregnant ? Opioid agonist therapy should be initiated or maintained during pregnancy, 7,16,87 labour

2018 Canadian Centre on Substance Abuse

49. Improving Quality of Life: Substance Use and Aging

). In absolute terms, this is equivalent to a $30.9-billion increase in healthcare expenditures, or $905 per Canadian. As older adults represent a fast-growing, economically significant population, determining strategies for promoting successful aging will be essential to ensuring positive aging outcomes and controlling healthcare costs (see Chapter 2 for more discussion on that topic). Before reviewing the research on successful aging, it is first necessary to describe how the typical aging process unfolds (...) functioning; and social and productive engagement. This model was then incorporated into the MacArthur Foundation Research Network on Successful Aging study, which followed 1,000 older adults and was the first large-scale longitudinal study of successful aging. Despite the influence of Rowe and Kahn’s definition, there is currently no consensus on how to define successful aging. Depp and Jeste (2006) reviewed 28 studies on successful aging and identified 29 distinct definitions. Consistent with Rowe

2018 Canadian Centre on Substance Abuse

50. HTA of extending the HPV vaccination to boys

types and 9-valent vaccine that protects against nine HPV types. Ireland has a nationally funded, school-based, girls-only HPV immunisation programme (through the National Schools Immunisation Programme), based on the 4-valent vaccine. The aim of this assessment is to ascertain the clinical and cost- effectiveness of providing the HPV vaccine to boys in their first year as well. Organisational and ethical issues were also considered. Work on the assessment was undertaken by an Evaluation Team from (...) to undertake the HTA following a formal request from the Department of Health. The HTA aimed to establish the clinical and cost-effectiveness of extending the current immunisation programme, which offers the 4-valent HPV vaccine to all girls in their first year of second-level education (12 to 13 year olds), to a programme that includes boys. The HTA also examined the organisational, societal and ethical implications of the proposed change. HIQA’s advice to the National Immunisation Office (NIO

2018 Health Information and Quality Authority

51. Renal Cell Carcinoma

. Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. Eur Urol, 2016. 69: 660. 147. Motzer, R.J., et al. Phase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma. J Clin Oncol, 2014. 32: 2765. 148. Wood, B.J., et al. Imaging guided biopsy of renal masses: indications, accuracy and impact on clinical management. J Urol, 1999

2018 European Association of Urology

52. Chronic Pelvic Pain

: guidance for study inclusion criteria, outcome measurement and clinical practice. Aliment Pharmacol Ther, 2010. 32: 1192. 274. Slieker-ten Hove, M.C., et al. Face validity and reliability of the first digital assessment scheme of pelvic floor muscle function conform the new standardized terminology of the International Continence Society. Neurourol Urodyn, 2009. 28: 295. 275. Wyndaele, J.J., et al. Reproducibility of digital testing of the pelvic floor muscles in men. Arch Phys Med Rehabil, 1996. 77

2018 European Association of Urology

53. Community design factors and their influence on physical activity in the aging population: A Rapid Review

? Issue and Context With a significant demographic shift towards an aging population, Peel Public Health would like to determine how well its approach to creating healthy communities addresses the specific attributes of the aging population. As older adults travel less frequently outside their own neighbourhood and have more mobility limitations, they may be more vulnerable to the influence of the built environment. Physical activity levels also decline with age. Emerging evidence indicates (...) , recreation and open space. Convenient access to public transportation and options for safe, non- motorized travel is also provided (1). Density refers to a measurement of the number of families, individuals, employees, dwelling units, households or housing structures per unit of land area. Land use mix refers to the composition of housing types, services, and employment in an area. i Unless otherwise indicated, definitions are taken from the Health Background Study Framework (2011) which can be accessed

2017 Peel Health Library

54. Screening for Hepatitis C Virus: A Systematic Review

of effect of HCV screening relative to a comparator. GRADE was likewise not used to assess confidence in findings for cost-effectiveness, as the methods for the assessment of evidence derived from cost-effectiveness analysis studies have not yet been established. A total of five main findings related to participant preferences and values related to HCV screening were evaluated with CERQual. The level of confidence was graded as moderate for the three main findings pertaining to the first descriptive (...) important considerations for the implementation of screening programs for these groups. A large range was observed for the proportion of patients who tested positive on both an Ab or Ag test and a PCR test. Based on results reported by studies conducted in a general population with a large sample size (n > 1,000), Ab tests may be acceptable as a first step in a screening pathway. These tests are sufficiently able to identify individuals with active HCV infection, indicated by the presence of viral RNA

2017 CADTH - Health Technology Assessment

55. HPV Testing for Primary Cervical Cancer Screening — Project Protocol

undergo screening. Therefore, screening improves survival from cervical cancer. 19 The evaluation of screening procedures can be considered using six criteria: validity, reliability, yield, cost, acceptance, and the availability of follow-up services. 20 The first three criteria are related to the performance of the screening test. Validity refers to the ability of the screening test to separate those with and without the condition of interest. Diagnostic test accuracy outcomes, such as sensitivity (...) reported that in the first screening round, significantly higher numbers of CIN2, CIN2+, and CIN3+ were detected in women who were screened with HPV testing compared with those who had cytology. In the second round, lower numbers of CIN2+ and CIN3+ were detected in the women who underwent HPV testing at first screening. An interpretation of these results proposes that HPV testing performs better than cytology as a tool for early detection of clinically significant CIN, allowing prompt follow-up

2017 CADTH - Optimal Use

56. Consolidated guideline on sexual and reproductive health and rights of women living with HIV

(Department of Reproductive Health and Research [RHR]), Rachel Baggaley (Department of HIV/ AIDS), John Beard (Department of Ageing and Life Course [ALC]), Ana Pilar Betrán Lazaga (Department of RHR), Francoise Bigirimana (WHO Regional Office for Africa), Sonja Caffe (WHO Regional Office for the Americas/Pan American Health Organization [PAHO]), Rebekah Bosco Thomas (Gender, Equity and Human Rights T eam), Nathalie Broutet (Department of RHR), T arun Dua (Department of Mental Health and Substance Abuse (...) [MSD]), Shaffiq Essajee (Department of HIV/AIDS), Jane Ferguson (Department of Maternal, Newborn, Child and Adolescent Health [MCA]), Mario Festin (Department of RHR), Bela Ganatra (Department of RHR), Claudia García Moreno (Department of RHR), Fahmy Hanna (Department of MSD), Rajat Khosla (Department of RHR), Gunta Lazdane (WHO Regional Office for Europe), Ramez Mahaini (WHO Regional Office for the Eastern Mediterranean), Léopold Ouedraogo (WHO Regional Office for Africa), Razia Pendse (WHO

2017 World Health Organisation Guidelines

57. British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017.

Past or current comorbid conditions (e.g., inflammatory bowel disease, cardiovascular disease) Conception plans Body weight The person's views and any stated preference on administration route or frequency Adherence. Recommendation 15 . Be aware that the recommended first-line choice of biologic therapy will not be appropriate for every individual; use the decision aid and reference to Recommendation 14 to inform the choice of alternative licensed biologic therapies. ( Strong recommendation (...) of an intervention ) Recommendation 18 . Consider secukinumab as a first-line biologic agent in adults with psoriasis, with or without psoriatic arthritis. ( Weak recommendation for the use of an intervention ) Choice of Biologic Therapy in Adults: Second Line Recommendation 19 . Offer any of the currently licensed biologic therapies when psoriasis has not responded to a first biologic therapy. Use the decision aid (see the "Availability of Companion Documents" field) and take into account all factors detailed

2017 National Guideline Clearinghouse (partial archive)

58. A literature review on community and institutional preparedness synergies

these meetings, such as lack of childcare or travel provision, must be addressed where possible to make sure those who want to play a role are able to [7]. EXAMPLE: In one Californian city, the police noticed a high level of violent crime. They first engaged with the community to obtain information on the frequency and nature of local crime and at the next community meeting, the police brought together a number of government departments including fire, housing authorities and public works. Community and city (...) preparedness synergies TECHNICAL REPORT iv Glossary Catastrophe An event is a catastrophe when the impact is regional, with most daily routines of individuals, families, businesses and governments completely disrupted. Most or all of the community area is heavily impacted and there are often many deaths. A key difference to a disaster is that, in a catastrophe, multiple regions are affected; thereby preventing help from communities close by, so national and international aid is required. However, this aid

2017 European Centre for Disease Prevention and Control - Literature Reviews

59. Handbook on using the ECDC preparedness checklist tool to strengthen preparedness against communicable disease outbreaks at migrant reception/detention centres

, preventing the outbreak from occurring in the first place by assessing the vulnerabilities/susceptibilities of the population hosted at the reception/detention centre. This involves the rapid identification and clinical/public health management (isolation if appropriate, or treatment) of any contagious individual who could potentially become an index case of an outbreak. Medium-term migrant reception/detention centres do not always receive migrants immediately upon arrival. If migrants are not offered (...) settings to prevent, detect and control communicable disease (details on the scoping review methodology and main findings are available in Box 1). The scope and structure of the tool described in this document are based on the review. One of the first elements adopted from the scoping review was the identification of the appropriate scope for the tool. The tool assesses preparedness capacity in relation to the medium-term accommodation of migrants within centres, thereby complementing an existing tool

2016 European Centre for Disease Prevention and Control - Technical Guidance

60. Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents

and Adolescents A detailed description of the methodology used to conduct the literature search and systematic review for this clinical practice guideline will be included in the forthcoming technical report. In brief, reference selection involved a multistep process. First, 2 subcommittee members reviewed the titles and abstracts of references identified for each key question. The epidemiologist provided a deciding vote when required. Next, 2 subcommittee members and the epidemiologist conducted full-text (...) adult guideline and facilitate the management of older adolescents with high BP. The percentile-based values in and are provided to aid researchers and others interested in a more precise classification of BP. 3.2a. Simplified BP Table This guideline includes a new, simplified table for initial BP screening (see ) based on the 90th percentile BP for age and sex for children at the 5th percentile of height, which gives the values in the table a negative predictive value of >99%. This simplified table

2017 American Academy of Pediatrics

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