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21. Optimisation of RIZIV – INAMI lump sums for incontinence

(doctoral study incontinence in elderly), Ronny Pieters (master studies nursing), Anja Declercq (BelRAI) Consultancy or employment for a company, an association or an organisation that may gain or lose financially due to the results of this report: Ronny Pieters (Coloplast – Teleflex), Rudi Wyffels (N.V. Paul Hartmann S.A. producer of incontinence material) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Els Bakker (various), Veerle Decalf (non (...) , TREATMENT AND TOILETING AIDS 178 8.8.1 Assessment of the current situation 178 8.8.2 Proposals for improvement 180 8.9 OPTIMISING THE PATHWAYS TO THE LUMP SUMS 182 8.9.1 Assessment of the current situation 182 8.9.2 Proposals for improvement 182 8.10 FINANCIAL ACCESSIBILITY OF TREATMENTS AND SUPPORT AIDS 183 8.10.1 Assessment of the current situation 183 8.10.2 Proposals for improvement 184 8.11 PATIENT INFORMATION ON SUPPORT AIDS 184 8.11.1 Assessment of the current situation 184 8.11.2 Proposals

2020 Belgian Health Care Knowledge Centre

22. Antimicrobial stewardship: changing risk-related behaviours in the general population

in the general population (NG63) © NICE 2019. All rights reserved. Subject to Notice of rights ( conditions#notice-of-rights). Page 13 of 44stewardship). Raise awareness of community pharmacists as an easily accessible first point of contact for advice about managing a self-limiting infection. 1.5.2 Consider using computer prompts or decision support aids to prompt healthcare professionals to share information with people on the appropriate use of antimicrobials, self-care (...) if they have been obtained from anywhere other than their healthcare professional or pharmacist (for example, prescription-only antimicrobials bought online without a prescription). Ask for antimicrobials as a preventive measure against becoming ill or as a 'stand-by' measure; for example, when going on holiday (unless the person has a specific condition that makes this necessary or there is a specific risk; for example, if travelling to areas where malaria is endemic [see the antimalarial medication

2017 National Institute for Health and Clinical Excellence - Clinical Guidelines

23. Systemic Adjuvant Therapy for Adult Patients at High Risk for Recurrent Melanoma

[Cotellic®], trametinib), KIT inhibitors (imatinib mesylate or imatinib [Gleevec® and generic products]), and vascular endothelial growth factor (VEGF) inhibitors (bevacizumab [Avastin® and generic products]). Signal transduction pathways regulate cell proliferation, cell differentiation, and cell death [73]. The mitogen-activated protein kinase (MAPK) pathway includes the RAS G protein and RAF, MEK, and ERK protein kinases; it is thus also referred to as the RAS-RAF-MEK-ERK pathway [74]. A signal from (...) patients after six to seven months [87,89], trials evaluating combination therapy have been conducted. As dabrafenib and vemurafenib share similar resistance mechanisms, combination with MEK inhibitors may be more effective [87,90,91]. This may also be the case for BRAF mutations other than V600E/K which have lower or unknown response to BRAF inhibitors alone. The phosphatidylinositol 3-kinase and protein kinase B pathway (PI3K-AKT) [88] is a strong regulator of melanoma growth and survival. The KIT

2019 Cancer Care Ontario

24. Management of Poisoning

to address the local lesion. Grade D, Level 4 D Secondary infection, chronic ulcer and osteomyelitis can occur. Prophylactic antibiotic should be given in contaminated wounds (pg 198). Grade D, Level 4 B First aid for stingray and stone? sh stings is hot, non-scalding (not higher than 45°C) water immersion as the venom is heat labile (pg 198). Grade B, Level 2++ A Hot water immersion may be useful for pain relief following jelly? sh stings after the tentacles have been removed (pg 198). Grade A, Level 1 (...) -release preparation; the poison slows gastrointestinal motility (pg 65). Grade D, Level 34 C Use of activated charcoal should not be used at home as ? rst aid because its bene? t has not been proven (pg 65). Grade C, Level 2+ Gastric lavage C Gastric lavage should not be employed routinely, if ever, in the management of poisoned patients. In certain cases where the procedure is of attractive theoretical bene? t (e.g. recent ingestion of a very toxic substance), the substantial risks should be weighed

2020 Ministry of Health, Singapore

25. A palliative approach to care in the last 12 months of life

. First, and most important, we thank the Government of Ontario, which recognizes RNAO’s capacity to lead a program that has gained worldwide recognition and is committed to funding it. We also thank the co-chairs of the RNAO expert panel, Lesley Hirst (Regional Palliative Care Network Director, Hamilton Niagara Haldimand Brant Local Health Integration Network) and Dr. Christine McPherson (Associate Professor, University of Ottawa), for their invaluable expertise and stewardship of this BPG. Thank you (...) capture of process and outcome measures. The ability to link structure and process indicators with specific client outcome indicators aids in determining the impact of BPG implementation on specific client health outcomes. Please visit for more information.21 BEST PRACTICE GUIDELINES • BACKGROUND A Palliative Approach to Care in the Last 12 Months of Life Registered Nurses’ Association of Ontario (RNAO) Best Practice Guidelines Development and Research Team

2020 Registered Nurses' Association of Ontario

26. Small Intestinal Bacterial Overgrowth

for patients not able to travel or in remote locations. Often these kits are directed to laboratories with Clinical Laboratory Improvement Amendments certification and as such have more stringent validation/calibration supervision as compared to clinicians offices. However, diet precautions before test, substrate ingestion, and breath test collection occur in a home setting that may not be strictly controlled. The premise of breath tests is that human cells are incapable of producing hydrogen and methane (...) abdominal pain, gas, bloating, diarrhea, and/or malabsorptive symptoms. DIAGNOSIS OF SIBO Breath testing Quantitative measurement of breath hydrogen and/or methane is a relatively inexpensive, noninvasive, easy, and widely available test. Since the clinical definition of SIBO is unclear in the absence of validated patient-reported outcomes (PROs), the use of breath testing for SIBO is recognized as a key concept in but not a GRADEable guideline. Newer mail-in kits are available for home testing

2020 American College of Gastroenterology

27. Preventing and Managing Infectious Diseases Among People who Inject Drugs in Ontario

of the problem and three elements for addressing it, in consultation with the Steering Committee and a number of key informants, and with the aid of several conceptual frameworks that organize thinking about ways to approach the issue; 3) identifying, selecting, appraising and synthesizing relevant research evidence about the problem, options and implementation considerations; 4) drafting the evidence brief in such a way as to present concisely and in accessible language the global and local research (...) and costs of a potentially comprehensive approach to address the problem may vary across groups. Implementation considerations may also vary across groups. One way to identify groups warranting particular attention is to use “PROGRESS,” which is an acronym formed by the first letters of the following eight ways that can be used to describe groups†: • place of residence (e.g., rural and remote populations); • race/ethnicity/culture (e.g., First Nations and Inuit populations, immigrant populations

2019 McMaster Health Forum

28. Treatment of Patients with Schizophrenia

Management and Recovery 52 Psychoeducation 54 Social Skills Training 58 Supported Employment 61 Supportive Therapy 65 Early Interventions for Patients With First-episode Psychosis 68 Co-occurring Substance Use and Schizophrenia 72 10 Acronyms/Abbreviations ACT Assertive community treatment AHRQ Agency for Healthcare Research and Quality AIMS Abnormal Involuntary Movement Scale APA American Psychiatric Association ANCs Absolute neutrophil counts BAP British Association for Psychopharmacology BMI Body mass (...) and Statistical Manual of Mental Disorders DSM-5 Diagnostic and Statistical Manual of Mental Disorders, 5th Edition ECG Electrocardiography ECT Electroconvulsive therapy ER Extended release FDA Food and Drug Administration FGA First-generation antipsychotic GAF Global Assessment of Functioning GRADE Grading of Recommendations Assessment, Development and Evaluation HIPAA Health Insurance Portability and Accountability Act HIV Human immunodeficiency virus HR Hazard ratio ICD International Classification

2020 American Psychiatric Association

29. Handbook on designing and implementing an immunisation information system

, and the place for IIS within it, before we discuss the eHealth environment and technical context that sets the stage for IIS development at the country level. - We recommend that this section be read first by all readers before moving on to the other sections as it provides a holistic perspective of IIS. • Section 2 (IIS functions and value) delves deeper into answering the core question of what an IIS is and what it delivers. We describe various potential functionalities and present the added value of IIS (...) centralised top-down and decentralised bottom-up strategies. We then discuss system-level considerations, considering the conceptual design behind each of the key IIS components, and illustrate each with an example of how the component has been implemented into SYSVAK, the Norwegian IIS, and other international systems. - We suggest first identifying the problem, and then the IIS needs and key functions that will meet them, before identifying the minimum fields required to support the key functions. We

2019 European Centre for Disease Prevention and Control - Technical Guidance

30. Community-based mental health and wellbeing support for refugees

, with programs near to where participants live facilitating access by reducing the need for travel and its associated expense. Programs with soft entry points, that is referral from trusted organisations/leaders within the refugee community, thus creating a sense of confidence for participants, are useful and should be encouraged. Some programs were noted to offer child minding which can be important in promoting the use of programs for those with childcare responsibilities. Cultural competence (...) and wellbeing in this population, a first step is to document and categorise the main types of programs that have been reported on in the evaluations. Our review demonstrated the diversity of psychosocial support programs that exist in this field. However, it is clear that while the types of programs vary, a very strong and consistent theme that emerged was a focus on being community or group based in setting and nature. This is not surprising since the characterisation of refugee trauma and disruption

2019 Sax Institute Evidence Check

31. Public health guidance on HIV, hepatitis B and C testing in the EU/EEA

de Carvalho Gomes from ECDC and the ECDC Library, and produced by a consortium led by CHIP/Region H, Rigshospitalet, University of Copenhagen (CHIP/Region H) with Public Health England (PHE), St Stephen’s AIDS Trust (SSAT) and the European Aids Treatment Group (EATG), framework contract ECDC/2016/035. Authors Ann Sullivan, SSAT, Ayla van Ahee, Pallas Health Research and Consultancy (Pallas (HRC), Caroline Rae, SSAT, Dorthe Raben, CHIP/Region H, Rigshospitalet, Lauren Combs, CHIP/Region H, Lauren (...) , United Kingdom Bartosz Szetela, Wroclaw Medical University, Poland Dagmar Hedrich, European Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Portugal Daniel Simões, EATG/Grupo de Ativistas em Tratamentos, Portugal Deniz Gokengin, IUSTI, Turkey Eve Robinson, Ireland Irena Klavs, National Institute of Public Health (NIJZ), Slovenia Irene Veldhuijzen, National Institute for Public Health and the Environment (RIVM), Netherlands Jan van Bergen, Soa Aids Nederland, Netherlands Jason Farrell

2019 European Centre for Disease Prevention and Control - Public Health Guidance

32. Evidence summary of immunity response following infection with COVID-19

transient mild conjunctivitis and a body temperature of 37.3). Seroconversion Patient was asymptomatic. Exposure could be as early as 20 January. Retrospective analysis of admission sample (17 days after first travel to Wuhan): IF results showed positivity for both IgG and IgM (=?1:640 and 1:80, respectively) at the same time point of the first viral RNA positive result. Re-detectable positive Nasopharyngeal swab was positive every day until day 11, negative day 12 and 13, positive day 14 to 16 (...) on the rate and timing of antibody detection after infection, the duration of the immune response, the reinfection rate and the association between these responses and the severity of initial disease. ? The detection rate or timing of antibodies following acute SARS-CoV-2 infection was assessed in 23 studies. Immunoglobulin M (IgM) titres were typically the first to rise in acute infection, followed by immunoglobulin G (IgG), with IgG tending to persist for much longer in the body. The median time

2020 Health Information and Quality Authority

33. Rapid HTA of alternative diagnostic testing for coronavirus 2 (SARS-CoV-2)

O’Brien, Dr Kieran Walsh, Dr Conor Teljeur, Dr Máirín Ryan. Conflicts of interest None reported. Version history Version Date Description of change V1.0 22.04.2020 Date of first publication V1.1 05.05.2020 Minor wording amendments in chapters 5 and 6 Updated Table A.1 in Appendix A Addition of Table A.2 in Appendix A Rapid HTA of Alternative Diagnostic Technologies for the Detection of SARS-CoV-2 Health Information and Quality Authority Page 5 of 121 List of abbreviations used in this report ARI acute (...) standard for clinical diagnostics. The initial identification of the SARS-CoV-2 virus was based on non-commercial RT-PCR laboratory protocols which were published on the World Health Organization (WHO) website. The testing protocols include multiple steps involving manual manipulation and take six to seven hours to complete. However, RT-PCR is not a new technology; it is widely used in specialised diagnostic virology laboratories. Therefore, companies have developed and commercialised RT-PCR test kits

2020 Health Information and Quality Authority

34. AIM Clinical Appropriateness Guidelines for Pharmacogenetic Testing and Genetic Testing for Thrombotic Disorders

results will impact long term medication management and at least one of the following: - There is concern for homozygous F2 or F5 or compound heterozygous F2/F5 PROPRIETARY Guidelines developed by, and used with permission from, Informed Medical Decisions, Inc. © 2019 Informed Medical Decisions, Inc. All Rights Reserved. 4 - The annual risk of recurrent VTE is estimated to be between 5% and 10% ? Individual who has a first-degree relative with F5 or F2 thrombophilia and one of the following: - Surgery (...) the clinical utility of panel testing for multiple genes. There are a number of clinically available combined pharmacogenomic panel tests designed to evaluate variants within multiple genes to provide guidance for prescribing and dosing various medications which may ultimately aid in addressing the recognized PROPRIETARY Guidelines developed by, and used with permission from, Informed Medical Decisions, Inc. © 2019 Informed Medical Decisions, Inc. All Rights Reserved. 8 need to alleviate prolonging

2020 AIM Specialty Health

35. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU

: Grade C) 8. Clinicians should not treat ASB in patients. (Strong Recommendation; Evidence Level: Grade B) Antibiotic Treatment 9. Clinicians should use first-line therapy (i.e., nitrofurantoin, TMP-SMX, fosfomycin) dependent on the local antibiogram for the treatment of symptomatic UTIs in women. (Strong Recommendation; Evidence Level: Grade B) 10. Clinicians should treat rUTI patients experiencing acute cystitis episodes with as short a duration of antibiotics as reasonable, generally no longer (...) . In the first phase, investigators reviewed full-text articles to identify systematic reviews for inclusion. In the second phase they reviewed full-text articles to address key questions not sufficiently answered by previously published systematic reviews, or recent publications to update previously published systematic reviews. Database searches resulted in 6,153 potentially relevant articles. After dual review of abstracts and titles, 214 systematic reviews and individual studies were selected for full

2019 Canadian Urological Association

36. Handbook on tuberculosis laboratory diagnostic methods in the European Union

and electrical emergencies. An emergency shower and an eyewash facility should also be installed. ? Suitably equipped and readily accessible first-aid areas or rooms should be available near the BSL3 laboratory. The personnel of a BSL3 laboratory should ideally have received first-aid training. ? A mechanical ventilation system should provide an inward flow of air without recirculation. ? There should be a reliable and adequate electricity supply and emergency lighting to permit safe exit. A back-up system (...) and Vladyslav Nikolayevskyy. This report was sent for consultation to the members of the ERLTB-Net network (see Appendix 1 for list of contributors). The first version of this ECDC technical report, previously published as ‘Mastering the basics of TB control: Development of a handbook on TB diagnostic methods’ (Stockholm 2011), concerned the development of the handbook that was included as an annex. This report was revised and renamed ‘Handbook on TB laboratory diagnostic methods in the European Union

2018 European Centre for Disease Prevention and Control - Technical Guidance

37. Masitinib mesylate (Alsitek) - Amyotrophic Lateral Sclerosis

-Rapporteur: Eleftheria Nikolaidi The application was received by the EMA on 12 September 2016 The procedure started on 29 September 2016 The Rapporteur's first Assessment Report was circulated to all CHMP members on 22 December 2016 The Co-Rapporteur's first Assessment Report was circulated to all CHMP members on 29 December 2016 The PRAC Rapporteur's first Assessment Report was circulated to all PRAC members on 3 January 2017 The CHMP agreed on the consolidated List of Questions to be sent (...) candidate gene studies have identified several susceptibility genes, although the relative contribution of every identified “at risk” gene rarely exceeds an odds ratio of 2.0, and the mechanism by which risk is conferred is not known The first onset of symptoms is usually between the ages of 50 and 65. The most common symptoms that appear in both types of ALS are muscle weakness, twitching, and cramping, which eventually can lead to the impairment of muscles. In the most advanced stages, ALS patients

2018 European Medicines Agency - EPARs

39. Diagnosis and management of gonorrhoea and syphilis

of research: Sarah Swannet (Guideline HIV for first line) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Charles Cazanave (fees for communication to congress GILEAD, MSD); Tania Crucitti (FWO fees to take part to congresses; fees from the European Society for Infection Diseases in Obstetrics and Gynaecology – ESIDOG – for training sessions), France Laurent (symposium on vaccination for travelling), Christiana Nöstlinger (Participation to European (...) : An Crepel (BCFI/CBIP), Agnes Cuyas (NGC), Nicolas Fairon (KCE), Virginie Maes (Sciensano), Romain Mahieu (Direction de la Santé, COCOM), Carole Schirvel (Cellule de surveillance des maladies infectieuses, AVIQ), Jørgen Skov Jensen (IUSTI), Irm Vinck (KCE) Reported interests: Membership of a stakeholder group on which the results of this report could have an impact: Nicole Dekker (Guideline first line for Chlamydia and HIV) Holder of intellectual property (patent, product developer, copyrights

2019 Belgian Health Care Knowledge Centre

40. Proposals for a more effective antibiotic policy in Belgium

for the execution of research described above: Jeroen Dewulf (PhD students) Consultancy or employment for a company, an association or an organisation that may gain or lose financially due to the results of this report: Pieter Boudrez (Medaxes), Els Goossens (Boerenbond), Davy Persoons (, Léonard Théron (HIPRA Benelux), Bill Vandaele (Consultant at UPV and representative of UPV at AMCRA) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Frédéric (...) Frippiat (Congress in Italy about endocarditis April 2018 (transport and accommodation)), Margaretha Haelterman (Training on quality policy at ULB and UCL), Jeroen Dewulf (Lectures for veterinary associations, farmers associations and feed companies), Koen Magerman (Vaccination for travellers and pneumococcal vaccine, BECTON Dickinson: MDRO (antimicrobial resistance)), Alain Schonbrodt (Travel costs paid by UPV), Bill Vandaele (Travel expences for AMCRA meetings), Ann Versporten (Travel support

2019 Belgian Health Care Knowledge Centre

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