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21. Preventing and Managing Infectious Diseases Among People who Inject Drugs in Ontario

of the problem and three elements for addressing it, in consultation with the Steering Committee and a number of key informants, and with the aid of several conceptual frameworks that organize thinking about ways to approach the issue; 3) identifying, selecting, appraising and synthesizing relevant research evidence about the problem, options and implementation considerations; 4) drafting the evidence brief in such a way as to present concisely and in accessible language the global and local research (...) and costs of a potentially comprehensive approach to address the problem may vary across groups. Implementation considerations may also vary across groups. One way to identify groups warranting particular attention is to use “PROGRESS,” which is an acronym formed by the first letters of the following eight ways that can be used to describe groups†: • place of residence (e.g., rural and remote populations); • race/ethnicity/culture (e.g., First Nations and Inuit populations, immigrant populations

2019 McMaster Health Forum

22. Systemic Adjuvant Therapy for Adult Patients at High Risk for Recurrent Melanoma

[Cotellic®], trametinib), KIT inhibitors (imatinib mesylate or imatinib [Gleevec® and generic products]), and vascular endothelial growth factor (VEGF) inhibitors (bevacizumab [Avastin® and generic products]). Signal transduction pathways regulate cell proliferation, cell differentiation, and cell death [73]. The mitogen-activated protein kinase (MAPK) pathway includes the RAS G protein and RAF, MEK, and ERK protein kinases; it is thus also referred to as the RAS-RAF-MEK-ERK pathway [74]. A signal from (...) patients after six to seven months [87,89], trials evaluating combination therapy have been conducted. As dabrafenib and vemurafenib share similar resistance mechanisms, combination with MEK inhibitors may be more effective [87,90,91]. This may also be the case for BRAF mutations other than V600E/K which have lower or unknown response to BRAF inhibitors alone. The phosphatidylinositol 3-kinase and protein kinase B pathway (PI3K-AKT) [88] is a strong regulator of melanoma growth and survival. The KIT

2019 Cancer Care Ontario

23. Optimisation of RIZIV – INAMI lump sums for incontinence

(doctoral study incontinence in elderly), Ronny Pieters (master studies nursing), Anja Declercq (BelRAI) Consultancy or employment for a company, an association or an organisation that may gain or lose financially due to the results of this report: Ronny Pieters (Coloplast – Teleflex), Rudi Wyffels (N.V. Paul Hartmann S.A. producer of incontinence material) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Els Bakker (various), Veerle Decalf (non (...) , TREATMENT AND TOILETING AIDS 178 8.8.1 Assessment of the current situation 178 8.8.2 Proposals for improvement 180 8.9 OPTIMISING THE PATHWAYS TO THE LUMP SUMS 182 8.9.1 Assessment of the current situation 182 8.9.2 Proposals for improvement 182 8.10 FINANCIAL ACCESSIBILITY OF TREATMENTS AND SUPPORT AIDS 183 8.10.1 Assessment of the current situation 183 8.10.2 Proposals for improvement 184 8.11 PATIENT INFORMATION ON SUPPORT AIDS 184 8.11.1 Assessment of the current situation 184 8.11.2 Proposals

2019 Belgian Health Care Knowledge Centre

24. Diagnosis and management of gonorrhoea and syphilis

of research: Sarah Swannet (Guideline HIV for first line) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Charles Cazanave (fees for communication to congress GILEAD, MSD); Tania Crucitti (FWO fees to take part to congresses; fees from the European Society for Infection Diseases in Obstetrics and Gynaecology – ESIDOG – for training sessions), France Laurent (symposium on vaccination for travelling), Christiana Nöstlinger (Participation to European (...) : An Crepel (BCFI/CBIP), Agnes Cuyas (NGC), Nicolas Fairon (KCE), Virginie Maes (Sciensano), Romain Mahieu (Direction de la Santé, COCOM), Carole Schirvel (Cellule de surveillance des maladies infectieuses, AVIQ), Jørgen Skov Jensen (IUSTI), Irm Vinck (KCE) Reported interests: Membership of a stakeholder group on which the results of this report could have an impact: Nicole Dekker (Guideline first line for Chlamydia and HIV) Holder of intellectual property (patent, product developer, copyrights

2019 Belgian Health Care Knowledge Centre

25. Proposals for a more effective antibiotic policy in Belgium

for the execution of research described above: Jeroen Dewulf (PhD students) Consultancy or employment for a company, an association or an organisation that may gain or lose financially due to the results of this report: Pieter Boudrez (Medaxes), Els Goossens (Boerenbond), Davy Persoons (, Léonard Théron (HIPRA Benelux), Bill Vandaele (Consultant at UPV and representative of UPV at AMCRA) Payments to speak, training remuneration, subsidised travel or payment for participation at a conference: Frédéric (...) Frippiat (Congress in Italy about endocarditis April 2018 (transport and accommodation)), Margaretha Haelterman (Training on quality policy at ULB and UCL), Jeroen Dewulf (Lectures for veterinary associations, farmers associations and feed companies), Koen Magerman (Vaccination for travellers and pneumococcal vaccine, BECTON Dickinson: MDRO (antimicrobial resistance)), Alain Schonbrodt (Travel costs paid by UPV), Bill Vandaele (Travel expences for AMCRA meetings), Ann Versporten (Travel support

2019 Belgian Health Care Knowledge Centre

26. Recurrent uncomplicated urinary tract infections in women: AUA/CUA/SUFU

: Grade C) 8. Clinicians should not treat ASB in patients. (Strong Recommendation; Evidence Level: Grade B) Antibiotic Treatment 9. Clinicians should use first-line therapy (i.e., nitrofurantoin, TMP-SMX, fosfomycin) dependent on the local antibiogram for the treatment of symptomatic UTIs in women. (Strong Recommendation; Evidence Level: Grade B) 10. Clinicians should treat rUTI patients experiencing acute cystitis episodes with as short a duration of antibiotics as reasonable, generally no longer (...) . In the first phase, investigators reviewed full-text articles to identify systematic reviews for inclusion. In the second phase they reviewed full-text articles to address key questions not sufficiently answered by previously published systematic reviews, or recent publications to update previously published systematic reviews. Database searches resulted in 6,153 potentially relevant articles. After dual review of abstracts and titles, 214 systematic reviews and individual studies were selected for full

2019 Canadian Urological Association

28. Heart Disease and Stroke Statistics

cause or a contributing cause (ie, the “any-mention” status). The number of deaths in 2016 with any mention of specific causes of death was tabulated by the NHLBI from the NCHS public-use electronic files on mortality. The first set of statistics for each disease in this Update includes the number of deaths for which the disease is the underlying cause. Two exceptions are Chapter 8 (High Blood Pressure) and Chapter 20 (Cardiomyopathy and Heart Failure). High BP, or hypertension, increases (...) of hospital discharges and numbers of procedures performed are for inpatients discharged from short-stay hospitals. Discharges include those discharged alive, dead, or with unknown status. Unless otherwise specified, discharges are listed according to the first-listed (primary) diagnosis, and procedures are listed according to all listed procedures (primary plus secondary). These estimates are from the HCUP 2014. Ambulatory care visit data include patient visits to primary providers’ offices and hospital

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2019 American Heart Association

29. Handbook on tuberculosis laboratory diagnostic methods in the European Union

and electrical emergencies. An emergency shower and an eyewash facility should also be installed. ? Suitably equipped and readily accessible first-aid areas or rooms should be available near the BSL3 laboratory. The personnel of a BSL3 laboratory should ideally have received first-aid training. ? A mechanical ventilation system should provide an inward flow of air without recirculation. ? There should be a reliable and adequate electricity supply and emergency lighting to permit safe exit. A back-up system (...) and Vladyslav Nikolayevskyy. This report was sent for consultation to the members of the ERLTB-Net network (see Appendix 1 for list of contributors). The first version of this ECDC technical report, previously published as ‘Mastering the basics of TB control: Development of a handbook on TB diagnostic methods’ (Stockholm 2011), concerned the development of the handbook that was included as an annex. This report was revised and renamed ‘Handbook on TB laboratory diagnostic methods in the European Union

2018 European Centre for Disease Prevention and Control - Technical Guidance

30. Prepregnancy Counseling

is designed as an educational resource to aid clinicians in providing obstetric and gynecologic care, and use of this information is voluntary. This information should not be considered as inclusive of all proper treatments or methods of care or as a statement of the standard of care. It is not intended to substitute for the independent professional judgment of the treating clinician. Variations in practice may be warranted when, in the reasonable judgment of the treating clinician, such course of action (...) with the following question: “ Would you like to become pregnant in the next year ?” The goal of prepregnancy care is to reduce the risk of adverse health effects for the woman, fetus, and neonate by working with the woman to optimize health, address modifiable risk factors, and provide education about healthy pregnancy. Women should be counseled to seek medical care before attempting to become pregnant or as soon as they believe they are pregnant to aid in correct dating and to be monitored for any medical

2019 American College of Obstetricians and Gynecologists

31. Guidelines for Monitoring and Management of Pediatric Patients Before, During, and After Sedation for Diagnostic and Therapeutic Procedures

not replace the practitioner’s responsibility to provide initial rescue for life-threatening complications. On-site Monitoring, Rescue Drugs, and Equipment An emergency cart or kit must be immediately accessible. This cart or kit must contain the necessary age- and size-appropriate equipment (oral and nasal airways, bag-valve-mask device, LMAs or other supraglottic devices, laryngoscope blades, tracheal tubes, face masks, blood pressure cuffs, intravenous catheters, etc) to resuscitate a nonbreathing (...) and unconscious child. The contents of the kit must allow for the provision of continuous life support while the patient is being transported to a medical/dental facility or to another area within the facility. All equipment and drugs must be checked and maintained on a scheduled basis (see for suggested drugs and emergency life support equipment to consider before the need for rescue occurs). Monitoring devices, such as electrocardiography (ECG) machines, pulse oximeters with size-appropriate probes, end

2019 American Academy of Pediatrics

32. WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

Development Goals – not just to improve health outcomes, but to transform the health systems on which billions of people depend. This first consolidated guideline on self-care interventions is a milestone for WHO. It is an important paradigm shift in normative guidance from WHO and paves the way for the years ahead in the links between primary health care, communities and health systems. The partnerships and experts who have contributed to the development of this guideline will also be important for its (...) / AIDS [UNAIDS]), Lucinda O’Hanlon (Office of the United Nations High Commissioner for Human Rights [OHCHR]), Shaffiq Essajee (United Nations Children’s Fund [UNICEF]), Kenechukwu Esom (United Nations Development Programme [UNDP]), Ayman Abdelmohsen, Petra ten Hoope-Bender and Tim Sladden (United Nations Population Fund [UNFPA]) and David Wilson (World Bank). The following WHO staff members contributed as members of the WHO Guideline Steering Group (SG), which managed the guideline development

2019 World Health Organisation Guidelines

33. WHO Guideline: recommendations on digital interventions for health system strengthening

be guided by evidence to establish sustainable harmonized digital systems, not seduced by every new gadget. That’s what this guideline is all about. At the Seventy-First World Health Assembly, WHO’s Member States asked us to develop a global strategy on digital health. This first WHO guideline establishes recommendations on digital interventions for health system strengthening and synthesizes the evidence for the most important and effective digital technologies. The nature of digital technologies (...) characteristics Health worker decision support via mobile devices Digitized job aids that combine an individual’s health information with the health worker’s knowledge and clinical protocols to assist health workers in making diagnosis and treatment decisions ? Clinical decision support systems (CDSS) ? Job aid and assessment tools to support service delivery, may or may not be linked to a digital health record ? Algorithms to support service delivery according to care plans and protocol Digital tracking

2019 World Health Organisation Guidelines

34. Chronic Pelvic Pain

: guidance for study inclusion criteria, outcome measurement and clinical practice. Aliment Pharmacol Ther, 2010. 32: 1192. 274. Slieker-ten Hove, M.C., et al. Face validity and reliability of the first digital assessment scheme of pelvic floor muscle function conform the new standardized terminology of the International Continence Society. Neurourol Urodyn, 2009. 28: 295. 275. Wyndaele, J.J., et al. Reproducibility of digital testing of the pelvic floor muscles in men. Arch Phys Med Rehabil, 1996. 77

2019 European Association of Urology

35. Renal Cell Carcinoma

. Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. Eur Urol, 2016. 69: 660. 147. Motzer, R.J., et al. Phase II randomized trial comparing sequential first-line everolimus and second-line sunitinib versus first-line sunitinib and second-line everolimus in patients with metastatic renal cell carcinoma. J Clin Oncol, 2014. 32: 2765. 148. Wood, B.J., et al. Imaging guided biopsy of renal masses: indications, accuracy and impact on clinical management. J Urol, 1999

2019 European Association of Urology

36. Recurrent Uncomplicated Urinary Tract Infections in Women

not treat ASB in patients. (Strong Recommendation; Evidence Level: Grade B) Antibiotic Treatment 9. Clinicians should use first-line therapy (i.e., nitrofurantoin, TMP-SMX, fosfomycin) dependent on the local antibiogram for the treatment of symptomatic UTIs in women. (Strong Recommendation; Evidence Level: Grade B) 10. Clinicians should treat rUTI patients experiencing acute cystitis episodes with as short a duration of antibiotics as reasonable, generally no longer than seven days. (Moderate (...) , or constipation; recent use of antibiotics for any medical condition; prior antibiotic-related problems (e.g., C. difficile infection); antibiotic allergies and sensitivities; back or flank pain; catheter usage; vaginal discharge or irritation; menopausal status; post-coital UTIs; contraceptive method; and use of spermicides or estrogen- or progesterone-containing products. Details of prior urinary tract or pelvic surgery should be obtained, and patients should be queried as to travel history. Baseline

2019 American Urological Association

37. Surveillance, Diagnosis and Management of Clostridium Difficile Infection in Ireland

Surveillance, Diagnosis and Management of Clostridium Difficile Infection in Ireland Surveillance, Diagnosis and Management of Clostridium difficile Infection in Ireland National Clinical Guideline No. 3 June 2014National Clinical Effectiveness Committee (NCEC) The National Clinical Effectiveness Committee (NCEC) was established as part of the Patient Safety First Initiative in September 2010. The NCECs mission is to provide a framework for national endorsement of clinical guidelines and audit (...) . Information on the NCEC and endorsed National Clinical Guidelines is available on the Patient Safety First website at, Disclaimer The Guideline Development Group’s expectation is that healthcare staff will use clinical judgement, medical, nursing and clinical knowledge in applying the general principles and recommendations contained in this document. Recommendations may not be appropriate in all circumstances and the decision to adopt

2019 National Clinical Guidelines (Ireland)

38. Masitinib mesylate (Alsitek) - Amyotrophic Lateral Sclerosis

-Rapporteur: Eleftheria Nikolaidi The application was received by the EMA on 12 September 2016 The procedure started on 29 September 2016 The Rapporteur's first Assessment Report was circulated to all CHMP members on 22 December 2016 The Co-Rapporteur's first Assessment Report was circulated to all CHMP members on 29 December 2016 The PRAC Rapporteur's first Assessment Report was circulated to all PRAC members on 3 January 2017 The CHMP agreed on the consolidated List of Questions to be sent (...) candidate gene studies have identified several susceptibility genes, although the relative contribution of every identified “at risk” gene rarely exceeds an odds ratio of 2.0, and the mechanism by which risk is conferred is not known The first onset of symptoms is usually between the ages of 50 and 65. The most common symptoms that appear in both types of ALS are muscle weakness, twitching, and cramping, which eventually can lead to the impairment of muscles. In the most advanced stages, ALS patients

2018 European Medicines Agency - EPARs

39. Optimal Care Pathway for Aboriginal and Torres Strait Islander people with cancer

, or Hospital Liaison Officer.Patients first – optimal care 2 Support: Assess supportive care needs at every step of the pathway and refer to appropriate health professionals or organisations. Step 2 Presentation, initial investigations and referral Presentation: Some Aboriginal and Torres Strait Islander people may: • present with multiple comorbidities • have multiple risk factors • present with a later stage of disease • avoid discussing gender-specific matters in the presence of a member of the opposite (...) and staging: The diagnostic workup depends on the type of cancer involved. Some procedures may require the patient to travel to receive care at a specialised centre, which could be arranged through jurisdictional Patient Assistance Travel Schemes and with assistance by an Aboriginal and/or Torres Strait Islander Hospital Liaison Officer. All patients should be assessed for medical comorbidities during the diagnostic workup. Treatment planning: Newly diagnosed patients should be discussed

2018 Cancer Australia

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