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Fetal Scalp pH

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101. Genetics of Skin Cancer (PDQ®): Health Professional Version

, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form a large variety of benign or malignant tumors with diverse biological behaviors. Several of these tumors are associated with familial syndromes. Overall, there are dozens of different histological subtypes of these tumors associated with individual components of the adnexal structures.[ ] Finally, the subcutis is a layer that extends below (...) benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas,[ ] mesenchymomas,[ ] basaloid follicular hamartomas,[ ] and nasal dermoid tumors. Development of meningiomas and ependymomas occurring postradiation therapy has been documented in the general pediatric population; radiation therapy for syndrome-associated intracranial processes may be partially responsible for a subset

2016 PDQ - NCI's Comprehensive Cancer Database

102. Operative Vaginal Delivery

scalp visible without separating the labia Fetal skull has reached the pelvic floor Sagittal suture is in the anterio-posterior diameter or right or left occiput anterior or posterior position (rotation does not exceed 45º) Fetal head is at or on the perineum Low Leading point of the skull (not caput) is at station plus 2 cm or more and not on the pelvic floor Two subdivisions: • rotation of 45º or less from the occipito-anterior position • rotation of more than 45º including the occipito-posterior (...) there is an increased chance of fetal abrasion or scalp trauma and to avoid fetal scalp clips or blood sampling during labour. 29 Vacuum extractors are contraindicated with a face presentation. It has been suggested that vacuum extractors should not be used at gestations of less than 36 weeks because of the risk of subgaleal and intracranial haemorrhage. 30,31 One case–control study suggests that this restriction may be unnecessary, but this study was small and undertaken outside the UK. 32 Below 34 weeks +0 days

2011 Royal College of Obstetricians and Gynaecologists

103. Fetal ST Segment and T Wave Analysis in Labor

concerns with the application of the technology to the United States. None of the randomized trials were performed in the United States where patient case-mix and obstetrical practice, such as the use of fetal scalp pH, differ from Europe, which may affect the impact of this technology on perinatal outcomes. Moreover, the results of the European studies are not uniformly positive. This protocol describes a randomized controlled trial of the STAN technology as an adjunct to electronic fetal heart rate (...) to Primary Outcome Measures : Number of Participants With Primary Composite Outcome [ Time Frame: From Delivery through 1 month of age ] Composite primary outcome of intrapartum fetal death, neonatal death, Apgar score <=3 at 5 minutes, neonatal seizure, umbilical artery blood pH <= 7.05 with base deficit >=12 mmol/L in extra-cellular fluid, intubation for ventilation at delivery, neonatal encelphalopathy Number of Intrapartum Fetal Deaths (Primary Outcome Component) [ Time Frame: During labor

2010 Clinical Trials

104. A randomised clinical trial of intrapartum fetal monitoring with computer analysis and alerts versus previously available monitoring. (Full text)

with real-time alerts (intervention arm) or continuous CTG monitoring as previously performed (control arm). Electrocardiographic monitoring and fetal scalp blood sampling will be available in both arms. The primary outcome measure is the incidence of fetal metabolic acidosis (umbilical artery pH < 7.05, BDecf > 12 mmol/L). Secondary outcome measures are: caesarean section and instrumental vaginal delivery rates, use of fetal blood sampling, 5-minute Apgar score < 7, neonatal intensive care unit (...) A randomised clinical trial of intrapartum fetal monitoring with computer analysis and alerts versus previously available monitoring. Intrapartum fetal hypoxia remains an important cause of death and permanent handicap and in a significant proportion of cases there is evidence of suboptimal care related to fetal surveillance. Cardiotocographic (CTG) monitoring remains the basis of intrapartum surveillance, but its interpretation by healthcare professionals lacks reproducibility

2010 BMC pregnancy and childbirth Controlled trial quality: predicted high PubMed abstract

105. Diagnosis and Management of Cerebral Venous Thrombosis (Full text)

region are often present; most common are hemiparesis and aphasia, but other cortical signs and sensory symptoms may occur. Psychosis, in conjunction with focal neurological signs, has also been reported. Clinical manifestations of CVT may also depend on the location of the thrombosis ( ). The superior sagittal sinus is most commonly involved, which may lead to headache, increased intracranial pressure, and papilledema. A motor deficit, sometimes with seizures, can also occur. Scalp edema and dilated (...) scalp veins may be seen on examination. For lateral sinus thromboses, symptoms related to an underlying condition (middle ear infection) may be noted, including constitutional symptoms, fever, and ear discharge. Pain in the ear or mastoid region and headache are typical. On examination, increased intracranial pressure and distention of the scalp veins may be noted. Hemianopia, contralateral weakness, and aphasia may sometimes be seen owing to cortical involvement. Approximately 16% of patients

2011 Congress of Neurological Surgeons PubMed abstract

106. Decisions to Perform Emergency Caesarean Sections at a University Hospital: Do obstetricians agree? (Full text)

be improved with the implementation of fetal scalp pH testing facilities, fetal heart trace interpretation training and cardiotocography review meetings. (...) in Muscat, Oman. Data on each procedure were collected from electronic patient records and independently reviewed by six senior obstetricians to determine agreement with the decision.Of the 50 women who underwent CS procedures, the mean age was 28.9 ± 5.1 years and 48% were primigravidae. A total of 65% of the CS procedures were category I. The most common indications for a CS was a non-reassuring fetal heart trace (40%) and dystocia (32%). There was complete agreement on the decision to perform 62

2016 Sultan Qaboos University medical journal PubMed abstract

107. Misoprostol for Labour Induction

measures: The primary outcomes were the time from induction to delivery and the caesarean section rate. Secondary outcomes included uterine tachysystole, tocolysis, fetal scalp blood testing, meconium-stained amniotic fluid, umbilical arterial pH, and Apgar score. Condition or disease Labour Induction Detailed Description: Open, non-interventional study in a tertiary referral center in Germany N/A The rationale of our observational study is to describe the efficacy and safety profile of the drug (...) Outcome Measures : Rate of participants receiving a caesarean section compared to all participants being induced [ Time Frame: September 2015 ] Number of participants with treatment-related tachysystole as assessed by cardiotocography [ Time Frame: September 2015 ] Number of participants with treatment-related adverse events following tocolysis with Partusisten [ Time Frame: September 2015 ] Number of participants with fetal compromise assessed by the APGAR-Score and the postpartum fetal pH-value

2016 Clinical Trials

108. Effect of Maternal Diabetes on Brain Development, as Measured by Neonatal Electroencephalogram (EEG)

pregnancy ETOH abuse or concern for abuse during pregnancy (>weekly use) Other maternal conditions that may compromise fetus Psychiatric medications beyond isolated SSRI use Anti-epileptic drugs (AEDs) during gestation Magnesium exposure within 3 days of delivery Neonatal Exclusion Criteria: Blood gas pH of less than 7.1, if obtained (cord or any prior to EEG) Apgar less than 8 at 5 min CNS malformations, seizures, subgaleal or intracranial bleeds Cardiac anomalies except asymptomatic small-moderate VSD (...) : February 26, 2019 Sponsor: University of Rochester Information provided by (Responsible Party): University of Rochester Study Details Study Description Go to Brief Summary: Alterations in the intrauterine environment can have profound effects on fetal development. Diabetes during gestation results in multiple deleterious short-term outcome differences, and is correlated with long-term developmental deficits. Multiple studies, in neonates through school-aged children, have demonstrated differences

2016 Clinical Trials

109. Outpatient Foley For Starting Induction of Labor at TErm

to 5-minutes post-delivery. ] Rates of umbilical artery cord pH < 7.1 [ Time Frame: Assessed at time of delivery up to 5-minutes post-delivery. ] Rates of umbilical cord artery base deficit < -12 [ Time Frame: Assessed at time of delivery up to 5-minutes post-delivery. ] Rates of birth injuries [ Time Frame: Assessed at time of delivery up to time of neonatal discharge, up to 30 days. ] Cephalohematomas, subgaleal hematomas, fracture of the clavicle, and scalp lacerations Rates of neonatal (...) ). The transcervical catheter will be placed in the office after confirmation of fetal well-being. They will then return the next morning to be admitted to labor and delivery for oxytocin administration. Other: Outpatient cervical ripening Subjects will undergo cervical ripening in the outpatient setting. The patients will then be scheduled to return the next morning for induction of labor. Outcome Measures Go to Primary Outcome Measures : Total time from admission to delivery [ Time Frame: From baseline

2016 Clinical Trials

110. Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial

hours. Once the cervix becomes favorable (Bishop score > 6), misoprostol administration will be discontinued. Similarly, further management will be left at the discretion of the labor team. In both groups, if IV oxytocin is indicated, it will be withheld until 4 hours after the last dose of misoprostol to prevent uterine hyperstimulation. Other aspects of labor management will be similar for both groups, including continuous electronic fetal monitoring with external Doppler device or fetal scalp (...) that obese women experience increased labor duration and oxytocin needs when compared to normal-weight women. This in turn results in increased rates for unplanned cesarean delivery (CD) as a result of failed induction of labor (IOL), arrest disorders and non-reassuring fetal heart rate tracing, that is dose-dependent with increasing class of obesity. The investigators hypothesize that obese pregnant women and unfavorable cervix (Bishop score ≤ 6), IOL ≥ 24 weeks gestation using the Foley balloon plus

2015 Clinical Trials

111. Continued Versus Discontinued Oxytocin Stimulation of Labour

readmission [ Time Frame: 0-168 hours ] Retention of urine [ Time Frame: 0-48 hours ] requiring catheterisation Vaginal explorations [ Time Frame: 0-48 hours ] number Cardiotocogram (CTG) classification [ Time Frame: 0-48 hours ] Parturition will be monitored with continous CTG. Suspicious, pathologic or terminal CTG will be registered. Fetal scalp pH values or Fetal scalp lactate [ Time Frame: 0-48 hours ] Apgar score at 1 and 5 minutes [ Time Frame: 0-48 hours ] Umbilical cord arterial pH [ Time Frame (...) for induction of labour (with or without cervical priming by prostaglandin) Exclusion Criteria: Unable to read and understand the Danish language or to give informed consent Cervical dilatation > 4 cm Non-cephalic presentation Multiple gestation Pathological fetal heart rate pattern (cardiotocogram, CTG) before Syntocinon® initiation Fetal weight estimation > 4500 g (clinical or ultrasonic) Subject declines participation Gestational age less than 37 completed weeks Definition: Stimulation with Syntocinon®

2015 Clinical Trials

112. Misodel or Angusta for Induction of Labour?

Measures Go to Primary Outcome Measures : Frequency of caesarean section [ Time Frame: 1,5 year ] No of patients with caesarean section, will be registered for every patient, in their chart after birth, and assessed after 1,5 year. Hyperstimulation [ Time Frame: 1,5 year ] No of patients with hyperstimulation will be registered in the patient chart and assessed after 1,5 year. Defined as tachysystoly with > 5 contractions in 10 minutes over a period of 30 minutes. Indeterminate or abnormal CTG. Scalp (...) -pH < 7,20 or umbilical cord pH < 7,10. Delivery within 24 hours [ Time Frame: 1,5 year ] Number of patients with delivery within 24 hours after induction, will be registered in the patient chart, and assessed after 1,5 year Secondary Outcome Measures : Timeline [ Time Frame: 1,5 year ] Number of hours from induction to delivery, daytime delivery Cost of primary induction method [ Time Frame: 1,5 year ] Cost of medication (DKK for primary method of induction ie. Angusta and Misodel) Experience

2015 Clinical Trials

113. Effects of Mother Position in Skin-to-skin Contact Newborn on Oxygen Saturation Levels.

, anticonvulsants, antipsychotics, benzodiazepines, anxiolytics, hypnotics, antidepressants and sedative plants. Post randomization exclusion criteria (at the end of delivery) Related to childbirth: Caesarean section or instrumental delivery (forceps, vacuum) Maternal fever >38 degrees Celsius Mother hemodynamic instability (hypotension, tachycardia, altered level of consciousness, poor perfusion, striking pallor) Cord prolapse Signs of fetal distress with lower pH fetal scalp <7.25 or umbilical artery pH <7.20 (...) this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 259 Days to 293 Days (Child) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Criteria Inclusion criteria: Single fetus pregnancy Pregnancy controlled or partially controlled(1) Normal pregnancy or with gestational diabetes treated with diet, high blood pressure controlled with only a drug as maximum

2015 Clinical Trials

114. Genetics of Skin Cancer

.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form a large variety of benign or malignant tumors with diverse biological behaviors. Several of these tumors are associated with familial syndromes. Overall, there are dozens (...) criterion for BCNS, but most groups do not include it at this time.[ ] Other associated benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas,[ ] mesenchymomas,[ ] basaloid follicular hamartomas,[ ] and nasal dermoid tumors. Development of meningiomas and ependymomas occurring postradiation therapy has been documented in the general pediatric population; radiation therapy for syndrome

2012 PDQ - NCI's Comprehensive Cancer Database

115. Sarcoma, Childhood Soft Tissue

Press, 2013. Dantonello TM, Int-Veen C, Leuschner I, et al.: Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer 112 (11): 2424-31, 2008. Steelman C, Katzenstein H, Parham D, et al.: Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33

2012 PDQ - NCI's Comprehensive Cancer Database

116. Guidelines for standard and diuretic renogram in children

into a peripheral vein. This has the advantage of being undertaken within the department of nuclear medicine by any skilful trained health personnel. Using a butterfly needle size 27/25 in a tiny vein (at the anterior side of the wrist or a scalp vein) results in many children not reacting to the injection. In many institutions anaesthetic cream (EMLA/Ametop) has been found unnecessary. After the injection is over, often the child will ask when will the injection be done. Furosemide stimulation test

2011 European Association of Nuclear Medicine

118. A consensus statement on the management of pregnancy and delivery in women who are carriers of or have bleeding disorders

, results of quantitative and functional assays for VWF) is desirable for delivery. If needed, factor replacement should be given to the mother as close to the time of delivery as possible. (Note: this does not normalise the baby’s factor levels.) Vacuum extraction is contraindicated. Use of forceps, fetal scalp blood sampling, and scalp electrodes should be avoided, if possible. DDAVP has poor efficacy in type 2 and type 3 von Willebrand disease, but may be used in carriers of haemophilia A. DDAVP may (...) of haemophilia A will develop “normal” factor levels as pregnancy progresses, and thus will not require replacement therapy. , , However, in carriers with a moderate-to-severe deficiency, factor levels may not adequately correct during pregnancy. , , Women with rare bleeding disorders, such as fibrinogen or factor XIII deficiency, may require antenatal treatment to prevent fetal loss. Women with type 1 von Willebrand disease (the most common and mildest form) also experience increased levels of factor VIII

2009 MJA Clinical Guidelines

119. Vacuum Extraction (Diagnosis)

position or station not resolved by examination or real-time ultrasound study Suspicion of fetopelvic disproportion (advanced cranial molding, bone overlap, caput) An inappropriate fetal presentation (eg, breech, face, brow) A known or suspected fetal bleeding diathesis or demineralizing bone disease Relative contraindications are as follows: Prior scalp sampling Prior failed forceps Gestational diabetes or pregestational diabetes Known or suspected fetal macrosomia Definitions The American Congress (...) of Obstetricians and Gynecologists (ACOG) has established standard definitions for instrumental delivery operations. These include outlet, low, and midpelvic operations. While the guidelines were originally written for forceps procedures, the same descriptions are easily applied to vacuum extraction operations with minor modifications. [ ] Outlet forceps/vacuum The leading point of the fetal skull has reached the pelvic floor, and at or on the perineum, the scalp is visible at the introitus without separating


120. Paraneoplastic Diseases (Diagnosis)

have papillomatous thickening of the oral mucosa. Patients who have AN associated with malignancies also have skin changes involving the scalp, areolae, and eyelids. The appearance of paraneoplastic AN usually coincides with the presence of malignancy, but it can precede or follow the diagnosis of cancer and thus may signal a relapse in patients with a history of cancer. Diagnosis The diagnosis of AN is based on clinical findings alone and can be supported by the histopathologic changes (...) include symmetrical, scaly, violaceous plaques on the acral surfaces, with severe forms progressing to bullae. The lesions predominantly occur on the hands, feet, ear helices, nose tip, and scalp. Skin changes may spread to involve the knees, elbows, and malar surface of the face. [ ] Bazex syndrome occurs more commonly in men older than 40 years. [ ] Alopecia and nail changes are common and can be early findings. Subungual hyperkeratosis, onychodystrophy, and white flaking of the nail surface


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