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Fetal Scalp pH

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81. British HIV Association guidelines for the management of HIV infection in pregnant women

Questions and PICO criteria A2.2 Search 1: safety and ef?cacy of antiretrovirals in pregnancy A2.3 Search 2: hepatitis viruses coinfection A2.4 Search 3: delivery, fetal monitoring and obstetric issues 88 BHIVA Writing Group © 2012 British HIV Association HIV Medicine (2012), 13 (Suppl. 2), 87–157A2.5 Search 4: paediatric issues A2.6 Search 5: investigations and monitoring in pregnancy Appendix 3: Search protocols (main databases search) A3.1 Search 1: when to initiate antiretroviral therapy A3.2 Search (...) 2: hepatitis coinfection A3.3 Search 3: fetal monitoring and obstetric issues A3.4 Search 4: paediatric issues A3.5 Search 5: investigations and monitoring in pregnancy Appendix 4 A4.1 Antiretroviral therapies for which suf?cient numbers of pregnancies with ?rst trimester exposure have been monitored to detect a two-fold increase in overall birth defects A4.2 Advisory Committee Consensus BHIVA guidelines for the management of HIV infection in pregnant women 2012 89 © 2012 British HIV Association

2012 The Children's HIV Association

82. Genetics of Skin Cancer (PDQ®): Health Professional Version

cell leukemia; cutaneous T-cell lymphoma is often confined to the skin throughout its course. Overall, 10% of leukemias and lymphomas have prominent expression in the skin.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form (...) by BCNS.[ , , ] BCNS-associated ovarian fibromas are more likely to be bilateral and calcified than sporadic ovarian fibromas.[ ] Ameloblastomas, aggressive tumors of the odontogenic epithelium, have also been proposed as a diagnostic criterion for BCNS, but most groups do not include it at this time.[ ] Other associated benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas

2016 PDQ - NCI's Comprehensive Cancer Database

83. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10): 1450-62, 2011. [ ] Alaggio R, Collini P, Randall RL, et al.: Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 13 (3): 209-17, 2010 May-Jun. [ ] Staging and Grading Systems

2016 PDQ - NCI's Comprehensive Cancer Database

84. Operative Vaginal Delivery

scalp visible without separating the labia Fetal skull has reached the pelvic floor Sagittal suture is in the anterio-posterior diameter or right or left occiput anterior or posterior position (rotation does not exceed 45º) Fetal head is at or on the perineum Low Leading point of the skull (not caput) is at station plus 2 cm or more and not on the pelvic floor Two subdivisions: • rotation of 45º or less from the occipito-anterior position • rotation of more than 45º including the occipito-posterior (...) there is an increased chance of fetal abrasion or scalp trauma and to avoid fetal scalp clips or blood sampling during labour. 29 Vacuum extractors are contraindicated with a face presentation. It has been suggested that vacuum extractors should not be used at gestations of less than 36 weeks because of the risk of subgaleal and intracranial haemorrhage. 30,31 One case–control study suggests that this restriction may be unnecessary, but this study was small and undertaken outside the UK. 32 Below 34 weeks +0 days

2011 Royal College of Obstetricians and Gynaecologists

85. The Misoprostol Vaginal Insert for Labour Induction

= 69) or adjusted (MVI-10, n = 69) criteria. Main outcome measures: The primary outcomes were the time from induction to delivery and the caesarean section rate. The secondary outcomes included the need for additional measures to induce labour, uterine tachysystole, tocolysis, fetal scalp blood testing, meconium-stained amniotic fluid, umbilical arterial pH, and Apgar score. Condition or disease Intervention/treatment Labour Induction Drug: Misoprostol vaginal insert Study Design Go to Layout table (...) and the postpartum fetal pH-value [ Time Frame: August 2016 ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Layout table for eligibility information Ages Eligible for Study: 18 Years

2017 Clinical Trials

86. Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents

pregnancy or because infants of HIV-positive mothers may be born somewhat prematurely (43). High maternal HCV viral load (>600,000 IU/mL) appears to favor mother-to-infant HCV transmission (44–46). Internal monitoring of the fetus (‘‘fetal scalp vein monitoring’’) (10), prolonged rupture of membranes (10,43), and fetal anoxia around the time of delivery, as indicated by decreased cord blood pH (46), may enhance the risk of infection. The role of amniocent- esis on the risk of mother-to-infant HCV (...) there are presently no effective strategies to prevent perinatal HCV transmission, universal screening of pregnant women is not recommended (91) Obstetrical-perinatal factors Vertical transmission of HCV is similar between infants born by C-section or vaginally; however, prolonged rupture of membranes and the use of fetal scalp probes are associated with increased HCV transmission rates and should be avoided (1B; AII) (92–94) Postnatal period The rate of vertical transmission is similar between breast- and bottle

2012 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

87. Diagnosis and Management of Cerebral Venous Thrombosis

region are often present; most common are hemiparesis and aphasia, but other cortical signs and sensory symptoms may occur. Psychosis, in conjunction with focal neurological signs, has also been reported. Clinical manifestations of CVT may also depend on the location of the thrombosis ( ). The superior sagittal sinus is most commonly involved, which may lead to headache, increased intracranial pressure, and papilledema. A motor deficit, sometimes with seizures, can also occur. Scalp edema and dilated (...) scalp veins may be seen on examination. For lateral sinus thromboses, symptoms related to an underlying condition (middle ear infection) may be noted, including constitutional symptoms, fever, and ear discharge. Pain in the ear or mastoid region and headache are typical. On examination, increased intracranial pressure and distention of the scalp veins may be noted. Hemianopia, contralateral weakness, and aphasia may sometimes be seen owing to cortical involvement. Approximately 16% of patients

2011 Congress of Neurological Surgeons

88. Effect of Maternal Diabetes on Brain Development, as Measured by Neonatal Electroencephalogram (EEG)

: February 26, 2019 Sponsor: University of Rochester Information provided by (Responsible Party): University of Rochester Study Details Study Description Go to Brief Summary: Alterations in the intrauterine environment can have profound effects on fetal development. Diabetes during gestation results in multiple deleterious short-term outcome differences, and is correlated with long-term developmental deficits. Multiple studies, in neonates through school-aged children, have demonstrated differences (...) -of Care Blood Sugar Testing Medical Record Data Extraction Maternal Questionnaire Other: Video Electroencephalogram (EEG) Single neonatal video EEG at 24 hrs to 5 days of life during birth hospitalization. Neonatal scalp leads, respiratory and nasal leads. Approximately 60 minute recording. Other: Point-of Care Blood Sugar Testing One-time heel-stick point-of-care blood sugar testing at time of EEG. Other: Medical Record Data Extraction Medical record data extraction from both maternal obstetric

2016 Clinical Trials

89. Misoprostol for Labour Induction

measures: The primary outcomes were the time from induction to delivery and the caesarean section rate. Secondary outcomes included uterine tachysystole, tocolysis, fetal scalp blood testing, meconium-stained amniotic fluid, umbilical arterial pH, and Apgar score. Condition or disease Labour Induction Detailed Description: Open, non-interventional study in a tertiary referral center in Germany N/A The rationale of our observational study is to describe the efficacy and safety profile of the drug (...) Outcome Measures : Rate of participants receiving a caesarean section compared to all participants being induced [ Time Frame: September 2015 ] Number of participants with treatment-related tachysystole as assessed by cardiotocography [ Time Frame: September 2015 ] Number of participants with treatment-related adverse events following tocolysis with Partusisten [ Time Frame: September 2015 ] Number of participants with fetal compromise assessed by the APGAR-Score and the postpartum fetal pH-value

2016 Clinical Trials

90. Outpatient Foley For Starting Induction of Labor at TErm

to 5-minutes post-delivery. ] Rates of umbilical artery cord pH < 7.1 [ Time Frame: Assessed at time of delivery up to 5-minutes post-delivery. ] Rates of umbilical cord artery base deficit < -12 [ Time Frame: Assessed at time of delivery up to 5-minutes post-delivery. ] Rates of birth injuries [ Time Frame: Assessed at time of delivery up to time of neonatal discharge, up to 30 days. ] Cephalohematomas, subgaleal hematomas, fracture of the clavicle, and scalp lacerations Rates of neonatal (...) ). The transcervical catheter will be placed in the office after confirmation of fetal well-being. They will then return the next morning to be admitted to labor and delivery for oxytocin administration. Other: Outpatient cervical ripening Subjects will undergo cervical ripening in the outpatient setting. The patients will then be scheduled to return the next morning for induction of labor. Outcome Measures Go to Primary Outcome Measures : Total time from admission to delivery [ Time Frame: From baseline

2016 Clinical Trials

91. Amnioinfusion

Related Chapters II. Indications Oligohydramnios with or without Preterm prolonged Recurrent s Cephalic presentation Thick particulate Meconium staining of amniotic fluid III. Contraindication Amnioinfusion should not delay definitive management (e.g. , ) Scalp pH < 7.20 s Uterine anomaly Undiagnosed IV. Efficacy Heavy meconium stained fluid Improved perinatal outcome Reduced risk Decreased NICU admissions Decreased risk of Cord Compression suspected Reduces s Lowers rate of ceserean sections V (...) . Technique Cervical exam Evaluate dilation and presentation Evaluate for Place fetal scalp electrode Place double lumen intrauterine pressure catheter Initial Bolus Warmed at 10-20 ml/minute Stop bolus at 250 to 500 cc Maintenance infusion of warmed Rate: 3 cc/min or 50 to 60 cc/hour Document intrauterine pressure continuously Goal: Maintain amniotic fluid index of 8-12 cm VI. Adverse Effects Uterine scar rupture VII. References Images: Related links to external sites (from Bing) These images

2018 FP Notebook

92. Eclamptic Seizure Management

in best option for control Concurrent anticonvulsant depresses respiration Avoid if possible Consider anticonvulsant if prolonged (caution adverse fetal effects) Amobarbital 250 mg IV in 10cc NS over 3 minutes 5-10 mg IV slow push 125mg IV Airway and respiratory management Protect airway from aspiration Place patient in left lateral decubitus position Suction oral secretions Anesthesia or other skilled clinician (e.g. emergency medicine) at bedside for possible intubation Consider Avoid unless pH (...) <7.10 Prevent injury Padding on side rails of bed Other post- measures Internal fetal monitor (Internal Scalp electrode) Consider catheter Single does not mandate cesarean delivery IV. Complications Maternal mortality Mortality in U.S.: 0.4% of cases Mortality in Mexico: 14% of ecamplsia cases : 5.5 to 23% of cases Fetal anoxia with severe neurologic deficits: 7% V. References Fontaine (2000) in ALSO, B:1-36 Sibai in Gabbe (2002) Obstetrics, p. 945-74 Images: Related links to external sites (from

2018 FP Notebook

93. Decisions to Perform Emergency Caesarean Sections at a University Hospital: Do obstetricians agree? (PubMed)

be improved with the implementation of fetal scalp pH testing facilities, fetal heart trace interpretation training and cardiotocography review meetings. (...) in Muscat, Oman. Data on each procedure were collected from electronic patient records and independently reviewed by six senior obstetricians to determine agreement with the decision.Of the 50 women who underwent CS procedures, the mean age was 28.9 ± 5.1 years and 48% were primigravidae. A total of 65% of the CS procedures were category I. The most common indications for a CS was a non-reassuring fetal heart trace (40%) and dystocia (32%). There was complete agreement on the decision to perform 62

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2016 Sultan Qaboos University medical journal

94. Guidelines for standard and diuretic renogram in children

into a peripheral vein. This has the advantage of being undertaken within the department of nuclear medicine by any skilful trained health personnel. Using a butterfly needle size 27/25 in a tiny vein (at the anterior side of the wrist or a scalp vein) results in many children not reacting to the injection. In many institutions anaesthetic cream (EMLA/Ametop) has been found unnecessary. After the injection is over, often the child will ask when will the injection be done. Furosemide stimulation test

2011 European Association of Nuclear Medicine

95. [Pulse oximetry as an additive procedure in modern fetal assessment during labour]. (PubMed)

((R))" software five consecutive deliveries were simultaneously analysed by the FIGO score and the saturation rate of fetal pulse oximetry. All CTGs were classified as pathological and at least one fetal scalp pH measurement was carried out. Fetal outcome and results of the fetal scalp pH values were evaluated against the fetal pulse oximetry rates.Signal loss was low at less than 5%. No fetus showed a hypoxic state. Only 0.98% of the fetal pulse oximetry saturation rates were below 30% oxygen (...) [Pulse oximetry as an additive procedure in modern fetal assessment during labour]. The low specificity, together with the high intra- and interobserver variability, of cardiotocography (CTG) necessitates the use of additive fetal assessment methods. The German Society of Obstetrics and Gynaecology (DGGG) advises the use of computerised CTG analysis software systems. In this study we have examined the use of computerised CTG analysis together with the fetal pulse oximetry.Using the "CTG-Online

2009 Zeitschrift für Geburtshilfe und Neonatologie Controlled trial quality: uncertain

96. Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. (PubMed)

women in labor (54 fetuses) with a gestational age of >36 weeks and fetal hypoxia, as indicated by abnormal/nonreassuring fetal heart rate tracing or fetal scalp pH of <7.20, received 500 mg of allopurinol or placebo intravenously. Severity of fetal hypoxia, brain damage and free radical formation were assessed by arterial cord blood lactate, S-100B and non-protein-bound-iron concentrations, respectively. At birth, maternal and cord blood concentrations of allopurinol and its active metabolite (...) Maternal allopurinol during fetal hypoxia lowers cord blood levels of the brain injury marker S-100B. Fetal hypoxia is an important determinant of neonatal encephalopathy caused by birth asphyxia, in which hypoxia-induced free radical formation plays an important role.Maternal treatment with allopurinol, will cross the placenta during fetal hypoxia (primary outcome) and reduce S-100B and free radical formation (secondary outcome).In a randomized, double-blind feasibility study, 53 pregnant

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2009 Pediatrics Controlled trial quality: predicted high

97. Otezla - apremilast

PD Pharmacodynamic PDE4 Phosphodiesterase 4 PGA Patient’s (Subject’s) Global Assessment Ph. Eur. European Pharmacopoeia PK Pharmacokinetic(s) EMA/CHMP/476353/2014 Page 6/189 PP Per protocol PsA Psoriatic arthritis PsARC Psoriatic Arthritis Response Criteria PVC Polyvinyl chloride RH Relative humidity SCQ SF-36v2 Sponsor created queries The Short Form (36) Health Survey SMQ Standardised MedDRA Queries TGA Thermal gravimetric analysis UPLC Ultra Performance Liquid Chromatography UV Ultraviolet XRPD (...) ). The 30 mg tablets also contain iron oxide yellow (E172) and iron oxide black (E172). The product is available in PVC/ aluminium foil blisters. 2.2.2. Active Substance General information The chemical name of apremilast is N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol -4-yl]acetamide and has the following structure: Apremilast is a white to pale-yellow non hygroscopic powder, practically insoluble in aqueous buffers irrespective of pH range, soluble

2015 European Medicines Agency - EPARs

98. Sonidegib (Odomzo)

label were revised for clarity, brevity, and consistency. Only clinically-relevant, substantive content changes will be discussed in this review (sections pertaining to CMC, clinical pharmacology, or nonclinical issues are not included), with agreed upon wording for the key clinical sections of the product label for sonidegib (Odomzo) provided in italics. Boxed Warning The label originally proposed by the Applicant included a boxed warning for the risk of embryo-fetal toxicity with sonidegib. FDA (...) recommended and provided rationale for longer term use of contraception (i.e. condom use for 8 months rather than months) following treatment with sonidegib based on preclinical studies, the 28 day half-life and pharmacokinetics (PK) of sonidegib. FDA and the Applicant agreed on the following text for the boxed warning: ? ODOMZO can cause embryo-fetal death or severe birth defects when administered to a pregnant woman. ODOMZO is embryotoxic, fetotoxic, and teratogenic in animals [see Warnings

2014 FDA - Drug Approval Package

100. Clinical Practice Guideline on Care in Normal Childbirth

for Women who Choose Neuraxial Analgesia 290 Appendix 10: Maternal supervision 291 Appendix 11: Intermittent Fetal Auscultation 292 Appendix 12: Flowchart for Decisions Based on Fetal pH Results 293 Appendix 13: Cardiotocographic Recordings 294 Appendix 14: Conflict of Interests Statement 297 Bibliography 299 It has been 5 years since the publication of this Clinical Practice Guideline and it is subject to updating. CLINICAL PRACTICE GUIDELINE ON CARE IN NORMAL CHILDBIRTH 7 It has been 5 years since (...) when there is an abnor- mal cardiotocography reading (CTGR)? 74. How effective are the following methods of fetal monitoring: CEFM with or with- out fetal scalp blood sampling (FBM)? 75. How effective are the following methods of fetal monitoring: CEFM with or with- out fetal stimulation test when there are alterations in fetal heart rate? 76. How does the use of a CEFM classification system influence neonatal outcomes? It has been 5 years since the publication of this Clinical Practice Guideline

2010 GuiaSalud

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