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Fetal Scalp pH

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61. Interventions Targeting Sensory Challenges in Children with Autism Spectrum Disorder - An Update

-42. doi: 10.1177/1362361309353613. PMID: 20923890.X-1 723. Leupen A. Helium and autism. Homoeopathic Links. 2011 2011 Summer;24(2):106- 1p. doi: 10.1055/s- 0030-1271051. PMID: 108231917. Language: English. Entry Date: 20110729. Revision Date: 20150712. Publication Type: Journal Article. Journal Subset: Alternative/Complementary Therapies.X-1, X-2 724. Li N, Jin BX, Li JL, et al. [Treatment of autism with scalp acupunctur]. Zhongguo Zhen Jiu. 2011 Aug;31(8):692-6. PMID: 21894689. X-1 725. Lim HA

2017 Effective Health Care Program (AHRQ)

63. MASAC Guidelines for Perinatal Management of Women with Bleeding Disorders and Carriers of Hemophilia A and B

and fetal risks of a vaginal delivery versus a planned caesarean delivery; the option of a planned caesarean delivery should be recommended when an affected or potentially affected male infant is anticipated.(9) (Grade B, Level III) In Those women who elect vaginal delivery, forceps and vacuum extraction, interventions that triple the risk of intracranial hemorrhage in affected male infants, should be avoided, as should fetal scalp electrode monitoring during labor. Umbilical Cord Blood Sampling (...) with bleeding disorders and possible carriers who plan to pursue a pregnancy. Women and their families should be acquainted with the various methods of diagnosing a potentially affected infant prior to delivery and the associated risks of each. Methods include preimplantation diagnosis, invasive prenatal diagnosis (chorionic villus sampling, amniocentesis, and cordocentesis), and ultrasound determination of fetal gender.(1-3) (Grade C, Level IV)* Pregnancy Management Pregnancy should be managed

2017 National Hemophilia Foundation

64. European Society of Endocrinology Clinical practice guidelines for the care of girls and women with Turner syndrome

of a dilated aorta with rapid increase in diameter (⨁◯◯◯). R 3.16. We suggest that in case of an acute ascending AoD before the fetus is viable, to perform emergency aortic surgery understanding that fetal viability may be at risk. If the fetus is viable, it is reasonable to perform cesarean section first, followed by aortic surgery, which should be performed under near-normothermia, pulsatile perfusion, high pump flow and avoidance of vasoconstrictors (⨁◯◯◯). R 3.17. We suggest that exercise testing (...) suspected or has been confirmed prenatally, a fetal echocardiogram should be performed (⨁⨁◯◯). R 4.11. We recommend that diagnosis of a bicuspid aortic valve or a left-sided obstructive lesion in a female fetus or child should prompt a genetic evaluation for TS (⨁⨁◯◯). R 4.12. We recommend referral to a pediatric cardiologist when congenital heart disease is detected prenatally in a fetus with TS to provide counseling regarding the anatomy and physiology of the specific defect, recommended site and mode

2017 European Society of Endocrinology

65. Intrapartum care for healthy women and babies

tr ansferred (% of total transferred from each ansferred from each setting) setting) F From home rom home (n=3,529) (n=3,529) F From a freestanding rom a freestanding midwifery unit (n=2,457) midwifery unit (n=2,457) F From an alongside rom an alongside midwifery unit midwifery unit (n=4,401) (n=4,401) Delay during first or second stage of labour 1,144 (32.4%) 912 (37.1%) 1,548 (35.2%) Abnormal fetal heart rate 246 (7.0%) 259 (10.5%) 477 (10.8%) Request for regional analgesia 180 (5.1%) 163 (6.6 (...) on ultrasound) Abnormal fetal heart rate/doppler studies Ultrasound diagnosis of oligo-/polyhydramnios Intrapartum care for healthy women and babies (CG190) © NICE 2019. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 13 of 89Previous gynaecological history Myomectomy Hysterotomy T T able able 8 Medical conditions indicating individual assessment when planning place of 8 Medical conditions indicating individual assessment when planning

2014 National Institute for Health and Clinical Excellence - Clinical Guidelines

66. Taltz (ixekizumab) - Psoriasis

NAPSI Nail Psoriasis Severity Index NMSC non-melanoma skin cancer NRI nonresponder imputation NRS Numeric Rating Scale PASI Psoriasis Area and Severity Index PPASI Psoriasis Palmoplantar Severity Index PSAB Psoriasis Skin Appearance Bothersomeness PSSI Psoriasis Scalp Severity Index Q2W every 2 weeks Q4W every 4 weeks Q12W every 12 weeks QIDS-SR16 Quick Inventory of Depressive Symptomatology–Self Report (16 Items) sPGA static Physician Global Assessment TE-ADA treatment-emergent anti-drug antibodies (...) ; International Federation of Psoriasis Associations [IFPA] 2014), with rates varying across ethnic groups and geographic regions. Psoriasis is characterized by red, scaly patches, papules and plaques that usually itch. Lesions vary in severity from minor localized patches to complete body coverage. The most common form, affecting up to 90% of people with psoriasis, is plaque psoriasis that appears on elbows, knees, scalp and back. Nail changes such as pitting or discolouration occur in up to 50% of people

2016 European Medicines Agency - EPARs

67. Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting (Full text)

of a dilated aorta with rapid increase in diameter (⨁◯◯◯). R 3.16. We suggest that in case of an acute ascending AoD before the fetus is viable, to perform emergency aortic surgery understanding that fetal viability may be at risk. If the fetus is viable, it is reasonable to perform cesarean section first, followed by aortic surgery, which should be performed under near-normothermia, pulsatile perfusion, high pump flow and avoidance of vasoconstrictors (⨁◯◯◯). R 3.17. We suggest that exercise testing (...) suspected or has been confirmed prenatally, a fetal echocardiogram should be performed (⨁⨁◯◯). R 4.11. We recommend that diagnosis of a bicuspid aortic valve or a left-sided obstructive lesion in a female fetus or child should prompt a genetic evaluation for TS (⨁⨁◯◯). R 4.12. We recommend referral to a pediatric cardiologist when congenital heart disease is detected prenatally in a fetus with TS to provide counseling regarding the anatomy and physiology of the specific defect, recommended site and mode

2016 European Society of Human Reproduction and Embryology PubMed abstract

68. Otezla - apremilast

PD Pharmacodynamic PDE4 Phosphodiesterase 4 PGA Patient’s (Subject’s) Global Assessment Ph. Eur. European Pharmacopoeia PK Pharmacokinetic(s) EMA/CHMP/476353/2014 Page 6/189 PP Per protocol PsA Psoriatic arthritis PsARC Psoriatic Arthritis Response Criteria PVC Polyvinyl chloride RH Relative humidity SCQ SF-36v2 Sponsor created queries The Short Form (36) Health Survey SMQ Standardised MedDRA Queries TGA Thermal gravimetric analysis UPLC Ultra Performance Liquid Chromatography UV Ultraviolet XRPD (...) ). The 30 mg tablets also contain iron oxide yellow (E172) and iron oxide black (E172). The product is available in PVC/ aluminium foil blisters. 2.2.2. Active Substance General information The chemical name of apremilast is N-[2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol -4-yl]acetamide and has the following structure: Apremilast is a white to pale-yellow non hygroscopic powder, practically insoluble in aqueous buffers irrespective of pH range, soluble

2015 European Medicines Agency - EPARs

70. Acute pain management: scientific evidence (3rd Edition)

with spinal cord injury 248 9.2 Simple analgesics for the treatment of migraine 266 9.3 Table of triptans 267 9.4 Pooled effectiveness data from emergency department studies of the treatment of migraine 296 10.1 Acute pain intensity measurement tools — neonates 344 10.2 Composite scales for infants and children 345 10.3 Self-report tools for children 346 11.1 ADEC drug categorisation according to fetal risk 387 11.2 Categorisation of drugs used in pain management 388 11.3 The breastfeeding patient

2015 National Health and Medical Research Council

71. Genetics of Skin Cancer (PDQ®): Health Professional Version

and is occasionally associated with mast cell leukemia; cutaneous T-cell lymphoma is often confined to the skin throughout its course. Overall, 10% of leukemias and lymphomas have prominent expression in the skin.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal (...) ,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas,[ ] mesenchymomas,[ ] basaloid follicular hamartomas,[ ] and nasal dermoid tumors. Development of meningiomas and ependymomas occurring postradiation therapy has been documented in the general pediatric population; radiation therapy for syndrome-associated intracranial processes may be partially responsible for a subset of these benign tumors in individuals with BCNS.[ - ] In addition, radiation therapy of malignant medulloblastomas in the BCNS population

2018 PDQ - NCI's Comprehensive Cancer Database

72. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

are most commonly coarctation of the aorta (coarctation is more proximal and affects longer segments), complex aortic arch anomalies, and ventricular and atrial septal defects. - E ye abnormalities. Ophthalmologic anomalies can include microphthalmos, retinal vascular abnormalities, persistent fetal retinal vessels, exophthalmos, coloboma, and optic nerve atrophy. These abnormalities are rare and occur in 7% to 10% of patients.[ ] Diagnosis of PHACE requires clinical examination, cardiac evaluation

2018 PDQ - NCI's Comprehensive Cancer Database

73. Guidelines for the use of local anesthesia in office-based dermatologic surgery (Full text)

, nerve blocks, tissue, face, head, neck, nose, ear, eye, lid, hands, feet, digits, penis, genitals. pregnancy, pediatrics, pain, tissue absorption, dose, time, slow, fast, volume, pharmacokinetics, serum levels, technique, method, laser, ethyl chloride, symptoms, systemic, toxicity, local anesthetic systemic toxicity (LAST), treatment, prevention, epinephrine, adrenaline, vasoconstriction, hyaluronidase, mixtures, solution, needle, cannula, sodium bicarbonate, pH, infusion rate, and tumescent (...) indication, topical agents were particularly useful for face and scalp wounds, where absorption may be highest. x 19 Ferguson, C., Loryman, B., and Body, R. Best evidence topic report. Topical anaesthetic versus lidocaine infiltration to allow closure of skin wounds in children. Emerg Med J . 2005 ; 22 : 507–509 | | | Most of these studies noted more patient discomfort associated with the injection of infiltration anesthesia than the application of topical anesthetic. In addition, single studies found

2016 American Academy of Dermatology PubMed abstract

75. Sonidegib (Odomzo)

and the Applicant agreed on inclusion of the following text in the PATIENT COUNSELING INFORMATION section of the label: Reference ID: 3796270Addendum to Clinical Review Denise Casey NDA 205266 Odomzo ® (sonidegib) 14 Advise the patient to read the FDA-approved patient labeling (Medication Guide). Embryo-Fetal Toxicity[see Warnings and Precautions (5.1) and Use in Specific Populations (8.1,8.3)]. ? Advise female patients of the potential risk to a fetus. ? Advise females of reproductive potential to use (...) label were revised for clarity, brevity, and consistency. Only clinically-relevant, substantive content changes will be discussed in this review (sections pertaining to CMC, clinical pharmacology, or nonclinical issues are not included), with agreed upon wording for the key clinical sections of the product label for sonidegib (Odomzo) provided in italics. Boxed Warning The label originally proposed by the Applicant included a boxed warning for the risk of embryo-fetal toxicity with sonidegib. FDA

2014 FDA - Drug Approval Package

77. Core Competencies for Management of Labour

monitor either externally or internally for the continuous evaluation of fetal heart rate pattern in labour. Fetal scalp electrode (FSE) – internal signal source for electronically monitoring the fetal heart rate inserted through vagina and cervix and attached to the presenting part External tocotransducer – Pressure sensitive electronic device for measuring uterine activity transabdominally – detects changes in surface pressure Intrauterine Pressure Catheter (IUPC) – catheter inserted into uterine (...) ) • Using the appropriate methods of fetal health surveillance – IA or EFM, assess and document fetal heart rate at the recommended frequency 2. Uterine Activity • Identify uterine contraction patterns that might adversely affect oxygen delivery to the fetus • Assessment of uterine activity is performed in conjunction with IA or EFM, and is necessary in order to correctly classify the fetal heart rate patterns with EFM • Palpate by hand and/or • Assess using an external tocotransducer or an internal

2014 British Columbia Perinatal Health Program

78. Acute Pain Management: Scientific Evidence

factors for the development of postoperative acute persistent pain. Trends Anaesth Critical Care 4: 67–70. Shipton EA (2014b) The transition of acute postoperative pain to chronic pain: Part 2 - Limiting the transition. Trends Anaesth Critical Care 4: 71–75. Vidaeff AC, Saade GR, Belfort MA (in press) Interpreting a randomized trial report: evidence-based practice for the clinician. J Matern Fetal Neonatal Med. Walsh M, Woodhouse LJ, Thomas SG, Finch E (2011) Strategies aimed at preventing chronic (...) of observational pain assessment scales for intellectually disabled children 420 Table 9.5 Suggested paracetamol dosing for infants and children 422 Table 9.6 Block height following caudal injection in children using different formulae 454 Table 9.7 Incidence of adverse effects in large-scale audits of paediatric regional analgesia 460 Table 10.1 TGA medicine categorisation according to fetal risk 519 Table 10.2 Categorisation of medicines used in pain management 519 Table 10.3 The breastfeeding patient

2015 Clinical Practice Guidelines Portal

79. Stivarga (regorafenib hydrate)

carcinoma-derived H129 cell line. ? Regorafenib (10 mg/kg) suppressed the tumor growth of the primary lesion and also decreased the number of metastatic tumors in the lungs in mice orthotopically implanted with mouse breast cancer-derived 4T1 cell line. 3.(i).A.(2) Secondary pharmacodynamics (Report PH-36660) Effects of regorafenib, M-2, and M-5 on blood pressure decrease induced by intravenous administration of vascular endothelial growth factor (VEGF) were evaluated in anesthetized rats (4-6 animals (...) nervous system (Reports PH-33840, PH-33856, PH-35438, PH-35409) Following single oral doses of 2, 10, or 50 mg/kg of regorafenib to male rats (6 animals per group), the effects on general symptoms, locomotor activity, and body temperature were evaluated. No effects of regorafenib were observed for any evaluation item. Following single oral doses of 2, 10, or 50 mg/kg of regorafenib to male rats (5-8 animals per group), the effects on hexobarbital- induced sleep, pentylenetetrazole-induced convulsion

2013 Pharmaceuticals and Medical Devices Agency, Japan

80. Management of Hepatitis C

positive transmitting infection to their babies in utero or during parturition is approximately 5%; the rate is twice as high for those co-infected with HIV. 48 The baby’s risk of acquiring HCV from a mother infected with HCV is not increased by mode of delivery or breast feeding. 48 one prospective study has indicated that fetal scalp monitoring may increase the risk of mother to child transmission. 49 A large retrospective study did not demonstrate any excess risk. 48 Vaginal delivery may increase

2013 SIGN

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