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Fetal Scalp pH

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62. Guidelines for the use of local anesthesia in office-based dermatologic surgery

, nerve blocks, tissue, face, head, neck, nose, ear, eye, lid, hands, feet, digits, penis, genitals. pregnancy, pediatrics, pain, tissue absorption, dose, time, slow, fast, volume, pharmacokinetics, serum levels, technique, method, laser, ethyl chloride, symptoms, systemic, toxicity, local anesthetic systemic toxicity (LAST), treatment, prevention, epinephrine, adrenaline, vasoconstriction, hyaluronidase, mixtures, solution, needle, cannula, sodium bicarbonate, pH, infusion rate, and tumescent (...) indication, topical agents were particularly useful for face and scalp wounds, where absorption may be highest. x 19 Ferguson, C., Loryman, B., and Body, R. Best evidence topic report. Topical anaesthetic versus lidocaine infiltration to allow closure of skin wounds in children. Emerg Med J . 2005 ; 22 : 507–509 | | | Most of these studies noted more patient discomfort associated with the injection of infiltration anesthesia than the application of topical anesthetic. In addition, single studies found

2016 American Academy of Dermatology

64. Genetics of Skin Cancer (PDQ®): Health Professional Version

cell leukemia; cutaneous T-cell lymphoma is often confined to the skin throughout its course. Overall, 10% of leukemias and lymphomas have prominent expression in the skin.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form (...) by BCNS.[ , , ] BCNS-associated ovarian fibromas are more likely to be bilateral and calcified than sporadic ovarian fibromas.[ ] Ameloblastomas, aggressive tumors of the odontogenic epithelium, have also been proposed as a diagnostic criterion for BCNS, but most groups do not include it at this time.[ ] Other associated benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas

2018 PDQ - NCI's Comprehensive Cancer Database

65. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

of the aorta (coarctation is more proximal and affects longer segments), complex aortic arch anomalies, and ventricular and atrial septal defects. - E ye abnormalities. Ophthalmologic anomalies can include microphthalmos, retinal vascular abnormalities, persistent fetal retinal vessels, exophthalmos, coloboma, and optic nerve atrophy. Diagnosis of PHACE requires clinical examination, cardiac evaluation with echocardiogram, ophthalmologic evaluation, and magnetic resonance imaging (MRI)/magnetic resonance

2018 PDQ - NCI's Comprehensive Cancer Database

66. Acute pain management: scientific evidence (3rd Edition)

with spinal cord injury 248 9.2 Simple analgesics for the treatment of migraine 266 9.3 Table of triptans 267 9.4 Pooled effectiveness data from emergency department studies of the treatment of migraine 296 10.1 Acute pain intensity measurement tools — neonates 344 10.2 Composite scales for infants and children 345 10.3 Self-report tools for children 346 11.1 ADEC drug categorisation according to fetal risk 387 11.2 Categorisation of drugs used in pain management 388 11.3 The breastfeeding patient

2015 National Health and Medical Research Council

67. Core Competencies for Management of Labour

monitor either externally or internally for the continuous evaluation of fetal heart rate pattern in labour. Fetal scalp electrode (FSE) – internal signal source for electronically monitoring the fetal heart rate inserted through vagina and cervix and attached to the presenting part External tocotransducer – Pressure sensitive electronic device for measuring uterine activity transabdominally – detects changes in surface pressure Intrauterine Pressure Catheter (IUPC) – catheter inserted into uterine (...) : Intra-uterine pressure monitoring ? FHR: Fetal scalp electrode • Apply label with addressograph information to beginning of tracing • Ensure the timing of nursing notation corresponds with the time on the monitor clock • Describe ¦ Baseline rate – average number in bpm rounded to increments of 5 bpm ¦ Baseline FHR variability as absent (undetectable), minimal (= 5 bpm), moderate (6 – 25 bpm) or marked (> 25 bpm) ¦ Presence/absence of accelerationsManaging Labour Decision Support Tool No. 2

2014 British Columbia Perinatal Health Program

68. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10): 1450-62, 2011. [ ] Alaggio R, Collini P, Randall RL, et al.: Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 13 (3): 209-17, 2010 May-Jun. [ ] Staging and Grading Systems

2017 PDQ - NCI's Comprehensive Cancer Database

69. Stivarga (regorafenib hydrate)

carcinoma-derived H129 cell line. ? Regorafenib (10 mg/kg) suppressed the tumor growth of the primary lesion and also decreased the number of metastatic tumors in the lungs in mice orthotopically implanted with mouse breast cancer-derived 4T1 cell line. 3.(i).A.(2) Secondary pharmacodynamics (Report PH-36660) Effects of regorafenib, M-2, and M-5 on blood pressure decrease induced by intravenous administration of vascular endothelial growth factor (VEGF) were evaluated in anesthetized rats (4-6 animals (...) nervous system (Reports PH-33840, PH-33856, PH-35438, PH-35409) Following single oral doses of 2, 10, or 50 mg/kg of regorafenib to male rats (6 animals per group), the effects on general symptoms, locomotor activity, and body temperature were evaluated. No effects of regorafenib were observed for any evaluation item. Following single oral doses of 2, 10, or 50 mg/kg of regorafenib to male rats (5-8 animals per group), the effects on hexobarbital- induced sleep, pentylenetetrazole-induced convulsion

2013 Pharmaceuticals and Medical Devices Agency, Japan

70. Management of Hepatitis C

positive transmitting infection to their babies in utero or during parturition is approximately 5%; the rate is twice as high for those co-infected with HIV. 48 The baby’s risk of acquiring HCV from a mother infected with HCV is not increased by mode of delivery or breast feeding. 48 one prospective study has indicated that fetal scalp monitoring may increase the risk of mother to child transmission. 49 A large retrospective study did not demonstrate any excess risk. 48 Vaginal delivery may increase

2013 SIGN

71. Acute Pain Management: Scientific Evidence

factors for the development of postoperative acute persistent pain. Trends Anaesth Critical Care 4: 67–70. Shipton EA (2014b) The transition of acute postoperative pain to chronic pain: Part 2 - Limiting the transition. Trends Anaesth Critical Care 4: 71–75. Vidaeff AC, Saade GR, Belfort MA (in press) Interpreting a randomized trial report: evidence-based practice for the clinician. J Matern Fetal Neonatal Med. Walsh M, Woodhouse LJ, Thomas SG, Finch E (2011) Strategies aimed at preventing chronic (...) of observational pain assessment scales for intellectually disabled children 420 Table 9.5 Suggested paracetamol dosing for infants and children 422 Table 9.6 Block height following caudal injection in children using different formulae 454 Table 9.7 Incidence of adverse effects in large-scale audits of paediatric regional analgesia 460 Table 10.1 TGA medicine categorisation according to fetal risk 519 Table 10.2 Categorisation of medicines used in pain management 519 Table 10.3 The breastfeeding patient

2015 Clinical Practice Guidelines Portal

72. Brodalumab (Kyntheum) - plaque psoriasis

contains 140 mg/mL brodalumab in glutamate, proline, and polysorbate 20, filled to deliver a volume of 1.5 mL to provide 210 mg of brodalumab. The main changes during the development of the 140 mg/mL PFS are the manufacturing site, the primary container (different syringes) and the manufacturing scale. Results of lot release and stability testing and additional characterisation studies were comparable for the commercial product. The container closure system complies with Ph. Eur. requirements (...) intermediates provided were supported by small-scale characterisation studies to evaluate the chemical stability. The Applicant’s approach as regards the pool holds which are controlled within the validated hold times but may be extended within the characterised acceptable hold times through additional validation studies, is considered acceptable. As per request, the maximal holding time for the low pH pool was reduced. Control of materials The presence of the heavy chain variant is one of the main

2017 European Medicines Agency - EPARs

74. Acute Otitis Externa

. The etiology of AOE is multifactorial. Regular cleaning of the ear canal removes cerumen, which is an important barrier to moisture and infection. Cerumen creates a slightly acidic pH that inhibits infection (especially by P aeruginosa ) but can be altered by water exposure, aggressive cleaning, soapy deposits, or alkaline eardrops. , Debris from dermatologic conditions may also encourage infections, , as can local trauma from attempts at self-cleaning, irrigation, and wearing hearing aids. , Other factors (...) , and hyperpigmentation depending on the stage of eczema. Management includes gentle skin care, application of emollients, prevention of secondary skin infection, and the use of topical corticosteroids and other antipruritics. Seborrheic dermatitis is a common condition affecting the ears, scalp, central face, and other sebaceous areas of the skin. Presenting with greasy yellowish scaling, itching, and secondary inflammation from Malassezia yeast, seborrheic dermatitis is more pronounced in patients with Down

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2014 American Academy of Otolaryngology - Head and Neck Surgery

75. Routine newborn assessment

Routine 5-7 days & 6 weeks • Chart head circumference, length, weight on centile charts • Head shape, size • Scalp, fontanelles, sutures • Eye size, position structure • Nose, position, structure • Ear position, structure • Mouth, palate, teeth, gums tongue, frenulum • Jaw size • Size, shape, symmetry, movement • Breast tissue, nipples • Heart sounds, rate, pulses • Breath sounds, resp rate • Pulse oximetry (optional) • Ortolani and Barlow’s manoeuvres • Leg length, proportions, symmetry and digits (...) of non-reassuring fetal status in labour (e.g. cord gases) o Presentation and mode of birth o Apgar scores and resuscitation at birth o Medication since birth (e.g. Vitamin K, Hepatitis B immunoglobulin/vaccine, antibiotics) • Gestational age • Observations since birth o Axillary temperature, o Weight o Urine/meconium o Finnegan score (if relevant) • Feeding since birth (e.g. suck behaviour, mode of feeding) Explanation • Introduce yourself to the parents with an explanation of the purpose, procedure

2014 Queensland Health

76. Safe Prevention of the Primary Cesarean Delivery

elements of the Category II tracing or provide reassurance of fetal well-being. Scalp stimulation to elicit a fetal heart rate acceleration is an easily employed tool when the cervix is dilated and can offer clinician reassurance that the fetus is not acidotic. Spontaneous or elicited heart rate accelerations are associated with a normal umbilical cord arterial pH (7.20 or greater) (54, ). Recurrent variable decelerations, thought to be a physiologic response to repetitive compression of the umbilical (...) or reduce cesarean delivery rates ( , ). Despite the evidence that fetal scalp sampling reduces the risk of cesarean delivery ( , ) and the poor ability of electronic fetal heart rate monitoring patterns to predict pH, intrapartum fetal scalp sampling has fallen out of favor in the United States. This predominantly is due to its invasive nature, the narrow clinical presentations for which it might be helpful, and the need for regulatory measures to maintain bedside testing availability. Currently

2014 American College of Obstetricians and Gynecologists

77. Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants

: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants Catherine a . Mazzola , M.D., 1 a si M F. Chou Dhri , M.D., 2,3 Kurtis i. a uguste , M.D., 4 Davi D D. l i Mbri CK Jr ., M.D., Ph .D., 5 Marta r ogi Do , M.D., 6 l aura Mit Chell , M.a ., 7 an D a nn Marie Flannery , M.D. 8 1 Division of Pediatric Neurological Surgery, Goryeb Children’ s Hospital, Morristown, New Jersey; 2 Departments of Radiology and Neurosurgery (...) . Fewer shunt revi- sions in both groups compared to control group. Lam & Heil- man, 2009 Single-institution, retrospective historical cohort study of 32 preterm infants w/ PHH. This study compared 2 cohorts of infants: those treated w/ VAD/Ommaya placement vs those treated w/ VSG shunts. There were no statistical differences in age or birth weight of the infants in the 2 groups. The groups were studied for IVH grade, need for daily CSF withdrawal, CSF leak from the scalp, CSF infection, & need

2014 Congress of Neurological Surgeons

78. Routine newborn assessment

Routine 5-7 days & 6 weeks • Chart head circumference, length, weight on centile charts • Head shape, size • Scalp, fontanelles, sutures • Eye size, position structure • Nose, position, structure • Ear position, structure • Mouth, palate, teeth, gums tongue, frenulum • Jaw size • Size, shape, symmetry, movement • Breast tissue, nipples • Heart sounds, rate, pulses • Breath sounds, resp rate • Pulse oximetry (optional) • Ortolani and Barlow’s manoeuvres • Leg length, proportions, symmetry and digits (...) of non-reassuring fetal status in labour (e.g. cord gases) o Presentation and mode of birth o Apgar scores and resuscitation at birth o Medication since birth (e.g. Vitamin K, Hepatitis B immunoglobulin/vaccine, antibiotics) • Gestational age • Observations since birth o Axillary temperature, o Weight o Urine/meconium o Finnegan score (if relevant) • Feeding since birth (e.g. suck behaviour, mode of feeding) Explanation • Introduce yourself to the parents with an explanation of the purpose, procedure

2014 Clinical Practice Guidelines Portal

79. The importance of the learning process in ST analysis interpretation and its impact in improving clinical and neonatal outcomes. (PubMed)

collected prospectively from labors monitored with ST analysis as an adjunct to conventional intrapartum fetal heart rate monitoring. Primary endpoints were the rates of metabolic acidosis (cord artery pH <7.05 and an extracellular fluid compartment base deficit >12.0 mmol/L), fetal scalp blood sampling, and operative deliveries. Comparisons of these outcomes were made between the initiation period (the first 2 years) and the subsequent usage period (the next 9 years).In the whole study population (...) the prevalence of cord pH <7.05 decreased from 1.5-0.81% (relative risk, 0.54; 95% confidence interval, 0.43-0.67), the rate of cesarean deliveries from 17.2-14.1% (relative risk, 0.82; 95% confidence interval, 0.89-0.97), and the rate of fetal scalp blood sampling from 1.75-0.82% (relative risk, 0.47; 95% confidence interval, 0.38-0.58) when the 2 study periods were compared. In the ST analysis group, the frequency of cord metabolic acidosis rate was reduced from 1.0-0.25% (relative risk, 0.33; 95

2018 American Journal of Obstetrics and Gynecology

80. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

of the aorta (coarctation is more proximal and affects longer segments), complex aortic arch anomalies, and ventricular and atrial septal defects. - E ye abnormalities. Ophthalmologic anomalies can include microphthalmos, retinal vascular abnormalities, persistent fetal retinal vessels, exophthalmos, coloboma, and optic nerve atrophy. Diagnosis of PHACE requires clinical examination, cardiac evaluation with echocardiogram, ophthalmologic evaluation, and magnetic resonance imaging (MRI)/magnetic resonance

2016 PDQ - NCI's Comprehensive Cancer Database

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