How to Trip Rapid Review

Step 1: Select articles relevant to your search (remember the system is only optimised for single intervention studies)

Step 2: press

Step 3: review the result, and maybe amend the or if you know better! If we're unsure of the overall sentiment of the trial we will display the conclusion under the article title. We then require you to tell us what the correct sentiment is.

272 results for

Fetal Scalp Stimulation

by
...
Latest & greatest
Alerts

Export results

Use check boxes to select individual results below

SmartSearch available

Trip's SmartSearch engine has discovered connected searches & results. Click to show

81. Mirabegron (Myrbetriq)

Trade and Generic Name} 19 4.3 Preclinical Pharmacology/Toxicology The product is designated a Pregnancy category C, wherein use is recommended in pregnancy only where the potential benefit would outweigh the risks to patient and fetus. Reproductive toxicology studies showed some fetal effects but only at substantial multiples of exposure (e.g., 22-fold and 36-fold exposures at the maximum recommended human dose). Mirabegron was neither genotoxic nor carcinogenic. There were no significant efficacy (...) , is not recommended for use in this patient population by the Sponsor. 2.2 Tables of Currently Available Treatments for Proposed Indications OAB can be managed by various treatment modalities, including bladder and behavioral training, biofeedback, electrical stimulation, surgery or pharmacotherapy. The pharmacotherapeutic treatment options indicated for OAB are muscarinic receptor antagonists, such as solifenacin, oxybutynin, trospium, darifenacin, tolterodine and fesoterodine. Reference ID: 3139101Clinical

2012 FDA - Drug Approval Package

82. Picato - ingenol mebutate

histologically by atypical epithelial proliferation. Actinic keratosis usually develops on areas that are frequently exposed to the sun (e.g., face, lips, ears, scalp, neck, forearms and back of the hands). Actinic keratosis is a carcinoma in situ with progression to invasive squamous cell carcinoma (SCC). Histological evidence shows that contiguous AK is present in 97% of SCC lesions on sun-damaged skin. Actinic keratosis lesions are currently the most common epithelial premalignant lesions seen (...) topical AK products. The applicant applied for the indication: Picato is indicated for the topical treatment of actinic keratosis in adults. The finally approved indication was: Picato is indicated for the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults. For AK on face and scalp in adults, Picato 150 mcg/g gel should be applied to the affected area once daily for 3 consecutive days. For AK on trunk and extremities in adults, Picato 500 mcg/g gel should

2012 European Medicines Agency - EPARs

83. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

Evaluation Initial evaluation of a child or adolescent with a thyroid nodule includes the following: Ultrasound of the thyroid. Serum thyroid-stimulating hormone (TSH) level. Serum thyroglobulin level. Tests of thyroid function are usually normal, but thyroglobulin can be elevated. Fine-needle aspiration as an initial diagnostic approach is sensitive and useful. However, in doubtful cases, open biopsy or resection should be considered.[ ] Treatment of Papillary and Follicular Thyroid Carcinoma Treatment (...) , further evaluation and treatment with radioactive iodine may need to be delayed for 2 to 3 months until total body iodine burden decreases. Chest imaging (x-ray or CT) may be considered for patients with substantial cervical lymph node disease. Thyroid nuclear scintigraphy should be pursued only if the patient presents with a suppressed thyroid-stimulating hormone (TSH). The routine use of bone scan or fluorine F 18-fludeoxyglucose positron emission tomography (PET) is not recommended. Surgery

2016 PDQ - NCI's Comprehensive Cancer Database

84. Genetics of Skin Cancer (PDQ®): Health Professional Version

, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form a large variety of benign or malignant tumors with diverse biological behaviors. Several of these tumors are associated with familial syndromes. Overall, there are dozens of different histological subtypes of these tumors associated with individual components of the adnexal structures.[ ] Finally, the subcutis is a layer that extends below (...) benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas,[ ] mesenchymomas,[ ] basaloid follicular hamartomas,[ ] and nasal dermoid tumors. Development of meningiomas and ependymomas occurring postradiation therapy has been documented in the general pediatric population; radiation therapy for syndrome-associated intracranial processes may be partially responsible for a subset

2016 PDQ - NCI's Comprehensive Cancer Database

85. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer 112 (11): 2424-31, 2008. [ ] Steelman C, Katzenstein H, Parham D, et al.: Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10): 1450-62, 2011. [ ] Alaggio R, Collini P, Randall RL

2016 PDQ - NCI's Comprehensive Cancer Database

86. Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents

pregnancy or because infants of HIV-positive mothers may be born somewhat prematurely (43). High maternal HCV viral load (>600,000 IU/mL) appears to favor mother-to-infant HCV transmission (44–46). Internal monitoring of the fetus (‘‘fetal scalp vein monitoring’’) (10), prolonged rupture of membranes (10,43), and fetal anoxia around the time of delivery, as indicated by decreased cord blood pH (46), may enhance the risk of infection. The role of amniocent- esis on the risk of mother-to-infant HCV (...) there are presently no effective strategies to prevent perinatal HCV transmission, universal screening of pregnant women is not recommended (91) Obstetrical-perinatal factors Vertical transmission of HCV is similar between infants born by C-section or vaginally; however, prolonged rupture of membranes and the use of fetal scalp probes are associated with increased HCV transmission rates and should be avoided (1B; AII) (92–94) Postnatal period The rate of vertical transmission is similar between breast- and bottle

2012 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

87. 2012 ACCF/SCAI Expert Consensus Document on Cardiac Catheterization Laboratory Standards Update

, some subset of all operators should be randomly reviewed at least annually. All operators should be required to attend regularly cardiac catheterization confer- ences and obtain a minimum of 12 CME hours per year. Stimulation training may assist in improving skills. The very low complication rate for diagnostic catheter- ization makes suggestions for a minimum volume threshold particularly dif?cult. The prior catheterization standards document suggested 150 cases per year as a minimum (...) after clear liquids or 6 hours after a light meal. Hydration should be considered an important component prior to contrast administration; and 4) women of child- bearing age should have a urine or serum beta-HCG test within 2 weeks of the procedure. There is little fetal risk during the ?rst 2 weeks of gestation. In addition, the committee could ?nd no data to suggest a concern regarding nitinol device use in patients with nickel allergies. For patients on warfarin, the drug is usually stopped 3

2012 Society for Cardiovascular Angiography and Interventions

88. Hyperthyroidism and Other Causes of Thyrotoxicosis: Management Guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists

Surgeons, Latin American Thyroid Society, Pediatric Endocrine Society, Italian Endocrine Society, and Society of Nuclear Medicine. RESULTS [A] Background In general, thyrotoxicosis can occur if (i) the thyroid is inappropriately stimulated by trophic factors; (ii) there is constituitive activation of thyroid hormone synthesis and secretion leading to autonomous release of excess thyroid hormone; (iii) thyroid stores of preformed hormone are passively released in excessive amounts owing to autoim- mune (...) , infectious, chemical, or mechanical insult; or (iv) there is exposure to extra-thyroidal sources of thyroid hormone, which may be either endogenous (struma ova- rii, metastatic differentiated thyroid cancer) or exogenous (factitious thyrotoxicosis). Subclinical hyperthyroidism (SH) is most often caused by release of excess thyroid hormone by the gland. This condition is defined as a low or undetectable serum thyroid-stimulating hormone (TSH) with values within the normal reference range for both

2011 American Association of Clinical Endocrinologists

89. Auricular acupuncture with seed or pellet attachments for primary insomnia: a systematic review and meta-analysis Full Text available with Trip Pro

and internal organs, and indicated that any physiological or pathological changes inside the body may reflect on the auricles. In the 1950s, Dr. Paul Nogier of France developed and refined the modern theory of auricular acupuncture, which was based on the concept of an inverted fetus map on the external ear [ ], suggesting a reflex system useful for the diagnosis and treatment of diseases [ ]. Clinically pellet attachments are utilized on a large scale to provide perfect stimuli to the ears without (...) , reported in the articles or measured by validated scales, e.g., Health Survey Questionnaire, Treatment Emergent Symptom Scale (TESS) et al. 6. Language restriction: English and Chinese records only. Exclusion criteria Studies that compared different auricular point prescriptions or stimulations in parallel groups were excluded. Studies without mention about randomization were excluded. Redundant publications were excluded. Data collection and analysis Two review authors were independently responsible

2015 BMC Complementary and Alternative Medicine

90. Hyperthyroidism (Treatment)

(albeit rarely) with cloacal and scalp (cutis aplasia) abnormalities when given during early gestation. [ , ] Generally, if a nonpregnant woman who is receiving methimazole desires pregnancy, she should be switched to propylthiouracil before conception. After 12 weeks of gestation, she can be switched back to methimazole, with frequent monitoring. Propylthiouracil remains the drug of choice in uncommon situations of life-threatening severe thyrotoxicosis (ie, thyroid storm) because of the additional (...) vasculitis. All of these adverse effects, except agranulocytosis, occur more frequently with propylthiouracil: agranulocytosis occurs in 0.2-0.5% of patients overall and is no more common with one drug than with the other. Patients with agranulocytosis usually present with fever and pharyngitis. After the drug is stopped, granulocyte counts usually start to rise within several days but may not normalize for 10-14 days. Granulocyte colony-stimulating factor (G-CSF) appears to accelerate recovery

2014 eMedicine.com

91. Postterm Pregnancy (Treatment)

be reviewed. Finally, intrapartum fetal surveillance in an attempt to document fetal intolerance to labor before it leads to acidosis is critical. Whether continuous fetal monitoring or intermittent auscultation is used, interpretation of the results by a well-trained clinician is of paramount importance. If the fetal heart rate tracing is equivocal, fetal scalp stimulation and/or fetal scalp blood sampling may provide the reassurance necessary to justify continuing the induction of labor (...) of a positive human chorionic gonadotropin (+hCG) test finding, 20 weeks of fetal heart tones have been established by a fetoscope or 30 weeks by a Doppler examination, or 39 weeks' gestation have been established by a CRL or by an ultrasound performed before 20 weeks of gestation consistent with dates by the patient's LMP. Perinatal outcomes in postterm pregnancies Recent studies have shown that the risks to the fetus [ , , , , , , , , , , , , ] and to the mother [ , , , , , , , ] of continuing

2014 eMedicine.com

92. Platelet Disorders (Overview)

the presence of petechiae and ecchymoses. The presence of lymphadenopathy or suggests other secondary causes of thrombocytopenia rather than ITP. The peripheral smear shows a decreased number of platelets. Often, the smear shows giant platelets, which is a reflection of increased thrombopoietin-induced stimulation of the bone marrow (see images below). Examination of the peripheral smears in immune thrombocytopenic purpura often shows giant platelets. These platelets reflect the increased megakaryocytic (...) mass in the marrow. Peripheral smear of a patient with Bernard-Soulier syndrome showing giant platelets. These platelets are not counted as platelets in most particle counters. At times, the smear may show eosinophilia and lymphocytosis, possibly reflecting hypersensitivity to the inciting viral antigens. The bone marrow shows an increase in the number of megakaryocytes and signs of thrombopoietin-induced megakaryocyte stimulation (increase in number and ploidy, decrease in cytoplasm), resulting

2014 eMedicine.com

93. Preoperative Evaluation and Management (Overview)

, can cause bone growth retardation and staining of dental enamel in the fetus. Lidocaine also appears to be safe in low doses, although excessive amounts can cause fetal CNS and cardiac depression. Acetaminophen (Class B) is routinely used during pregnancy despite its ability to cross the placenta. [ ] Drugs should also be selected carefully during lactation. [ ] Snoring/sleep apnea Eighty percent of patients with breathing problems related to sleep disorders are male. Conscious sedation may (...) controlled, and the insulin doses should be adjusted as needed. Management of hypoglycemic agents and different types of insulin can be pivotal. [ ] Hypertension A history of hypertension should alert the physician to check the patient's blood pressure. Patients with elevated pressures may bleed profusely. This is especially true when working on larger areas of the body or in highly vascular regions, such as the scalp. Hypertension is an important cause of perioperative bleeding and hematoma formation

2014 eMedicine.com

94. Postterm Pregnancy (Overview)

be reviewed. Finally, intrapartum fetal surveillance in an attempt to document fetal intolerance to labor before it leads to acidosis is critical. Whether continuous fetal monitoring or intermittent auscultation is used, interpretation of the results by a well-trained clinician is of paramount importance. If the fetal heart rate tracing is equivocal, fetal scalp stimulation and/or fetal scalp blood sampling may provide the reassurance necessary to justify continuing the induction of labor (...) of a positive human chorionic gonadotropin (+hCG) test finding, 20 weeks of fetal heart tones have been established by a fetoscope or 30 weeks by a Doppler examination, or 39 weeks' gestation have been established by a CRL or by an ultrasound performed before 20 weeks of gestation consistent with dates by the patient's LMP. Perinatal outcomes in postterm pregnancies Recent studies have shown that the risks to the fetus [ , , , , , , , , , , , , ] and to the mother [ , , , , , , , ] of continuing

2014 eMedicine.com

95. Preoperative Evaluation and Management (Treatment)

, can cause bone growth retardation and staining of dental enamel in the fetus. Lidocaine also appears to be safe in low doses, although excessive amounts can cause fetal CNS and cardiac depression. Acetaminophen (Class B) is routinely used during pregnancy despite its ability to cross the placenta. [ ] Drugs should also be selected carefully during lactation. [ ] Snoring/sleep apnea Eighty percent of patients with breathing problems related to sleep disorders are male. Conscious sedation may (...) controlled, and the insulin doses should be adjusted as needed. Management of hypoglycemic agents and different types of insulin can be pivotal. [ ] Hypertension A history of hypertension should alert the physician to check the patient's blood pressure. Patients with elevated pressures may bleed profusely. This is especially true when working on larger areas of the body or in highly vascular regions, such as the scalp. Hypertension is an important cause of perioperative bleeding and hematoma formation

2014 eMedicine.com

96. Platelet Disorders (Treatment)

the presence of petechiae and ecchymoses. The presence of lymphadenopathy or suggests other secondary causes of thrombocytopenia rather than ITP. The peripheral smear shows a decreased number of platelets. Often, the smear shows giant platelets, which is a reflection of increased thrombopoietin-induced stimulation of the bone marrow (see images below). Examination of the peripheral smears in immune thrombocytopenic purpura often shows giant platelets. These platelets reflect the increased megakaryocytic (...) mass in the marrow. Peripheral smear of a patient with Bernard-Soulier syndrome showing giant platelets. These platelets are not counted as platelets in most particle counters. At times, the smear may show eosinophilia and lymphocytosis, possibly reflecting hypersensitivity to the inciting viral antigens. The bone marrow shows an increase in the number of megakaryocytes and signs of thrombopoietin-induced megakaryocyte stimulation (increase in number and ploidy, decrease in cytoplasm), resulting

2014 eMedicine.com

97. Paraneoplastic Diseases (Overview)

have papillomatous thickening of the oral mucosa. Patients who have AN associated with malignancies also have skin changes involving the scalp, areolae, and eyelids. The appearance of paraneoplastic AN usually coincides with the presence of malignancy, but it can precede or follow the diagnosis of cancer and thus may signal a relapse in patients with a history of cancer. Diagnosis The diagnosis of AN is based on clinical findings alone and can be supported by the histopathologic changes (...) include symmetrical, scaly, violaceous plaques on the acral surfaces, with severe forms progressing to bullae. The lesions predominantly occur on the hands, feet, ear helices, nose tip, and scalp. Skin changes may spread to involve the knees, elbows, and malar surface of the face. [ ] Bazex syndrome occurs more commonly in men older than 40 years. [ ] Alopecia and nail changes are common and can be early findings. Subungual hyperkeratosis, onychodystrophy, and white flaking of the nail surface

2014 eMedicine.com

98. Lyme Disease (Overview)

by erythematous skin lesions. In the United States, Lyme disease was not recognized until the early 1970s, when a statistically improbable cluster of pediatric arthritis cases occurred in the region around Lyme, Connecticut. This outbreak was investigated by Allen Steere, MD, and others from Yale and stimulated intense clinical and epidemiologic research that led to the discovery of the causative agent and its ecology and an expanding geographic range and list of clinical manifestations. The recognition (...) and that it is not directly responsible for adverse fetal outcomes. Post-treatment Lyme disease syndrome Lingering symptoms, which may persist for more than 6 months, affect 10-20% of patients who receive recommended treatment for Lyme disease. [ ] Common complaints include cognitive disturbances, fatigue, joint or muscle pain, headaches, hearing loss, vertigo, mood disturbances, paresthesias, and difficulty sleeping. This condition is often termed chronic Lyme disease, but is more appropriately called post-treatment

2014 eMedicine.com

99. Lyme Disease (Overview)

by erythematous skin lesions. In the United States, Lyme disease was not recognized until the early 1970s, when a statistically improbable cluster of pediatric arthritis cases occurred in the region around Lyme, Connecticut. This outbreak was investigated by Allen Steere, MD, and others from Yale and stimulated intense clinical and epidemiologic research that led to the discovery of the causative agent and its ecology and an expanding geographic range and list of clinical manifestations. The recognition (...) and that it is not directly responsible for adverse fetal outcomes. Post-treatment Lyme disease syndrome Lingering symptoms, which may persist for more than 6 months, affect 10-20% of patients who receive recommended treatment for Lyme disease. [ ] Common complaints include cognitive disturbances, fatigue, joint or muscle pain, headaches, hearing loss, vertigo, mood disturbances, paresthesias, and difficulty sleeping. This condition is often termed chronic Lyme disease, but is more appropriately called post-treatment

2014 eMedicine.com

100. Lyme Disease (Overview)

by erythematous skin lesions. In the United States, Lyme disease was not recognized until the early 1970s, when a statistically improbable cluster of pediatric arthritis cases occurred in the region around Lyme, Connecticut. This outbreak was investigated by Allen Steere, MD, and others from Yale and stimulated intense clinical and epidemiologic research that led to the discovery of the causative agent and its ecology and an expanding geographic range and list of clinical manifestations. The recognition (...) and that it is not directly responsible for adverse fetal outcomes. Post-treatment Lyme disease syndrome Lingering symptoms, which may persist for more than 6 months, affect 10-20% of patients who receive recommended treatment for Lyme disease. [ ] Common complaints include cognitive disturbances, fatigue, joint or muscle pain, headaches, hearing loss, vertigo, mood disturbances, paresthesias, and difficulty sleeping. This condition is often termed chronic Lyme disease, but is more appropriately called post-treatment

2014 eMedicine.com

To help you find the content you need quickly, you can filter your results via the categories on the right-hand side >>>>