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Fetal Scalp Stimulation

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61. Guideline on the management of premature ovarian insufficiency

) antibodies should be performed in women with POI of unknown cause or if an immune disorder is suspected. In patients with a positive TPO-Ab test, thyroid stimulating hormone (TSH) should be measured every year. C 10 There is insufficient evidence to recommend routinely screening POI women for diabetes. D There is no indication for infection screening in women with POI. D The possibility of POI being a consequence of a medical or surgical intervention should be discussed with women as part (...) and quality of primordial follicles. Low ovarian reserve is a condition in which the ovary loses its normal reproductive potential. Women with low ovarian reserve often respond poorly to controlled ovarian stimulation resulting in retrieval of fewer oocytes, producing poorer quality embryos and reduced implantation rates and pregnancy rates (Narkwichean, et al., 2013). Incidence of poor ovarian response, a measure of low ovarian reserve, over all assisted conception cycles ranges from 9 to 24% (Keay, et

2015 European Society of Human Reproduction and Embryology

62. Otezla - apremilast

/antiangiogenic activity (Table 1) (Report 5042-107; Report 5424-11; Report 5478-159; Report 5299-148; Report 5197-130; Report 5279-153; Report 5127-132; Report 5478-100; Report 5638-35). Table 1: Cellular Pharmacologic activity of apremilast Human whole blood, pre-treated for 1 hour with apremilast (0.5 and 1.5 µM), was stimulated with LPS for 18 hours using a TruCulture™ System (Report 7600-043). Apremilast had significant inhibitory effects at 0.5 and 1.5 µM on TNF- a, IL-12/IL-23 p40, interferon gamma (...) inducible protein 10 (IP-10), and MCP-1 EMA/CHMP/476353/2014 Page 19/189 production in LPS-stimulated human whole blood (p 100 µM under LPS, TNF- a, or TGF-ß1 stimulated conditions). The apremilast antiproliferative activity improved in the 48-hour assay with IC 50 values of 92, 40 and 52 µM for the LPS, TNF- a, and TGF-ß1 conditions, respectively. Human dermal fibroblasts (HDFs) were treated for 1 hour with apremilast (0.00001 - 10 µM), followed by incubation with IL-1ß (1 ng/mL), TNF- a (5 ng/mL

2015 European Medicines Agency - EPARs

63. Management of hepatitis C

positive transmitting infection to their babies in utero or during parturition is approximately 5%; the rate is twice as high for those co-infected with HIV. 48 The baby’s risk of acquiring HCV from a mother infected with HCV is not increased by mode of delivery or breast feeding. 48 one prospective study has indicated that fetal scalp monitoring may increase the risk of mother to child transmission. 49 A large retrospective study did not demonstrate any excess risk. 48 Vaginal delivery may increase

2013 SIGN

64. Stivarga (regorafenib hydrate)

EPHA2 85 40 44 RET 0, 0 0 0 PTK5 8 6 5 FGFR-1 33, 22 49 60 p38a 44 41 56 PDGFR a 0.5, 1.2 0.1 0.3 p38ß 56 51 54 PDGFR ß 0, 0.05 0 0 LYN 44 46 79 EGFR 69, 81 79 77 TrkA 74 16 16 EGFR > 1000 > 1000 > 1000 n = 1 or 2 (for n = 2, values are indicated for each measurement.) The inhibitory effects of regorafenib, M-2, and M-5 on the phosphorylation of TIE2, c-Kit, and BRAF V600E in response to ligand stimulation were measured in cell lines expressing each 13 kinase by enzyme-linked immunoassay (ELISA (...) for M-2 and 1.8 µmol/L for M-5. The inhibitory effect of these metabolites persisted even after washout. ii) Effects on action potential in Purkinje fibers (Report PH-33827 [non-GLP study, reference data]) In Purkinje fibers isolated from rabbit hearts, effects of regorafenib (0.2, 2, 20 µmol/L) on myocardial action potential were evaluated (n = 5) with stimulation at 0.2, 1, and 2.5 Hz, using the resting membrane potential, action potential amplitude, maximum depolarization rate, and action

2013 Pharmaceuticals and Medical Devices Agency, Japan

65. Genetics of Skin Cancer (PDQ®): Health Professional Version

and is occasionally associated with mast cell leukemia; cutaneous T-cell lymphoma is often confined to the skin throughout its course. Overall, 10% of leukemias and lymphomas have prominent expression in the skin.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal (...) ,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas,[ ] mesenchymomas,[ ] basaloid follicular hamartomas,[ ] and nasal dermoid tumors. Development of meningiomas and ependymomas occurring postradiation therapy has been documented in the general pediatric population; radiation therapy for syndrome-associated intracranial processes may be partially responsible for a subset of these benign tumors in individuals with BCNS.[ - ] In addition, radiation therapy of malignant medulloblastomas in the BCNS population

2018 PDQ - NCI's Comprehensive Cancer Database

66. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

Evaluation Initial evaluation of a child or adolescent with a thyroid nodule includes the following: Ultrasound of the thyroid. Serum thyroid-stimulating hormone (TSH) level. Serum thyroglobulin level. Tests of thyroid function are usually normal, but thyroglobulin can be elevated. Fine-needle aspiration as an initial diagnostic approach is sensitive and useful. However, in doubtful cases, open biopsy or resection should be considered.[ ] Treatment of Papillary and Follicular Thyroid Carcinoma Treatment (...) , further evaluation and treatment with radioactive iodine may need to be delayed for 2 to 3 months until total body iodine burden decreases. Chest imaging (x-ray or CT) may be considered for patients with substantial cervical lymph node disease. Thyroid nuclear scintigraphy should be pursued only if the patient presents with a suppressed thyroid-stimulating hormone (TSH). The routine use of bone scan or fluorine F 18-fludeoxyglucose positron emission tomography (PET) is not recommended. Surgery

2018 PDQ - NCI's Comprehensive Cancer Database

67. Core Competencies for Management of Labour

monitor either externally or internally for the continuous evaluation of fetal heart rate pattern in labour. Fetal scalp electrode (FSE) – internal signal source for electronically monitoring the fetal heart rate inserted through vagina and cervix and attached to the presenting part External tocotransducer – Pressure sensitive electronic device for measuring uterine activity transabdominally – detects changes in surface pressure Intrauterine Pressure Catheter (IUPC) – catheter inserted into uterine (...) ) • Using the appropriate methods of fetal health surveillance – IA or EFM, assess and document fetal heart rate at the recommended frequency 2. Uterine Activity • Identify uterine contraction patterns that might adversely affect oxygen delivery to the fetus • Assessment of uterine activity is performed in conjunction with IA or EFM, and is necessary in order to correctly classify the fetal heart rate patterns with EFM • Palpate by hand and/or • Assess using an external tocotransducer or an internal

2014 British Columbia Perinatal Health Program

68. Evidence Map of Acupuncture

is the stimulation of specific acupuncture points through penetration of the skin with needles, which aims to correct imbalances in the flow of qi, a concept of energy in traditional Chinese medicine (TCM), through meridians (ie, energy channels). The available published literature on acupuncture is extensive. PubMed searches in 2013 identified almost 20,000 citations with the term “acupuncture” and almost 1,500 randomized controlled trials (RCTs) with “acupuncture” in the title. Not surprisingly, a large number (...) using needles, including traditional Chinese acupuncture and other related acupuncture concepts, with or without electro stimulation, with or without moxibustion, and whole body as well as microsystem acupuncture, were eligible. Reviews or RCTs exclusively targeting acupressure, laser acupuncture, transcutaneous electrical nerve simulation, or dry needling were excluded. Reviews on the effectiveness of acupuncture, alone or in combination with other traditional Chinese medicine approaches, were

2014 Veterans Affairs Evidence-based Synthesis Program Reports

70. Acute Pain Management: Scientific Evidence

factors for the development of postoperative acute persistent pain. Trends Anaesth Critical Care 4: 67–70. Shipton EA (2014b) The transition of acute postoperative pain to chronic pain: Part 2 - Limiting the transition. Trends Anaesth Critical Care 4: 71–75. Vidaeff AC, Saade GR, Belfort MA (in press) Interpreting a randomized trial report: evidence-based practice for the clinician. J Matern Fetal Neonatal Med. Walsh M, Woodhouse LJ, Thomas SG, Finch E (2011) Strategies aimed at preventing chronic (...) Cognitive-behavioural interventions 262xvii CONTENTS 7.2 Transcutaneous electrical nerve stimulation 265 7.3 Acupuncture and acupressure 265 7.3.1 Postoperative pain 265 7.3.2 Other acute pain states 267 7.4 Physical therapies 269 7.4.1 Manual and massage therapies 269 7.4.2 Warming and cooling intervention 270 7.4.3 Other therapies 271 References 271 8. SPECIFIC CLINICAL SITUATIONS 279 8.1 Postoperative pain 279 8.1.1 Multimodal postoperative pain management 279 8.1.2 Procedure-specific postoperative

2015 Clinical Practice Guidelines Portal

71. Prevention of skin cancer

a known precursor stage: actinic keratosis (AK, also known as solar keratosis). AK is a small, intraepidermal lesion that occurs on chronically sun-(UV-) exposed areas such as the face, scalp, lips, lower arms and hands in middle-aged and elderly light-skinned people. Cumulative UV exposure to the sun is regarded as the main reason for the occurrence of AK [57, 58]. The incidence of AK therefore increases with age. AK constitutes a precursor stage of SCC [59]. In the literature there are conversion

2014 German Guideline Program in Oncology

72. Safe Prevention of the Primary Cesarean Delivery

elements of the Category II tracing or provide reassurance of fetal well-being. Scalp stimulation to elicit a fetal heart rate acceleration is an easily employed tool when the cervix is dilated and can offer clinician reassurance that the fetus is not acidotic. Spontaneous or elicited heart rate accelerations are associated with a normal umbilical cord arterial pH (7.20 or greater) (54, ). Recurrent variable decelerations, thought to be a physiologic response to repetitive compression of the umbilical (...) to such factors will optimize clinical decision making regarding the management of abnormal or indeterminate fetal heart rate patterns and the need for cesarean delivery. Specifically, amnioinfusion for repetitive variable fetal heart rate decelerations may safely reduce the rate of cesarean delivery (Table 3). Scalp stimulation can be used as a means of assessing fetal acid–base status when abnormal or indeterminate (formerly, nonreassuring) fetal heart patterns (eg, minimal variability) are present

2014 American College of Obstetricians and Gynecologists

75. Von Willebrand Disease in Women

Willebrand disease can be transmitted as an autosomal dominant or recessive trait, the fetus can have up to a 50% risk of being affected. Procedures, such as fetal scalp electrode or fetal scalp sampling, are better avoided, and circumcision should be postponed until the newborn’s vWD status is determined (2). Operative vaginal deliveries, in which there may be an increased risk of trauma to the newborn, should be avoided because of the potential risk of intracranial hemorrhage (15). In many women, vWF (...) acetate, recombinant factor VIII, and vWF complex infusion (7, 10). Desmopressin acetate is a synthetic derivative of the antidiuretic hormone vasopressin and works by stimulating the release of vWF from endothelial cells (7). Recombinant factor VIII and vWF complex infusion are plasma-derived concentrates used to replace factor VIII and vWF, respectively. One study demonstrated that women with bleeding disorders had reduced menstrual flow with the use of either intranasal desmopressin or tranexamic

2013 American College of Obstetricians and Gynecologists

76. Brain Targets in Patients With Bladder Emptying Difficulties

. The amount and frequency of therapy are prescribed by the physician, and the device is custom configured to the patient to deliver the required amount of treatment. The device does not turn on until it is time for the treatment. It consists of three main parts: Neoprene cap with microstimulator(s), stimulator console (device controller box) and the tablet with TRPMS app which activates the console. The neoprene cap prevents the microstimulator(s) from coming in direct contact with the scalp (...) as seen in patients with neurogenic bladder dysfunction and will be used for this study. After characterizing brain regions involved in bladder emptying, the investigator propose to use noninvasive transcutaneous magnetic stimulation in a subset of patients with voiding dysfunction in aim 3. Condition or disease Intervention/treatment Neurogenic Bladder Multiple Sclerosis Parkinson Disease Voiding Dysfunction Device: Transcranial Rotating Permanent Magnet Stimulator (TRPMS) Detailed Description

2018 Clinical Trials

77. Imaging Laterality in Chronic Stroke Patients

including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system Pregnancy as the effect of MRI on the fetus is unknown, females of child bearing age must undergo a pregnancy test to confirm eligibility History of seizure disorder or post-stroke seizure Preexisting scalp lesion or wound or bone defect or hemicraniectomy Left-hand dominance (before the stroke in the stroke patients) as the typical pattern of laterality is not as strong in left-handed healthy (...) pulse transcranial magnetic stimulation (TMS), and 2) neurochemically, using magnetic resonance spectroscopy (MRS). Another factor that may contribute to elevated activity in the contralesional PMC is a loss of transcallosal inhibition between the hemispheres (Aim 2). During right hand movement, the left PMC of healthy individuals actively inhibits the right PMC via inhibitory projections through the corpus callosum. In left MCA stroke patients, elevated activity in the contralesional (right) PMC

2018 Clinical Trials

78. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

.: Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer 112 (11): 2424-31, 2008. [ ] Steelman C, Katzenstein H, Parham D, et al.: Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10

2017 PDQ - NCI's Comprehensive Cancer Database

79. British HIV Association guidelines for the management of HIV infection in pregnant women

Questions and PICO criteria A2.2 Search 1: safety and ef?cacy of antiretrovirals in pregnancy A2.3 Search 2: hepatitis viruses coinfection A2.4 Search 3: delivery, fetal monitoring and obstetric issues 88 BHIVA Writing Group © 2012 British HIV Association HIV Medicine (2012), 13 (Suppl. 2), 87–157A2.5 Search 4: paediatric issues A2.6 Search 5: investigations and monitoring in pregnancy Appendix 3: Search protocols (main databases search) A3.1 Search 1: when to initiate antiretroviral therapy A3.2 Search (...) 2: hepatitis coinfection A3.3 Search 3: fetal monitoring and obstetric issues A3.4 Search 4: paediatric issues A3.5 Search 5: investigations and monitoring in pregnancy Appendix 4 A4.1 Antiretroviral therapies for which suf?cient numbers of pregnancies with ?rst trimester exposure have been monitored to detect a two-fold increase in overall birth defects A4.2 Advisory Committee Consensus BHIVA guidelines for the management of HIV infection in pregnant women 2012 89 © 2012 British HIV Association

2012 The Children's HIV Association

80. Zyclara - imiquimod

in accordance with Article 8(3) of Directive 2001/83/EC. The applicant applied for the following indication: topical treatment of clinically typical, visible or palpable actinic keratoses (AK) of the full face or balding scalp in adults. The legal basis for this application refers to: Hybrid application (Article 10(3) of Directive No 2001/83/EC). The application submitted is composed of administrative information, complete quality data and appropriate clinical data. Information on paediatric requirements (...) of the central transcription factor nuclear factor-kappaB (nf ?B), which leads to induction of proinflammatory cytokines and other mediators. Cutaneous dendritic cells are the primary responsive cell type and initiate a strong T-helper-cell (Th1) weighted antitumoural cellular immune response. Recent research has shown that dendritic cells themselves acquire direct antitumoural activity upon stimulation by imiquimod. In addition, there are a number of secondary effects on the molecular and cellular level

2012 European Medicines Agency - EPARs

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