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Fetal Scalp Stimulation

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61. Acute Pain Management: Scientific Evidence

factors for the development of postoperative acute persistent pain. Trends Anaesth Critical Care 4: 67–70. Shipton EA (2014b) The transition of acute postoperative pain to chronic pain: Part 2 - Limiting the transition. Trends Anaesth Critical Care 4: 71–75. Vidaeff AC, Saade GR, Belfort MA (in press) Interpreting a randomized trial report: evidence-based practice for the clinician. J Matern Fetal Neonatal Med. Walsh M, Woodhouse LJ, Thomas SG, Finch E (2011) Strategies aimed at preventing chronic (...) Cognitive-behavioural interventions 262xvii CONTENTS 7.2 Transcutaneous electrical nerve stimulation 265 7.3 Acupuncture and acupressure 265 7.3.1 Postoperative pain 265 7.3.2 Other acute pain states 267 7.4 Physical therapies 269 7.4.1 Manual and massage therapies 269 7.4.2 Warming and cooling intervention 270 7.4.3 Other therapies 271 References 271 8. SPECIFIC CLINICAL SITUATIONS 279 8.1 Postoperative pain 279 8.1.1 Multimodal postoperative pain management 279 8.1.2 Procedure-specific postoperative

2015 Clinical Practice Guidelines Portal

62. Evidence Map of Acupuncture

is the stimulation of specific acupuncture points through penetration of the skin with needles, which aims to correct imbalances in the flow of qi, a concept of energy in traditional Chinese medicine (TCM), through meridians (ie, energy channels). The available published literature on acupuncture is extensive. PubMed searches in 2013 identified almost 20,000 citations with the term “acupuncture” and almost 1,500 randomized controlled trials (RCTs) with “acupuncture” in the title. Not surprisingly, a large number (...) using needles, including traditional Chinese acupuncture and other related acupuncture concepts, with or without electro stimulation, with or without moxibustion, and whole body as well as microsystem acupuncture, were eligible. Reviews or RCTs exclusively targeting acupressure, laser acupuncture, transcutaneous electrical nerve simulation, or dry needling were excluded. Reviews on the effectiveness of acupuncture, alone or in combination with other traditional Chinese medicine approaches, were

2014 Veterans Affairs Evidence-based Synthesis Program Reports

63. Stivarga (regorafenib hydrate)

EPHA2 85 40 44 RET 0, 0 0 0 PTK5 8 6 5 FGFR-1 33, 22 49 60 p38a 44 41 56 PDGFR a 0.5, 1.2 0.1 0.3 p38ß 56 51 54 PDGFR ß 0, 0.05 0 0 LYN 44 46 79 EGFR 69, 81 79 77 TrkA 74 16 16 EGFR > 1000 > 1000 > 1000 n = 1 or 2 (for n = 2, values are indicated for each measurement.) The inhibitory effects of regorafenib, M-2, and M-5 on the phosphorylation of TIE2, c-Kit, and BRAF V600E in response to ligand stimulation were measured in cell lines expressing each 13 kinase by enzyme-linked immunoassay (ELISA (...) for M-2 and 1.8 µmol/L for M-5. The inhibitory effect of these metabolites persisted even after washout. ii) Effects on action potential in Purkinje fibers (Report PH-33827 [non-GLP study, reference data]) In Purkinje fibers isolated from rabbit hearts, effects of regorafenib (0.2, 2, 20 µmol/L) on myocardial action potential were evaluated (n = 5) with stimulation at 0.2, 1, and 2.5 Hz, using the resting membrane potential, action potential amplitude, maximum depolarization rate, and action

2013 Pharmaceuticals and Medical Devices Agency, Japan

64. Management of Hepatitis C

positive transmitting infection to their babies in utero or during parturition is approximately 5%; the rate is twice as high for those co-infected with HIV. 48 The baby’s risk of acquiring HCV from a mother infected with HCV is not increased by mode of delivery or breast feeding. 48 one prospective study has indicated that fetal scalp monitoring may increase the risk of mother to child transmission. 49 A large retrospective study did not demonstrate any excess risk. 48 Vaginal delivery may increase

2013 SIGN

66. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

.: Mesenchymal chondrosarcoma of soft tissues and bone in children, adolescents, and young adults: experiences of the CWS and COSS study groups. Cancer 112 (11): 2424-31, 2008. [ ] Steelman C, Katzenstein H, Parham D, et al.: Unusual presentation of congenital infantile fibrosarcoma in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10

2017 PDQ - NCI's Comprehensive Cancer Database

67. Zyclara - imiquimod

in accordance with Article 8(3) of Directive 2001/83/EC. The applicant applied for the following indication: topical treatment of clinically typical, visible or palpable actinic keratoses (AK) of the full face or balding scalp in adults. The legal basis for this application refers to: Hybrid application (Article 10(3) of Directive No 2001/83/EC). The application submitted is composed of administrative information, complete quality data and appropriate clinical data. Information on paediatric requirements (...) of the central transcription factor nuclear factor-kappaB (nf ?B), which leads to induction of proinflammatory cytokines and other mediators. Cutaneous dendritic cells are the primary responsive cell type and initiate a strong T-helper-cell (Th1) weighted antitumoural cellular immune response. Recent research has shown that dendritic cells themselves acquire direct antitumoural activity upon stimulation by imiquimod. In addition, there are a number of secondary effects on the molecular and cellular level

2012 European Medicines Agency - EPARs

68. Picato - ingenol mebutate

histologically by atypical epithelial proliferation. Actinic keratosis usually develops on areas that are frequently exposed to the sun (e.g., face, lips, ears, scalp, neck, forearms and back of the hands). Actinic keratosis is a carcinoma in situ with progression to invasive squamous cell carcinoma (SCC). Histological evidence shows that contiguous AK is present in 97% of SCC lesions on sun-damaged skin. Actinic keratosis lesions are currently the most common epithelial premalignant lesions seen (...) topical AK products. The applicant applied for the indication: Picato is indicated for the topical treatment of actinic keratosis in adults. The finally approved indication was: Picato is indicated for the cutaneous treatment of non-hyperkeratotic, non-hypertrophic actinic keratosis in adults. For AK on face and scalp in adults, Picato 150 mcg/g gel should be applied to the affected area once daily for 3 consecutive days. For AK on trunk and extremities in adults, Picato 500 mcg/g gel should

2012 European Medicines Agency - EPARs

69. Mirabegron (Myrbetriq)

Trade and Generic Name} 19 4.3 Preclinical Pharmacology/Toxicology The product is designated a Pregnancy category C, wherein use is recommended in pregnancy only where the potential benefit would outweigh the risks to patient and fetus. Reproductive toxicology studies showed some fetal effects but only at substantial multiples of exposure (e.g., 22-fold and 36-fold exposures at the maximum recommended human dose). Mirabegron was neither genotoxic nor carcinogenic. There were no significant efficacy (...) , is not recommended for use in this patient population by the Sponsor. 2.2 Tables of Currently Available Treatments for Proposed Indications OAB can be managed by various treatment modalities, including bladder and behavioral training, biofeedback, electrical stimulation, surgery or pharmacotherapy. The pharmacotherapeutic treatment options indicated for OAB are muscarinic receptor antagonists, such as solifenacin, oxybutynin, trospium, darifenacin, tolterodine and fesoterodine. Reference ID: 3139101Clinical

2012 FDA - Drug Approval Package

70. British HIV Association guidelines for the management of HIV infection in pregnant women

Questions and PICO criteria A2.2 Search 1: safety and ef?cacy of antiretrovirals in pregnancy A2.3 Search 2: hepatitis viruses coinfection A2.4 Search 3: delivery, fetal monitoring and obstetric issues 88 BHIVA Writing Group © 2012 British HIV Association HIV Medicine (2012), 13 (Suppl. 2), 87–157A2.5 Search 4: paediatric issues A2.6 Search 5: investigations and monitoring in pregnancy Appendix 3: Search protocols (main databases search) A3.1 Search 1: when to initiate antiretroviral therapy A3.2 Search (...) 2: hepatitis coinfection A3.3 Search 3: fetal monitoring and obstetric issues A3.4 Search 4: paediatric issues A3.5 Search 5: investigations and monitoring in pregnancy Appendix 4 A4.1 Antiretroviral therapies for which suf?cient numbers of pregnancies with ?rst trimester exposure have been monitored to detect a two-fold increase in overall birth defects A4.2 Advisory Committee Consensus BHIVA guidelines for the management of HIV infection in pregnant women 2012 89 © 2012 British HIV Association

2012 The Children's HIV Association

71. Brain Targets in Patients With Bladder Emptying Difficulties

. The amount and frequency of therapy are prescribed by the physician, and the device is custom configured to the patient to deliver the required amount of treatment. The device does not turn on until it is time for the treatment. It consists of three main parts: Neoprene cap with microstimulator(s), stimulator console (device controller box) and the tablet with TRPMS app which activates the console. The neoprene cap prevents the microstimulator(s) from coming in direct contact with the scalp (...) as seen in patients with neurogenic bladder dysfunction and will be used for this study. After characterizing brain regions involved in bladder emptying, the investigator propose to use noninvasive transcutaneous magnetic stimulation in a subset of patients with voiding dysfunction in aim 3. Condition or disease Intervention/treatment Neurogenic Bladder Multiple Sclerosis Parkinson Disease Voiding Dysfunction Device: Transcranial Rotating Permanent Magnet Stimulator (TRPMS) Detailed Description

2018 Clinical Trials

72. Imaging Laterality in Chronic Stroke Patients

including cardiac pacemaker, intracerebral vascular clips or any other electrically sensitive support system Pregnancy as the effect of MRI on the fetus is unknown, females of child bearing age must undergo a pregnancy test to confirm eligibility History of seizure disorder or post-stroke seizure Preexisting scalp lesion or wound or bone defect or hemicraniectomy Left-hand dominance (before the stroke in the stroke patients) as the typical pattern of laterality is not as strong in left-handed healthy (...) pulse transcranial magnetic stimulation (TMS), and 2) neurochemically, using magnetic resonance spectroscopy (MRS). Another factor that may contribute to elevated activity in the contralesional PMC is a loss of transcallosal inhibition between the hemispheres (Aim 2). During right hand movement, the left PMC of healthy individuals actively inhibits the right PMC via inhibitory projections through the corpus callosum. In left MCA stroke patients, elevated activity in the contralesional (right) PMC

2018 Clinical Trials

73. Prevention of skin cancer

a known precursor stage: actinic keratosis (AK, also known as solar keratosis). AK is a small, intraepidermal lesion that occurs on chronically sun-(UV-) exposed areas such as the face, scalp, lips, lower arms and hands in middle-aged and elderly light-skinned people. Cumulative UV exposure to the sun is regarded as the main reason for the occurrence of AK [57, 58]. The incidence of AK therefore increases with age. AK constitutes a precursor stage of SCC [59]. In the literature there are conversion

2014 German Guideline Program in Oncology

74. Safe Prevention of the Primary Cesarean Delivery

elements of the Category II tracing or provide reassurance of fetal well-being. Scalp stimulation to elicit a fetal heart rate acceleration is an easily employed tool when the cervix is dilated and can offer clinician reassurance that the fetus is not acidotic. Spontaneous or elicited heart rate accelerations are associated with a normal umbilical cord arterial pH (7.20 or greater) (54, ). Recurrent variable decelerations, thought to be a physiologic response to repetitive compression of the umbilical (...) to such factors will optimize clinical decision making regarding the management of abnormal or indeterminate fetal heart rate patterns and the need for cesarean delivery. Specifically, amnioinfusion for repetitive variable fetal heart rate decelerations may safely reduce the rate of cesarean delivery (Table 3). Scalp stimulation can be used as a means of assessing fetal acid–base status when abnormal or indeterminate (formerly, nonreassuring) fetal heart patterns (eg, minimal variability) are present

2014 American College of Obstetricians and Gynecologists

76. Von Willebrand Disease in Women

Willebrand disease can be transmitted as an autosomal dominant or recessive trait, the fetus can have up to a 50% risk of being affected. Procedures, such as fetal scalp electrode or fetal scalp sampling, are better avoided, and circumcision should be postponed until the newborn’s vWD status is determined (2). Operative vaginal deliveries, in which there may be an increased risk of trauma to the newborn, should be avoided because of the potential risk of intracranial hemorrhage (15). In many women, vWF (...) acetate, recombinant factor VIII, and vWF complex infusion (7, 10). Desmopressin acetate is a synthetic derivative of the antidiuretic hormone vasopressin and works by stimulating the release of vWF from endothelial cells (7). Recombinant factor VIII and vWF complex infusion are plasma-derived concentrates used to replace factor VIII and vWF, respectively. One study demonstrated that women with bleeding disorders had reduced menstrual flow with the use of either intranasal desmopressin or tranexamic

2013 American College of Obstetricians and Gynecologists

78. Diagnosis and Management of Hepatitis C Infection in Infants, Children, and Adolescents

pregnancy or because infants of HIV-positive mothers may be born somewhat prematurely (43). High maternal HCV viral load (>600,000 IU/mL) appears to favor mother-to-infant HCV transmission (44–46). Internal monitoring of the fetus (‘‘fetal scalp vein monitoring’’) (10), prolonged rupture of membranes (10,43), and fetal anoxia around the time of delivery, as indicated by decreased cord blood pH (46), may enhance the risk of infection. The role of amniocent- esis on the risk of mother-to-infant HCV (...) there are presently no effective strategies to prevent perinatal HCV transmission, universal screening of pregnant women is not recommended (91) Obstetrical-perinatal factors Vertical transmission of HCV is similar between infants born by C-section or vaginally; however, prolonged rupture of membranes and the use of fetal scalp probes are associated with increased HCV transmission rates and should be avoided (1B; AII) (92–94) Postnatal period The rate of vertical transmission is similar between breast- and bottle

2012 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

79. 2012 ACCF/SCAI Expert Consensus Document on Cardiac Catheterization Laboratory Standards Update

, some subset of all operators should be randomly reviewed at least annually. All operators should be required to attend regularly cardiac catheterization confer- ences and obtain a minimum of 12 CME hours per year. Stimulation training may assist in improving skills. The very low complication rate for diagnostic catheter- ization makes suggestions for a minimum volume threshold particularly dif?cult. The prior catheterization standards document suggested 150 cases per year as a minimum (...) after clear liquids or 6 hours after a light meal. Hydration should be considered an important component prior to contrast administration; and 4) women of child- bearing age should have a urine or serum beta-HCG test within 2 weeks of the procedure. There is little fetal risk during the ?rst 2 weeks of gestation. In addition, the committee could ?nd no data to suggest a concern regarding nitinol device use in patients with nickel allergies. For patients on warfarin, the drug is usually stopped 3

2012 Society for Cardiovascular Angiography and Interventions

80. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

effective contraception (given their potential fetal toxicity). Flutamide is of limited value because of associated hepatotoxicity. In addition, drospirenone is not antiandrogenic in the dosage usedasacomponentofsomeOCPs.Insulin-sensitizingagents, such asmetformin andpioglitazone, have little effecton hir- sutism or acne (13, 14). Physical approaches to remove unwanted hair, including electrolysis and laser treatments, maybe acceptabletomanypatients. Insevereacne,isotretinoincanbebene?cial,butindivid (...) excess in utero. This may have long-term effects, particularly on female offspring. Fetal hyperandrogenism maydisturbepigeneticprogramming,inparticularthosegenes regulating reproduction and metabolism. Data in relation to the risk of miscarriage in women with PCOS are con?icting, althoughmiscarriageratesaregenerallythoughttobecompa- rable with other subfertile populations (29, 30). When pregnancy occurs in women with PCOS, there is a higher incidence of gestational diabetes (GDM) (40% to 50

2012 Society for Assisted Reproductive Technology

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