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Fetal Scalp Stimulation

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41. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

.[ , ] (Refer to the section of the PDQ summary on for more information.) For children with de novo RET mutations and no familial history, nonendocrine manifestations, such as intestinal ganglioneuromatosis or skeletal or ocular stigmata, may facilitate early diagnosis and result in better outcomes.[ ] Diagnostic Evaluation Initial evaluation of a child or adolescent with a thyroid nodule includes the following: Ultrasound of the thyroid. Serum thyroid-stimulating hormone (TSH) level. Serum thyroglobulin (...) for patients with substantial cervical lymph node disease. Thyroid nuclear scintigraphy should be pursued only if the patient presents with a suppressed thyroid-stimulating hormone (TSH). The routine use of bone scan or fluorine F 18-fludeoxyglucose positron emission tomography (PET) is not recommended. Surgery.[ ] Pediatric thyroid surgery is ideally completed by a surgeon who has experience performing endocrine procedures in children and in a hospital with the full spectrum of pediatric specialty care

2018 PDQ - NCI's Comprehensive Cancer Database

42. Acute pain management: scientific evidence (3rd Edition)

anaesthetics 204 7.5.5 Safety 205 References 208 8. NON-PHARMACOLOGICAL TECHNIQUES 225 8.1 Psychological interventions 225 8.1.1 Provision of information 225 8.1.2 Stress and tension reduction 226 8.1.3 Attentional techniques 227 8.1.4 Cognitiv e-behavioural interventions 228 8.2 Transcutaneous electrical nerve stimulation 230 8.3 Acupuncture 231 8.4 Other physical therapies 232 8.4.1 Manual and massage therapies 232 8.4.2 Heat and cold 232 8.4.3 Other therapies 232 References 233 Acute Pain Management (...) depressant drugs 434 11.8.3 CNS stimulant drugs 435 11.8.4 Drugs used in the treatment of addiction disorders 435 11.8.5 Recovering patients 437 References 437 APPENDIX A 457 The working party, contributors and members of the multidisciplinary consultative committee 457 APPENDIX B 467 Process report 467 ABBREVIATIONS AND ACRONYMS 479 INDEX 485xviii Acute Pain Management: Scientific Evidence CONTENTS Tables 1.1 Examples of primary afferent and dorsal horn receptors and ligands 2 1.2 Incidence of chronic

2015 National Health and Medical Research Council

44. Core Competencies for Management of Labour

monitor either externally or internally for the continuous evaluation of fetal heart rate pattern in labour. Fetal scalp electrode (FSE) – internal signal source for electronically monitoring the fetal heart rate inserted through vagina and cervix and attached to the presenting part External tocotransducer – Pressure sensitive electronic device for measuring uterine activity transabdominally – detects changes in surface pressure Intrauterine Pressure Catheter (IUPC) – catheter inserted into uterine (...) : Intra-uterine pressure monitoring ? FHR: Fetal scalp electrode • Apply label with addressograph information to beginning of tracing • Ensure the timing of nursing notation corresponds with the time on the monitor clock • Describe ¦ Baseline rate – average number in bpm rounded to increments of 5 bpm ¦ Baseline FHR variability as absent (undetectable), minimal (= 5 bpm), moderate (6 – 25 bpm) or marked (> 25 bpm) ¦ Presence/absence of accelerationsManaging Labour Decision Support Tool No. 2

2014 British Columbia Perinatal Health Program

45. Evidence Map of Acupuncture

is the stimulation of specific acupuncture points through penetration of the skin with needles, which aims to correct imbalances in the flow of qi, a concept of energy in traditional Chinese medicine (TCM), through meridians (ie, energy channels). The available published literature on acupuncture is extensive. PubMed searches in 2013 identified almost 20,000 citations with the term “acupuncture” and almost 1,500 randomized controlled trials (RCTs) with “acupuncture” in the title. Not surprisingly, a large number (...) using needles, including traditional Chinese acupuncture and other related acupuncture concepts, with or without electro stimulation, with or without moxibustion, and whole body as well as microsystem acupuncture, were eligible. Reviews or RCTs exclusively targeting acupressure, laser acupuncture, transcutaneous electrical nerve simulation, or dry needling were excluded. Reviews on the effectiveness of acupuncture, alone or in combination with other traditional Chinese medicine approaches, were

2014 Veterans Affairs Evidence-based Synthesis Program Reports

46. Hypothyroidism

Hypothyroidism Hypothyroidism - NICE CKS Share Hypothyroidism: Summary Hypothyroidism is the clinical result of impaired production of thyroid hormones (thyroxine [T4] and tri-iodothyronine [T3]). Thyroid hormones are released from the thyroid gland when it is stimulated by thyroid-stimulating hormone (TSH) from the anterior pituitary. Primary hypothyroidism (95% of cases) occurs when the thyroid gland is unable to produce thyroid hormones because of iodine deficiency or an abnormality within (...) when it is stimulated by thyrotrophin (also known as thyroid-stimulating hormone [TSH]) from the anterior pituitary. The pituitary gland releases TSH when it is stimulated by thyrotrophin-releasing hormone (TRH) from the hypothalamus [ ]. Circulating thyroid hormone levels are controlled through the process of negative feedback on the hypothalamus and pituitary [ ; ]. Primary hypothyroidism (95% of cases) occurs when the thyroid gland is unable to produce thyroid hormones because of iodine

2018 NICE Clinical Knowledge Summaries

47. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10): 1450-62, 2011. [ ] Alaggio R, Collini P, Randall RL, et al.: Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 13 (3): 209-17, 2010 May-Jun. [ ] Staging and Grading Systems

2017 PDQ - NCI's Comprehensive Cancer Database

48. Stivarga (regorafenib hydrate)

EPHA2 85 40 44 RET 0, 0 0 0 PTK5 8 6 5 FGFR-1 33, 22 49 60 p38a 44 41 56 PDGFR a 0.5, 1.2 0.1 0.3 p38ß 56 51 54 PDGFR ß 0, 0.05 0 0 LYN 44 46 79 EGFR 69, 81 79 77 TrkA 74 16 16 EGFR > 1000 > 1000 > 1000 n = 1 or 2 (for n = 2, values are indicated for each measurement.) The inhibitory effects of regorafenib, M-2, and M-5 on the phosphorylation of TIE2, c-Kit, and BRAF V600E in response to ligand stimulation were measured in cell lines expressing each 13 kinase by enzyme-linked immunoassay (ELISA (...) for M-2 and 1.8 µmol/L for M-5. The inhibitory effect of these metabolites persisted even after washout. ii) Effects on action potential in Purkinje fibers (Report PH-33827 [non-GLP study, reference data]) In Purkinje fibers isolated from rabbit hearts, effects of regorafenib (0.2, 2, 20 µmol/L) on myocardial action potential were evaluated (n = 5) with stimulation at 0.2, 1, and 2.5 Hz, using the resting membrane potential, action potential amplitude, maximum depolarization rate, and action

2013 Pharmaceuticals and Medical Devices Agency, Japan

49. Management of Hepatitis C

positive transmitting infection to their babies in utero or during parturition is approximately 5%; the rate is twice as high for those co-infected with HIV. 48 The baby’s risk of acquiring HCV from a mother infected with HCV is not increased by mode of delivery or breast feeding. 48 one prospective study has indicated that fetal scalp monitoring may increase the risk of mother to child transmission. 49 A large retrospective study did not demonstrate any excess risk. 48 Vaginal delivery may increase

2013 SIGN

50. Acute Pain Management: Scientific Evidence

factors for the development of postoperative acute persistent pain. Trends Anaesth Critical Care 4: 67–70. Shipton EA (2014b) The transition of acute postoperative pain to chronic pain: Part 2 - Limiting the transition. Trends Anaesth Critical Care 4: 71–75. Vidaeff AC, Saade GR, Belfort MA (in press) Interpreting a randomized trial report: evidence-based practice for the clinician. J Matern Fetal Neonatal Med. Walsh M, Woodhouse LJ, Thomas SG, Finch E (2011) Strategies aimed at preventing chronic (...) Cognitive-behavioural interventions 262xvii CONTENTS 7.2 Transcutaneous electrical nerve stimulation 265 7.3 Acupuncture and acupressure 265 7.3.1 Postoperative pain 265 7.3.2 Other acute pain states 267 7.4 Physical therapies 269 7.4.1 Manual and massage therapies 269 7.4.2 Warming and cooling intervention 270 7.4.3 Other therapies 271 References 271 8. SPECIFIC CLINICAL SITUATIONS 279 8.1 Postoperative pain 279 8.1.1 Multimodal postoperative pain management 279 8.1.2 Procedure-specific postoperative

2015 Clinical Practice Guidelines Portal

51. Brodalumab (Kyntheum) - plaque psoriasis

-stimulating factor GD Gestation day GROa growth-regulated oncogene alpha HADS Hospital Anxiety and Depression Scale HFF Human foreskin fibroblasts IC50 50% inhibitory concentration ICH International Conference on Harmonisation IL-17 Interleukine 17 IL-17RA Interleukine 17 receptor A IL-17RC Interleukin-17 receptor C IL-17RF Interleukin-17 receptor F I max maximum inhibition IV Intravenous k a first-order absorption rate constant K deg first-order removal rate constant kgf kilogram forces KHK Kiowa Hakko (...) Assessment of Psoriasis Th17 T-helper 17 cells TK Toxicokinetics t max time at which the maximum observed serum concentration was observed TNFa Tumornecrosefactor alpha ULN upper limit of normal US United States Vz/F Volume of distribution WBS whole blood stimulation Assessment report EMA/381484/2017 Page 6/135 1. Background information on the procedure 1.1. Submission of the dossier The applicant AstraZeneca UK Limited submitted on 13 November 2015 an application for marketing authorisation

2017 European Medicines Agency - EPARs

52. Clinical practice guideline on Systemic Lupus Erythematosus

and contraception 50. Are assisted reproduction procedures safe and efficient in systemic lupus erythe- matosus? Is ovarian stimulation safe in women with systemic lupus erythemato- sus? 51. What contraception methods are safe in women with systemic lupus erythemato- sus? COMORBIDITY Cardiovascular risk 52. Have people with systemic lupus erythematosus got a greater cardiovascular risk? Is this risk similar in different ethnic groups? Should the cardiovascular risk be evaluated in people with systemic lupus (...) , although this measure is not risk-free.42 CLINICAL PRACTICE GUIDELINES IN THE SNS Fertility and Contraception Assisted reproduction techniques v We suggest carrying out a comprehensive assessment of the cardiovascular risk and of the activity of the disease before starting assisted reproduction procedures, including ovarian stimulation, programming them under controlled disease situation. v We suggest administering prophylactic treatment with low molecular weight heparin in patients with positive

2015 GuiaSalud

53. Safe Prevention of the Primary Cesarean Delivery

elements of the Category II tracing or provide reassurance of fetal well-being. Scalp stimulation to elicit a fetal heart rate acceleration is an easily employed tool when the cervix is dilated and can offer clinician reassurance that the fetus is not acidotic. Spontaneous or elicited heart rate accelerations are associated with a normal umbilical cord arterial pH (7.20 or greater) (54, ). Recurrent variable decelerations, thought to be a physiologic response to repetitive compression of the umbilical (...) to such factors will optimize clinical decision making regarding the management of abnormal or indeterminate fetal heart rate patterns and the need for cesarean delivery. Specifically, amnioinfusion for repetitive variable fetal heart rate decelerations may safely reduce the rate of cesarean delivery (Table 3). Scalp stimulation can be used as a means of assessing fetal acid–base status when abnormal or indeterminate (formerly, nonreassuring) fetal heart patterns (eg, minimal variability) are present

2014 American College of Obstetricians and Gynecologists

54. Clinical practice guideline for care in pregnancy and puerperium

Women with low back pain after childbirth should receive the same therapeutic treatments as the general population. Treatments for constipation Strong Women with constipation in the puerperium period should be offered advice to reinforce the intake of natural fiber and fluids in their diet. Strong An osmotic or intestinal motility stimulant should be administered to women in whom constipation persists despite an increased intake of natural fibers and liquid laxative. Benefits of rehabilitation (...) of breastfeeding with frequent voiding to solve infectious mastitis. Weak We suggest encouraging to Women to start breastfeeding as soon as possible to prevent complications such as engorgement or pain and injury to the nipple. Weak We suggest providing advice to omen with breast engorgement aboutbreastfeeding their babies frequently and on a continuous basis, with the possibility of performing massages in the breast and stimulate it for milk to be ejected manually. Weak We suggest offering educational

2014 GuiaSalud

55. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

.[ , ] (Refer to the section of the PDQ summary on for more information.) For children with de novo RET mutations and no familial history, nonendocrine manifestations, such as intestinal ganglioneuromatosis or skeletal or ocular stigmata, may facilitate early diagnosis and result in better outcomes.[ ] Diagnostic Evaluation Initial evaluation of a child or adolescent with a thyroid nodule includes the following: Ultrasound of the thyroid. Serum thyroid-stimulating hormone (TSH) level. Serum thyroglobulin (...) for patients with substantial cervical lymph node disease. Thyroid nuclear scintigraphy should be pursued only if the patient presents with a suppressed thyroid-stimulating hormone (TSH). The routine use of bone scan or fluorine F 18-fludeoxyglucose positron emission tomography (PET) is not recommended. Surgery.[ ] Pediatric thyroid surgery is ideally completed by a surgeon who has experience performing endocrine procedures in children and in a hospital with the full spectrum of pediatric specialty care

2016 PDQ - NCI's Comprehensive Cancer Database

56. Primary Care Management of Headache in Adults

both diphenhydramine (an H1 antagonist that mediates the anti-emetic effect), and a theophylline derivative (a CNS stimulant related to caffeine). Dimenhydrinate has some abuse potential. Given the lack of evidence for its efficacy in migraine, metoclopramide or domperidone is a better choice for treating migraine-related nausea. Similarly, there is no good evidence that ondansetron is effective in migraine-related nausea. See Appendix E: Table E.1: Medications Used for Acute (Symptomatic (...) on Page 43) Can result in a number of side effects including hair loss, tremor, and weight gain. Is associated with serious fetal malformations (neural tube defects) when used during pregnancy. RCT (G1a) X Gabapentin is no longer recommended for episodic migraine prophylaxis. ? Additional clinical trial data has become available since the first edition of these guidelines, and these indicate that gabapentin is not useful for prophylaxis of episodic migraine. SR (IHE Database) Vitamins, Minerals

2012 Toward Optimized Practice

57. British HIV Association guidelines for the management of HIV infection in pregnant women

Questions and PICO criteria A2.2 Search 1: safety and ef?cacy of antiretrovirals in pregnancy A2.3 Search 2: hepatitis viruses coinfection A2.4 Search 3: delivery, fetal monitoring and obstetric issues 88 BHIVA Writing Group © 2012 British HIV Association HIV Medicine (2012), 13 (Suppl. 2), 87–157A2.5 Search 4: paediatric issues A2.6 Search 5: investigations and monitoring in pregnancy Appendix 3: Search protocols (main databases search) A3.1 Search 1: when to initiate antiretroviral therapy A3.2 Search (...) 2: hepatitis coinfection A3.3 Search 3: fetal monitoring and obstetric issues A3.4 Search 4: paediatric issues A3.5 Search 5: investigations and monitoring in pregnancy Appendix 4 A4.1 Antiretroviral therapies for which suf?cient numbers of pregnancies with ?rst trimester exposure have been monitored to detect a two-fold increase in overall birth defects A4.2 Advisory Committee Consensus BHIVA guidelines for the management of HIV infection in pregnant women 2012 89 © 2012 British HIV Association

2012 The Children's HIV Association

58. Genetics of Skin Cancer (PDQ®): Health Professional Version

cell leukemia; cutaneous T-cell lymphoma is often confined to the skin throughout its course. Overall, 10% of leukemias and lymphomas have prominent expression in the skin.[ ] Epidermal appendages are also found in the dermal compartment. These are derivatives of the epidermal keratinocytes, such as hair follicles, sweat glands, and the sebaceous glands associated with the hair follicles. These structures are generally formed in the first and second trimesters of fetal development. These can form (...) by BCNS.[ , , ] BCNS-associated ovarian fibromas are more likely to be bilateral and calcified than sporadic ovarian fibromas.[ ] Ameloblastomas, aggressive tumors of the odontogenic epithelium, have also been proposed as a diagnostic criterion for BCNS, but most groups do not include it at this time.[ ] Other associated benign neoplasms include gastric hamartomatous polyps,[ ] pulmonary cysts,[ ] cardiac fibromas,[ ] meningiomas,[ - ] craniopharyngiomas,[ ] fetal rhabdomyomas,[ ] leiomyomas

2016 PDQ - NCI's Comprehensive Cancer Database

59. Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

in seven infants with molecular-genetic analysis. Fetal Pediatr Pathol 30 (5): 329-37, 2011. [ ] Evans HL: Low-grade fibromyxoid sarcoma: a clinicopathologic study of 33 cases with long-term follow-up. Am J Surg Pathol 35 (10): 1450-62, 2011. [ ] Alaggio R, Collini P, Randall RL, et al.: Undifferentiated high-grade pleomorphic sarcomas in children: a clinicopathologic study of 10 cases and review of literature. Pediatr Dev Pathol 13 (3): 209-17, 2010 May-Jun. [ ] Staging and Grading Systems

2016 PDQ - NCI's Comprehensive Cancer Database

60. Von Willebrand Disease in Women

Willebrand disease can be transmitted as an autosomal dominant or recessive trait, the fetus can have up to a 50% risk of being affected. Procedures, such as fetal scalp electrode or fetal scalp sampling, are better avoided, and circumcision should be postponed until the newborn’s vWD status is determined (2). Operative vaginal deliveries, in which there may be an increased risk of trauma to the newborn, should be avoided because of the potential risk of intracranial hemorrhage (15). In many women, vWF (...) acetate, recombinant factor VIII, and vWF complex infusion (7, 10). Desmopressin acetate is a synthetic derivative of the antidiuretic hormone vasopressin and works by stimulating the release of vWF from endothelial cells (7). Recombinant factor VIII and vWF complex infusion are plasma-derived concentrates used to replace factor VIII and vWF, respectively. One study demonstrated that women with bleeding disorders had reduced menstrual flow with the use of either intranasal desmopressin or tranexamic

2013 American College of Obstetricians and Gynecologists

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