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Fetal Head Circumference

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101. International standards for fetal growth based on serial ultrasound measurements: the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project. Full Text available with Trip Pro

a reliable estimate of gestational age confirmed by ultrasound measurement of fetal crown-rump length in the first trimester. The five primary ultrasound measures of fetal growth--head circumference, biparietal diameter, occipitofrontal diameter, abdominal circumference, and femur length--were obtained every 5 weeks (within 1 week either side) from 14 weeks to 42 weeks of gestation. The best fitting curves for the five measures were selected using second-degree fractional polynomials and further modelled (...) . For each of the five fetal growth measures, the mean differences between the observed and smoothed centiles for the 3rd, 50th, and 97th centiles, respectively, were small: 2·25 mm (SD 3·0), 0·02 mm (3·0), and -2·69 mm (3·2) for head circumference; 0·83 mm (0·9), -0·05 mm (0·8), and -0·84 mm (1·0) for biparietal diameter; 0·63 mm (1·2), 0·04 mm (1·1), and -1·05 mm (1·3) for occipitofrontal diameter; 2·99 mm (3·1), 0·25 mm (3·2), and -4·22 mm (3·7) for abdominal circumference; and 0·62 mm (0·8), 0·03 mm

2014 Lancet

102. Fetal alcohol spectrum disorder : identification

/Alcool_et_grossesse_parlons-en2.pdf. 2. Prenatal or postnatal height, weight or head circumference equal to or lower than the 10 th percentile (1.5 standard deviation below the mean). Key messages© Haute Autorité de Santé 2013 www.has-sante.fr 2 avenue du Stade de France - 93218 Saint-Denis La Plaine CEDEX Tel.: +33 (0) 1 55 93 70 00 - Fax: +33 (0) 1 55 93 74 00 THE ORIGINAL FRENCH VERSION IS THE LEGALLY BINDING TEXT ´ Fetal alcohol spectrum disorder describes the disabilities that may affect an individual whose mother (...) , weight or head circumference); prenatal, postnatal or both; • neurodevelopmental disorders, demonstrated: ? sometimes by an intellectual disability , ? most often by lear ning dif ficulties (with attention, memory or abstract r easoning disor ders), tr ouble with calculations, language disor ders, sensory disabilities (especially visual), behavioural disor ders, of adaptation and social behavior disor ders, a sour ce of social integration dif ficulties. ´ Nervous system abnormalities are directly

2013 HAS Guidelines

103. Novel Plasma Proteins in Nepalese School-aged Children are Associated with a Small Head Size at Birth Full Text available with Trip Pro

Novel Plasma Proteins in Nepalese School-aged Children are Associated with a Small Head Size at Birth Fetal growth restriction increases the risk of poor childhood growth and development and chronic disease in adulthood. Yet, little is known about biological pathways that mediate the long-lasting effects of suboptimal intrauterine growth. We explored the plasma proteome in a cohort of 500 Nepalese children 6-8 years of age to identify plasma proteins associated with multiple anthropometric size (...) indicators at birth. Among 982 proteins analyzed, no proteins differed by birth weight, length, or weight-for-length indicators. However, 25 proteins were differentially abundant in children with a small vs normal head circumference at birth (<-2 vs. ≥-2 z-scores of the WHO growth standards). Angiopoietin-like 6 was 19.4% more abundant and the other 24 proteins were 7-21% less abundant in children with a small vs normal head circumference at birth, adjusted for potential confounders. The less abundant

2018 Scientific reports

104. Investigating the Structured Use of Ultrasound Scanning for Fetal Growth

collected ultrasound fetal measurements - Head Circumference. Physiological parameter Risk Factors for adverse outcomes - ultrasound abdomen circumference [ Time Frame: 4 yrs ] Routinely collected ultrasound fetal measurements - Abdominal Circumference.Physiological parameter Risk Factors for adverse outcomes - ultrasound femur length [ Time Frame: 4 yrs ] Routinely collected ultrasound fetal measurements - Femur Length. Physiological parameter Risk Factors for adverse outcomes - ultrasound presentation (...) Frame: 6 yrs ] Number of Ultrasound Scans (>24 weeks gestation) performed per pregnancy Impact of the OxGRIP Pathway on service - Consultant time [ Time Frame: 6 yrs ] Number of Consultant appointments Impact of the OxGRIP Pathway on service - intrapartum interventions [ Time Frame: 6 yrs ] Proportion of all birth delivered as emergency and elective cesarean sections and instrumental deliveries Risk Factors for adverse outcomes - ultrasound head circumference [ Time Frame: 4 yrs ] Routinely

2017 Clinical Trials

105. Quality control of ultrasound for fetal biometry: results from the INTERGROWTH-21<sup>st</sup> Project. Full Text available with Trip Pro

examination, three fetal biometric variables (head circumference (HC), abdominal circumference (AC) and femur length (FL)) were measured in triplicate on separately generated images. All measurements were taken in a blinded fashion. QC had two elements: (1) qualitative QC: visual assessment by sonographers at each study site of their images based on specific criteria, with 10% of images being re-assessed at the Oxford-based Ultrasound Quality Unit (compared using an adjusted kappa statistic); and (2 (...) Quality control of ultrasound for fetal biometry: results from the INTERGROWTH-21st Project. To assess a comprehensive package of ultrasound quality control in the Fetal Growth Longitudinal Study of the INTERGROWTH-21st Project, a large multicenter study of fetal growth.Quality control (QC) measures were performed for 20 313 ultrasound scan images obtained prospectively from 4321 fetuses at 14-41 weeks' gestation in eight geographical locations. At the time of each ultrasound

2017 Ultrasound in Obstetrics and Gynecology

106. Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. Full Text available with Trip Pro

score decrease (∼8.5 g) in birth weight (β = -0.41 for ln-transformed FT4; 95% confidence interval, -0.64 to -0.18). FT4 was also inversely associated with repeated measurements of estimated fetal weight, head circumference, and abdominal circumference. We observed weaker inverse associations for total T4 and a positive relationship between total triiodothyronine and birth weight z scores. We did not observe any associations for thyroid-stimulating hormone.In pregnant women without overt thyroid (...) Subclinical Changes in Maternal Thyroid Function Parameters in Pregnancy and Fetal Growth. Overt thyroid disease in pregnancy is a known risk factor for abnormal fetal growth and development. Data on the effects of milder forms of variation in maternal thyroid function on intrauterine growth are less well examined.We explored these associations using repeated thyroid hormone and ultrasound measurements.Data were obtained from 439 pregnant women without diagnosed thyroid disease who were

2017 Journal of Clinical Endocrinology and Metabolism

107. Fetal growth and birth anthropometrics in metformin exposed offspring born to mothers with PCOS. Full Text available with Trip Pro

analysis of a randomized controlled trial.Double-blind, placebo-controlled, multicenter study.258 offspring born to mothers with PCOS.2000 mg metformin (n = 131) or placebo (n = 121) from first trimester to delivery.Mean abdominal diameter and biparietal diameter (BPD) at gestational weeks 19 and 32. Head circumference (HC), birth length, and weight related to a reference population of healthy offspring, expressed as gestational age- and sex-adjusted z-scores.Metformin- versus placebo-exposed offspring (...) Fetal growth and birth anthropometrics in metformin exposed offspring born to mothers with PCOS. Metformin is used in an attempt to reduce pregnancy complications associated with polycystic ovary syndrome (PCOS). Little is known about the effect of metformin on fetal development and growth.To compare the effect of metformin versus placebo on fetal growth and birth anthropometrics in PCOS offspring compared with a reference population in relation to maternal body mass index (BMI).Post hoc

2017 Journal of Clinical Endocrinology and Metabolism Controlled trial quality: predicted high

108. The satisfactory growth and development at 2 years of age of the INTERGROWTH-21<sup>st</sup> Fetal Growth Standards cohort support its appropriateness for constructing international standards. Full Text available with Trip Pro

contributed data to the construction of the international fetal growth, newborn infant size and body composition at birth, and preterm postnatal growth standards. Clinical care, feeding practices, anthropometric measures, and assessment of morbidity were standardized across study sites and documented at 1 and 2 years of age. Weight, length, and head circumference age- and sex-specific z-scores and percentiles and motor development milestones were estimated with the use of the World Health Organization (...) mortality rate was 3 per 1000; neonatal mortality rate was 1.6 per 1000. At the 2-year visit, the children included in the INTERGROWTH-21st Fetal Growth Standards were at the 49th percentile for length, 50th percentile for head circumference, and 58th percentile for weight of the World Health Organization Child Growth Standards. Similar results were seen for the preterm subgroup that was included in the INTERGROWTH-21st Preterm Postnatal Growth Standards. The cohort overlapped between the 3rd and 97th

2017 American Journal of Obstetrics and Gynecology

109. Fetal somatic growth trajectory differs by type of congenital heart disease. Full Text available with Trip Pro

Fetal somatic growth trajectory differs by type of congenital heart disease. BackgroundThe growth trajectories of common measurements, including estimated fetal weight (EFW), head circumference (HC), and abdominal circumference (AC), in fetuses with congenital heart disease (CHD) have not been described for different cardiac lesions. We hypothesized that (i) fetuses with CHD have differential growth in utero, and (ii) different categories of CHD demonstrate different in utero growth (...) curves.MethodsWe performed a retrospective observational cohort study of pregnancies with known fetal CHD seen from January 2000 to June 2013. For analysis, the infants were divided into single ventricle (SV), biventricular conotruncal, d-transposition of great arteries (d-TGA), biventricular septal defects (SD; including atrial, ventricular, and atrioventricular SD), and all others (Other).ResultsA total of 194 newborns met inclusion criteria. There was significant differential growth of EFW in all CHD types

2017 Pediatric Research

110. Fetal growth standards in gastroschisis: Reference values for ultrasound measurements. (Abstract)

, 10th, 50th, 90th, and 95th centiles being established for biometric parameters according to gestational age. Curves were obtained, comparing with normal reference via the Mann-Whitney test. UA Doppler velocimetry patterns were obtained.A total of 434 examinations were performed, and centiles were established for biparietal diameter, head circumference, abdominal circumference, femur length, and estimated fetal weight. A significant difference was observed between the gastroschisis measurements when (...) compared to control, with all curves shifted downwards. Abdominal circumference was the parameter presenting the largest difference. Estimated fetal weight was also lower, with mean difference of 256.3 ± 166.8 g for the 50th centile (P < .0001). UA Doppler velocimetry was normal in 97.5%.Fetuses with gastroschisis show symmetrical growth deficits in the second and third trimesters, with normal UA Doppler velocimetry. These results reinforce the hypothesis that they are constitutionally smaller, yet

2017 Prenatal diagnosis

111. Fetal biometric parameters: Reference charts for a non-selected risk population from Uberaba, Brazil Full Text available with Trip Pro

) was measured at the level of the thalami and cavum septi pellucidi. Head circumference (HC) was calculated by the following formula: HC = 1.62*(BPD + occipital frontal diameter, OFD). Abdominal circumference (AC) was measured using the following formula: AC = (anteroposterior diameter + transverse abdominal diameter) × 1.57. Femur diaphysis length (FDL) was obtained in the longest axis of femur without including the distal femoral epiphysis. The estimated fetal weight (EFW) was obtained by the Hadlock (...) Fetal biometric parameters: Reference charts for a non-selected risk population from Uberaba, Brazil To establish reference charts for fetal biometric parameters in a non-selected risk population from Uberaba, Southeast of Brazil.A retrospective cross-sectional study was performed among 5656 non-selected risk singleton pregnant women between 14 and 41 weeks of gestation. The ultrasound exams were performed during routine visits of second and third trimesters. Biparietal diameter (BPD

2017 Journal of Ultrasonography

112. Smoking in Pregnancy and Fetal Growth: The Case for More Intensive Assessment Full Text available with Trip Pro

Smoking in Pregnancy and Fetal Growth: The Case for More Intensive Assessment Many studies on prenatal tobacco exposure (PTE) effects have relied on single item retrospective measures of PTE. However, it is unclear how these single item measures may relate to more intensive maternal self-reports and to biological markers of maternal use and/or fetal exposure. It is also unclear whether these measures may be more valid predictors of fetal growth (gestational age, birthweight, head circumference (...) was not related to fetal growth. However, the more intensive calendar based self-report measure and the biological assays of PTE (ie, maternal salivary assays and infant meconium) were significant predictors of poor fetal growth, even with the single item measure in the model.The negative effects of PTE on important child outcomes may be greatly underestimated in the literature as many studies use single item self-report measures to ascertain PTE. Whereas more intensive self-report measures or biological

2017 Nicotine & Tobacco Research

113. Replication of High Fetal Alcohol Spectrum Disorders Prevalence Rates, Child Characteristics, and Maternal Risk Factors in a Second Sample of Rural Communities in South Africa Full Text available with Trip Pro

Replication of High Fetal Alcohol Spectrum Disorders Prevalence Rates, Child Characteristics, and Maternal Risk Factors in a Second Sample of Rural Communities in South Africa Background: Prevalence and characteristics of fetal alcohol syndrome (FAS) and total fetal alcohol spectrum disorders (FASD) were studied in a second sample of three South African rural communities to assess change. Methods: Active case ascertainment focused on children with height, weight and/or head circumference ≤25th (...) centile and randomly-selected children. Final diagnoses were based on dysmorphology, neurobehavioral scores, and maternal risk interviews. Results: Cardinal facial features, head circumference, and total dysmorphology scores differentiated specific FASD diagnostic categories in a somewhat linear fashion but all FASD traits were significantly worse than those of randomly-selected controls. Neurodevelopmental delays were significantly worse for children with FASD than controls. Binge alcohol use

2017 International journal of environmental research and public health

114. Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques Full Text available with Trip Pro

in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester (...) Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity

2017 PLoS pathogens

115. A Systematic Evaluation of Ultrasound-based Fetal Weight Estimation Models on Indian Population Full Text available with Trip Pro

, gestational age ≥34 weeks and ultrasound scan to delivery duration ≤7 days. Cases with fetal growth restriction or malformation were excluded. The cases were divided into standard weight bands of 500 g each based on newborns' actual birth weights (ABW). For each weight band, performance of 12 different models based on abdominal circumference (AC), biparietal diameter (BPD), head circumference (HC) and femur length (FL) was evaluated by mean percentage error (MPE) and its standard deviation (random error (...) A Systematic Evaluation of Ultrasound-based Fetal Weight Estimation Models on Indian Population The purpose of this study was to systematically evaluate ultrasound-based fetal weight estimation models on Indian population to find out their performance across different weight bands and ability to correctly categorize low birth weight (LBW) and high birth weight (HBW) fetuses.We used retrospectively collected data of 154 cases for the study. Inclusion criteria were a live singleton pregnancy

2017 Journal of medical ultrasound

116. Patterns of Fetal Growth Based on Ultrasound Measurement and its Relationship with Small for Gestational Age at Birth in Rural Vietnam. (Abstract)

micronutrient supplementation in Thai Nguyen province, Vietnam. Ultrasound examinations included biparietal diameter (BPD), head circumference (HC) and abdominal circumference (AC), and femur length (FL). Measures were assessed using the new international fetal growth standards (INTERGROWTH-21st Project). Generalised linear mixed logit regression models were used to examine the association between ultrasound measures and SGA at birth.Overall fetal growth restriction began in early pregnancy and continued (...) Patterns of Fetal Growth Based on Ultrasound Measurement and its Relationship with Small for Gestational Age at Birth in Rural Vietnam. Small for gestational age (SGA) is a global health problem. Identifying the timing of fetal growth faltering is critical for developing preventive interventions. We aim to describe patterns of fetal growth and to predict SGA at birth using fetal ultrasound measurements.We studied 1412 pregnant women enrolled in a randomised-controlled trial evaluating maternal

2017 Paediatric and perinatal epidemiology Controlled trial quality: uncertain

117. Maternal stress and neonatal anthropometry: the NICHD Fetal Growth Studies. Full Text available with Trip Pro

model to identify distinct groupings (ie, classes) of the Perceived Stress Survey trajectories over pregnancy. Trend analysis was used to determine whether neonatal measurements including birthweight, length, head circumference, and abdominal circumference differed by Perceived Stress Survey class and whether this relationship was modified by maternal race/ethnicity, after adjustment for gestational age at delivery, maternal height, age, and parity.Of the 2334 women enrolled in the study, 1948 women (...) had complete neonatal anthropometry and were included in the analysis. Latent class analysis identified 3 Perceived Stress Survey trajectory classes, with mean Perceived Stress Survey scores of 2.82 (low), 7.95 (medium), and 14.80 (high). Neonatal anthropometric measures of birthweight, length, head circumference and abdominal circumference were similar (P=.78, =.10, =.18, and =.40 respectively), regardless of the participants' Perceived Stress Survey class. There was no effect modification

2017 American Journal of Obstetrics and Gynecology

118. Development of Customized Fetal Growth Charts in Twins. (Abstract)

characteristics.Fetal biometric measurements obtained from serial ultrasound examinations in uncomplicated twin pregnancies delivering after 36 weeks of gestation were collected by 19 Italian fetal medicine units under the auspices of the Società Italiana di Ecografia Ostetrica e Ginecologica. The measurements acquired in each fetus at each examination included biparietal diameter, head circumference, abdominal circumference, and femur length. Multilevel linear regression models were used to adjust for the serial (...) ultrasonographic measurements obtained and the clustering of each fetus in twin pregnancy. The impact of maternal and paternal characteristics (height, weight, ethnicity), parity, fetal sex, and mode of conception was also considered. Models for each parameter were stratified by fetal chorionicity and compared with our previously constructed growth curves for singletons.The data set included 1781 twin pregnancies (dichorionic, n = 1289; monochorionic diamniotic, n = 492) with 8923 ultrasonographic examinations

2017 American Journal of Obstetrics and Gynecology

119. Severe Apparently Isolated Fetal Ventriculomegaly And Neurodevelopmental Outcome. (Abstract)

fulfilled the study criteria. SVM was diagnosed at an average gestational age of 30 weeks (range 22-37 weeks). Head circumference was >95th centile in 39% of them. The etiology of SVM was intraventricular hemorrhage in 6 (29%), stenosis of the aqueduct of Sylvius in 3 (14%), and undetermined in 12 (57%). Neurosurgery was performed in four infants, and ventriculoperitoneal shunts were inserted in three. At a mean age at last follow-up of 8.4 years, neurodevelopmental outcome was normal in 62 (...) Severe Apparently Isolated Fetal Ventriculomegaly And Neurodevelopmental Outcome. Our aim is to assess the neurodevelopmental outcome of children with a prenatal diagnosis of apparently isolated severe ventriculomegaly (SVM).This is a retrospective cohort study from 1994 to 2011. We included fetuses with unilateral or bilateral ventriculomegaly equal to or greater than 15 mm at prenatal ultrasound and confirmed by magnetic resonance imaging, whose parents chose continuation of pregnancy past 22

2017 Prenatal diagnosis

120. Effects of prenatal music stimulation on fetal cardiac state, newborn anthropometric measurements and vital signs of pregnant women: A randomized controlled trial. (Abstract)

heart rate and systolic and diastolic blood pressure), and anthropometric measurements of the newborns were taken after birth (weight, height, head circumference and chest circumference).The strip charts showed a significantly increased basal fetal heart rate and higher fetal reactivity, with accelerations of fetal heart rate in pregnant women with music stimulation. After the fetal monitoring cardiotocograph, a statistically significant decrease in systolic blood pressure, diastolic blood pressure (...) and heart rate in women receiving music stimulation was observed.Music can be used as a tool which improves the vital signs of pregnant women during the third trimester, and can influence the fetus by increasing fetal heart rate and fetal reactivity.Copyright © 2017 Elsevier Ltd. All rights reserved.

2017 Complementary Therapies in Clinical Practice Controlled trial quality: uncertain

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