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Fetal Foot Measurement

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781. Management of Thyroid Cancer

22 iii Contents 7 External beam radiotherapy 7.1 Adjuvant external beam radiotherapy 24 7.2 High-dose external beam radiotherapy as part of primary treatment 24 8 Post-treatment follow-up 8.1 Voice dysfunction 25 8.2 Management of hypocalcaemia 25 8.3 Long-term suppression of serum thyrotrophin 26 8.4 Measurement of serum thyroglobulin in long-term follow-up 26 8.5 Role of imaging by ultrasonography and whole-body 131 I scanning in routine follow-up 29 9 Recurrent/persistent differentiated (...) measurements and possibly earlier detection of recurrent or metastatic disease. 9,113 vi The acute and late side effects of radioiodine (also see section 6.4) should be discussed with the patient (IV, C), particularly stressing: moderate risk of a dry mouth and sialadenitis very small risk of second malignancies. vii Whenever possible the patient should make an informed decision based on the above risks and benefits (IV, C). In the absence of randomised trials, recommendations on 131 I ablation have

2007 British Association of Endocrine and Thyroid Surgeons

782. Growth hormone in children (for growth hormone deficiency, Turner's syndrome, chronic renal failure and idiopathic short stature)

and resource use data were derived from published studies dating from 1987 to 1995. The prices were derived from the British National Formulary 1995. Source of effectiveness data The effectiveness data were derived from a systematic review of the literature. Outcomes assessed in the review Height gain was the primary outcome measurement in this review. A variety of measures were employed in the reporting of this outcome, such as changes in standard deviation score (SDS), height change and height velocity (...) per year. Other outcomes included psychological, academic and behavioural measures. Adverse events were also considered. Study designs and other criteria for inclusion in the review The inclusion criteria were not stated. The included studies comprised randomised controlled trials (RCTs), a controlled trial and case series. Sources searched to identify primary studies The authors searched MEDLINE (from 1985 to May 1996), HealthPLAN (from 1985 to December 1995) and GEARS, and also consulted a local

1996 NHS Economic Evaluation Database.

783. Clinical practice guidelines for the psychosocial care of adults with cancer

controlled trials in patients with cancer, those receiving psychological therapies showed, on average, a significant improvement of 12% in measures of emotional adjustment, 10% in social functioning, 14% in treatment and disease-related symptoms, and 14% in overall improvement in their quality of life, compared with those not receiving psychological therapies (Level I). 17 A meta-analysis of 116 intervention studies found that patients with cancer receiving psycho-educational or psychosocial (...) provide practitioners with evidence-based criteria against which their service and interventions can be monitored.The use of guidelines-based audit criteria will assist the identification of local strengths and weaknesses in the provision of psychological care, and provide a measure by which changes in service delivery may be evaluated over time. Target Audience These guidelines were developed for use by all members of the diagnostic and treatment team, which may include surgeons, radiation

2002 Cancer Australia

785. Clinical practice guidelines for the psychosocial care of adults with cancer

controlled trials in patients with cancer, those receiving psychological therapies showed, on average, a significant improvement of 12% in measures of emotional adjustment, 10% in social functioning, 14% in treatment and disease-related symptoms, and 14% in overall improvement in their quality of life, compared with those not receiving psychological therapies (Level I). 17 A meta-analysis of 116 intervention studies found that patients with cancer receiving psycho-educational or psychosocial (...) provide practitioners with evidence-based criteria against which their service and interventions can be monitored.The use of guidelines-based audit criteria will assist the identification of local strengths and weaknesses in the provision of psychological care, and provide a measure by which changes in service delivery may be evaluated over time. Target Audience These guidelines were developed for use by all members of the diagnostic and treatment team, which may include surgeons, radiation

2003 National Breast and Ovarian Cancer Centre

786. Smith-Lemli-Opitz syndrome

, and nystagmus are observed. Other clinical features include cleft palate or bifid uvula (1/3 of patients), photosensitivity, rhizomelia and postaxial polydactyly of the hands or feet, syndactyly of the 2nd and 3rd toes (95% of cases), and short and proximally placed thumbs. Genital anomalies (small penis, hypospadias, ambiguous genitalia) are frequent in males (70% of cases). Cardiovascular anomalies (atrial and ventricular septal defects, patent ductus arteriosus, atrioventricular canal) can be present (...) analysis confirms the diagnosis. Imaging studies (CT, MRI, echocardiogram) may be performed to detect malformations. Differential diagnosis he differential diagnosis includes lathosterolosis, desmosterolosis, Dubowitz syndrome, Cornelia De Lange syndrome, oculo-digito-esophago-duodenal syndrome, Noonan syndrome, Pallister-Hall syndrome, trisomy 13 and trisomy 18 (see these terms), and pseudotrisomy 13. Antenatal diagnosis Prenatal diagnosis may be suspected at fetal ultrasonography and should

2005 Orphanet

787. B12 / Folate

consult your doctor or the laboratory that performed the test(s) to obtain the reference range if you do not have the lab report. For more information on reference ranges, please read . What is being tested? These tests measure the concentration of folate and vitamin B12 in the serum (liquid portion of the blood). Vitamin B12 and folate are both part of the B complex of vitamins. Folate is found in leafy green vegetables, citrus fruits, dry beans and peas, liver, and yeast. Vitamin B12 is found (...) in animal products such as red meat, fish, poultry, milk, and eggs. In recent years fortified cereals, breads, and other grain productshas also become an important dietary sources of folate (identified as "folic acid" on nutritional labels). Both vitamin B12 and folate are necessary for normal red cell formation, tissue and cellular repair, and synthesis. Vitamin B12 is also important for nerve health, while folate is necessary for cell division such as is seen in a foetus during pregnancy. A deficiency

2004 Lab Tests Online UK

788. Long-term Follow-Up of Patients Who Participated in Study 27025 (REFLEX)

(normal) to 10 (death due to MS) was calculated. The change in EDSS score at Month 36 was calculated as EDSS score at Month 36 minus EDSS score at baseline. Change From Baseline in Multiple Sclerosis Functional Composite (MSFC) Score at Month 36 [ Time Frame: Baseline (Day 1 of Study 27025), Month 36 ] The MSFC is a multidimensional clinical outcome measure which consists of three sub-tests; Timed 25-Foot Walk, 9-Hole Peg Test and Paced Auditory Serial Addition Test-3(PASAT-3). The Timed 25-Foot Walk (...) ), Month 60 ] EDSS assesses disability in 8 functional systems. An overall score ranging from 0 (normal) to 10 (death due to MS) was calculated. The change in EDSS score at Month 60 was calculated as EDSS score at Month 60 minus EDSS score at baseline. Change From Baseline in Multiple Sclerosis Functional Composite (MSFC) Score at Month 60 [ Time Frame: Baseline (Day 1 of Study 27025), Month 60 ] The MSFC is a multidimensional clinical outcome measure which consists of three sub-tests; Timed 25-Foot

2008 Clinical Trials

789. Hormone Ablation Therapy, Doxorubicin, and Zoledronate With or Without Strontium 89 in Treating Patients With Androgen-Dependent Prostate Cancer and Bone Metastases

: Zoladex Drug: Leuprolide acetate Other Name: Lupron Depot Drug: Zoledronic acid 4 mg given intravenously over 15 minutes every 28 days for a total of 6 doses. Other Names: Zoledronate Zometa Procedure: orchiectomy Outcome Measures Go to Primary Outcome Measures : Progression Free Survival (PFS) [ Time Frame: Up to 90 months with evaulation in 4 week intervals for up to 6 months of treatment, then follow up until disease progression ] Study's primary endpoint of PFS duration/time to progression (...) was defined as the time from the date of randomization to the date of first evidence of disease progression or patient death. Prostate-specific antigen (PSA) progression is usually the first evidence of progression. PSA progression is defined as a 25% increase over the baseline or the nadir provided that the increase is a minimum of 1 ng/ml. Secondary Outcome Measures : Major Bone Scan Response [ Time Frame: Week 13 ] Bone scan performed at baseline and at Week 13 provided if baseline scan was positive

2004 Clinical Trials

790. Pulsed Electromagnetic Stimulation for Treatment of Overactive Bladder

the device will decrease the number of episodes of involuntary urine loss due to frequency/urgency in comparison to historical controls. To evaluate the potential of the device for improving patient quality of life as measured by a clinically validated scale, such as the Incontinence Quality of Life Instrument (I-QOL) or equivalent To periodically employ a micturition diary to record variables such as day/night urgency/frequency episodes, number of voids per day, severity of leaks, number of absorbent (...) by the National Library of Medicine related topics: Arms and Interventions Go to Intervention Details: Device: MagPro R30 Study treatments will be administered by a commercially available MagPro R30, with a cooled figure eight coil. The figure eight coil is placed directly over the posterior tibial nerve and the MagPro R30 will be activated. The coil will stimulate the posterior tibial nerve at 20 pulses per second for a 30 minute session. Outcome Measures Go to Primary Outcome Measures : Improved urinary

2008 Clinical Trials

791. A Phase II Study of Bevacizumab, Irinotecan and Capecitabine in Patients With Previously Untreated Metastatic Colorectal Cancer

as part of the BEAT (Bevcizumab Expanded Access Trial ) study up to October, 2005. Of 10 patients who were treated with 3 or more cycles of chemotherapy, there were 7 confirmed partial responses and 2 additional patients with stable disease. One patient with non-measurable but evaluable disease had marked reduction in infiltration in the sacrum. There were no instances of GI perforation, febrile neutropenia, or toxic death. The median number of cycles of treatment was 6, and 9 of 12 patients are still (...) receiving treatment. There were, however, a total of 8 dose reductions of capecitabine in 6 patients, with majority of dose reductions as a result of hand-foot syndrome. Although these efficacy and toxicity data are extremely encouraging, the small number of patients limits the potential application of these data.Because of the encouraging preliminary results, it is necessary to conduct a prospective clinical study to further evaluate the efficacy and toxicity of irinotecan, capecitabine and bevacizumab

2007 Clinical Trials

792. The Safety, Tolerability And Metabolism Of GSK221149A, In Pregnant Women (30-36 Weeks), In Pre-Term Labor

hands and feet, 3=completely pink or good color. APGAR total score is the sum of sub-scores ranging from 0 to 10, where lower score indicates worst condition and higher score indicates best condition. Neonatal Weight Gain Measured at 4 to 12 Weeks Post Adjusted Gestational Age in Part C [ Time Frame: At birth and Follow-up (Week 12) ] Neonatal safety was assessed through assessment of weight gain. Weight gain was measured at birth and follow-up (Week 12). Mean weight gain is presented. Neonatal Head (...) -term Labor Between 300/7 and 356/7 Weeks' Gestation Actual Study Start Date : October 12, 2007 Actual Primary Completion Date : July 7, 2011 Actual Study Completion Date : July 7, 2011 Arms and Interventions Go to Arm Intervention/treatment Experimental: Treatment GSK221149A Drug: GSK221149A 6mg/h and 12 mg/h Placebo Comparator: Placebo Placebo Drug: Placebo Matched Placebo to Drug Outcome Measures Go to Primary Outcome Measures : Number of Participants With Vital Sign Values of Potential Clinical

2006 Clinical Trials

793. Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects

weeks) and visit 4 (36 weeks) [ Time Frame: 5 years ] Heart rate and blood pressure variability as measured by ECG and power spectral analysis. [ Time Frame: 5 years ] BIOMECHANICAL STUDY - All measures taken at visit 1 (30 weeks) and visit 4 (36 weeks) [ Time Frame: 5 years ] Step length as measured by the GAITRite walkway. [ Time Frame: 5 years ] Foot angle of progression as measured by the GAITRite walkway. [ Time Frame: 5 years ] Gait Symmetry as measured by the GAITRite walkway. [ Time Frame: 5 (...) , such as increased fluid volume and sympathetic tone, may lead to consequences such as edema, preterm labor, and meconium-staining of the amniotic fluid. The biomechanical state of the woman's body is also drastically affected; as the fetus grows and the uterus expands, the center of gravity shifts forward, rotating the pelvis anteriorly and increasing the lordosis of the low back, and may also affect the motion of the hips and legs. These postural changes also have consequences such as low back pain, decreased

2007 Clinical Trials

794. Gait Training and Brain Changes in Stroke Patients

for up to a few minutes at a time and to perform movements of their foot. Day 2: motor testing with TMS. Session 3 Day 1: fMRI Day 2: motor testing with TMS Condition or disease Gait Training Locomotion Detailed Description: OBJECTIVES: The purpose of this protocol is to study the mechanisms underlying the beneficial effects of locomotor training in hemiplegic patients. The locomotor training will be performed under an approved protocol already started at the National Rehabilitation Hospital (NRH (...) learning. Therefore, it is likely that SI and SII activity plays a major contributory role in training-dependent locomotor improvement after stroke. Electrophysiological measurements can provide important insights into sensorimotor integration processes in humans. Indeed, cortical facilitation induced by peripheral nerve afferent input is useful to probe sensorimotor interaction in health and disease. The specific hypotheses are that performance improvements with locomotor training will be associated

2006 Clinical Trials

795. Can Acupuncture be Used as Preparation for Induction of Labour

of membranes there is an increased risk of umbilical prolapse, maternal and neonatal infection, affected fetal heart rate, scratches on the scalp and placental bleeding. By using misoprostol there has been seen hyperstimulation of uterus causing affected fetal heart rate. Many women are asking for alternatives to the existing methods used in obstetric dept.s. In order to assess the effect, or lack of, acupuncture might have, we want to use acupuncture in the study group on acupuncture points on hands, feet (...) information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: Female Accepts Healthy Volunteers: Yes Criteria Inclusion Criteria: Gestational age 41+6 Normal pregnancy, expecting a healthy baby Verified due date Exclusion Criteria: Women who do not speak or understand Danish Multiple pregnancy In active labour Previous sectio Maternal diseases (i.e. Diabetes, preeclampsia, heart diseases) Fetal diseases (i.e. foetus mors, IUGR, hydrocephalus) Previous complicated delivery i.e

2005 Clinical Trials

796. Development Training in Babies Born Preterm

Training This group of infants underwent specific movement training activities two times per day with their parents. Outcome Measures Go to Primary Outcome Measures : The primary outcome is to evaluate the effectiveness of movement training in preterm babies. This will be measured by number of toy contacts, hand/foot-toy distance, duration of toy contact, and duration of visual attention. [ Time Frame: 8 weeks ] Eligibility Criteria Go to Information from the National Library of Medicine Choosing (...) gestation (up to and including 32 6/7 weeks) Infants born weighing less than 2500 grams Exclusion Criteria: Orthopedic, visual or hearing impairments Fetal drug exposure Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00268931 Locations Layout table

2005 Clinical Trials

797. The diagnostic accuracy of external pelvimetry and maternal height to predict dystocia in nulliparous women: a study in Cameroon. (Abstract)

of maternal height with external pelvimetry, and with foot length and symphysis-fundus height.A prospective cohort study.Three maternity units in Yaoundé, Cameroon.A total of 807 consecutive nulliparous women at term who completed a trial of labour and delivered a single fetus in vertex presentation.Anthropometric measurements were recorded at the antenatal visit by a researcher and concealed from the staff managing labour. After delivery, the accuracy of individual and combined measurements

2007 BJOG

798. Recurrent Miscarriage

Guidelines. You may find the article more useful, or one of our other . In this article In This Article Recurrent Miscarriage In this article Recurrent miscarriage is defined as the loss of three or more consecutive pregnancies. Epidemiology , the most common complication of pregnancy, is the spontaneous loss of a pregnancy before the fetus has reached viability at 24 weeks of gestation. (20 weeks of gestation is taken in some parts of the world.) Miscarriage occurs in 12-24% of recognised pregnancies. 1 (...) supplementation to prevent recurrent miscarriage is equivocal; higher-quality evidence shows no benefit [ ] . Immunotherapy Paternal cell immunisation, third-party donor leukocytes, trophoblast membranes, and intravenous immunoglobulin have all been used to treat women with otherwise unexplained miscarriage. None has shown any significant benefit over placebo in improving the live birth rate [ ] . Surgical treatment [ ] Cervical cerclage (a Shirodkar or McDonald suture) is a prophylactic measure inserted

2008 Mentor

799. Puerperal Pyrexia

necessary - eg, wound swabs, throat swabs. FBC. Blood culture x 2. Ultrasound scan may be required to assist diagnosis of retained products of conception. Sputum culture if indicated. Management General measures Ice packs may be helpful for pain from perineal wounds or mastitis. Rest and adequate fluid intake are required, particularly for mothers who are breast-feeding. The following signs and symptoms should prompt urgent referral for hospital assessment and, if the woman appears seriously unwell (...) Gynecol Surv. 2007 Jun62(6):400-6. ; Oliver Wendell Holmes (1809-1894) and his essay on puerperal fever. Arch Dis Child Fetal Neonatal Ed. 2007 Jul92(4):F325-7. ; Royal College of Obstetricians and Gynaecologists (April 2012) ; Maternal sepsis: epidemiology, etiology and outcome. Curr Opin Infect Dis. 2010 Jun23(3):249-54. doi: 10.1097/QCO.0b013e328339257c. ; MBRRACE-UK, Dec 2015 ; NICE Clinical Guideline (November 2011) ; Antibiotic prophylaxis versus no prophylaxis for preventing infection after

2008 Mentor

800. Small for Gestational Age (SGA) Babies

healthy. 50-70% of SGA fetuses are constitutionally small, with fetal growth appropriate for maternal size and ethnicity [ ] . Growth is normal in the early part of pregnancy but slows in utero by at least two measurements (normally from ultrasound assessments). This is due to . The newborn baby has a wasted appearance with little subcutaneous fat and a greater risk of complications. Non-placenta mediated growth restriction - eg, structural or chromosomal anomaly, inborn errors of metabolism or fetal (...) been shown to be independently associated with an SGA neonate and fetal demise. Diagnosis [ ] Abdominal palpation has limited accuracy for the prediction of an SGA neonate and thus should not be routinely performed in this context. Serial measurement of symphysis fundal height (SFH) is recommended at each antenatal appointment from 24 weeks of pregnancy as this improves prediction of an SGA neonate. SFH should be plotted on a customised chart rather than a population-based chart as this may improve

2008 Mentor

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