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Fetal Foot Measurement

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61. Clinical Practice Guidelines for the Perioperative Nutrition, Metabolic, and Nonsurgical Support of Patients Undergoing Bariatric Procedures

been criticized as an insensitive marker of disease, it currently provides the most useful population-level measurement of overweight and obesity, and its utility as an estimate of risk has been validated in multiple large population studies across multiple continents. The j-shaped curve for BMI and mortality has recently been confirmed in a large meta-analysis (9) and a systematic review (10) that included 10.6 million and 30 million participants, respectively. These DOI:10.4158/GL-2019-0406 © (...) /files/lipid-guidelines.pdf and (Grade D). R17. (2013*). Candidates for bariatric procedures should avoid pregnancy pre- procedure and for 12 to 18 months post-procedure (Grade D). Women who become pregnant after bariatric procedures should be counseled and monitored for appropriate weight gain, nutritional supplementation, and fetal health (Grade C; BEL 3). All women DOI:10.4158/GL-2019-0406 © 2019 AACE. 30 of reproductive age should be counseled on contraceptive

2019 American Association of Clinical Endocrinologists

62. Pruritus

types of CP may lead to a significant improvement [e.g. therapy of polycythemia vera- associated aquagenic pruritus with janus kinase (JAK) inhibitors]. Still, there is a significant lack of randomised controlled trials (RCTs) investigating different types of CP in detail, which can be explained by the diversity and complexity of this symptom, the multifactorial aetiologies of pruritus and the lack of well-defined outcome measures, biomarkers and therapy targets. To complicate matters, RCTs exist (...) (Lewis-Jones and Finlay 1995) and ItchyQoL (Desai, Poindexter et al. 2008). Instruments that measure the effect of the families' quality of life include the dermatitis family impact questionnaire (Lawson, Lewis-Jones et al. 1998). The course of advanced learning for the management of itch (CALM-IT) task force recommend a multidisciplinary and multidimensional approach for children CP (Metz, Wahn et al. 2013). It must be assumed that systemic causes of CP in children are mostly based on genetic

2019 European Dermatology Forum

63. Stillbirth care

. For permissions beyond the scope of this licence, contact: Intellectual Property Officer, Queensland Health, GPO Box 48, Brisbane Qld 4001, email, phone (07) 3234 1479. Queensland Clinical Guideline: Stillbirth care Refer to online version, destroy printed copies after use Page 3 of 34 Flow Chart: Stillbirth care Abbreviations: CTG: Cardiotocograph; FGR: fetal growth restriction; GP: General Practitioner; PPM: Private Practice Midwife; PSANZ: Perinatal Society of Australia and New (...) referrals · Complete documentation Communication Labour and birth Consider birthing options · Discuss timing and options for birth with parents–provide written information · Vaginal birth is generally preferable · Consider method of induction relevant to gestation and clinical circumstances (especially obstetric surgical history) · Ensure adequate analgesia · Consider active third stage management Antenatal Diagnosis of fetal death · Diagnose with USS Investigations of fetal death · Refer to Flowchart

2019 Queensland Health

64. Single Event Multi-Level Surgeries for Children, Adolescents, and Young Adults with Cerebral Palsy or Other Similar Neuromotor Conditions

, Definitions for terms marked with *, and How to Cite this Guideline may be found in the Appendices. INTRODUCTION / BACKGROUND Cerebral Palsy (CP) is a disorder of movement and posture caused by a static, non-progressive, neurological incident, occurring in the fetal or infant brain. As a result, individuals often have secondary impairments including musculoskeletal pathologies consisting of abnormal muscle tone, loss of selective motor control, impaired balance, impaired posture, and impaired mobility (...) [*]). The domains of the ICF include body structures and function (functioning at the level of the body); activities (functioning at the level of the individual); participation (functioning of a person as a member of society) and environmental factors (facilitators or barriers) (WHO, 2001 [*]). Researchers and clinicians have used the ICF to classify outcomes and develop rehabilitation programs (Wilson, 2014 [1b]; Dodd, 2003 [2a]; McGinley, 2012 [1b]; Thomason, 2012 [*]). Outcome measures that cross the ICF can

2019 Cincinnati Children's Hospital Medical Center

65. Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada

MBBS, PhD, FACP, FRACP, FRCPC, Peter Senior MBBS, PhD, FRCP S210 Retinopathy Filiberto Altomare MD, FRCSC, Amin Kherani MD, FRCSC, Julie Lovshin MD, FRCPC S217 Neuropathy Vera Bril MD, FRCPC, Ari Breiner MD, FRCPC, Bruce A. Perkins MD, MPH, FRCPC, Douglas Zochodne MD, FRCPC S222 Foot Care John M. Embil MD, FRCPC, FACP, Zaina Albalawi MD, FRCPC, Keith Bowering MD, FRCPC, FACP, Elly Trepman MD S228 Sexual Dysfunction and Hypogonadism in Men With Diabetes Richard Bebb MD, ABIM, FRCPC, Adam Millar MD (...) 12: Monofilament Testing in the Diabetic Foot S323 Appendix 13: Diabetes and Foot Care: A Checklist S324 Appendix 14: Diabetic Foot Ulcers—Essentials of Management S325 Appendix 15: Glycated Hemoglobin Conversion ChartCan J Diabetes 42 (2018) A6–A16 Contents lists available at ScienceDirect Canadian Journal of Diabetes journal homepage: Executive Committee Ron Goldenberg MD FRCPC FACE Sub-Group Chair, Diagnosis & Classification Consultant Endocrinologist North

2018 Diabetes Canada

66. Cutaneous melanoma

induction are unknown. 4 Sunburn is mainly due to ultraviolet B (UVB) (280 to 320 nm) radiation, implicating UVB as a contributing factor to the pathogenesis of melanoma. There is accumulating evidence for the role of ultraviolet A (UVA) (and sunbeds) in the pathogenesis of melanoma. 6 3.3 PRIMARY PREVENTION Primary prevention is defined as prevention targeted towards the general population. There is indirect evidence that sun avoidance and other sun-protective measures (for example clothing, hats (...) found in sunscreens may be carcinogenic. 7,8 Case-control studies and clinical trials have shown no reduction or increase in melanoma incidence with broad-spectrum sunscreen use. Little is known about the potential long-term effects of sunscreen use. 7,8 Given these potentially adverse effects of sunscreens in relation to risk of melanoma, physical protection measures should be regarded as more important than sunscreen use. 7,8 There may be theoretical risks associated with sun avoidance, 9

2017 SIGN

67. Guidelines for the Management of Genital Herpes in New Zealand

– Management of Recurrent Episodes of Genital Herpes 18 GENITAL HERPES IN PREGNANCY 18 Maternal Fetal Transmission 19 Use of Antivirals in Pregnancy and Breastfeeding 19 Mode of Delivery 21 Special Situations in Pregnancy 21 Prevention of HSV in the Neonate 21 Summary of Clinical Management of First Episode Genital Herpes in Pregnancy 22 Treatment algorithm – Management of Women with Suspected Genital Herpes in Pregnancy 23 First Episode Genital Herpes: First and Second Trimester Acquisition 23 First (...) Episode Genital Herpes: Third Trimester Acquisition 23 Management of Pregnant Women with Recurrent Genital Herpes 24 Treatment algorithm – Management of Women with History of Genital Gerpes Prior to Pregnancy and Women with First Clinical Episode Greater than 6 Weeks Prior to Delivery 25 NEONATAL HSV INFECTION 25 Transmission to the Fetus and Newborn 26 Disease Classification 26 Table 2: Classification of Neonatal HSV Infection46 27 Management of Neonatal HSV Infection 29 Guidelines for Talking

2017 New Zealand Sexual Health Society

68. Management Of Haemophilia

Synovitis 30 7.2 Joint Arthropathy 31 7.3 Pseudotumour 31 8. INHIBITORS 33 8.1 Treatment of Acute Bleeding 34 8.2 Prophylaxis Therapy 34 8.3 Eradication of Inhibitors 35 9. HOME THERAPY 37 10. ADHERENCE IN HAEMOPHILIA TREATMENT 39 11. SPECIAL SITUATIONS 41 11.1 Surgeries and Invasive Procedures 41 11.2 Management of Pregnant Carrier 42 11.3 Vaccination 43 11.4 Circumcision 43 12. DENTAL CARE 44 12.1 Preventive Dental Measures 44 12.2 Dental Procedures 44 12.3 Management of Oral Bleeding 46 13 (...) . MONITORING 48 13.1 Inhibitors 48 13.2 Bleeding Frequency 48 13.3 Joint Health 49 13.4 Radiological Measures 49 14. IMPLEMENTING THE GUIDELINES 50 14.1 Facilitating and Limiting Factors 51 14.2 Potential Resource Implications 51 REFERENCES 53 Appendix 1 Example of Search Strategy 59 Appendix 2 Clinical Questions 60 Appendix 3 Guidelines on Sample Collection and 62 TransportationManagement of Haemophilia Appendix 4 Recommended Sports/Physical Activities in 63 Haemophilia Appendix 5 Development of Abnormal

2018 Ministry of Health, Malaysia

69. Treatment for Bipolar Disorder in Adults: A Systematic Review

Aripiprazole Venlafaxine Lithium Ziprasidone and Mood Stabilizers Mood Stabilizers alone (placebo) Psychosocial Interventions Psychoeducation Inactive* Comparators Psychoeducation Active** Comparators CBT Inactive Comparators CBT (for Relapse, Global Function, Other Measures of Function) Active Comparators Systematic or Collaborative Care (for Depression, Mania, Global Function, Other Measures of Function) Inactive Comparators Family or Partner Interventions Inactive Comparators Family or Partner (...) to placebo, and those using olanzapine reported more clinically significant weight gain. Lithium showed short-term benefit for acute mania and longer time to relapse to any mood episode in adults with BD-I versus placebo. Of all acute mania treatments, lithium treatment was closest to reaching a clinically meaningful difference for all the participants as measured by the MID. Evidence was generally insufficient for benefits from nondrug interventions for adults with BD. Low-strength evidence showed

2018 Effective Health Care Program (AHRQ)

70. Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update

C. Benefits and harms of biologic DMARDs for early RA treatment ES-8 Table 1. Corticosteroids and disease-modifying antirheumatic drugs (DMARDs) approved by the U.S. Food and Drug Administration 3 Table 2. Eligibility criteria for review of treatments for early rheumatoid arthritis 7 Table 3. Outcomes and hierarchy of preferred measures for data abstraction 10 Table 4. Definitions of the grades of overall strength of evidence 13 Table 5. Number of studies included for each KQ, by drug therapy (...) previously used MTX specifically: 58 19 and 79 20 percent of patients in two studies, and three studies (all trials) enrolling samples that were entirely MTX resistant (i.e., 100% prior use). 8-10 All included studies enrolled patients with moderate to high disease activity at baseline as measured with mean or median Disease Activity Score (DAS) 28 scores (range of 0 to 10); ES-4 DAS28 scores in these studies ranged from 3.4 to 7.1. A DAS28 score of 3.2 is the threshold for low disease activity; a score

2018 Effective Health Care Program (AHRQ)

71. Diabetes Type 1

are those who are insensate to 5.07 monofilament at any site on either foot or who have bunions, excessive corns, or callus. ? Patients at average risk are those with none of the aforementioned complications. Encourage patients to check their feet regularly. If the patient or a family member cannot perform the patient’s foot care, encourage the patient to find someone who can provide assistance. 5 Sick-day management Patients experiencing acute illnesses need to be extra vigilant about glucose (...) the abnormal test on a different day. An abnormal result on the repeated test is diagnostic for diabetes. Diagnosis for a patient with classic symptoms of hyperglycemia (i.e., polyuria, polydipsia, weight loss) can be made with a single random plasma glucose result of 200 mg/dL or higher. A repeat measurement is not needed. Table 1. Diagnosing diabetes Test Results Interpretation HbA1c 6.5% or higher Diabetes 5.7–6.4% Impaired glucose tolerance 1 Lower than 5.7% Normal Random plasma glucose 200 mg/dL

2017 Kaiser Permanente Clinical Guidelines

72. Management of Pregnancy

? Measure fundal height ? Screen for GDM with one-hour GCT (for women with dumping syndrome, use fasting and two- hour post-prandial glucose value) a ( ) Recommendation 10 ? Perform fetal fibronectin test for women with signs/symptoms of preterm labor ( ) Recommendation 16 ? Assess and educate regarding fetal movement/kick counts and preterm labor symptoms ? Recommend Tdap vaccination for mother and family ? Administer Rh immune globulin to Rh negative pregnant women ? Discuss family planning (...) complications and morbidity • Emphasize the use of patient-centered care (PCC) II. Background A. Description of Pregnancy Pregnancy is the reproductive time during which a developing fetus grows inside of the uterus. It is a time of dramatic change for a developing fetus and a woman’s body. Most pregnancies are uncomplicated and labor results in a normal vaginal birth with a healthy mother and baby. Rarely, complications arise, which have the potential to lead to lifelong implications. As the fetus

2018 VA/DoD Clinical Practice Guidelines

73. Inotuzumab ozogamicin (Besponsa) - B-cell precursor acute lymphoblastic leukaemia (ALL)

) No 1901/2006, the application included an EMA Decision(s) P/0304/2014 on the agreement of a paediatric investigation plan (PIP) and a product-specific waiver. At the time of the submission of the application, the PIP P/0304/2014 was not yet completed as some measures were deferred. Information relating to orphan market exclusivity Similarity Pursuant to Article 8 of Regulation (EC) No. 141/2000 and Article 3 of Commission Regulation (EC) No 847/2000, the applicant did submit a critical report

2017 European Medicines Agency - EPARs

74. Environmental Factors Associated with Increased Rat Populations: A Focused Practice Question

by the World Health Organization (WHO) was to identify the public health risks posed by various urban pests and appropriate measures to prevent and control them. The WHO invited international experts in various fields including pests, pest-related diseases and pest management to provide evidence to develop policies to manage and reduce the risk of exposure to urban pests including rodents. The quality of the literature review was rated as weak to moderate. There was a chapter in this report on commensal (...) provides education to residents on prevention and control measures. The PHI may also work in collaboration with the municipal by-law department if a private residential property is the source of a rat infestation. In Canada, communicable diseases are identified by the federal, provincial and territories’ governments as priorities for monitoring and control efforts 2 . Each year National Notifiable disease data are voluntarily submitted by the provinces and territories through the Canadian Notifiable

2018 Peel Health Library

75. Nusinersen sodium (Spinraza) - Spinal Muscular Atrophy

of Regulation (EC) No 1901/2006, the application included an EMA Decision P/0251/2016 on the agreement of a paediatric investigation plan (PIP). At the time of submission of the application, the PIP Decision P/0251/2016 was not yet completed as some measures were deferred. Information relating to orphan market exclusivity Similarity Pursuant to Article 8 of Regulation (EC) No. 141/2000 and Article 3 of Commission Regulation (EC) No 847/2000, the applicant did not submit a critical report addressing (...) in the presence of drug, thereby allowing these to be called fixation-induced vacuoles. Vacuolation in the inferior hippocampus was absent in tissues immersion-fixed in Carnoy’s or perfusion-fixed with Karnovsky’s fixative. Results of the two developmental and reproductive toxicity studies were negative for drug- related effects on fertility and embryo-fetal development. Biodistribution results indicated that nusinersen did not cross the placenta and, therefore, maternal exposure does not lead to any

2017 European Medicines Agency - EPARs

76. CRACKCast E144 – High Altitude Medicine

Concepts All forms of altitude illness can be treated with oxygen and rapid descent . The diagnosis of AMS requires the presence of headache in the setting of recent elevation change to greater than 8000 feet. Additional nonspecific symptoms may include nausea, anorexia, fatigue, and insomnia. Patients with AMS should not ascend further until symptoms improve. Patients with mild HAPE may be treated in place if experience providers and treatment options exist. Patients with moderate HAPE or HACE should (...) . Symptoms can be controls with analgesia (ibuprofen and antiemetics). HAPE may be prevented using nifedipine, inhaled salmeterol, and phosphodiesterase type 5 inhibitors (sildenafil [40 mg every 8 hours] and tadalafil [10 mg every 12 hours]). Temazepam (7.5 mg qhs) can safely improve sleep quality. We will accidentally talk in both feet and meters because Canadian are a weird hybrid bunch. To convert multiple meters by 3 Rosens in Perspective Acute high altitude illnesses, are completely preventable

2018 CandiEM

77. Niraparib (Zejula) - Fallopian Tube Neoplasms, Ovarian Neoplasms, Peritoneal Neoplasms

to the positive control amphetamine in mice following a single ip administration. Niraparib did not impact dopamine release, but increased intracellular dopamine and metabolite (DOPAC and HVA) levels in the cortex by 330%, 295% and 236%, respectively. These results suggest that niraparib can cause a build-up of intracellular dopamine in the cortex without increasing dopamine availability at its site of action in the CNS. In vivo measurement of niraparib binding to the central dopamine transporter (DAT (...) ) in mice (study PD015) Niraparib occupancy of DAT in vivo was measured by PET in the mouse brain using the DAT specific tracer [ 11 C]-CFT (PD015). Niraparib did not occupy DAT in the striatum at anti-tumour exposure levels, measured by PET on the mouse brain. Assessment report EMA/648982/2017 Page 25/122 A comparison of niraparib and d-amphetamine induced locomotor behaviour (study PD013) Niraparib was examined for its ability to influence motor activity compared to amphetamine as a positive control

2017 European Medicines Agency - EPARs

78. Guselkumab (Tremfya) - Psoriasis

and/or feet HPRA Health Products Regulatory Authority GPP generalized pustular psoriasis IBD inflammatory bowel disease IGA Investigator’s Global Assessment IgG1? immunoglobulin G1 lambda Assessment report EMA/692068/2017 Page 6/148 IL interleukin ISR injection-site reactions IV intravenous k a first-order absorption rate constant MAA Marketing Authorization Application mAb monoclonal antibody MACE major adverse cardiovascular events MedDRA Medical Dictionary for Regulatory Activities MI myocardial (...) ) No 1901/2006, the application included an EMA Decision(s) P/0073/2016 on the agreement of a paediatric investigation plan (PIP). At the time of submission of the application, the PIP not yet completed as some measures were deferred. Information relating to orphan market exclusivity Similarity Pursuant to Article 8 of Regulation (EC) No. 141/2000 and Article 3 of Commission Regulation (EC) No 847/2000, the applicant did not submit a critical report addressing the possible similarity with authorised

2017 European Medicines Agency - EPARs

79. Guidelines on autopsy practice: Third trimester antepartum and intrapartum stillbirth

for gestational assessment, malformation, etc. Recommended in all cases; mandatory for suspected skeletal dysplasia. If available, this may be replaced by other imaging modalities e.g. CT, MRI. · Photography recommended in all cases, essential to document external and internal abnormalities. Digital photography and secure storage preferred. · Routine external body measurements (body weight, crown-rump length, crown-heel length, foot length, occipito-frontal circumference) · Detailed external examination (...) , including: nutritional status/soft tissue and muscle bulk, maceration, local/generalised oedema, pallor, meconium staining, dysmorphic features, evidence of trauma (intrapartum death) and other iatrogenic lesions, assessment of CEff 150617 7 V1 Draft patency of orifices (including choanae) and palatal fusion, limbs, hands and feet and genitalia · Longitudinal skin incision on front of body (typically T- or Y-shaped); measurement of fat thickness over sternum (if appropriate) · Central nervous system

2017 Royal College of Pathologists

80. The communication of critical and unexpected pathology results

to consider when formulating the local policy: • new positive microscopy or significant culture or viral DNA or RNA detection from normally sterile sites, e.g. blood, CSF, joint fluid, unless there is reasonable evidence of contamination or the nature of the infection is already known • new isolates from tissue or bone may need to be phoned (unless the details indicate a chronic infection, such as infected ulcers or diabetic feet) • new results that indicate an urgent need to isolate the patient (...) or initiate other infection control measures. This depends not only on the result, but the location of the patient. For example: a) one would urgently phone a new smear positive TB in an inpatient, but could either email a chest clinic TB result or make a non-urgent call the next working day b) unexpected results with significant clinical/infection control/public health impact, e.g. S. typhi, E. coli O157, S. dysenteriae, Campylobacter, salmonella or norovirus must be phoned if inpatients or nursing home

2017 Royal College of Pathologists

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