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Fetal Hydantoin Syndrome

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1. Fetal Hydantoin Syndrome

, Phenytoin Embryopathy , Fetal Hydantoin Syndrome , Fetal phenytoin syndrome (disorder) , Meadow's syndrome , Fetal hydantoin syndrome (disorder) , Meadow , fetal; hydantoin syndrome , fetus; hydantoin syndrome , hydantoin syndrome; fetus , hydantoin; fetal syndrome , hydantoin; syndrome, fetal , syndrome; fetal, hydantoin , syndrome; hydantoin, fetal Dutch hydantoïnesyndroom, foetaal , fenytoïnesyndroom, foetaal , foetaal; hydantoïnesyndroom , foetus; hydantoïnesyndroom , hydantoïne; foetaal syndroom (...) distal phalanges and nails, growth delay and delayed psychomotor development.(NICHD) Concepts Congenital Abnormality ( T019 ) , Disease or Syndrome ( T047 ) MSH ICD10 SnomedCT 205789007 , 70065001 English Fetal hydantoin syndrome , Foetal hydantoin syndrome , Fetal phenytoin syndrome , Foetal phenytoin syndrome , FHS , FETAL HYDANTOIN SYNDROME , fetal hydantoin syndrome (diagnosis) , fetal hydantoin syndrome , Dilantin Embryopathy , dilantin syndrome , fetal dilantin syndrome , hydantoin syndrome

2018 FP Notebook

2. Fetal Hydantoin Syndrome

, Phenytoin Embryopathy , Fetal Hydantoin Syndrome , Fetal phenytoin syndrome (disorder) , Meadow's syndrome , Fetal hydantoin syndrome (disorder) , Meadow , fetal; hydantoin syndrome , fetus; hydantoin syndrome , hydantoin syndrome; fetus , hydantoin; fetal syndrome , hydantoin; syndrome, fetal , syndrome; fetal, hydantoin , syndrome; hydantoin, fetal Dutch hydantoïnesyndroom, foetaal , fenytoïnesyndroom, foetaal , foetaal; hydantoïnesyndroom , foetus; hydantoïnesyndroom , hydantoïne; foetaal syndroom (...) distal phalanges and nails, growth delay and delayed psychomotor development.(NICHD) Concepts Congenital Abnormality ( T019 ) , Disease or Syndrome ( T047 ) MSH ICD10 SnomedCT 205789007 , 70065001 English Fetal hydantoin syndrome , Foetal hydantoin syndrome , Fetal phenytoin syndrome , Foetal phenytoin syndrome , FHS , FETAL HYDANTOIN SYNDROME , fetal hydantoin syndrome (diagnosis) , fetal hydantoin syndrome , Dilantin Embryopathy , dilantin syndrome , fetal dilantin syndrome , hydantoin syndrome

2015 FP Notebook

3. Pediatrics—Epitomes of Progress: The Fetal Hydantoin Syndrome Full Text available with Trip Pro

Pediatrics—Epitomes of Progress: The Fetal Hydantoin Syndrome 18748159 2010 06 30 2018 11 13 0093-0415 128 3 1978 Mar The Western journal of medicine West. J. Med. Pediatrics-epitomes of progress: the fetal hydantoin syndrome. 229 Jones K L KL eng Journal Article United States West J Med 0410504 0093-0415 1978 3 1 0 0 1978 3 1 0 1 1978 3 1 0 0 ppublish 18748159 PMC1238058 J Pediatr. 1976 Oct;89(4):662-8 957016 Am J Dis Child. 1974 May;127(5):645-53 4825584

1978 Western Journal of Medicine

4. Evidence-based guidelines for treating bipolar disorder

operational criteria properly (S). Organic conditions, such as thyroid disease, multiple sclerosis or any lesion(s) involving right-sided sub-cortical or cortical Goodwin et al. 501 areas may be associated with secondary mania (II) and should be considered in the differential diagnosis (S). These conditions are most likely to occur in the elderly (I). The diagnosis of bipolar disorder in childhood has been con- troversial. The narrow definition of the condition, now endorsed in DSM-5 and described (...) a lifetime perspective. Anxiety symptoms are often persistent between episodes and may contribute to mood insta- bility (I). Anxiety disorders are associated with increased illness burden and poor outcome (I): they require assessment and treatment (S). Stimulant drugs may mimic manic symptoms (II). A drug- induced state, including psychosis, should wane with the clear- ance of the offending drug (II): use 5 half-lives as the relevant interval (and the longest half-life stated in a range). Levodopa

2016 British Association for Psychopharmacology

5. Evidence-based Guidelines for Treating Bipolar Disorder

operational criteria properly (S). Organic conditions, such as thyroid disease, multiple sclerosis or any lesion(s) involving right-sided sub-cortical or cortical Goodwin et al. 501 areas may be associated with secondary mania (II) and should be considered in the differential diagnosis (S). These conditions are most likely to occur in the elderly (I). The diagnosis of bipolar disorder in childhood has been con- troversial. The narrow definition of the condition, now endorsed in DSM-5 and described (...) a lifetime perspective. Anxiety symptoms are often persistent between episodes and may contribute to mood insta- bility (I). Anxiety disorders are associated with increased illness burden and poor outcome (I): they require assessment and treatment (S). Stimulant drugs may mimic manic symptoms (II). A drug- induced state, including psychosis, should wane with the clear- ance of the offending drug (II): use 5 half-lives as the relevant interval (and the longest half-life stated in a range). Levodopa

2016 British Association for Psychopharmacology

6. Seizure Disorders in Pregnancy (Diagnosis)

of abnormal electroencephalogram (EEG) findings, higher rates of developmentally delayed children, and lower intelligence quotient (IQ) scores. Phenytoin Fetal hydantoin syndrome was first described in 1973 by Loughnan et al. [ ] It consists of an array of anomalies, including craniofacial anomalies, distal digital hypoplasia, epicanthal folds, hypertelorism, low-set ears, and developmental delay. The early descriptions of this syndrome were noted in 12 infants, 11 of whom had been exposed to other AEDs (...) and with normal controls. Phenobarbital and primidone Infants exposed to phenobarbital have been reported to have many of the findings observed in infants with fetal hydantoin syndrome and fetal alcohol syndrome. Furthermore, many of the infants initially described as having fetal hydantoin syndrome were also exposed to phenobarbital. A drug registry reported 5 (6.5%) of 77 patients who had received phenobarbital monotherapy had fetuses with major malformations, compared with a background rate of 1.6

2014 eMedicine.com

7. Seizure Disorders in Pregnancy (Overview)

of abnormal electroencephalogram (EEG) findings, higher rates of developmentally delayed children, and lower intelligence quotient (IQ) scores. Phenytoin Fetal hydantoin syndrome was first described in 1973 by Loughnan et al. [ ] It consists of an array of anomalies, including craniofacial anomalies, distal digital hypoplasia, epicanthal folds, hypertelorism, low-set ears, and developmental delay. The early descriptions of this syndrome were noted in 12 infants, 11 of whom had been exposed to other AEDs (...) and with normal controls. Phenobarbital and primidone Infants exposed to phenobarbital have been reported to have many of the findings observed in infants with fetal hydantoin syndrome and fetal alcohol syndrome. Furthermore, many of the infants initially described as having fetal hydantoin syndrome were also exposed to phenobarbital. A drug registry reported 5 (6.5%) of 77 patients who had received phenobarbital monotherapy had fetuses with major malformations, compared with a background rate of 1.6

2014 eMedicine.com

8. Seizure Disorders in Pregnancy (Treatment)

of abnormal electroencephalogram (EEG) findings, higher rates of developmentally delayed children, and lower intelligence quotient (IQ) scores. Phenytoin Fetal hydantoin syndrome was first described in 1973 by Loughnan et al. [ ] It consists of an array of anomalies, including craniofacial anomalies, distal digital hypoplasia, epicanthal folds, hypertelorism, low-set ears, and developmental delay. The early descriptions of this syndrome were noted in 12 infants, 11 of whom had been exposed to other AEDs (...) and with normal controls. Phenobarbital and primidone Infants exposed to phenobarbital have been reported to have many of the findings observed in infants with fetal hydantoin syndrome and fetal alcohol syndrome. Furthermore, many of the infants initially described as having fetal hydantoin syndrome were also exposed to phenobarbital. A drug registry reported 5 (6.5%) of 77 patients who had received phenobarbital monotherapy had fetuses with major malformations, compared with a background rate of 1.6

2014 eMedicine.com

9. Seizure Disorders in Pregnancy (Follow-up)

of abnormal electroencephalogram (EEG) findings, higher rates of developmentally delayed children, and lower intelligence quotient (IQ) scores. Phenytoin Fetal hydantoin syndrome was first described in 1973 by Loughnan et al. [ ] It consists of an array of anomalies, including craniofacial anomalies, distal digital hypoplasia, epicanthal folds, hypertelorism, low-set ears, and developmental delay. The early descriptions of this syndrome were noted in 12 infants, 11 of whom had been exposed to other AEDs (...) and with normal controls. Phenobarbital and primidone Infants exposed to phenobarbital have been reported to have many of the findings observed in infants with fetal hydantoin syndrome and fetal alcohol syndrome. Furthermore, many of the infants initially described as having fetal hydantoin syndrome were also exposed to phenobarbital. A drug registry reported 5 (6.5%) of 77 patients who had received phenobarbital monotherapy had fetuses with major malformations, compared with a background rate of 1.6

2014 eMedicine.com

10. Acute pain management: scientific evidence (3rd Edition)

and cultural groups 413 11.5 The patient with obstructive sleep apnoea 415 11.6 The patient with concurrent hepatic or renal disease 418 11.6.1 Patients with renal disease 418 11.6.2 Patients with hepatic disease 419 11.7 The opioid-tolerant patient 426 11.7.1 Definitions and clinical implications 426 11.7.2 Patient groups 427 11.7.3 Management of acute pain 427 11.8 The patient with an addiction disorder 431 11.8.1 Management of acute pain in pregnant patients with an addiction disorder .. 433 11.8.2 CNS (...) in every case, early recognition and treatment of incipient chronic pain by a vigilant healthcare system is necessary for cost- effective intervention. The National Pain Strategy document that underpins the 2010 Australian Pain Summit summarises the emerging literature on social, human and economic costs of undertreated acute and chronic pain — establishing pain as a major disease burden (www.painsummit.org.au) and proposing an integrated new framework for management of acute, chronic and cancer pain

2015 National Health and Medical Research Council

11. Acute Pain Management: Scientific Evidence

Pharmacological treatment 352 8.8.5 Guillain-Barre syndrome 354 8.8.6 Procedure-related pain 354 8.9 Acute pain management in emergency departments 355 8.9.1 Systemic analgesics 355 8.9.2 Analgesia in specific conditions 357 8.9.3 Nonpharmacological management of pain 359 8.10 Prehospital analgesia 360 8.10.1 Assessment of pain in the prehospital environment 361 8.10.2 Systemic analgesics 361 8.10.3 Anxiolytics 364 8.10.4 Regional analgesia 364 8.10.5 Nonpharmacological management of pain 364 8.10.6 Analgesia (...) and implementation of clinical practice guidelines . https:// www.nhmrc.gov.au/guidelines-publications/cp30 Accessed 29 August 2014. painaustralia (2010) National Pain Strategy. Available from Painaustralia at: www.painaustralia.org.au Accessed 24 October 2015. Reardon DP , Anger KE, Szumita PM (2015) Pathophysiology, assessment, and management of pain in critically ill adults. Am J Health Syst Pharm 72(18):1531–43. Shipton EA (2014a) The transition of acute postoperative pain to chronic pain: Part 1 - Risk

2015 Clinical Practice Guidelines Portal

12. Tetralogy of Fallot (Diagnosis)

with fetal hydantoin syndrome or fetal carbamazepine syndrome. In addition, as one of the conotruncal malformations, tetralogy of Fallot can be associated with a spectrum of lesions known as CATCH 22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia). Cytogenetic analysis may demonstrate deletions of a segment of chromosome band 22q11 (DiGeorge critical region). Ablation of cells of the neural crest has been shown to reproduce conotruncal malformations. These abnormalities (...) peak RV–to–left ventricular pressure ratio Multiple ventricular septal defects (VSDs) Right-sided heart failure See and for more detail, as well as the section for the 2018 American Heart Association/American College of Cardiology (AHA/ACC) recommendations for the management of adults with tetralogy of Fallot. Next: Background Tetralogy of Fallot (TOF) (pronounced te-tral-uh-jee of Fal-oh) is one of the most common congenital heart disorders (CHDs). This condition is classified as a cyanotic heart

2014 eMedicine.com

13. Teratology and Drug Use During Pregnancy (Diagnosis)

, have performed many studies in this area. Specific drugs should be investigated before they are used. Risk-benefit assessment and counseling should involve the patient in the setting of her current state of health. The physician must consider the effects of drug exposure on the developing fetus or embryo and acknowledge specific susceptibilities at each point in fetal development, as balanced against the risks of worsening maternal illness. The patient must consider her symptoms, quality of life (...) spaced nipples, umbilical or inguinal hernia, and rib anomalies. Internal abnormalities include variable coarctation of the aorta, endocardial cushion defect, double-outlet right ventricle, ventricular septal defect, atrial septal defect, bicuspid pulmonic valve, and intestinal malrotation. Ambiguous genitalia are rarely associated with this syndrome. A patient with the dysmorphic characteristics of fetal hydantoin syndrome presented with unusual hyperpigmentation of several fingernails. Another

2014 eMedicine.com

14. Psychosocial and Environmental Pregnancy Risks (Diagnosis)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU5MzQ2LW92ZXJ2aWV3 processing > Psychosocial and Environmental Pregnancy Risks Updated: Aug 29, 2017 Author: Kelly S Acharya, MD; Chief Editor: Christine Isaacs, MD Share Email Print Feedback Close Sections Sections Psychosocial and Environmental Pregnancy Risks Overview Overview The purpose of obstetrics is to maintain the health of the pregnant woman and to ensure optimal health of the fetus. Preconception and postconception risks exist for both mother and child. Certain fetal and maternal conditions have been (...) dose because the fetus is in direct line with the x-ray beam, but the average exposure is still only 100 mrad. Trauma series radiographs of the extremities, skull, and ribs deliver low doses because of fetal distance to the target area, except for the hip or pelvic radiograph, which delivers about 200 mrad Computed tomography (CT) scanning This important imaging modality is used commonly to evaluate for multiple disorders. Newer generation tomography equipment is more sensitive and there is less

2014 eMedicine.com

15. Psychosocial and Environmental Pregnancy Risks (Overview)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU5MzQ2LW92ZXJ2aWV3 processing > Psychosocial and Environmental Pregnancy Risks Updated: Aug 29, 2017 Author: Kelly S Acharya, MD; Chief Editor: Christine Isaacs, MD Share Email Print Feedback Close Sections Sections Psychosocial and Environmental Pregnancy Risks Overview Overview The purpose of obstetrics is to maintain the health of the pregnant woman and to ensure optimal health of the fetus. Preconception and postconception risks exist for both mother and child. Certain fetal and maternal conditions have been (...) dose because the fetus is in direct line with the x-ray beam, but the average exposure is still only 100 mrad. Trauma series radiographs of the extremities, skull, and ribs deliver low doses because of fetal distance to the target area, except for the hip or pelvic radiograph, which delivers about 200 mrad Computed tomography (CT) scanning This important imaging modality is used commonly to evaluate for multiple disorders. Newer generation tomography equipment is more sensitive and there is less

2014 eMedicine.com

16. Vitamin K Deficiency (Overview)

with prothrombin synthesis, lack of VK in breast milk, and the sterile gut in neonates account for VK deficiency. [ , , , ] Neonatal diseases that cause cholestasis can result in VK deficiency. [ ] Parental refusal of VK prophylaxis at childbirth can result in bleeding sequela. [ ] In adults, the causes of VK deficiency include the following [ , ] : Chronic illness Malnutrition Alcoholism Multiple abdominal surgeries Long-term parenteral nutrition Malabsorption syndromes Infectious diarrhea Cholestatic disease (...) synthesized by colonic bacteria. (See Etiology and Epidemiology.) The 3 main types of VK are K-1 (also known as phylloquinone or phytonadione), which is derived from plants; K-2 (menaquinone), which is produced by the intestinal flora; and K-3 (menadione), which is a synthetic, water-soluble form used for treatment. Infants with VK deficiency are at risk for hemorrhagic disease of newborn, caused by a lack of VK reaching the fetus across the placenta, the low level of VK in breast milk, and low colonic

2014 eMedicine.com

17. Women's Health and Epilepsy (Overview)

% in women with epilepsy taking AEDs. [ ] Minor malformations such as facial dysmorphisms and digital hypoplasia occur in 6-20% of pregnancies with in utero exposure to AEDs. [ ] These malformations are often subtle and disappear with maturation through the first year of life. Evidence for medication-specific syndromes (eg, fetal hydantoin syndrome, fetal barbiturate syndrome) is lacking; because similar minor anomalies have been reported with in utero exposure to multiple different AEDs, fetal (...) that the prevalence of epilepsy was slightly higher in males than females (6.5 vs 6.0 per 1000 persons). [ ] As these higher rates in males may be attributable to the higher frequency of some major etiologies of seizures in men (eg, cerebrovascular disease, head trauma, alcohol-related seizures), it may be that increasing rates of such conditions in women may result in less difference between the sexes. The risk for recurrent seizure is similar between males and females, [ ] as is the likelihood of ultimate

2014 eMedicine.com

18. Teratology and Drug Use During Pregnancy (Overview)

, have performed many studies in this area. Specific drugs should be investigated before they are used. Risk-benefit assessment and counseling should involve the patient in the setting of her current state of health. The physician must consider the effects of drug exposure on the developing fetus or embryo and acknowledge specific susceptibilities at each point in fetal development, as balanced against the risks of worsening maternal illness. The patient must consider her symptoms, quality of life (...) spaced nipples, umbilical or inguinal hernia, and rib anomalies. Internal abnormalities include variable coarctation of the aorta, endocardial cushion defect, double-outlet right ventricle, ventricular septal defect, atrial septal defect, bicuspid pulmonic valve, and intestinal malrotation. Ambiguous genitalia are rarely associated with this syndrome. A patient with the dysmorphic characteristics of fetal hydantoin syndrome presented with unusual hyperpigmentation of several fingernails. Another

2014 eMedicine.com

19. Psychosocial and Environmental Pregnancy Risks (Treatment)

=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjU5MzQ2LW92ZXJ2aWV3 processing > Psychosocial and Environmental Pregnancy Risks Updated: Aug 29, 2017 Author: Kelly S Acharya, MD; Chief Editor: Christine Isaacs, MD Share Email Print Feedback Close Sections Sections Psychosocial and Environmental Pregnancy Risks Overview Overview The purpose of obstetrics is to maintain the health of the pregnant woman and to ensure optimal health of the fetus. Preconception and postconception risks exist for both mother and child. Certain fetal and maternal conditions have been (...) dose because the fetus is in direct line with the x-ray beam, but the average exposure is still only 100 mrad. Trauma series radiographs of the extremities, skull, and ribs deliver low doses because of fetal distance to the target area, except for the hip or pelvic radiograph, which delivers about 200 mrad Computed tomography (CT) scanning This important imaging modality is used commonly to evaluate for multiple disorders. Newer generation tomography equipment is more sensitive and there is less

2014 eMedicine.com

20. Women's Health and Epilepsy (Treatment)

% in women with epilepsy taking AEDs. [ ] Minor malformations such as facial dysmorphisms and digital hypoplasia occur in 6-20% of pregnancies with in utero exposure to AEDs. [ ] These malformations are often subtle and disappear with maturation through the first year of life. Evidence for medication-specific syndromes (eg, fetal hydantoin syndrome, fetal barbiturate syndrome) is lacking; because similar minor anomalies have been reported with in utero exposure to multiple different AEDs, fetal (...) that the prevalence of epilepsy was slightly higher in males than females (6.5 vs 6.0 per 1000 persons). [ ] As these higher rates in males may be attributable to the higher frequency of some major etiologies of seizures in men (eg, cerebrovascular disease, head trauma, alcohol-related seizures), it may be that increasing rates of such conditions in women may result in less difference between the sexes. The risk for recurrent seizure is similar between males and females, [ ] as is the likelihood of ultimate

2014 eMedicine.com

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