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Fetal Growth

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1. Prediction of fetal growth restriction and complications: individual participant data (IPD) meta-analysis with decision curve analysis. International Prediction of Complications in Pregnancy: Fetal Growth restriction (IPPIC-FGR)

Prediction of fetal growth restriction and complications: individual participant data (IPD) meta-analysis with decision curve analysis. International Prediction of Complications in Pregnancy: Fetal Growth restriction (IPPIC-FGR) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate

2019 PROSPERO

2. Fetal Growth Restriction

Fetal Growth Restriction Sign In (ACOG) Sign in to your ACOG account Email is required. Please enter valid Email. was not found in our system. Would you like to associated with your account? Forgot your email address? JSOG Member? © 2019 - American College of Obstetricians and Gynecologists

2019 American College of Obstetricians and Gynecologists

3. Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restricti (PubMed)

Detailed statistical analysis plan for the Dutch STRIDER (Sildenafil TheRapy In Dismal prognosis Early-onset fetal growth Restriction) randomised clinical trial on sildenafil versus placebo for pregnant women with severe early onset fetal growth restricti The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal (...) mortality in pregnant women with severe early-onset fetal growth restriction. The objective of this detailed statistical analysis plan is to minimize the risks of selective reporting and data-driven analysis.The setting is 10 tertiary care hospitals and one secondary care hospital in The Netherlands.The participants will be 360 pregnant women with severe early-onset fetal growth restriction.The intervention is sildenafil 25 mg or placebo orally three times a day.The primary outcome is a composite

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2019 Trials

4. Fetal Growth Patterns in Pregnancy-Associated Hypertensive Disorders: NICHD Fetal Growth Studies. (PubMed)

Fetal Growth Patterns in Pregnancy-Associated Hypertensive Disorders: NICHD Fetal Growth Studies. Fetal growth patterns in pregnancy-associated hypertensive disorders is poorly understood since prospective longitudinal data are lacking.To compare longitudinal fetal growth trajectories between normotensive women and those with pregnancy-associated hypertensive disorders.This is a study based on data from a prospective longitudinal cohort study of fetal growth performed at 12 U.S. sites (2009 (...) constituted the normotensive group. Growth curves for estimated fetal weight and individual biometric parameters including biparietal diameter, head circumference, abdominal circumference, femur and humerus length were calculated for each group using linear mixed models with cubic splines. Global and weekly pairwise comparisons were performed between women with a hypertensive disorder compared with normotensive women to analyze differences while adjusting for confounding variables. Delivery gestational

2019 American Journal of Obstetrics and Gynecology

5. The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects - Pasupathy - - BJOG: An International Journal of Obstetrics & Gynaecology - Wiley Online Library By continuing to browse this site, you agree to its use of cookies as described in our (...) . Search within Search term Search term RCOG Scientific Impact Paper Free Access The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects Scientific Impact Paper No. 60 Corresponding Author E-mail address: Correspondence : Royal College of Obstetricians and Gynaecologists, 27 Sussex Place, Regent's Park, London NW1 4RG. Email: Corresponding Author E-mail address: Correspondence : Royal College

2019 Royal College of Obstetricians and Gynaecologists

6. Perinatal mortality in early-onset fetal growth restriction by estimated fetal weight and gestational age: a meta-analysis of individual participant data (IGRO)

Perinatal mortality in early-onset fetal growth restriction by estimated fetal weight and gestational age: a meta-analysis of individual participant data (IGRO) Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content

2019 PROSPERO

7. Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. (PubMed)

Placental exosomes profile in maternal and fetal circulation in intrauterine growth restriction - Liquid biopsies to monitoring fetal growth. Placenta-derived exosomes may represent an additional pathway by which the placenta communicates with the maternal system to induce maternal vascular adaptations to pregnancy and it may be affected during Fetal growth restriction (FGR). The objective of this study was to quantify the concentration of total and placenta-derived exosomes in maternal (...) ]. The contribution of placental exosomes to the total exosome concentration in maternal and fetal circulation showed a significant decrease among cases, with lower PLAP+ve ratios in FGR compared to controls and SGA cases.Quantification of placental exosomes in maternal plasma reflects fetal growth and it may be a useful indicator of placental function.Copyright © 2018. Published by Elsevier Ltd.

2018 Placenta

8. Fetal Growth Velocity: the NICHD Fetal Growth Studies. (PubMed)

Fetal Growth Velocity: the NICHD Fetal Growth Studies. Accurately identifying pregnancies with accelerated or diminished fetal growth is challenging and generally based on cross-sectional percentile estimates of fetal weight. Longitudinal growth velocity might improve identification of abnormally grown fetuses.We sought to complement fetal size standards with fetal growth velocity, develop a model to compute fetal growth velocity percentiles for any given set of gestational week intervals (...) , and determine association between fetal growth velocity and birthweight.This was a prospective cohort study with data collected at 12 US sites (2009 through 2013) from 1733 nonobese, low-risk pregnancies included in the singleton standard. Following a standardized sonogram at 10w0d-13w6d, each woman was randomized to 1 of 4 follow-up visit schedules with 5 additional study sonograms (targeted ranges: 16-22, 24-29, 30-33, 34-37, and 38-41 weeks). Study visits could occur ± 1 week from the targeted GA

2018 American Journal of Obstetrics and Gynecology

9. Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS−/− Mouse Model of Fetal Growth Restriction (PubMed)

Pomegranate Juice Supplementation Alters Utero-Placental Vascular Function and Fetal Growth in the eNOS−/− Mouse Model of Fetal Growth Restriction The eNOS-/- mouse provides a well-characterized model of fetal growth restriction (FGR) with altered uterine and umbilical artery function and reduced utero- and feto-placental blood flow. Pomegranate juice (PJ), which is rich in antioxidants and bioactive polyphenols, has been posited as a beneficial dietary supplement to promote cardiovascular (...) health. We hypothesized that maternal supplementation with PJ will improve uterine and umbilical artery function and thereby enhance fetal growth in the eNOS-/- mouse model of FGR. Wild type (WT, C57Bl/6J) and eNOS-/- mice were supplemented from E12.5-18.5 with either PJ in their drinking water or water alone. At E18.5 uterine (UtA) and umbilical (UmbA) arteries were isolated for study of vascular function, fetuses and placentas were weighed and fetal biometric measurements taken. PJ supplementation

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2018 Frontiers in physiology

10. Are selection criteria for healthy pregnancies responsible for the gap between fetal growth in the French national Elfe birth cohort and the Intergrowth-21st fetal growth standards? (PubMed)

Are selection criteria for healthy pregnancies responsible for the gap between fetal growth in the French national Elfe birth cohort and the Intergrowth-21st fetal growth standards? The Intergrowth-21st (IG) project proposed prescriptive fetal growth standards for global use based on ultrasound measurements from a multicounty study of low-risk pregnancies selected using strict criteria. We examined whether the IG standards are appropriate for fetal growth monitoring in France and whether (...) yielded very similar results.Intergrowth standards differed from fetal biometric measures in France, including among low-risk pregnancies selected to replicate IG's healthy pregnancy sample. These results challenge the project's assumption that careful constitution of a low-risk population makes it possible to describe normative fetal growth across populations.© 2018 John Wiley & Sons Ltd.

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2018 Paediatric and perinatal epidemiology

11. Fetal growth standards: the NICHD fetal growth study approach in context with INTERGROWTH-21st and the World Health Organization Multicentre Growth Reference Study. (PubMed)

Fetal growth standards: the NICHD fetal growth study approach in context with INTERGROWTH-21st and the World Health Organization Multicentre Growth Reference Study. Three recently completed longitudinal cohort studies have developed intrauterine fetal growth charts, one in the United States and two international. This expert review compares and contrasts the Eunice Kennedy Shriver National Institute of Child Health and Human Development Fetal Growth Studies, INTERGROWTH-21st and World Health (...) Organization Multicentre Growth Reference Study conclusions in light of differences in aims, sampling frames, and analytical approaches. An area of controversy is whether a single growth reference is representative of growth, regardless of ethnic or country origin. The INTERGROWTH and World Health Organization Fetal studies used a similar approach as the World Health Organization Multicentre Growth Reference Study for infants and children, the aim of which was to create a single international reference

2017 American Journal of Obstetrics and Gynecology

12. Protect-me: a parallel-group, triple blinded, placebo-controlled randomised clinical trial protocol assessing antenatal maternal melatonin supplementation for fetal neuroprotection in early-onset fetal growth restriction. (PubMed)

Protect-me: a parallel-group, triple blinded, placebo-controlled randomised clinical trial protocol assessing antenatal maternal melatonin supplementation for fetal neuroprotection in early-onset fetal growth restriction. Fetal growth restriction (FGR) is a serious pregnancy complication, associated with increased rates of perinatal death and morbidity among survivors. Most commonly FGR results from placental insufficiency, where the placenta fails to deliver the oxygen and nutrients required (...) for normal fetal growth. This leads to fetal oxidative stress, resulting in organ damage through lipid peroxidation. The early developing brain is particularly susceptible, such that FGR is associated with poorer neurodevelopment, witnessed as cognitive and behavioural dysfunction, and cerebral palsy. Promisingly, melatonin, a lipid soluble antioxidant is neuroprotective in animal models of FGR. We present a protocol outlining a randomised, placebo-controlled trial to explore whether antenatal maternal

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2019 BMJ open

13. Evaluating the accuracy and precision of sonographic fetal weight estimation models in extremely early-onset fetal growth restriction. (PubMed)

Evaluating the accuracy and precision of sonographic fetal weight estimation models in extremely early-onset fetal growth restriction. Birthweight is a critical predictor of survival in extremely early-onset fetal growth restriction (fetal growth restriction diagnosed pre-28 weeks' gestation, with abnormal umbilical/uterine artery Doppler waveforms), therefore accurate fetal weight estimation is a crucial component of antenatal management. Currently available sonographic fetal weight estimation (...) models were predominantly developed in populations of mixed gestational age and varying fetal weights, but not specifically tested within the context of extremely early-onset fetal growth restriction. This study aimed to determine the accuracy and precision of fetal weight estimation in this population and investigate if model performance is affected by other factors.Cases where a growth scan was performed within 48 hours of delivery (n=65) were identified from a cohort of extremely early-onset fetal

2019 Acta Obstetricia et Gynecologica Scandinavica

14. Computerized fetal heart rate analysis in early preterm fetal growth restriction. (PubMed)

Computerized fetal heart rate analysis in early preterm fetal growth restriction. To assess the use of computerized cardiotocography (cCTG) with calculation of short term fetal heart rate variability (STV) in early preterm fetal growth restriction (FGR) for prevention of fetal death and neonatal asphyxia, morbidity, and two-year infant neurodevelopmental impairment.Retrospective cohort study of all women who were admitted at the Amsterdam University Medical Centre - AMC, between 2003 and 2015 (...) for FGR and / or preeclampsia, and who were delivered by pre-labor Cesarean delivery or had a fetal death before 32 weeks. STV of all available cCTG registrations during the last five days before delivery or fetal death was calculated retrospectively, and decelerations were classified (none, 1-2 / hour or recurrent = 3 or more / hour). Adverse outcome endpoints were defined as fetal death, neonatal asphyxia at birth (including fetal death), major neonatal morbidity and infant's 2-year

2019 Ultrasound in Obstetrics and Gynecology

15. Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. (PubMed)

Fetal cardiac remodeling and dysfunction is associated with both preeclampsia and fetal growth restriction. Preeclampsia and fetal growth restriction share some pathophysiologic features and are both associated with placental insufficiency. Fetal cardiac remodeling has been described extensively in fetal growth restriction, whereas little is known about preeclampsia with a normally grown fetus.To describe fetal cardiac structure and function in pregnancies complicated by preeclampsia (...) and/or fetal growth restriction as compared with uncomplicated pregnancies.This was a prospective, observational study including pregnancies complicated by normotensive fetal growth restriction (n=36), preeclampsia with a normally grown fetus (n=35), preeclampsia with fetal growth restriction (preeclampsia with a normally grown fetus-fetal growth restriction, n=42), and 111 uncomplicated pregnancies matched by gestational age at ultrasound. Fetal echocardiography was performed at diagnosis for cases

2019 American Journal of Obstetrics and Gynecology

16. Outcome in early-onset fetal growth restriction is best combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe. (PubMed)

Outcome in early-onset fetal growth restriction is best combining computerized fetal heart rate analysis with ductus venosus Doppler: insights from the Trial of Umbilical and Fetal Flow in Europe. Early-onset fetal growth restriction represents a particular dilemma in clinical management balancing the risk of iatrogenic prematurity with waiting for the fetus to gain more maturity, while being exposed to the risk of intrauterine death or the sequelae of acidosis.The Trial of Umbilical and Fetal (...) Flow in Europe was a European, multicenter, randomized trial aimed to determine according to which criteria delivery should be triggered in early fetal growth restriction. We present the key findings of the primary and secondary analyses.Women with fetal abdominal circumference <10th percentile and umbilical pulsatility index >95th percentile between 26-32 weeks were randomized to 1 of 3 monitoring and delivery protocols. These were: fetal heart rate variability based on computerized

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2018 American Journal of Obstetrics and Gynecology

17. STRIDER NZAus: A multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction

STRIDER NZAus: A multicentre randomised controlled trial of sildenafil therapy in early-onset fetal growth restriction To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early-onset fetal growth restriction.A randomised placebo-controlled trial.Thirteen maternal-fetal medicine units across New Zealand and Australia.Women with singleton pregnancies affected by fetal growth restriction at 22+0 to 29+6 weeks.Women were randomised to oral 25mg sildenafil citrate (...) or visually matching placebo three times daily until 32+0 weeks, birth or fetal death (whichever occurred first).The primary outcome was the proportion of pregnancies with an increase in fetal growth velocity. Secondary outcomes included livebirth, survival to hospital discharge free of major neonatal morbidity and preeclampsia.Sildenafil did not affect the proportion of pregnancies with an increase in fetal growth velocity; 32/61 (52.5%) sildenafil-treated 39/57 (68.4%) placebo-treated, adjusted OR 0.49

2019 EvidenceUpdates

18. Diagnostic performance of third-trimester ultrasound for the prediction of late-onset fetal growth restriction: a systematic review and meta-analysis

Diagnostic performance of third-trimester ultrasound for the prediction of late-onset fetal growth restriction: a systematic review and meta-analysis The objective of the study was to establish the diagnostic performance of ultrasound screening for predicting late smallness for gestational age and/or fetal growth restriction.A systematic search was performed to identify relevant studies published since 2007 in English, Spanish, French, Italian, or German, using the databases PubMed, ISI Web (...) of Science, and SCOPUS.We used rrospective and retrospective cohort studies in low-risk or nonselected singleton pregnancies with screening ultrasound performed at ≥32 weeks of gestation.The estimated fetal weight and fetal abdominal circumference were assessed as index tests for the prediction of birthweight <10th (i.e. smallness for gestational age), less than the fifth, and less than the third centile and fetal growth restriction (estimated fetal weight less than the third or estimated fetal weight

2019 EvidenceUpdates

19. An abnormal cerebroplacental ratio (CPR) is predictive of early childhood delayed neurodevelopment in the setting of fetal growth restriction

An abnormal cerebroplacental ratio (CPR) is predictive of early childhood delayed neurodevelopment in the setting of fetal growth restriction Fetal growth restriction accounts for a significant proportion of perinatal morbidity and death. The cerebroplacental ratio is gaining much interest as a useful tool in differentiating the "at-risk" fetus in both fetal growth restriction and appropriate-for-gestational-age pregnancies. The Prospective Observational Trial to Optimize Pediatric Health (...) in Fetal Growth Restriction group has demonstrated previously that the presence of this "brain-sparing" effect is associated significantly with adverse perinatal outcomes in the fetal growth restriction cohort. However, data about neurodevelopment in children from pregnancies that are complicated by fetal growth restriction are sparse and conflicting.The aim of the Prospective Observational Trial to Optimize Pediatric Health in Fetal Growth Restriction NeuroDevelopmental Assessment Study

2019 EvidenceUpdates

20. Fetal Origins of Adult Cardiac Disease: A Novel Approach to Prevent Fetal Growth Restriction Induced Cardiac Dysfunction Using Insulin Like Growth Factor. (PubMed)

Fetal Origins of Adult Cardiac Disease: A Novel Approach to Prevent Fetal Growth Restriction Induced Cardiac Dysfunction Using Insulin Like Growth Factor. Fetal growth restriction (FGR) is a risk factor for adult cardiovascular disease. Intraplacental gene transfer of human insulin-like growth factor-1 (IGF-1) corrects birth weight in our mouse model of FGR. This study addresses long term effects of FGR on cardiac function and the potential preventive effect of IGF-1.Laparotomy was performed

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2017 Pediatric Research

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