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Fetal Alcohol Syndrome

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1. A Brief History of Awareness of the Link Between Alcohol and Fetal Alcohol Spectrum Disorder

. Further research will be required to fully appreciate the scientific, medical, and societal ills associated with prenatal alcohol exposure. Publication Type: Journal Articles Year of Publication: 2018 Topics: Fetal Alcohol Spectrum Disorder (FASD) Authors: Jasmine Brown, Roger Bland, Egon Jonsson, Andrew Greenshaw ISSN: 0706-7437 ISSN (online): 1497-0015 Journal Title: The Canadian Journal of Psychiatry Copyright © 2019 Institute of Health Economics F: (1) 780.448.0018 Links Never miss an update! (...) A Brief History of Awareness of the Link Between Alcohol and Fetal Alcohol Spectrum Disorder Institute of Health Economics | Toggle navigation MENU / Advanced Search A Brief History of Awareness of the Link Between Alcohol and Fetal Alcohol Spectrum Disorder May 28, 2018 Objective: Fetal alcohol spectrum disorder (FASD) is a medical term used to describe a range of mental and physical disabilities caused by maternal alcohol consumption. The role of alcohol as a teratogen and its effects

2018 Institute of Health Economics

2. Fetal alcohol spectrum disorders

problems. Definition Fetal alcohol spectrum disorders (FASDs) refers to a group of conditions that may result from fetal exposure to alcohol. Streissguth AP, O'Malley K. Neuropsychiatric implications and long-term consequences of fetal alcohol spectrum disorders. Semin Clin Neuropsychiatry. 2000;5:177-190. http://www.ncbi.nlm.nih.gov/pubmed/11291013?tool=bestpractice.com Disorders include fetal alcohol syndrome (FAS), partial FAS, alcohol-related neurodevelopmental disorder, and alcohol-related birth (...) Fetal alcohol spectrum disorders Fetal alcohol spectrum disorders - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Fetal alcohol spectrum disorders Last reviewed: February 2019 Last updated: April 2018 Summary Considered a spectrum of disorders that includes fetal alcohol syndrome, partial fetal alcohol syndrome, alcohol-related neurodevelopmental disorder, and alcohol-related birth defects. Caused by fetal exposure

2018 BMJ Best Practice

4. Identifying Effective Approaches to Support Parents and Caregivers of Children with Fetal Alcohol Spectrum Disorder

>> Action KEY MESSAGES Questions • What approaches have been found to be effective for parent support groups of children with fetal alcohol spectrum disorder (FASD) and other neurodevelopmental conditions? • In Ontario, Canada, what approaches have been successful in parent support groups for parents and caregivers of those with FASD, what is needed to further tailor or enhance support groups and other supports available through its health and social systems, and what is needed to make these approaches (...) sustainable? Why the issue is important • Fetal Alcohol Spectrum Disorder (FASD) is used “to describe a broader spectrum of presentations and disabilities resulting from alcohol exposure in utero.” • FASD affects between 2% and 3% of elementary school students in the greater Toronto area. • There has been increasing evidence that the right information, supports and services provided in a timely manner can significantly reduce the burden of this condition on individuals, families and caregivers. • Given

2018 McMaster Health Forum

6. The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health

The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health Institute of Health Economics | Toggle navigation MENU / Advanced Search The Standardization of Diagnostic Criteria for Fetal Alcohol Spectrum Disorder (FASD): Implications for Research, Clinical Practice and Population Health May 22, 2018 Objective: Fetal Alcohol Spectrum Disorder (FASD) is a preventable disorder caused by maternal alcohol (...) of existing gaps in research on the conditions and factors that influence fetal vulnerability to damage from exposure. This discordance has led to variability in research findings, inconsistencies in government messaging, and misdiagnoses or missed diagnoses. The objective measurement of the timing and level of prenatal alcohol exposure is key to bridging these gaps; however, there is conflicting or limited evidence to support the use of existing measures. Publication Type: Journal Articles Year

2018 Institute of Health Economics

7. Diagnosis, Assessment, and Treatment of Fetal Alcohol Spectrum Disorders: A Review of Clinical and Cost-Effectiveness and Guidelines

Diagnosis, Assessment, and Treatment of Fetal Alcohol Spectrum Disorders: A Review of Clinical and Cost-Effectiveness and Guidelines Diagnosis, Assessment, and Treatment of Fetal Alcohol Spectrum Disorders: A Review of Clinical and Cost-Effectiveness and Guidelines | CADTH.ca Find the information you need Diagnosis, Assessment, and Treatment of Fetal Alcohol Spectrum Disorders: A Review of Clinical and Cost-Effectiveness and Guidelines Diagnosis, Assessment, and Treatment of Fetal Alcohol (...) Spectrum Disorders: A Review of Clinical and Cost-Effectiveness and Guidelines Published on: May 3, 2017 Project Number: RC0880-000 Product Line: Research Type: Other Diagnostics Report Type: Summary with Critical Appraisal Result type: Report Question What is the diagnostic test accuracy of tools or tests for the diagnosis and/or assessment of fetal alcohol spectrum disorder in individuals of any age? What is the clinical utility of diagnosis and/or assessment of fetal alcohol spectrum disorder

2017 Canadian Agency for Drugs and Technologies in Health - Rapid Review

8. Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. Full Text available with Trip Pro

Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. Although prenatal alcohol exposure (PAE) reduces offspring growth, it may increase obesity risk at adolescence. Animal models of PAE display glucose intolerance and increased adiposity, suggesting that PAE causes metabolic reprogramming. We tested this hypothesis in a mouse model of binge PAE, wherein pregnant C57Bl/6J females received 3 g/kg alcohol (ETOH) daily from (...) three caloric groups (MCT, MD, ETOH), such that caloric groups had greater post-weaning weight gain (both sexes), reduced gonadal fat weight (males), and reduced glucose clearance (males) compared against H2O offspring. PAE did not affect body composition, respiratory exchange ratio, metabolic adaption to high-fat or low-fat diet, eating behavior, and blood pressure, and ETOH values did not differ from those obtained from isocaloric controls. Exposure to a higher alcohol dose (4.5 g/kg) or a high

2018 PLoS ONE

9. The postural stability of children with foetal alcohol spectrum disorders during one-leg stance: A feasibility study Full Text available with Trip Pro

The postural stability of children with foetal alcohol spectrum disorders during one-leg stance: A feasibility study Postural control may be impaired in children with foetal alcohol spectrum disorders (FASD). The study assessed the protocol feasibility in terms of (1) recruiting children with FASD in a rural, small town; (2) using the measurement instruments in a real-life setting; (3) the one-leg standing (OLS) task and (4) presenting preliminary results on postural stability of children

2018 African journal of disability

10. Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. Full Text available with Trip Pro

Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities. Fetal alcohol spectrum disorders are costly, life-long disabilities. Older data suggested the prevalence of the disorder in the United States was 10 per 1000 children; however, there are few current estimates based on larger, diverse US population samples.To estimate the prevalence of fetal alcohol spectrum disorders, including fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental (...) disorder, in 4 regions of the United States.Active case ascertainment methods using a cross-sectional design were used to assess children for fetal alcohol spectrum disorders between 2010 and 2016. Children were systematically assessed in the 4 domains that contribute to the fetal alcohol spectrum disorder continuum: dysmorphic features, physical growth, neurobehavioral development, and prenatal alcohol exposure. The settings were 4 communities in the Rocky Mountain, Midwestern, Southeastern

2018 JAMA

11. Ear abnormalities and hearing problems among children with prenatal alcohol exposure and fetal alcohol spectrum disorder: a systematic review and meta-analysis

Ear abnormalities and hearing problems among children with prenatal alcohol exposure and fetal alcohol spectrum disorder: a systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content (...) species); sex (stratified per sex); duration of index ischemia (linear); stem cell dose (linear); blinding of outcome assessment reported (stratified yes vs no). For stratified analyses, a minimum number of 8 studies per subgroup is required. ">Subgroup analyses A sensitivity analysis is conducted to assess the impact of decisions taken in the review process on the meta-analysis outcome. These decisions may have been made in various stages of the review, e.g. the decision to exclude certain disease

2020 PROSPERO

12. Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model. Full Text available with Trip Pro

Retinal Wnt signaling defect in a zebrafish fetal alcohol spectrum disorder model. Fetal alcohol spectrum disorder caused by prenatal alcohol exposure includes ocular abnormalities (microphthalmia, photoreceptor dysfunction, cataracts). Zebrafish embryos exposed to ethanol from gastrulation through somitogenesis show severe ocular defects, including microphthalmia and photoreceptor differentiation defects. Ethanol-treated zebrafish had an enlarged ciliary marginal zone (CMZ) relative

2018 PLoS ONE

13. The Combined Use of Ultrasound and Fetal Magnetic Resonance Imaging for a Comprehensive Fetal Neurological Assessment in Fetal Congenital Cardiac Defects

. For example, the prevalence of CHD in Down syndrome is approximately 45%, other associated chromosomal aneuploidies include trisomy 13 and 18 and Turner syndrome. Single gene defects account for a further 3–5% of cases of CHD, including DiGeorge syndrome, Alagille syndrome, Holt–Oram syndrome and Noonan syndrome. - Nonchromosomal or genetic causes include some well recognised associations, such as maternal diabetes, phenylketonuria, maternal obesity, rubella infection, alcohol use and drug exposure (e.g (...) corrective or palliative surgery in the neonatal period, and the use of cardiopulmonary bypass, deep hypothermic circulatory arrest, and various surgical and postoperative factors have all been implicated in contributing to adverse neurodevelopmental outcomes. - Chromosomal and other syndromic conditions associated with CHDs are independently associated with impaired neurodevelopmental status. Other genetic factors, for example expression of neuroprotective apolipoprotein E, may help to modulate brain

2019 Royal College of Obstetricians and Gynaecologists

14. Legal Issues of Fetal alcohol spectrum disorder (FASD) - Proceedings from a consensus development conference

Legal Issues of Fetal alcohol spectrum disorder (FASD) - Proceedings from a consensus development conference application/octet-stream

2015 Institute of Health Economics

15. The international charter on prevention of fetal alcohol spectrum disorder

The international charter on prevention of fetal alcohol spectrum disorder application/octet-stream

2015 Institute of Health Economics

16. Comparing diagnostic classification of neurobehavioral disorder associated with prenatal alcohol exposure with the Canadian fetal alcohol spectrum disorder guidelines: a cohort study Full Text available with Trip Pro

Comparing diagnostic classification of neurobehavioral disorder associated with prenatal alcohol exposure with the Canadian fetal alcohol spectrum disorder guidelines: a cohort study Diagnostic criteria have recently been introduced in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), for neurobehavioral disorder associated with prenatal alcohol exposure (ND-PAE). The purpose of this study is to assess the classification of this condition using the Canadian fetal (...) alcohol spectrum disorder (FASD) multidisciplinary diagnostic guidelines as the standard of comparison. First, classification of ND-PAE was compared with Canadian FASD diagnoses of fetal alcohol syndrome (FAS), partial FAS and alcohol-related neurodevelopmental disorder. Second, classification of ND-PAE was compared with FAS and pFAS only, a criterion for which includes facial features highly predictive of prenatal alcohol exposure and effects.Eighty-two patients underwent multidisciplinary clinical

2017 CMAJ open

17. Population-based prevalence of fetal alcohol spectrum disorder in Canada. Full Text available with Trip Pro

Population-based prevalence of fetal alcohol spectrum disorder in Canada. Fetal alcohol spectrum disorder (FASD) is one of the most disabling potential outcomes of prenatal alcohol exposure. The population-based prevalence of FASD among the general population of Canada was unknown. The objective of this study was to determine the population-based prevalence of FASD among elementary school students, aged 7 to 9 years, in the Greater Toronto Area (GTA) in Ontario, Canada.This screening study used (...) is approximately double or possibly even triple previous crude estimates. FASD prevalence exceeds that of other common birth defects such as Down's syndrome, spina bifida, trisomy 18, as well as autism spectrum disorder in Canada. More effective prevention strategies targeting alcohol use during pregnancy, surveillance of FASD, and timely interventions and support to individuals with FASD and their families are urgently needed.

2019 BMC Public Health

18. Accuracy of motor assessment in the diagnosis of fetal alcohol spectrum disorder. Full Text available with Trip Pro

Accuracy of motor assessment in the diagnosis of fetal alcohol spectrum disorder. To evaluate the accuracy of motor assessment tools listed in Fetal alcohol spectrum disorder: a guideline for diagnosis across the lifespan (Canadian Guideline) for the purpose of fetal alcohol spectrum disorder (FASD) diagnosis. Specifically, we aimed to determine: 1) diagnostic accuracy of motor assessment tools and subtests; 2) accuracy of multiple subtests versus total scores; and 3) accuracy of alternate cut

2019 BMC Pediatrics

19. Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. Full Text available with Trip Pro

Clinical presentation, diagnosis, and management of fetal alcohol spectrum disorder. Although prenatal alcohol exposure causes craniofacial anomalies, growth retardation, neurological abnormalities, cognitive impairment, and birth defects, fetal alcohol spectrum disorder is underdiagnosed. Global prevalence of fetal alcohol spectrum disorder is 0·77%, with a higher prevalence of 2-5% in Europe and North America, highlighting the need for increased diagnosis and treatment. However, diagnosis (...) remains challenging because of the poor reliability of self-reported maternal drinking histories, an absence of sensitive biomarkers, and the infrequency of diagnostic dysmorphic facial features among individuals with fetal alcohol spectrum disorder. Different diagnostic systems and disagreements over criteria have slowed progress in the diagnosis and management of the disorder. Neuroimaging shows abnormalities in brain structure, cortical development, white matter microstructure, and functional

2019 Lancet Neurology

20. Protocol for the Yapatjarrathati project: a mixed-method implementation trial of a tiered assessment process for identifying fetal alcohol spectrum disorders in a remote Australian community. Full Text available with Trip Pro

Protocol for the Yapatjarrathati project: a mixed-method implementation trial of a tiered assessment process for identifying fetal alcohol spectrum disorders in a remote Australian community. Fetal alcohol spectrum disorder (FASD) is a highly prevalent neurodevelopmental disorder associated with prenatal alcohol exposure. Early identification can improve functioning for individuals and reduce costs to society. Gold standard methods of diagnosing FASD rely on specialists to deliver intensive

2019 BMC health services research

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