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Feltys Syndrome

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2. Felty's syndrome

Felty's syndrome Felty's syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Felty's syndrome Last reviewed: February 2019 Last updated: March 2018 Summary Rare, extra-articular manifestation of rheumatoid arthritis (RA), characterised by persistent, idiopathic neutropenia and, in some cases, splenomegaly. Estimated to occur in <1% of RA patients. Tends to occur in the fifth to seventh decades of life, typically (...) . Definition First described by A.R. Felty in 1924, Felty's syndrome (FS) is a rare, extra-articular manifestation of rheumatoid arthritis. It is characterised by persistent, idiopathic neutropenia and frequently (>90% cases) by splenomegaly. Felty AR. Chronic arthritis in the adult associated with splenomegaly and leucopenia. Bull Johns Hopkins Hosp. 1924;35:16-20. Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features

2018 BMJ Best Practice

3. Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids (PubMed)

Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids In severe cases of pancytopenia with subsequent infections due to long-term untreated Felty's syndrome, the initiation of immunosuppressive treatment with sole prednisone (1 mg/kg iv) should be considered, despite that, the low neutrocytes count would make one physician hesitant. A full resolution of whole blood count within 3 weeks and a 30% reduction in spleens sized

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2018 Clinical Case Reports

4. Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. (PubMed)

Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Felty syndrome is a rare disease defined by neutropenia, splenomegaly, and rheumatoid arthritis. Sometimes the differential diagnosis between Felty syndrome and large granular lymphocyte leukemia is problematic. Recently, somatic STAT3 and STAT5B mutations were discovered in 30-40% of patients with large granular lymphocyte leukemia. Herein, we aimed to study whether (...) these mutations can also be detected in Felty syndrome, which would imply the existence of a common pathogenic mechanism between these two disease entities. We collected samples and clinical information from 14 Felty syndrome patients who were monitored at the rheumatology outpatient clinic for Felty syndrome. Somatic STAT3 mutations were discovered in 43% (6/14) of Felty syndrome patients with deep amplicon sequencing targeting all STAT3 exons. Mutations were located in the SH2 domain of STAT3, which

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2017 Haematologica

5. Felty's Syndrome

Felty's Syndrome Feltys Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Felty's Syndrome Felty's Syndrome Aka: Felty's (...) Syndrome , Felty Syndrome From Related Chapters II. Pathophysiology associated Hematologic changes III. Signs Pigmented on extremities IV. Labs: Complete Blood Count Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Feltys Syndrome." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Felty Syndrome (C0015773) Definition (MSH) A rare complication

2018 FP Notebook

6. Presentation of three cases followed up with a diagnosis of Felty syndrome (PubMed)

Presentation of three cases followed up with a diagnosis of Felty syndrome An effective treatment strategy for Felty syndrome (FS) has not been developed so far. In this article, three cases with FS, who responded to different treatment modalities, have been presented. Case 1 was a 52-year-old male patient who initially received methotrexate, and then, he was switched to granulocyte colony-stimulating factor (G-CSF) and cyclosporine treatment when his neutropenia was further deteriorated

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2014 European journal of rheumatology

7. Non-articular Felty's syndrome: An uncommon diagnosis. (PubMed)

Non-articular Felty's syndrome: An uncommon diagnosis. Felty's syndrome is a triad of rheumatoid arthritis, neutropenia, and splenomegaly. We hereby report an unusual case of non-articular Felty's syndrome and its management along with discussing the importance of appropriately ruling out alternate causes of neutropenia with splenomegaly.

2015 Netherlands Journal of Medicine

8. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. (PubMed)

A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 25673081 2016 03 23 2015 06 24 1651-2057 95 6 2015 Jul Acta dermato-venereologica Acta Derm. Venereol. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 754-5 10.2340/00015555-2067 Shu En E Department of Dermatology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. ghifuka@gifu-u.ac.jp. Kanoh Hiroyuki H Kito Yusuke Y Seishima Mariko M eng (...) Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Felty Syndrome complications diagnosis Female Humans Leg Ulcer complications pathology Lymphoma, Extranodal NK-T-Cell complications pathology Middle Aged Sjogren's Syndrome complications 2015 2 13 6 0 2015 2 13 6 0 2016 3 24 6 0 ppublish 25673081 10.2340/00015555-2067

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2015 Acta Dermato-Venereologica

9. Felty Syndrome (Overview)

Felty Syndrome (Overview) Felty Syndrome: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LW92ZXJ2aWV3 processing > Felty Syndrome Updated: Mar 10, 2018 Author (...) : Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Overview Practice Essentials Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF]–positive) (RA). [ ] FS is characterized by the classic triad of RA, , and . Although many patients with FS are asymptomatic, some develop serious and life-threatening infections secondary

2014 eMedicine.com

10. Felty Syndrome (Diagnosis)

Felty Syndrome (Diagnosis) Felty Syndrome: Practice Essentials, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LW92ZXJ2aWV3 processing > Felty Syndrome Updated: Mar 10, 2018 (...) Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Overview Practice Essentials Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF]–positive) (RA). [ ] FS is characterized by the classic triad of RA, , and . Although many patients with FS are asymptomatic, some develop serious and life-threatening infections

2014 eMedicine.com

11. Felty Syndrome (Treatment)

Felty Syndrome (Treatment) Felty Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Splenectomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LXRyZWF0bWVudA== processing (...) > Felty Syndrome Treatment & Management Updated: Mar 10, 2018 Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Treatment Approach Considerations The best way of treating Felty syndrome (FS) is to control the underlying rheumatoid arthritis (RA). Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the immune-mediated nature of FS. Most of the traditional

2014 eMedicine.com

12. Felty Syndrome (Follow-up)

Felty Syndrome (Follow-up) Felty Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Splenectomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LXRyZWF0bWVudA== processing (...) > Felty Syndrome Treatment & Management Updated: Mar 10, 2018 Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Treatment Approach Considerations The best way of treating Felty syndrome (FS) is to control the underlying rheumatoid arthritis (RA). Immunosuppressive therapy for RA often improves granulocytopenia and splenomegaly; this finding reflects the immune-mediated nature of FS. Most of the traditional

2014 eMedicine.com

13. Biological agents in the management of Felty's syndrome: a systematic review. (PubMed)

Biological agents in the management of Felty's syndrome: a systematic review. To review and summarize the information available on the effectiveness and safety of biological therapies in refractory Felty's syndrome (FS).We describe a case of FS with severe neutropenia and recurrent bacterial infections unresponsive to disease-modifying antirheumatic drug treatment and long-term administration with granulocyte colony-stimulating factor, in which treatment with rituximab (RTX) was useful

2012 Seminars in arthritis and rheumatism

14. Felty's Syndrome

Felty's Syndrome Feltys Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Felty's Syndrome Felty's Syndrome Aka: Felty's (...) Syndrome , Felty Syndrome From Related Chapters II. Pathophysiology associated Hematologic changes III. Signs Pigmented on extremities IV. Labs: Complete Blood Count Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Feltys Syndrome." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Felty Syndrome (C0015773) Definition (MSH) A rare complication

2015 FP Notebook

15. Two Cases of Felty's Syndrome with Features of Sjögren's Syndrome (PubMed)

Two Cases of Felty's Syndrome with Features of Sjögren's Syndrome 14941824 2004 02 15 2018 12 01 0035-9157 45 5 1952 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Two cases of Felty's syndrome with features of Sjögren's syndrome. 253-4 PEARSON B B eng Journal Article England Proc R Soc Med 7505890 0035-9157 OM Arthritis Arthritis, Rheumatoid Felty Syndrome Humans Sjogren's Syndrome 5222:27972:43:420 ARTHRITIS, RHEUMATOID SJOEGREN SYNDROME 1952 5 1 1952 5 1 0 1 1952 5 1 0

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1952 Proceedings of the Royal Society of Medicine

16. Felty's Syndrome (Chauffard-Still Syndrome) (PubMed)

Felty's Syndrome (Chauffard-Still Syndrome) 19991147 2010 06 24 2010 06 24 0035-9157 30 8 1937 Jun Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Felty's Syndrome (Chauffard-Still Syndrome). 932-3 Weber F P FP Schlüter A A eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1937 6 1 0 0 1937 6 1 0 1 ppublish 19991147 PMC2076322

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1937 Proceedings of the Royal Society of Medicine

17. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps. (PubMed)

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular traps. To test the hypothesis that autoantigen modifications by peptidylarginine deiminase type 4 (PAD-4) increase immunoreactivity.We assembled sera from patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Felty's syndrome (FS), and antineutrophil cytoplasmic antibody-associated vasculitides (AAVs), as well as sera from control subjects without autoimmune diseases. The sera were

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2011 Arthritis and Rheumatism

18. The spectrum of LGL and Felty's Syndrome (PubMed)

The spectrum of LGL and Felty's Syndrome Patients with chronic large granular lymphocyte (LGL) leukemia often have rheumatoid arthritis (RA), neutropenia and splenomegaly, thereby resembling the manifestations observed in patients with Felty's syndrome, which is a rare complication of RA characterized by neutropenia and splenomegaly. Both entities have similar clinical and laboratory presentation, as well as a common genetic determinant, HLA-DR4, indicating they may be part of the same disease (...) spectrum. This review paper seeks to discuss the underlying pathogenesis and therapeutic algorithm of RA, neutropenia and splenomegaly in the spectrum of LGL leukemia and Felty's syndrome.We hypothesize that there may be a common pathogenic mechanism between LGL leukemia and typical Felty's syndrome. Phenotypic and functional data have strongly suggested that CD3 LGL leukemia is antigen-activated. Aberrations in the T-cell repertoire with the emergence of oligoclonal/clonal lymphoid populations have

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2011 Current Opinion in Hematology

19. Granulopoietic activity in Felty's syndrome. (PubMed)

Granulopoietic activity in Felty's syndrome. The levels of urinary and serum granulopoietic factor have been determined in nine patients with Felty's syndrome and compared with similar levels in patients with rheumatoid arthritis without Felty's syndrome and patients with neutropenic disorders of other causes. These studies have shown that urinary and serum levels of colony stimulating activity (CSA) in patients with Felty's syndrome are low (mean urine CSA 10.0 and serum CSA 4.0) when compared (...) to patients with neutropenic disorders without rheumatoid arthritis (mean urinary CSA 26.8 and serum CSA 9.4). These findings suggest that Felty's syndrome may be, in part, the result of decreased production or activity of granulopoietic factors rather than due simply to increased granulocyte destruction.

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1975 Annals of the Rheumatic Diseases

20. Familial Felty's syndrome. (PubMed)

Familial Felty's syndrome. A family is described in which the mother and 2 of the 5 children had Felty's syndrome, a pattern of inheritance suggesting a dominant defect and one which has not previously been reported. The family is also of interest in that the other sib had rheumatoid arthritis.

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1976 Annals of the Rheumatic Diseases

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