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Feltys Syndrome

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1. Felty's syndrome

Felty's syndrome Felty's syndrome - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Felty's syndrome Last reviewed: February 2019 Last updated: March 2018 Summary Rare, extra-articular manifestation of rheumatoid arthritis (RA), characterised by persistent, idiopathic neutropenia and, in some cases, splenomegaly. Estimated to occur in <1% of RA patients. Tends to occur in the fifth to seventh decades of life, typically (...) . Definition First described by A.R. Felty in 1924, Felty's syndrome (FS) is a rare, extra-articular manifestation of rheumatoid arthritis. It is characterised by persistent, idiopathic neutropenia and frequently (>90% cases) by splenomegaly. Felty AR. Chronic arthritis in the adult associated with splenomegaly and leucopenia. Bull Johns Hopkins Hosp. 1924;35:16-20. Campion G, Maddison PJ, Goulding N, et al. The Felty syndrome: a case-matched study of clinical manifestations and outcome, serologic features

2018 BMJ Best Practice

3. Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids Full Text available with Trip Pro

Severe pancytopenia and splenomegaly associated with felty's syndrome, both fully responsive solely to corticosteroids In severe cases of pancytopenia with subsequent infections due to long-term untreated Felty's syndrome, the initiation of immunosuppressive treatment with sole prednisone (1 mg/kg iv) should be considered, despite that, the low neutrocytes count would make one physician hesitant. A full resolution of whole blood count within 3 weeks and a 30% reduction in spleens sized

2018 Clinical Case Reports

4. Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Full Text available with Trip Pro

Somatic STAT3 mutations in the Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia. Felty syndrome is a rare disease defined by neutropenia, splenomegaly, and rheumatoid arthritis. Sometimes the differential diagnosis between Felty syndrome and large granular lymphocyte leukemia is problematic. Recently, somatic STAT3 and STAT5B mutations were discovered in 30-40% of patients with large granular lymphocyte leukemia. Herein, we aimed to study whether (...) these mutations can also be detected in Felty syndrome, which would imply the existence of a common pathogenic mechanism between these two disease entities. We collected samples and clinical information from 14 Felty syndrome patients who were monitored at the rheumatology outpatient clinic for Felty syndrome. Somatic STAT3 mutations were discovered in 43% (6/14) of Felty syndrome patients with deep amplicon sequencing targeting all STAT3 exons. Mutations were located in the SH2 domain of STAT3, which

2017 Haematologica

5. Felty's Syndrome

arthritis with splenoadenomegaly and leukopenia , Felty's syndrome, unspecified site , Felty's syndrome, site unspecified , feltys syndrome , felty's syndrome , felty syndrome , Felty's Syndrome , Syndrome, Felty , Felty Syndrome , Felty Syndrome [Disease/Finding] , Felty's syndrome , Felty's syndrome (disorder) , Rheumatoid arthritis, leucopenia AND splenomegaly , Rheumatoid arthritis, leukopenia AND splenomegaly , Felty , rheumatoid; arthritis, with splenoadenomegaly and leukopenia , arthritis (...) Felty's Syndrome Feltys Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Felty's Syndrome Felty's Syndrome Aka: Felty's

2018 FP Notebook

6. Presentation of three cases followed up with a diagnosis of Felty syndrome Full Text available with Trip Pro

Presentation of three cases followed up with a diagnosis of Felty syndrome An effective treatment strategy for Felty syndrome (FS) has not been developed so far. In this article, three cases with FS, who responded to different treatment modalities, have been presented. Case 1 was a 52-year-old male patient who initially received methotrexate, and then, he was switched to granulocyte colony-stimulating factor (G-CSF) and cyclosporine treatment when his neutropenia was further deteriorated (...) , and their health status normalized at 2 months. Different treatment strategies have been tried for the management of FS; disease-modifying anti-rheumatic drugs have been used successfully alone or in combination with G-CSF. As seen in the last case, it should be kept in mind that patients can present predominantly with symptoms of infection or hematologic disorders.

2014 European journal of rheumatology

7. Non-articular Felty's syndrome: An uncommon diagnosis. (Abstract)

Non-articular Felty's syndrome: An uncommon diagnosis. Felty's syndrome is a triad of rheumatoid arthritis, neutropenia, and splenomegaly. We hereby report an unusual case of non-articular Felty's syndrome and its management along with discussing the importance of appropriately ruling out alternate causes of neutropenia with splenomegaly.

2015 Netherlands Journal of Medicine

8. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. Full Text available with Trip Pro

A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 25673081 2016 03 23 2015 06 24 1651-2057 95 6 2015 Jul Acta dermato-venereologica Acta Derm. Venereol. A Case of Felty's Syndrome Associated with Skin Ulcers and Extranodal NK/T-cell Lymphoma. 754-5 10.2340/00015555-2067 Shu En E Department of Dermatology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City 501-1194, Japan. ghifuka@gifu-u.ac.jp. Kanoh Hiroyuki H Kito Yusuke Y Seishima Mariko M eng (...) Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 IM Felty Syndrome complications diagnosis Female Humans Leg Ulcer complications pathology Lymphoma, Extranodal NK-T-Cell complications pathology Middle Aged Sjogren's Syndrome complications 2015 2 13 6 0 2015 2 13 6 0 2016 3 24 6 0 ppublish 25673081 10.2340/00015555-2067

2015 Acta Dermato-Venereologica

9. Felty Syndrome (Overview)

encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles According to Rheumatologists Recommended 2002 1287449-overview Procedures Procedures 2002 2094158-overview Laboratory Medicine Laboratory Medicine 2002 331715-overview Diseases & Conditions Diseases & Conditions 2002 329734-overview Diseases & Conditions Diseases & Conditions Need a Curbside Consult? Share cases (...) : Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Overview Practice Essentials Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF]–positive) (RA). [ ] FS is characterized by the classic triad of RA, , and . Although many patients with FS are asymptomatic, some develop serious and life-threatening infections secondary

2014 eMedicine.com

10. Felty Syndrome (Treatment)

Community Medical Group Disclosure: Nothing to disclose. What would you like to print? What would you like to print? Sections Felty Syndrome Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective (...) Felty Syndrome (Treatment) Felty Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Splenectomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LXRyZWF0bWVudA== processing

2014 eMedicine.com

11. Felty Syndrome (Follow-up)

Community Medical Group Disclosure: Nothing to disclose. What would you like to print? What would you like to print? Sections Felty Syndrome Find Us On About Membership WebMD Network Editions All material on this website is protected by copyright, Copyright © 1994-2019 by WebMD LLC. This website also contains material copyrighted by 3rd parties. Close encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective (...) Felty Syndrome (Follow-up) Felty Syndrome Treatment & Management: Approach Considerations, Pharmacologic Therapy, Splenectomy Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMzI5NzM0LXRyZWF0bWVudA== processing

2014 eMedicine.com

12. Felty Syndrome (Diagnosis)

by 3rd parties. Close encoded search term (Felty Syndrome) and Felty Syndrome What to Read Next on Medscape Related Conditions and Diseases Medscape Consult News & Perspective Tools Slideshow Most Popular Articles According to Rheumatologists Recommended 2002 1287449-overview Procedures Procedures 2002 2094158-overview Laboratory Medicine Laboratory Medicine 2002 331715-overview Diseases & Conditions Diseases & Conditions 2002 329734-overview Diseases & Conditions Diseases & Conditions Need (...) Author: Richard M Keating, MD, FACR, FACP; Chief Editor: Herbert S Diamond, MD Share Email Print Feedback Close Sections Sections Felty Syndrome Overview Practice Essentials Felty syndrome (FS), which was first described in 1924, is a potentially serious condition that is associated with seropositive (rheumatoid factor [RF]–positive) (RA). [ ] FS is characterized by the classic triad of RA, , and . Although many patients with FS are asymptomatic, some develop serious and life-threatening infections

2014 eMedicine.com

13. Two Cases of Felty's Syndrome with Features of Sjögren's Syndrome Full Text available with Trip Pro

Two Cases of Felty's Syndrome with Features of Sjögren's Syndrome 14941824 2004 02 15 2018 12 01 0035-9157 45 5 1952 May Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Two cases of Felty's syndrome with features of Sjögren's syndrome. 253-4 PEARSON B B eng Journal Article England Proc R Soc Med 7505890 0035-9157 OM Arthritis Arthritis, Rheumatoid Felty Syndrome Humans Sjogren's Syndrome 5222:27972:43:420 ARTHRITIS, RHEUMATOID SJOEGREN SYNDROME 1952 5 1 1952 5 1 0 1 1952 5 1 0

1952 Proceedings of the Royal Society of Medicine

14. Felty's Syndrome (Chauffard-Still Syndrome) Full Text available with Trip Pro

Felty's Syndrome (Chauffard-Still Syndrome) 19991147 2010 06 24 2010 06 24 0035-9157 30 8 1937 Jun Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. Felty's Syndrome (Chauffard-Still Syndrome). 932-3 Weber F P FP Schlüter A A eng Journal Article England Proc R Soc Med 7505890 0035-9157 2009 12 9 6 0 1937 6 1 0 0 1937 6 1 0 1 ppublish 19991147 PMC2076322

1937 Proceedings of the Royal Society of Medicine

15. Felty's Syndrome

arthritis with splenoadenomegaly and leukopenia , Felty's syndrome, unspecified site , Felty's syndrome, site unspecified , feltys syndrome , felty's syndrome , felty syndrome , Felty's Syndrome , Syndrome, Felty , Felty Syndrome , Felty Syndrome [Disease/Finding] , Felty's syndrome , Felty's syndrome (disorder) , Rheumatoid arthritis, leucopenia AND splenomegaly , Rheumatoid arthritis, leukopenia AND splenomegaly , Felty , rheumatoid; arthritis, with splenoadenomegaly and leukopenia , arthritis (...) Felty's Syndrome Feltys Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Felty's Syndrome Felty's Syndrome Aka: Felty's

2015 FP Notebook

16. Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. (Abstract)

Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. Felty's syndrome (FS) is a severe arthritic disorder that features chronic neutrophil activation and progresses to neutropenia and susceptibility to unabated infections. The life‑threatening manifestations of FS have focused the attention of clinical experimenters who have made persistent efforts to find new and effective therapies. This review highlights important milestones in the research on FS and draws (...) peptides. These observations suggest that NETosis, the type of cell death that is defined by the release of NETs, provides autoantigens that stimulate B cell responses in this patient group. This insight parallels recent observations in other autoimmune conditions and lends support to the paradigm that NETosis plays a leading role in the pathogenesis of antiself immune responses. 

2012 Polskie Archiwum Medycyny Wewnetrznej

17. SPLENIC NEUTROPENIA WITH RHEUMATOID ARTHRITIS: (Felty's Syndrome) Full Text available with Trip Pro

SPLENIC NEUTROPENIA WITH RHEUMATOID ARTHRITIS: (Felty's Syndrome) 15427053 2004 09 30 2018 12 01 0008-4409 63 1 1950 Jul Canadian Medical Association journal Can Med Assoc J Primary splenic neutropenia with rheumatoid arthritis. (Felty's syndrome). 72-4 SUGARMAN H H BALTZAN D M DM eng Journal Article Canada Can Med Assoc J 0414110 0008-4409 OM Arthritis Arthritis, Rheumatoid Felty Syndrome Humans Neutropenia Splenomegaly 5019:17360:16:229 ARTHRITIS, RHEUMATOID SPLENOMEGALY 1950 7 1 1950 7 1 0 1

1950 Canadian Medical Association Journal

18. Association of Sjögren's and Felty's Syndromes Full Text available with Trip Pro

Association of Sjögren's and Felty's Syndromes 13105213 2003 05 01 2018 12 01 0003-4967 12 3 1953 Sep Annals of the rheumatic diseases Ann. Rheum. Dis. Association of Sjögren's and Felty's syndromes. 212-6 GURLING K J KJ eng Journal Article England Ann Rheum Dis 0372355 0003-4967 OM Arthritis Arthritis, Rheumatoid complications Felty Syndrome Humans Sjogren's Syndrome complications 5425:26371:46:425 ARTHRITIS, RHEUMATOID/complications SJOEGREN SYNDROME/complications 1953 9 1 1953 9 1 0 1 1953

1953 Annals of the Rheumatic Diseases

19. Felty's Syndrome Treated by Splenectomy Full Text available with Trip Pro

Felty's Syndrome Treated by Splenectomy 20788189 2011 04 04 2011 04 04 0007-1447 2 4851 1953 Dec 26 British medical journal Br Med J Felty's Syndrome Treated by Splenectomy. 1415 Rackow F F eng Journal Article England Br Med J 0372673 0007-1447 2010 8 27 6 0 1953 12 26 0 0 1953 12 26 0 1 ppublish 20788189 PMC2030445

1953 British medical journal

20. Splenic Neutropenia in Felty's Syndrome Full Text available with Trip Pro

Splenic Neutropenia in Felty's Syndrome 13472060 2000 07 01 2018 12 01 0007-1447 2 5053 1957 Nov 09 British medical journal Br Med J Splenic neutropenia in Felty's syndrome. 1094-5 BLAU J N JN WILLCOX A A eng Journal Article England Br Med J 0372673 0007-1447 OM Agranulocytosis complications Arthritis Arthritis, Rheumatoid complications Felty Syndrome Humans Neutropenia Spleen surgery 5833:14949:16:54:477 AGRANULOCYTOSIS/complications ARTHRITIS, RHEUMATOID/complications SPLEEN/surgery 1957 11 9

1957 British medical journal

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