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Family Practice Notebook Updates 2016

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2521. idiopathic childhood constipation

idiopathic childhood constipation idiopathic childhood constipation - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search idiopathic childhood constipation Constipation is common in childhood prevalent in around 5-30% of the child population, depending on the criteria used for diagnosis symptoms become chronic in more than one third of patients and constipation is a common reason for referral to secondary care Constipation (...) appetite, lack of energy, an unhappy, angry or irritable mood and general malaise. Note that there is a high degree of normal variation in the frequency of bowel habit. It is essential to enquire of the parents as to how regular they are. Reference: 1) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any

2010 GP Notebook

2522. alpha1 antitrypsin deficiency

alpha1 antitrypsin deficiency alpha1 antitrypsin deficiency - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search alpha1 antitrypsin deficiency Alpha-1 antitrypsin is a member of the serine protease inhibitor family of plasma proteins. Alpha-1 antitrypsin has a wide spectrum of antiprotease activity, however, its important physiological role is the inhibition of neutrophil elastase. Alpha-1 antitrypsin is primarily synthesised (...) in the liver and normally constitutes about 90% of the circulating blood alpha-1 globulin. Severe alpha-1 antitrypsin deficiency is associated with lung and liver disease. Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions Ltd®. Any distribution

2010 GP Notebook

2523. WHO / Fredrickson classification of primary hyperlipidaemias

WHO / Fredrickson classification of primary hyperlipidaemias WHO / Fredrickson classification of primary hyperlipidaemias - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search WHO / Fredrickson classification of primary hyperlipidaemias Frederickson Classification of Lipid Disorders Type Average of overnight serum Elevated particles Associated clinical disorders Serum TC Serum TG I Creamy top layer Chylomicrons Lipoprotein (...) classification is simply a biochemical phenotypic classification based on which lipoprotein is raised. Also the classification was devised before the importance of HDL as a prognostic indicator was recognised. * IDL = intermediate-density lipoproteins; LDL = low-density lipoproteins; TC = total cholesterol; TG = triglycerides; VLDL = very low-density lipoproteins; + = increased; ++ = greatly increased; N= normal; N+ = normal or increased Links: General Practice Notebook General Practice Notebook

2010 GP Notebook

2524. primary hyperlipidaemias (WHO/Fredrickson classification)

primary hyperlipidaemias (WHO/Fredrickson classification) primary hyperlipidaemias (WHO/Fredrickson classification) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search primary hyperlipidaemias (WHO/Fredrickson classification) Frederickson Classification of Lipid Disorders Type Average of overnight serum Elevated particles Associated clinical disorders Serum TC Serum TG I Creamy top layer Chylomicrons Lipoprotein lipase (...) is simply a biochemical phenotypic classification based on which lipoprotein is raised. Also the classification was devised before the importance of HDL as a prognostic indicator was recognised. * IDL = intermediate-density lipoproteins; LDL = low-density lipoproteins; TC = total cholesterol; TG = triglycerides; VLDL = very low-density lipoproteins; + = increased; ++ = greatly increased; N= normal; N+ = normal or increased Links: General Practice Notebook General Practice Notebook The information

2010 GP Notebook

2525. generalised hyperpigmentation

generalised hyperpigmentation generalised hyperpigmentation - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search generalised hyperpigmentation Causes of diffuse hyperpigmentation include: congenital: familial or racial irradiation, especially UV light endocrine: chronic primary hypoadrenalism Cushing's syndrome with high ACTH - not adrenal adenoma acromegaly oestrogens, pregnancy systemic disease: chronic renal failure (...) cachexia e.g. TB or malignancy primary biliary cirrhosis haemochromatosis malabsorption - e.g. Whipples disease, coeliac disease drug-induced: cytotoxic drugs - busulphan, bleomycin and cyclophosphamide may cause generalized brown pigmentation phenothiazines e.g. chlorpromazine - bluish pigmentation on light exposed skin arsenic Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed

2010 GP Notebook

2526. pigmentation of the skin (differential diagnosis)

pigmentation of the skin (differential diagnosis) pigmentation of the skin (differential diagnosis) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search pigmentation of the skin (differential diagnosis) Causes of diffuse hyperpigmentation include: congenital: familial or racial irradiation, especially UV light endocrine: chronic primary hypoadrenalism Cushing's syndrome with high ACTH - not adrenal adenoma acromegaly (...) oestrogens, pregnancy systemic disease: chronic renal failure cachexia e.g. TB or malignancy primary biliary cirrhosis haemochromatosis malabsorption - e.g. Whipples disease, coeliac disease drug-induced: cytotoxic drugs - busulphan, bleomycin and cyclophosphamide may cause generalized brown pigmentation phenothiazines e.g. chlorpromazine - bluish pigmentation on light exposed skin arsenic Links: General Practice Notebook General Practice Notebook The information provided herein should not be used

2010 GP Notebook

2527. alpha1 protease inhibitor deficiency

alpha1 protease inhibitor deficiency alpha1 protease inhibitor deficiency - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search alpha1 protease inhibitor deficiency Alpha-1 antitrypsin is a member of the serine protease inhibitor family of plasma proteins. Alpha-1 antitrypsin has a wide spectrum of antiprotease activity, however, its important physiological role is the inhibition of neutrophil elastase. Alpha-1 antitrypsin (...) is primarily synthesised in the liver and normally constitutes about 90% of the circulating blood alpha-1 globulin. Severe alpha-1 antitrypsin deficiency is associated with lung and liver disease. Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions

2010 GP Notebook

2528. rabies

rabies rabies - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search rabies Rabies is an acute infectious viral disease resulting in acute encephalitis or meningoencephalitis that is almost always fatal in humans (1). the condition is caused by the rabies virus, of the lyssavirus genus, within the family Rhabdoviridae. several different rabies and rabies-like viruses have been found to be responsible but presentations (...) human disease under the Public Health (Infectious Diseases) Regulations 1988 (1) Reference: (1) (2) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions Ltd®. Any distribution or duplication of the information contained herein is strictly

2010 GP Notebook

2529. Parkinson's disease

with Parkinson's disease should be seen at regular intervals of 6-12 months to review their diagnosis.) (1) The condition may progress to cause significant impairments, adversely affecting quality of life and, indirectly, the quality of life of family and carers. Reference: 1. 2. 3. 4. Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis (...) Parkinson's disease Parkinson's disease - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search Parkinson's disease Parkinson's disease is a progressive neurodegenerative condition of unknown aetiology (idiopathic) (1,2). It is the second most common neurodegenerative disorder after Alzheimer's disease (3). The disease results from the degeneration of dopaminergic neurones in the substantia nigra. Clinically the disease becomes

2010 GP Notebook

2530. WHO/Fredrickson classification of primary hyperlipidaemias

WHO/Fredrickson classification of primary hyperlipidaemias WHO/Fredrickson classification of primary hyperlipidaemias - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search WHO/Fredrickson classification of primary hyperlipidaemias Frederickson Classification of Lipid Disorders Type Average of overnight serum Elevated particles Associated clinical disorders Serum TC Serum TG I Creamy top layer Chylomicrons Lipoprotein lipase (...) is simply a biochemical phenotypic classification based on which lipoprotein is raised. Also the classification was devised before the importance of HDL as a prognostic indicator was recognised. * IDL = intermediate-density lipoproteins; LDL = low-density lipoproteins; TC = total cholesterol; TG = triglycerides; VLDL = very low-density lipoproteins; + = increased; ++ = greatly increased; N= normal; N+ = normal or increased Links: General Practice Notebook General Practice Notebook The information

2010 GP Notebook

2531. constipation in children

constipation in children constipation in children - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search constipation in children Constipation is common in childhood prevalent in around 5-30% of the child population, depending on the criteria used for diagnosis symptoms become chronic in more than one third of patients and constipation is a common reason for referral to secondary care Constipation in children can be divided (...) , an unhappy, angry or irritable mood and general malaise. Note that there is a high degree of normal variation in the frequency of bowel habit. It is essential to enquire of the parents as to how regular they are. Reference: 1) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions

2010 GP Notebook

2532. alpha -1 - antitrypsin deficiency

alpha -1 - antitrypsin deficiency alpha -1 - antitrypsin deficiency - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search alpha -1 - antitrypsin deficiency Alpha-1 antitrypsin is a member of the serine protease inhibitor family of plasma proteins. Alpha-1 antitrypsin has a wide spectrum of antiprotease activity, however, its important physiological role is the inhibition of neutrophil elastase. Alpha-1 antitrypsin is primarily (...) synthesised in the liver and normally constitutes about 90% of the circulating blood alpha-1 globulin. Severe alpha-1 antitrypsin deficiency is associated with lung and liver disease. Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions. Copyright 2016 Oxbridge Solutions Ltd®. Any

2010 GP Notebook

2533. Epstein-Barr virus

Epstein-Barr virus Epstein-Barr virus - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search Epstein-Barr virus Epstein Barr virus (EBV) is a member of the herpes family. It is the causative agent of infectious mononucleosis and has been implicated in the pathogenesis of various types of human tumour: Burkitt's lymphoma B-cell lymphomas in immunocompromised individuals undifferentiated nasopharyngeal carcinoma recent studies (...) have identified other virus-associated malignancies, including Hodgkin's lymphoma, various T-cell lymphomas, and some carcinomas (undifferentiated carcinomas of the nasal type have been observed in the stomach, salivary glands, thymus and the lungs; although these tumours are not invariably associated with EBV) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical

2010 GP Notebook

2534. EBV

EBV EBV - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search EBV Epstein Barr virus (EBV) is a member of the herpes family. It is the causative agent of infectious mononucleosis and has been implicated in the pathogenesis of various types of human tumour: Burkitt's lymphoma B-cell lymphomas in immunocompromised individuals undifferentiated nasopharyngeal carcinoma recent studies have identified other virus-associated (...) malignancies, including Hodgkin's lymphoma, various T-cell lymphomas, and some carcinomas (undifferentiated carcinomas of the nasal type have been observed in the stomach, salivary glands, thymus and the lungs; although these tumours are not invariably associated with EBV) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis

2010 GP Notebook

2535. atherosclerosis

These are the typical components of a mature atheromatous plaque. There are a number of risk factors for the development of atherosclerosis. Some of these, e.g. age, sex and family history cannot be modified. Other risk factors such as serum cholesterol, smoking habits, and hypertension can be altered. Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted (...) atherosclerosis atherosclerosis - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search atherosclerosis Atherosclerosis is a patchy, focal disease of the intima and inner media of large and medium sized musculo-elastic arteries including the aorta. Atherosclerosis is characterised by: proliferation of: smooth muscle cells macrophages fibroblasts lipid deposition and increase in ground substance and collagen necrosis

2010 GP Notebook

2536. human herpesvirus 4

human herpesvirus 4 human herpesvirus 4 - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search human herpesvirus 4 Epstein Barr virus (EBV) is a member of the herpes family. It is the causative agent of infectious mononucleosis and has been implicated in the pathogenesis of various types of human tumour: Burkitt's lymphoma B-cell lymphomas in immunocompromised individuals undifferentiated nasopharyngeal carcinoma recent studies (...) have identified other virus-associated malignancies, including Hodgkin's lymphoma, various T-cell lymphomas, and some carcinomas (undifferentiated carcinomas of the nasal type have been observed in the stomach, salivary glands, thymus and the lungs; although these tumours are not invariably associated with EBV) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical

2010 GP Notebook

2537. HHV-4

HHV-4 HHV-4 - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search HHV-4 Epstein Barr virus (EBV) is a member of the herpes family. It is the causative agent of infectious mononucleosis and has been implicated in the pathogenesis of various types of human tumour: Burkitt's lymphoma B-cell lymphomas in immunocompromised individuals undifferentiated nasopharyngeal carcinoma recent studies have identified other virus-associated (...) malignancies, including Hodgkin's lymphoma, various T-cell lymphomas, and some carcinomas (undifferentiated carcinomas of the nasal type have been observed in the stomach, salivary glands, thymus and the lungs; although these tumours are not invariably associated with EBV) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis

2010 GP Notebook

2538. skin hyperpigmentation (generalised)

skin hyperpigmentation (generalised) skin hyperpigmentation (generalised) - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search skin hyperpigmentation (generalised) Causes of diffuse hyperpigmentation include: congenital: familial or racial irradiation, especially UV light endocrine: chronic primary hypoadrenalism Cushing's syndrome with high ACTH - not adrenal adenoma acromegaly oestrogens, pregnancy systemic disease: chronic (...) renal failure cachexia e.g. TB or malignancy primary biliary cirrhosis haemochromatosis malabsorption - e.g. Whipples disease, coeliac disease drug-induced: cytotoxic drugs - busulphan, bleomycin and cyclophosphamide may cause generalized brown pigmentation phenothiazines e.g. chlorpromazine - bluish pigmentation on light exposed skin arsenic Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical

2010 GP Notebook

2539. childhood constipation

childhood constipation childhood constipation - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search childhood constipation Constipation is common in childhood prevalent in around 5-30% of the child population, depending on the criteria used for diagnosis symptoms become chronic in more than one third of patients and constipation is a common reason for referral to secondary care Constipation in children can be divided (...) , an unhappy, angry or irritable mood and general malaise. Note that there is a high degree of normal variation in the frequency of bowel habit. It is essential to enquire of the parents as to how regular they are. Reference: 1) Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner should be consulted for diagnosis and treatment of any and all medical conditions

2010 GP Notebook

2540. generalised hypermelanosis

generalised hypermelanosis generalised hypermelanosis - General Practice Notebook This site is intended for healthcare professionals General Practice Notebook | Medical search generalised hypermelanosis Causes of diffuse hyperpigmentation include: congenital: familial or racial irradiation, especially UV light endocrine: chronic primary hypoadrenalism Cushing's syndrome with high ACTH - not adrenal adenoma acromegaly oestrogens, pregnancy systemic disease: chronic renal failure cachexia e.g. TB (...) or malignancy primary biliary cirrhosis haemochromatosis malabsorption - e.g. Whipples disease, coeliac disease drug-induced: cytotoxic drugs - busulphan, bleomycin and cyclophosphamide may cause generalized brown pigmentation phenothiazines e.g. chlorpromazine - bluish pigmentation on light exposed skin arsenic Links: General Practice Notebook General Practice Notebook The information provided herein should not be used for diagnosis or treatment of any medical condition. A licensed medical practitioner

2010 GP Notebook

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