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Famciclovir

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101. Study of Efficacy and Safety, Tolerability and Pharmacokinetics of Telbivudine in Children and Adolescents With Compensated Chronic Hepatitis B Virus Infection

treatment (approved or investigational) at any time before screening Patient has a medical condition that requires frequent use of systemic acyclovir or famciclovir, systemic corticosteroids, potentially hepatotoxic drugs or nephrotoxic drugs or chemotherapy Patient has one or more additional known primary or secondary causes of liver disease, other than CHB; has a decompensated liver disease ; is a Liver transplant recipient or organ or bone marrow transplant recipient. History of any other acute

2014 Clinical Trials

102. Genetically Engineered HSV-1 Phase 1 Study

ganglia, or posterior fossa inoculation or would require access through a ventricle in order to deliver treatment. Prior history of encephalitis, multiple sclerosis, or other CNS infection. Required steroid increase within 2 weeks of scheduled M032 administration. Active oral herpes lesion. Concurrent therapy with any drug active against HSV (acyclovir, valacyclovir, penciclovir, famciclovir, gancyclovir, foscarnet, cidofovir). Uncontrolled intercurrent illness including, but not limited to ongoing

2014 Clinical Trials

104. Herpes simplex - genital

five times a day for 5–10 days, or alternatively: Valaciclovir 500 mg orally twice a day for 5–10 days. Famciclovir 250 mg orally three times a day for 5–10 days. Advise all people about appropriate to help relieve symptoms. Topical antiviral drugs are not recommended, as they offer minimal clinical benefit. Basis for recommendation Basis for recommendation These recommendations are based on the British Association for Sexual Health and HIV (BASHH) UK national guideline for the management (...) recommends using clinical judgement when determining the dose of antivirals and the duration of treatment. Topical antivirals Topical agents are less effective than oral agents, and combining oral and topical treatment is of no additional benefit over oral treatment alone [ ]. Choice of oral antiviral There is no evidence of a difference in efficacy, tolerability, or toxicity between aciclovir, valaciclovir, or famciclovir in the management of primary genital herpes [ ]. UK guidelines recommend aciclovir

2012 NICE Clinical Knowledge Summaries

105. Postherpetic Neuralgia (Overview)

for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA . 1998 Dec 2. 280(21):1837-42. . Rowbotham MC, Davies PS, Fields HL. Topical lidocaine gel relieves postherpetic neuralgia. Ann Neurol . 1995 Feb. 37(2):246-53. . Tyring S, Barbarash RA, Nahlik JE, et al. Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neuralgia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med

2014 eMedicine.com

107. Esophagitis (Overview)

complications Treatment of reflux esophagitis may include the following: Histamine-2 receptor antagonists (H2RAs) Proton pump inhibitors (PPIs) Cisapride (a gastroprokinetic agent) Sucralfate (a coating agent) Treatment of infectious esophagitis is directed at the underlying cause, as follows: Fungal esophagitis – Topical, oral, or parenteral antifungals HSV esophagitis – Acyclovir, foscarnet (for acyclovir-resistant cases), or famciclovir CMV esophagitis – Ganciclovir and foscarnet HIV esophagitis – Oral (...) corticosteroids in conjunction with antiretroviral therapy Varicella-zoster virus (VZV) esophagitis – Acyclovir, famciclovir, or foscarnet (for acyclovir-resistant cases) Epstein-Barr virus (EBV) esophagitis – Acyclovir Human papillomavirus (HPV) esophagitis – No treatment, in most cases; systemic interferon alfa, bleomycin, or etoposide Tuberculous esophagitis – Standard antituberculous therapy Bacterial esophagitis – Broad-spectrum beta-lactam antibiotics, usually with an aminoglycoside, adjusted

2014 eMedicine.com

108. Acute Retinal Necrosis (Follow-up)

acyclovir, valacyclovir, ganciclovir, famciclovir, and foscarnet. An anti-inflammatory, such as prednisone, should be started 24-48 hours after antiviral therapy is initiated. Antiplatelets (aspirin) should be started 24-48 hours after beginning antiviral therapy. Previous Next: Deterrence/Prevention Prophylactic barrier laser to the peripheral retina posterior to the areas of retinal necrosis is required to reduce the risk of retinal detachment. Previous Next: Complications Complications of acute

2014 eMedicine.com

109. Benign Cervical Lesions (Follow-up)

Azithromycin 1 g PO or Doxycycline 100 mg PO bid for 7 d Erythromycin base 500 mg PO qid for 7 d or Erythromycin ethylsuccinate 800 mg PO qid for 7 d N gonorrhoeae Cefixime 400 mg PO or Ceftriaxone 125 mg IM or Azithromycin 1 g PO or Doxycycline 100 mg PO bid for 7 d Spectinomycin 2 g IM or Ceftizoxime 500 mg IM or Cefotaxime 500 mg IM or Cefotetan 1 g IM or Cefoxitin 2 g + probenecid 1 g PO HSV Acyclovir 400 mg PO tid for 7-10 d or Acyclovir 200 mg PO 5 times/d for 7-10 d or Famciclovir 250 mg PO tid (...) or Acyclovir 200 mg PO 5 times/d for 7-10 d or Famciclovir 250 mg PO tid for 7-10 d or Valacyclovir 1 g PO bid for 7-10 d T vaginalis Metronidazole 2 g PO or Metronidazole 500 mg bid for 7 d Contributor Information and Disclosures Author Khanh-Ha D Nguyen, MD, MPH Clinical Fellow in Medical Genetics, National Human Genome Research Institute, National Institutes of Health Khanh-Ha D Nguyen, MD, MPH is a member of the following medical societies: , , , Disclosure: Nothing to disclose. Specialty Editor Board

2014 eMedicine.com

110. Skin Resurfacing, Laser: Erbium YAG

. Erbium:YAG laser resurfacing of the hands, arms, and neck. Dermatol Surg . 1999 Nov. 25(11):831-4; discussion 834-5. . Kaufmann R. Role of Erbium:YAG laser in the treatment of aged skin. Clin Exp Dermatol . 2001 Oct. 26(7):631-6. . Monheit GD. Facial resurfacing may trigger the herpes simplex virus. Cosmet Derm . 1995. 8:9-16. Alster TS, Nanni CA. Famciclovir prophylaxis of herpes simplex virus reactivation after laser skin resurfacing. Dermatol Surg . 1999 Mar. 25(3):242-6. . West TB, Alster TS. Effect

2014 eMedicine Surgery

112. Cutaneous Laser Resurfacing: Erbium:YAG (Follow-up)

to reactivation of latent herpes simplex virus infection or predispose the patient to a primary infection during the reepithelialization phase of healing. It is recommended that prophylactic antiviral medication be prescribed during the postoperative period, regardless of a patient's herpes simplex virus history. Commonly used regimens include famciclovir 250 mg twice daily, acyclovir 400 mg 3 times a day, or valacyclovir 500 mg twice daily. The medication may be administered the day before, or morning

2014 eMedicine.com

113. Cutaneous Laser Resurfacing: Carbon Dioxide (Follow-up)

are recommended to routinely prescribe the prophylactic use of an antiviral medication during the postoperative period, regardless of a patient's herpes simplex virus history. Some surgeons begin the regimen 24 h prior to surgery, while others initiate treatment on the morning of surgery. Commonly used regimens include famciclovir 250 mg PO bid, acyclovir 400 mg PO tid, and valacyclovir 500 mg PO bid for 7-10 d. Antibiotics Some surgeons routinely prescribe antibiotics for bacterial prophylaxis; however

2014 eMedicine.com

114. Conjunctivitis, Viral (Follow-up)

. Valacyclovir 1000 mg or famciclovir 500 mg PO TID for 7-10 days is also approved for herpes zoster infection. Topical corticosteroids usually are not indicated for conjunctivitis or keratitis. Molluscum contagiosum For conjunctivitis associated with molluscum contagiosum, disease will persist until the skin lesion is treated. Removal of the central core of the lesion or inducement of bleeding within the lesion usually is enough to cure the infection. Occasionally, surgical excision is required

2014 eMedicine.com

115. Conjunctivitis, Allergic (Follow-up)

(valacyclovir, acyclovir, famciclovir), as needed. Topical trifluridine (Viroptic) requires 9-times-per-day dosing and contains a thimerosal-based preservative, thereby exposing the already compromised ocular surface to unnecessary toxicity. A subset of patients with recalcitrant and debilitating AKC may benefit from plasmapheresis, as was described by Aswad in 2 patients, one of whom had hyperimmunoglobulinemia E. [ ] Penetrating keratoplasty may be undertaken in cases of severe corneal scarring

2014 eMedicine.com

116. Cutaneous Laser Resurfacing: Erbium:YAG (Diagnosis)

to reactivation of latent herpes simplex virus infection or predispose the patient to a primary infection during the reepithelialization phase of healing. It is recommended that prophylactic antiviral medication be prescribed during the postoperative period, regardless of a patient's herpes simplex virus history. Commonly used regimens include famciclovir 250 mg twice daily, acyclovir 400 mg 3 times a day, or valacyclovir 500 mg twice daily. The medication may be administered the day before, or morning

2014 eMedicine.com

117. Cutaneous Laser Resurfacing: Carbon Dioxide (Diagnosis)

are recommended to routinely prescribe the prophylactic use of an antiviral medication during the postoperative period, regardless of a patient's herpes simplex virus history. Some surgeons begin the regimen 24 h prior to surgery, while others initiate treatment on the morning of surgery. Commonly used regimens include famciclovir 250 mg PO bid, acyclovir 400 mg PO tid, and valacyclovir 500 mg PO bid for 7-10 d. Antibiotics Some surgeons routinely prescribe antibiotics for bacterial prophylaxis; however

2014 eMedicine.com

119. Gynecologic Pain (Diagnosis)

during an outbreak, and cultures or PCR testing. Treatment includes acyclovir, famciclovir and valacyclovir for acute cases and for longer term prophylaxis. Prevention of secondary infection is also important. Bacterial infections can also be quite painful. Those include Streptococcus , and MRSA. Colon-based organisms may at times be problematic, especially in patients with fistulae, and/or Crohn’s Disease. Clinicians should also be aware vaginal infections can results in vulvar pain, secondary

2014 eMedicine.com

120. Herpes Simplex Encephalitis (Diagnosis)

with antiviral therapy in the form of acyclovir. Start empiric acyclovir therapy promptly in patients with suspected HSE pending confirmation of the diagnosis, because acyclovir is relatively nontoxic and because the prognosis for untreated HSE is poor. Pharmacotherapy Medications used in the management of HSE include the following: Antivirals (eg, acyclovir, famciclovir): Drug of choice for HSE; to shorten the clinical course, prevent complications, prevent development of latency and subsequent recurrences

2014 eMedicine.com

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