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61. Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections (PubMed)

Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections Treatment for herpes simplex virus-1 and -2 (HSV-1 and -2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir. Drug troughs caused by missed doses may result

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2018 Journal of drug delivery

62. Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes (PubMed)

Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes Our previous articles showed that suppressive or preventive treatment with the herbal Gene-Eden-VIR/Novirin reduced the number and duration of genital herpes outbreaks with no adverse effects. These studies also revealed that the herbal Gene-Eden-VIR/Novirin is mostly superior to acyclovir, valacyclovir, and famciclovir drugs in genital herpes. This study tested the effect of Gene-Eden-VIR/Novirin in oral herpes (also

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2018 Journal of Evidence-based Integrative Medicine Controlled trial quality: uncertain

63. [Shallow Fire-needle Acupuncture Stimulation Plus Cupping Relieves Neuralgia and Down-regulates Serum Substance P Level in Patients with Acute Herpes Zoster]. (PubMed)

in each). Patients of both groups were ordered to take Famciclovir (0.25 g/time, three times a day) and Mecobalamin (0.5 g/time, three times a day) orally for 7 days. In addition, patients of the treatment group were also treated by repeated shallow fire-needle stimulation and cupping, once a day for 7 days. Before and after the treatment, the patient's pain severity was assessed using visual analogue scale (VAS) and serum SP concentration was measured using ELISA.After the treatment, the VAS scores

2018 Zhen ci yan jiu = Acupuncture research Controlled trial quality: uncertain

66. Herpes simplex - oral

the time of onset of prodromal symptoms before vesicles appear, if possible, until lesions have healed, for a minimum of 5 days. The choice between the oral antiviral drugs aciclovir or valaciclovir depends on the preference of the person, drug cost, dosage regimen, likely adherence, and local prescribing policies. Note: famciclovir is not licensed for the treatment of oral herpes simplex infections. For more prescribing information on recommended drug doses, contraindications and cautions, and adverse

2016 NICE Clinical Knowledge Summaries

67. Dynamic Changes of Monocytes and NK Cells of CHC Patient Treated by DAAs

decompensation (Child-Pugh Grade B or C) or ascites, esophageal variceal bleeding, hepatic encephalopathy, or spontaneous bacterial peritonitis. Patient has a history of hepatocellular carcinoma (HCC) or suspected symptoms of HCC, such as suspicious foci on imaging studies and/or serum alpha-fetoprotein (AFP)>50ng/mL. Patient has received IFN or other immunomodulatory treatment within 52 weeks before Screening. Patient has a medical condition that requires frequent use of systemic acyclovir or famciclovir

2017 Clinical Trials

68. Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised Adults

, hematopoietic-cell or solid organ transplantation, and chronic glucocorticoid use) men and women of any ethnic group aged ≥18 years. Acyclovir resistant mucocutaneous HSV infection based on clinical failure (no improvement after at least 5 days with FDA approved high doses with acyclovir, valacyclovir or famciclovir) requiring switch to foscarnet treatment. Lesion accessible for size measurement and photography. Willingness to abstain from the application of lotions and/or creams to the area with HSV

2017 Clinical Trials

69. A Study to Evaluate CSJ148 in Pregnant Women With Primary HCMV Infection

/day oral), famciclovir (>1500 mg/day oral), HCMV immune globulin, immune globulin (>500 mg/kg), or any other medication with anti-HCMV activity. Any surgical or medical condition (other than pregnancy) which might increase the risk for thrombotic events if the patient is given immune-globulins. These conditions include cryoglobulinemia, monoclonal gammopathies, and hypertriglyceridemia (fasting level >1000 mg/dL). The investigator should make this determination based on the patient's medical

2017 Clinical Trials

70. Zoster Eye Disease Study

surgery, within 5 years of enrollment, or keratoplasty of the involved eye with zoster. On systemic antivirals with activity against herpes within the past 30 days, including acyclovir, valacyclovir, or famciclovir, for any reason except for treatment of acute HZO, including investigational drug trial. History of another condition that may require treatment with one of these three antivirals listed above in exclusion criterion #7, during the course of the study; study participants who require chronic

2017 Clinical Trials

71. Neoadjuvant Trial of Nivolumab in Combination With HF10 Oncolytic Viral Therapy in Resectable Stage IIIB, IIIC, IVM1a Melanoma

metastases melanoma (Stage IVM1b or IVM1c). Patients whose primary diagnosis was ocular melanoma. Patients receiving anti-herpes medication (i.e., acyclovir, famciclovir, or valacyclovir) within 1 week prior to initiating HF10 treatment. Patients may not require intermittent or chronic systemic (intravenous or oral) treatment with an antiherpetic drug other than intermittent topical use. Patients who have an active herpetic skin lesion(s) or prior complications of HSV-1 infection. Uncontrolled

2017 Clinical Trials

72. Ketogenic Diet (KD) in Alcoholism

agents (systemic); antihistamines (sedating); antihypertensives (except angiotensinconverting enzymeace (ACE) inhibitors such as Lisinopril, or Angiotensin receptor blockers (ARB) such as Losartan); anti-inflammatory drugs (systemic); antineoplastics; antiobesity; antivirals (except for treatment of HSV with agents without CNS activity, e.g. acyclovir, ganciclovir, famciclovir, valacyclovir); cough/cold preparations (dextromethorphan preparations, pseudoephedrine); hormones (exceptions: thyroid

2017 Clinical Trials

73. Dopaminergic Modulation of Brain Activation Using Simultaneous PET/Pharmacological MRI

; anticonvulsants; antidepressants; antidiarrheal preparations; antifungal agents (systemic); antihistamines (sedating); antihypertensives; anti-inflammatory drugs (systemic); antineoplastics; antiobesity; antipsychotics; antivirals (except for treatment of HSV with agents without CNS activity, e.g. acyclovir, ganciclovir, famciclovir, valacyclovir); anxiolytics (benzodiazepine or barbiturates); hormones (exceptions: thyroid hormone replacement, oral contraceptives, and estrogen replacement therapy); insulin

2017 Clinical Trials

74. Brain Dopaminergic Signaling in Opioid Use Disorders

agents (systemic); antihistamines (sedating); beta-blocker antihypertensives; anti-inflammatory drugs (systemic); antineoplastics; antiobesity; antipsychotics; antivirals (except for treatment of HSV with agents without CNS activity, e.g. acyclovir, ganciclovir, famciclovir, valacyclovir); anxiolytics (benzodiazepine or barbiturates); hormones (exceptions: thyroid hormone replacement, oral contraceptives, and estrogen replacement therapy); insulin; lithium; muscle relaxants; psychotropic drugs

2017 Clinical Trials

75. The Relationship Between MDSCs and NK Cells Activity of CHC Patient Treated by DAAs

Grade B or C) or ascites, esophageal variceal bleeding, hepatic encephalopathy, or spontaneous bacterial peritonitis. Patient has a history of hepatocellular carcinoma (HCC) or suspected symptoms of HCC, such as suspicious foci on imaging studies and/or serum alpha-fetoprotein (AFP)>50ng/mL. Patient has received IFN or other immunomodulatory treatment within 52 weeks before Screening. Patient has a medical condition that requires frequent use of systemic acyclovir or famciclovir. Patient has

2017 Clinical Trials

76. Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia

standard treatment in acute herpes zoster patients will decrease the incidence of post-herpetic neuralgia. Condition or disease Intervention/treatment Phase Herpes Zoster Post-herpetic Neuralgia Drug: Oxycodone Drug: Gabapentin Drug: Famciclovir Not Applicable Detailed Description: Herpes zoster (HZ) results from reactivation of the latent varicella zoster virus in sensory ganglia, with characteristic symptom of painful skin rash and localized blisters. Usually, the rash heals and pain resolves within (...) by the National Library of Medicine related topics: related topics: available for: Arms and Interventions Go to Arm Intervention/treatment Experimental: oxycodone Oxycodone 20mg/day, for 4 weeks and famciclovir 500mg three-times daily for 7 days. Drug: Oxycodone Oxycodone 20mg/day, for 4 weeks Other Name: Oxycontin Drug: Gabapentin Gabapentin 900mg/day, titrated up to max tolerated dose or 1800mg/day, for 4-12 weeks Other Name: neurontin Drug: Famciclovir Famciclovir 500mg three-times daily for 7 days Other

2017 Clinical Trials

77. A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2

Recurrent glioma where injection in either arm A or B of the biologic agent would require access and/or considerable spillage into the ventricular system. Prior participant in another protocol using an investigational agent or device within 5 half-lives of the investigational agent. Known HIV seropositivity. Concurrent therapy with drugs active against HSV (acyclovir, valaciclovir, penciclovir, famciclovir, ganciclovir, foscarnet, cidofovir). Participants must be off treatment with these agents

2017 Clinical Trials

78. Amenamevir, a novel helicase–primase inhibitor, for treatment of herpes zoster: A randomized, double‐blind, valaciclovir‐controlled phase 3 study (PubMed)

Amenamevir, a novel helicase–primase inhibitor, for treatment of herpes zoster: A randomized, double‐blind, valaciclovir‐controlled phase 3 study Amenamevir is a potent helicase-primase inhibitor and a novel class of antiviral agent other than nucleoside compounds, such as aciclovir, valaciclovir and famciclovir. This study is the first randomized, double-blind, valaciclovir-controlled phase 3 study to evaluate the efficacy and safety of amenamevir in Japanese patients with herpes zoster

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2017 The Journal of dermatology Controlled trial quality: predicted high

80. Treatment of Bell's Palsy - Should antivirals be added to prednisolone?

. Corticosterids vs corticosteroids plus antiviral agents in the treatment of Bell Palsy Arch Otolaryngol Head Neck Surg. 2009;135(6):558-564. Chen WL, Yang ZH, Huang ZQ. Outcome of treatment 46 patients with Bell's palsy with aciclovir and prednisone. [Chinese] Shanghai Kou Qiang Yi Xue/Shanghai Journal of Stomatology. 2005;14(6):590-2. Shahidullah M, Haque A, Islam MR, et al. Comparative Study between Combination of Famciclovir and Prednisolone with Prednisolone Alone in Acute Bell's Palsy. Mymensingh

2012 BestBETS

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