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Famciclovir

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41. Chickenpox in Pregnancy

that there is no increase in the risk of major fetal malformation with aciclovir exposure in pregnancy. 42–44 A Danish registry-based cohort study of 837 795 live births between 1996 and 2008 43 reported the pregnancy outcome in 1804 pregnancies exposed to aciclovir, valciclovir or famciclovir in the first trimester. The rate of major birth defects in the exposed group was 2.2% compared to 2.4% in the unexposed (adjusted prevalence odds ratio 0.89, 95% CI 0.65–1.22). The most common antiviral drug used was aciclovir (...) systemic prenatal acyclovir exposure: Conclusions from the international acyclovir pregnancy registry, 1984–99. Birth Defects Res A Clin Mol Teratol 2004;70:201–7. 43. Pasternak B, Hviid A. Use of acyclovir, valacyclovir and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010;304:859–66. 44. Mills JL, Carter TC. Acyclovir exposure and birth defects: an important advance, but more are needed. JAMA 2010;304:905–6. 45. Daley AJ, Thorpe S, Garland SM. Varicella

2015 Royal College of Obstetricians and Gynaecologists

42. Management of Genital Herpes in Pregnancy

effects have been reported. Aciclovir is well tolerated in pregnancy. For treatment courses no dose adjustment is necessary. 23,24 There is no evidence of an increased risk of birth defects with aciclovir, famciclovir or valaciclovir if used in the first trimester. 22 Safety data for aciclovir may be extrapolated to valaciclovir in late pregnancy, as it is the valine ester, but as there is less experience with the use of valaciclovir or famciclovir, they are not recommended as a first- line treatment (...) , Sørensen HT. Adverse pregnancy outcome in women exposed to acyclovir during pregnancy: a population-based observational study. Scand J Infect Dis 2003;35:255–9. 22. Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010;304:859–66. 23. Frenkel LM, Brown ZA, Bryson YJ, Corey L, Unadkat JD, Hensleigh PA, et al. Pharmacokinetics of acyclovir in the term human pregnancy and neonate. Am J Obstet Gynecol 1991;164:569

2014 Royal College of Obstetricians and Gynaecologists

44. Varicella Zoster Virus glycoprotein E antigen (Shingrix) - Herpes Zoster

Oral antiviral therapy should be commenced as early as possible, within 72 hours of rash onset. Treatment is usually given for 7 days in the absence of complications of herpes zoster. Antiviral therapies, such as Acyclovir, Famciclovir and Valacyclovir are used in the acute phase of infection with the main aims of reducing and/or stopping viral replication, which is thought to play a role in relieving pain and shortening duration of symptoms. Management of acute pain associated with herpes zoster

2018 European Medicines Agency - EPARs

45. Shingles

is healthcare professionals working within the NHS in the UK, and providing first contact or primary health care. How up-to-date is this topic? How up-to-date is this topic? Changes Changes May 2018 — minor update. Eligible ages for shingles vaccination updated in line with PHE guidance. See . October 2017 — minor update. Addition to adverse effects of seizure for famciclovir. January 2017 — minor update. Correction made to advice on NSAIDs for children with shingles. November to December 2016 — reviewed (...) or widespread rash or multiple dermatomal involvement; immunocompromised children; or pregnant or breastfeeding women. For more information on these groups (and other people who may need admission to hospital, referral, or management guided by a specialist) see the section on . If specialist advice or referral is not required, start oral aciclovir, valaciclovir, or famciclovir (use clinical judgement, taking into account cost and compliance issues for each individual) within 72 hours of rash onset

2017 NICE Clinical Knowledge Summaries

48. UK National Guideline for the Management of Anogenital Herpes

with the probability of this over HSV-2 being greater at younger age, (females 500) although there is very limited trial evidence to support this approach. One trial with famciclovir has reported this effect. 85 Dosage of antivirals • Providing there is no evidence of immune failure standard doses of antivirals should suffice (Ib,A). In those with advanced disease it may be necessary to double the standard dose and to continue therapy beyond 5 days (Ib,B). Currently there is no evidence to support the use (...) be substituted. In others, where the pre-treatment pattern of recurrences resumes, suppressive treatment may need to restart (Evidence level IV, C) • Recommended drug regimens for daily suppressive treatment 23,86,87 o Aciclovir 400 mg orally twice to three times a day o Valaciclovir 500 mg orally twice a day • If these options do not adequately control disease then the first option should be to double the dose. If control is still not achieved then famciclovir 500 mg orally twice a day can be tried. (IIa,B

2015 British Association for Sexual Health and HIV

49. Pharmacologic Interventions for Bell's Palsy

% confidence intervals [CI], -18% to 17.6%). However, the analysis lacked the statistical precision to exclude an important beneficial effect (or harm) from the addition of valacyclovir. A Class IV study observed a significant improvement in recovery (RD 26.6%) between patients with severe Bell palsy treated with prednisone alone and patients with severe Bell palsy treated with prednisone plus famciclovir (House-Brackmann Scale score of 5 or 6). This study had a high risk of bias because

2014 National Guideline Clearinghouse (partial archive)

52. Variation in the Reported Management of Canine Prolapsed Nictitans Gland and Feline Herpetic Keratitis (PubMed)

FHV-1 keratitis with topical antibiotics (76.4%), with a minority suggesting topical antivirals (32.2%). GPs favoured topical acyclovir whilst PGs more frequently recommended topical trifluorothymidine. A significantly larger proportion of PGs nominated systemic famciclovir and lysine supplement for FHV-1 keratitis. This survey revealed moderate treatment variation for these conditions, both between and within practitioner groups. Additional research is needed to assess the reasons

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2018 Veterinary Sciences

53. A Phase 2 Trial to Evaluate the Safety and Efficacy of UB-621 in Adults With Recurrent Genital HSV-2 Infection.

, Older Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: No Criteria Inclusion Criteria: Subject must be HSV-2 seropositive Subjects have a history of recurrent genital herpes in the past year Subjects have a negative result on the HIV Ab/Ag assay Subjects must agree to use contraception during study participation Exclusion Criteria: Documented HSV resistance to acyclovir, valacyclovir, famciclovir, or penciclovir History or current evidence of malignancy except for a localized non

2018 Clinical Trials

54. Trial of C134 in Patients With Recurrent GBM

within 2 weeks of scheduled IRS1-chimeric HSV1 administration. Active oral herpes lesion. Concurrent therapy with any drug active against HSV (acyclovir, valaciclovir, penciclovir, famciclovir, ganciclovir, foscarnet, cidofovir). Uncontrolled intercurrent illness including, but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or any other medical condition that precludes surgery . Also, psychiatric illness/social

2018 Clinical Trials

55. Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002)

to receive during the study any of the following anti-CMV IgG antibody treatment or anti-CMV drug therapy including the following: Cidofovir, CMV hyper-immune globulin, Any investigational CMV antiviral agent/biologic therapy. Has received within 7 days prior to randomization or plans to receive during the study any of the following anti-CMV drug therapy: LET, GCV, VGCV, Foscarnet, ACV, Valacyclovir, Famciclovir. Is a user of recreational or illicit drugs or has had a recent history (within the last year

2018 Clinical Trials

56. Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes (PubMed)

Clinical Trial of Herbal Treatment Gene-Eden-VIR/Novirin in Oral Herpes Our previous articles showed that suppressive or preventive treatment with the herbal Gene-Eden-VIR/Novirin reduced the number and duration of genital herpes outbreaks with no adverse effects. These studies also revealed that the herbal Gene-Eden-VIR/Novirin is mostly superior to acyclovir, valacyclovir, and famciclovir drugs in genital herpes. This study tested the effect of Gene-Eden-VIR/Novirin in oral herpes (also

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2018 Journal of Evidence-based Integrative Medicine

57. Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections (PubMed)

Volatile Acid-Solvent Evaporation (VASE): Molecularly Homogeneous Distribution of Acyclovir in a Bioerodable Polymer Matrix for Long-Term Treatment of Herpes Simplex Virus-1 Infections Treatment for herpes simplex virus-1 and -2 (HSV-1 and -2) patients who suffer from recurrent outbreaks consists of multiple daily doses of the antiviral drugs acyclovir (ACV), penciclovir, or their more orally bioavailable derivatives valacyclovir or famciclovir. Drug troughs caused by missed doses may result

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2018 Journal of drug delivery

60. Herpes simplex - oral

to take the oral antiviral drug from the time of onset of prodromal symptoms before vesicles appear, if possible, until lesions have healed, for a minimum of 5 days. The choice between the oral antiviral drugs aciclovir or valaciclovir depends on the preference of the person, drug cost, dosage regimen, likely adherence, and local prescribing policies. Note: famciclovir is not licensed for the treatment of oral herpes simplex infections. For more prescribing information on recommended drug doses

2016 NICE Clinical Knowledge Summaries

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