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Famciclovir

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461. In Vitro Antihepadnaviral Activities of Combinations of Penciclovir, Lamivudine, and Adefovir Full Text available with Trip Pro

against HBV in their respective prodrug forms (famciclovir and adefovir dipivoxil [bis-(POM)-PMEA]). Since multidrug combinations are likely to be used to control HBV infection, investigation of potential interactions between PCV, 3TC, and PMEA is important. Primary duck hepatocyte cultures which were either acutely or congenitally infected with the duck hepatitis B virus (DHBV) were used to investigate in vitro interactions between PCV, 3TC, and PMEA. Here we show that the anti-DHBV effects of all

2000 Antimicrobial Agents and Chemotherapy

462. Cross-Resistance Testing of Antihepadnaviral Compounds Using Novel Recombinant Baculoviruses Which Encode Drug-Resistant Strains of Hepatitis B Virus Full Text available with Trip Pro

-resistance profiles of drug-resistant HBV strains are described here. For these studies, novel recombinant HBV baculoviruses which encoded the L526M, M550I, and L526M M550V drug resistance mutations were generated and used to examine the effects of these substitutions on viral sensitivity to lamivudine, penciclovir (the active form of famciclovir), and adefovir, three compounds of clinical importance. The following observations were made: (i) the L526M mutation confers resistance to penciclovir

2001 Antimicrobial Agents and Chemotherapy

463. In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to (−)-β-d-2,6-Diaminopurine Dioxolane and 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil Full Text available with Trip Pro

In Vitro Susceptibilities of Wild-Type or Drug-Resistant Hepatitis B Virus to (−)-β-d-2,6-Diaminopurine Dioxolane and 2′-Fluoro-5-Methyl-β-l-Arabinofuranosyluracil Prolonged treatment of chronic hepatitis B virus (HBV) infection with lamivudine ([-]-beta-L-2',3'-dideoxy-3' thiacytidine) or famciclovir may select for viral mutants that are drug resistant due to point mutations in the polymerase gene. Determining whether such HBV mutants are sensitive to new antiviral agents is therefore (...) important. We used a transient transfection system to compare the sensitivities of wild-type HBV and four lamivudine- and/or famciclovir-resistant HBV mutants to adefovir [9-(2-phosphonyl-methoxyethyl)-adenine; PMEA] and the nucleoside analogues (-)-beta-D-2, 6-diaminopurine dioxolane (DAPD) and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil (L-FMAU). The drug-resistant mutants contained amino acid substitutions in the polymerase protein. We found that the M550I and M550V plus L526M substitutions

2001 Antimicrobial Agents and Chemotherapy

464. Improving the care of patients with genital herpes Full Text available with Trip Pro

Valacyclovir QIC03ANI02 Famciclovir X4HES1O11F Acyclovir AIM IM BMJ. 2001 Feb 17;322(7283):434 11179175 2-Aminopurine analogs & derivatives therapeutic use Acyclovir analogs & derivatives therapeutic use Adult Antiviral Agents therapeutic use Cesarean Section Drug Administration Schedule Famciclovir Female Herpes Genitalis diagnosis drug therapy epidemiology Humans Immunocompromised Host Infant, Newborn Male Patient Education as Topic Pemphigoid Gestationis drug therapy prevention & control Pregnancy

2000 BMJ : British Medical Journal

465. Necrotising herpetic retinopathy in patients with advance HIV disease. Full Text available with Trip Pro

with intravenous aciclovir for 6 weeks: three subsequently received oral famciclovir and one oral valaciclovir; two patients also had intravitreal injections of foscarnet. In none of the four did treatment bring about improvement in visual acuity, but in all four visual loss from retinitis was halted.NHR occurs in HIV infected patients with advanced HIV disease and is strongly associated with evidence of VZV infection. With aggressive use of antiviral drugs the outcome is not uniformly poor.

1997 Genitourinary Medicine

466. Dilemmas in care of the elderly. Full Text available with Trip Pro

Dilemmas in care of the elderly. 9426930 1998 01 30 2018 12 01 0008-350X 43 1997 Dec Canadian family physician Medecin de famille canadien Can Fam Physician Dilemmas in care of the elderly. 2123 Pereles L L Division of Geriatric Medicine, University of Alberta. Triscott J J Meiring P P eng Case Reports Journal Article Canada Can Fam Physician 0120300 0008-350X 0 Antiviral Agents 0 Prodrugs 452-06-2 2-Aminopurine QIC03ANI02 Famciclovir IM 2-Aminopurine administration & dosage analogs (...) & derivatives economics therapeutic use Age Factors Aged Aged, 80 and over Antiviral Agents administration & dosage economics therapeutic use Costs and Cost Analysis Famciclovir Female Herpes Zoster drug therapy economics physiopathology Humans Middle Aged Pain etiology prevention & control Prodrugs economics Time Factors 1998 1 14 1998 1 14 0 1 1998 1 14 0 0 ppublish 9426930 PMC2255083 BMJ. 1989 Feb 18;298(6671):431 2495051 Hosp Pract (Off Ed). 1990 Oct 30;25(10A):61-71, 75-6 2120265 N Engl J Med. 1994 Mar

1997 Canadian Family Physician

467. Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials. (Abstract)

Profiling penciclovir susceptibility and prevalence of resistance of herpes simplex virus isolates across eleven clinical trials. Asusceptibility testing program was established to determine the prevalence of resistance to penciclovir among herpes simplex virus isolates collected from patients participating in 11 world-wide clinical trials involving penciclovir (topical or intravenous formulations) or famciclovir, the oral prodrug of penciclovir. These trials represented nine randomised double (...) the susceptibility profile for a total of 2145 herpes simplex virus isolates from 913 immunocompetent and 288 immunocompromised patients treated with penciclovir, famciclovir, aciclovir or placebo (depending on trial design). HSV isolates were tested for susceptibility to penciclovir using the plaque reduction assay (PRA) in MRC-5 cells. Resistance was defined as an IC(50)>or=2.0 microg/ml or an IC(50)> 10-fold above the wild type control virus IC(50) within that particular assay. Penciclovir-resistant HSV

2003 Archives of virology Controlled trial quality: uncertain

468. Lamivudine as first- and second-line treatment of hepatitis B infection after liver transplantation. (Abstract)

Lamivudine as first- and second-line treatment of hepatitis B infection after liver transplantation. Lamivudine and famciclovir have expanded therapeutical options for HBV infection after liver transplantation. First studies confirm good antiviral effects of both, but at present the major problem seems to be a rapid resistance formation in immunosuppressed patients. Thirty-four adult patients with HBV recurrence despite passive immunoprophylaxis and seven with de novo infection after orthotopic (...) liver transplantation (OLT) were treated with 100-150 mg lamivudine daily. Patients were either treated directly after infection (n = 14) or after breakthrough of viral replication during an initial famciclovir therapy (n = 27). All patients except two responded to treatment with a reduction of serum HBV-DNA of over 50%. Thirty-one patients (76%) turned HBV-DNA-negative during lamivudine therapy. Viral breakthrough was observed in 14 of these patients after 4-13 months of treatment. A total of 17

2000 Transplant international : official journal of the European Society for Organ Transplantation Controlled trial quality: uncertain

469. Factors associated with hepatitis B virus DNA breakthrough in patients receiving prolonged lamivudine therapy. (Abstract)

HBeAg seroconversion. There was no increase in the rate of development of YMDD variants or L528M mutation in patients receiving lamivudine 25 mg daily or famciclovir 500 mg 3 times a day before being given lamivudine 100 mg daily.

2001 Hepatology Controlled trial quality: uncertain

470. The role of antivirals in the management of neuropathic pain in the older patient with herpes zoster. (Abstract)

zoster pain. Valaciclovir (valacyclovir), famciclovir and brivudine (brivudin) are comparably effective in the reduction of the incidence and/or prevention of zoster-associated pain and postherpetic neuralgia. Brivudine 125mg once daily is as effective as famciclovir 250mg three times daily in reducing the prevalence and the duration of zoster-associated pain and postherpetic neuralgia, especially if therapy is combined with a structured-pain therapy. The intensity of the therapy for pain should (...) depend on the intensity of the pain that it is treating. Famciclovir and brivudine offer an advantage over other antivirals because they are administered less frequently; this is particularly relevant for elderly patients who may already be taking a number of medications for other diseases. Therefore, antiviral therapy in combination with adequate pain management should be given to all elderly patients as soon as herpes zoster is diagnosed.

2003 Drugs & Aging

471. Treatment of recurrent hepatitis B infection in liver transplant recipients. (Abstract)

of therapy, is its main limitation. 3. Famciclovir is safe in liver transplant recipients; however, virological and clinical responses are less consistent than with lamivudine. Thus, lamivudine is favored over famciclovir as first-line therapy in transplant recipients with no previous exposure to nucleoside analogues. 4. Although limited in availability, adefovir dipivoxil appears safe and effective in treating liver transplant recipients with lamivudine-resistant HBV disease. Close monitoring of renal (...) function is recommended, with dose adjustment in patients with reduced creatinine clearances. 5. Limited data suggest that intravenous ganciclovir, tenofovir disoproxil fumarate, and interferon alfa may be useful as rescue therapies for patients with lamivudine- or famciclovir-resistant HBV disease. 6. Antiviral therapy with two or more suitable agents may minimize the chance for viral resistance; therefore, future therapeutic strategies likely will use combination therapy in the long-term management

2002 Liver Transplantation

472. Challenges in genital herpes simplex virus management. Full Text available with Trip Pro

acyclovir, famciclovir, and valacyclovir, treatment of mucocutaneous HSV is a practice of everyday medical care. Yet, despite effective drugs, there is widespread discontent by clients and providers about care of patients with genital herpes. Much of this relates to transmission complexities and the varied natural history of the infection. However, over time, most patients adjust to their disease and the medical and psychosocial complications. Recent studies show condoms reduce transmission, providing

2002 Journal of Infectious Diseases

473. Progress in meeting today's demands in genital herpes: an overview of current management. (Abstract)

simplex infection are common and patient education is essential. Patient concerns extend beyond disease frequency and severity-the psychological impact should not be underestimated. Antiviral therapy is relevant at all stages of infection. Acyclovir, valacyclovir, and famciclovir are effective and well tolerated for genital herpes treatment. Continuous suppressive therapy controls all symptoms of recurrent disease and helps to relieve disease complications. The prodrugs valacyclovir and famciclovir

2002 Journal of Infectious Diseases

474. Fatal hepatitis B reactivation following discontinuation of nucleoside analogues for chronic hepatitis B. Full Text available with Trip Pro

are described who developed hepatitis B reactivation and liver decompensation after stopping therapy. One of the three patients was participating in a famciclovir trial and the other two were receiving lamivudine therapy for active hepatitis B infection. All three patients had documented hepatitis B flares, and all had hepatitis B virus DNA detected at that time. All patients developed decompensated liver disease despite one patient having had a prior liver biopsy showing absence of cirrhosis

2002 Gut

475. Systemic acyclovir reaction subsequent to acyclovir contact allergy: which systemic antiviral drug should then be used? (Abstract)

with the components of Zovirax cream (acyclovir, propylene glycol and sodium lauryl sulfate) and with other antiviral drugs. Patch tests were positive to Zovirax cream, acyclovir, valacyclovir and propylene glycol. Patch and prick tests with famciclovir were negative, but its oral administration caused an itchy erythematous dermatitis on the trunk and extremities. Our patient developed a systemic acyclovir reaction subsequent to acyclovir allergic contact dermatitis, with cross-reactions to valacyclovir (...) and famciclovir. Their common chemical structure is the 2-aminopurine nucleus. It is probably this part of the molecule that provokes both contact allergy and systemic reactions. The only antiviral drugs not having this core are foscarnet and cidofovir, and these could therefore be alternatives.

2003 Contact Dermatitis

476. Characterization of hepatitis B virus surface antigen and polymerase mutations in liver transplant recipients pre- and post-transplant. (Abstract)

and/or famciclovir. Four of six patients with HBIG breakthrough without nucleoside analogue treatment failure yielded potentially significant HBsAg mutations post transplant. These data do not support previous reports highlighting the disappearance of HBsAg mutants in liver transplant recipients after discontinuation of HBIG. Determination of HBV genotype, as well as identification of HBV polymerase and S gene mutations in liver transplant candidates may be warranted to optimize HBV management strategies post

2003 American Journal of Transplantation

477. Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia

Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Economic evaluation of famciclovir in reducing the duration of postherpetic neuralgia Huse D M, Schainbaum S, Kirsch A J, Tyring S Record Status This is a critical abstract of an economic evaluation that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results (...) and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. Health technology Famciclovir therapy for reducing the duration of post-herpetic neuralgia (PHN). Type of intervention Secondary prevention. Economic study type Cost-effectiveness analysis. Study population Immunocompetent adults with uncomplicated herpes zoster, diagnosed within 72 hours of onset of rash. Setting Primary care centres in the US, Canada and Australia. Dates to which data relate

1997 NHS Economic Evaluation Database.

478. Is there any evidence for the use of famciclovir in cutaneous H Simplex infections ie H Labialis?

Is there any evidence for the use of famciclovir in cutaneous H Simplex infections ie H Labialis? Is there any evidence for the use of famciclovir in cutaneous H Simplex infections ie H Labialis? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe (...) across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any evidence for the use of famciclovir in cutaneous H Simplex infections ie H Labialis? We found little evidence to support the use of famciclovir in the prevention or treatment of herpes

2006 TRIP Answers

479. If a rugby player is getting recurrent attacks of scrumpox currently treated with Famciclovir 750mg daily for 1 week - is there evidence for the benefits of more longterm prophylactic antivirals?

If a rugby player is getting recurrent attacks of scrumpox currently treated with Famciclovir 750mg daily for 1 week - is there evidence for the benefits of more longterm prophylactic antivirals? If a rugby player is getting recurrent attacks of scrumpox currently treated with Famciclovir 750mg daily for 1 week - is there evidence for the benefits of more longterm prophylactic antivirals? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only (...) If a rugby player is getting recurrent attacks of scrumpox currently treated with Famciclovir 750mg daily for 1 week - is there evidence for the benefits of more longterm prophylactic antivirals? We searched the NLH Specialist Library for Skin Conditions and the TRIP and Medline databases but found no guidance on the management of recurrent scrum pox/herpes simplex of the skin. The BNF offers the following general prescribing information for famciclovir: “ Indications: treatment of herpes zoster, acute

2006 TRIP Answers

480. Is there any evidence that use of aciclovir/famciclovir reduces the risk of postherpetic neuralgia after shingles?

Is there any evidence that use of aciclovir/famciclovir reduces the risk of postherpetic neuralgia after shingles? Is there any evidence that use of aciclovir/famciclovir reduces the risk of postherpetic neuralgia after shingles? - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere (...) clinicians to search across other content types including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Is there any evidence that use of aciclovir/famciclovir reduces the risk of postherpetic neuralgia after shingles? Clinical Evidence contains a chapter on postherpetic neuralgia (1

2008 TRIP Answers

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