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21. Treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus-8 replication in HIV-1 seropositive men. Full Text available with Trip Pro

Treatment with valacyclovir, famciclovir, or antiretrovirals reduces human herpesvirus-8 replication in HIV-1 seropositive men. Human herpesvirus-8 (HHV-8) replication is a key factor in Kaposi sarcoma, primary effusion lymphoma, and Castleman disease pathogenesis. In vitro data suggest that antivirals inhibit HHV-8 replication, but little data exist in humans. Daily oropharyngeal swabs were analyzed from HIV/HHV-8 dually infected men enrolled in three previous clinical trials of valacyclovir (...) and famciclovir for HIV-1 and/or HSV-2 suppression. Fifty-eight participants contributed 6,036 swabs. HHV-8 was detected in 1,128 (19%) of 6,036 swabs, including 618 (21%) of 2,992 on placebo, 323 (15%) of 2,221 on valacyclovir, and 187 (23%) of 823 on famciclovir. After adjusting for baseline HIV viral load and highly active antiretroviral therapy (HAART) use, an 18% reduction in HHV-8 shedding frequency (IRR 0.822; P = 0.011) was found in participants on valacyclovir and a 30% reduction (IRR 0.700; P

2011 Journal of medical virology Controlled trial quality: uncertain

22. Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster

Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01327144 Recruitment Status : Unknown Verified February 2017 by EMS. Recruitment status was: Recruiting First Posted : April 1, 2011 Last Update

2011 Clinical Trials

23. Viral rash in pregnancy

, and Famciclovir in the First Trimester of Pregnancy and the Risk of Birth Defects. JAMA. 2010 Aug; 304(8): 859-66. 64. Wallace MR, Bowler WA, Murray NB, Brodine SK, Oldfield EC, III. Treatment of adult varicella with oral acyclovir. A randomized, placebo-controlled trial. Ann Intern Med 1992 Sep 1;117(5):358-63. 65. Cohen J, Breuer J. Chickenpox: treatment. Clinical Evidence 2015 Jun;06:912. 66. Kempf W, Meylan P, Gerber S, Aebi C, Agosti R, Buchner S, et al. Swiss recommendations for the management

2019 Public Health England

24. Herpes simplex infection

lesions involving the oropharynx and perioral mucosa. Aciclovir, famciclovir, and valaciclovir are effective at shortening the duration and severity of an outbreak. Daily suppressive therapy reduces recurrences by 80% and reduces transmission risk by approximately 50%. HSV type-specific antibody tests are used to diagnose infection with or without lesions and distinguish between type 1 and 2. Definition Infection with HSV-1 or HSV-2 can cause oral, genital, and ocular ulcers. The primary episode

2018 BMJ Best Practice

25. Celecoxib

thrice daily, or naproxen 375-500mg twice daily. All patients were provided with a proton pump inhibitor. The outcome was major NSAID toxicity, including time to first occurrence of major adverse cardiovascular events, important gastrointestinal events, renal events and all-cause mortality. RESULTS 2017 12. A famciclovir + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia. 28260944 2017 03 06 2017 03 09 10 2017 Journal of pain research J Pain Res A famciclovir (...) + celecoxib combination treatment is safe and efficacious in the treatment of fibromyalgia. 451-460 10.2147/JPR.S127288 Infections and other stressors have been implicated in the development of fibromyalgia. We hypothesized that these stressors could result in recurrent reactivations of latent herpes (...) virus infections, which could lead to the development of fibromyalgia. This study evaluated a famciclovir + celecoxib drug combination (IMC-1), active against suspected herpes virus reactivation

2018 Trip Latest and Greatest

26. Acyclovir

were included in this systematic review. One provided weak evidence that acyclovir is an effective 2010 7. A comparative study to evaluate the efficacy and safety of acyclovir and famciclovir in the management of herpes zoster. 24551671 2014 02 19 2014 02 19 2017 02 20 2249-782X 7 12 2013 Dec Journal of clinical and diagnostic research : JCDR J Clin Diagn Res A comparative study to evaluate the efficacy and safety of acyclovir and famciclovir in the management of herpes zoster. 2904-7 10.7860/JCDR (...) /2013/7884.3670 Over the years, acyclovir has been the oral antiviral agent approved for the treatment (...) of patients with acute herpes zoster,Its effectiveness in lessening the acute signs and symptoms of herpes zoster has been established but the effects on post herpetic neuralgia are less clear cut. Famciclovir is a new member of guanine nucleoside family of drugs. It is a well absorbed oral form of penciclovir with longer half life. This was a open comparative randomized study carried out

2018 Trip Latest and Greatest

28. Varicella Zoster Virus glycoprotein E antigen (Shingrix) - Herpes Zoster

Oral antiviral therapy should be commenced as early as possible, within 72 hours of rash onset. Treatment is usually given for 7 days in the absence of complications of herpes zoster. Antiviral therapies, such as Acyclovir, Famciclovir and Valacyclovir are used in the acute phase of infection with the main aims of reducing and/or stopping viral replication, which is thought to play a role in relieving pain and shortening duration of symptoms. Management of acute pain associated with herpes zoster

2018 European Medicines Agency - EPARs

29. Letermovir (Prevymis) - for prophylaxis of cytomegalovirus (CMV) reactivation and disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT)

to and including 3200mg daily), valaciclovir (at doses up to and including 3000mg daily) and famciclovir (at doses up to and including 1500mg daily). 2 The generalisability of the study may be limited, since the placebo group of PN001 is not reflective of current Scottish practice. Subgroup analyses were consistent with the primary outcome across subgroups defined by risk category for CMV reactivation (i.e. high versus low risk, stem cell source, donor mismatch and haploidentical donor) patient characteristics

2019 Scottish Medicines Consortium

30. Shingles

to another person: Keep fluid-filled blisters and rash covered. Wash hands often. Do not touch or scratch the rash. Avoid use of topical antibiotics and dressings with adhesives as these may cause irritation and delay rash healing. Sterile dressings (wet or dry) may help relieve discomfort in some patients Pharmacologic treatment Systemic antivirals (acyclovir, famciclovir, valacyclovir). Treatment of most benefit for patients at risk for prolonged or severe symptoms, i.e., immunocompromised people (...) , immunocompromised patients initiation of an antiviral imay be considered up to 7 days after onset (these patients must also be referred to a physician). Reduce duration of viral shedding, acute pain, appearance of new lesions, and hasten time to resolution. Most data suggests lesion healing in 5 days with anti-viral treatment vs. 7 days without treatment. Valacyclovir and famciclovir may provide greater pain reduction than acyclovir. Valacyclovir may provide faster resolution of pain than acyclovir (38 days vs

2018 medSask

31. Guidelines for the Management of Genital Herpes in New Zealand

HSV-2 in isolation is uncommon. Oral-genital contact should be avoided when oral lesions are present. GRADE C Antivirals Aciclovir, famciclovir and valaciclovir all suppress symptomatic and asymptomatic shedding, by up to 80–95%. 15 Also, it has been shown that suppressive once-daily valaciclovir results in reduced transmission to the discordant partner. 16 For partners, there was a 48% reduction in acquisition of HSV infection and a 75% reduction in clinical symptomatic genital herpes. Other (...) . Episodic treatment • Valaciclovir 500mg bd for 3/7. • Alternative: oral aciclovir 800mg 3 times daily for 2 days. Prescribe enough tablets for patients to be able to self-initiate treatment at onset of symptoms. Note: Famciclovir is not subsidised or marketed in New Zealand. Suppressive antiviral therapy Suppressive therapy is an oral antiviral taken continuously over a given period of time that effectively reduces the frequency of recurrences. 28,29 GRADE A The main aims of suppressive therapy

2017 New Zealand Sexual Health Society

32. Acyclovir for Mechanically Ventilated Patients With Herpes Simplex Virus Oropharyngeal Reactivation: A Randomized Clinical Trial

, valacyclovir or famciclovir in pacients experien … Show more similar articles Cited by 2 PubMed Central articles H Huang et al. Ann Intensive Care 10 (1), 10. 2020. PMID 31993803. S Hraiech et al. Ann Intensive Care 9 (1), 142. 2019. PMID 31872319. Herpesviridae reactivation is frequent among patients with severe ARDS under veno-venous ECMO and is associated with a longer duration of mechanical ventilation. The dire … Associated data ClinicalTrials.gov/NCT02152358 Actions LinkOut - more resources Full Text

2020 EvidenceUpdates

33. Cold Sore - Guidelines for Prescribing Oral Antivirals

recurrences. Prescription drug option Oral Antivirals Can be prescribed for treatment of recurrent orolabial herpes ocurring in immunocompetent adults (level 1 evidence ). There are no published trials evaluating the use of valacyclovir or famciclovir for orolabial herpes in children <12 years of age. Only acyclovir has an official indication for orolabial herpes in children 2 years of age and older. Treatment should be started within 1 - 2 hours after onset of first symptoms (tingling, itching or burning (...) formed, patients may be issued a prescription to keep on hand to facilitate early initiation of therapy for future episodes. Oral anti-virals indicated for cold sore treatment ACYCLOVIR: 400mg 5 times per day for 5 days (adults); 15mg/kg (max of 200mg per dose) 5 times per day for 5 days VALACYCLOVIR: 2000 mg BID for 2 doses (every 12 hours) FAMCICLOVIR: 750mg BID for 2 doses (every 12 hours) or one dose of 1500 mg Suppressive therapy with acyclovir may also be prescribed if there is a known trigger

2017 medSask

34. Herpes Zoster - Treatment

be demonstrated for the sys- temic application of aciclovir 3–6 and famciclovir 7 when com- pared to placebo. A meta-analysis of four placebo-controlled trials of oral aciclovir could demonstrate statically signi?cant superiority over placebo regarding time to cessation of pain. 8 Results from RCTs suggest superiority of valaciclovir over aci- clovir considering duration and/or severity of ZAP. 9,10 In these studies, no statistically signi?cant differences were seen for the resolution of cutaneous symptoms (...) . No statistically signi?cant differencesregardingpaincessationandresolutionofskinsymp- toms were seen in RCTs comparing famciclovir with aci- clovir, 11,12 brivudin with aciclovir 13 and valaciclovir with famciclovir. 14 One RCT, contrary to the previously mentioned trials, demonstrated superiority of famciclovir when compared to aciclovir regarding cessation of pain. However, this difference only occurred in the 500 mg famciclovir group and was of ques- tionable clinical signi?cance. 15 Another RCT, contrary

2017 European Dermatology Forum

35. Herpes Zoster - Diagnosis

asherpes simplex. BrJ Dermatol 1997;137: 259–261. 28 Tyring S, Barbarash RA, Nahlik JE, et al.Famciclovir for the treatment of acute herpes zoster: effects on acute disease and postherpetic neural- gia. A randomized, double-blind, placebo-controlled trial. Collaborative Famciclovir Herpes Zoster Study Group. Ann Intern Med 1995;123:89– 96. 29 Yamamoto S, Shimomura Y, Kinoshita S,Tano Y. Differentiating zoster- iform herpes simplex from ophthalmic zoster. ArchOphthalmol 1994; 112: 1515–1516. © 2016

2017 European Dermatology Forum

36. CRACKCast E120 – Dermatologic presentations

and are typically transmitted primarily by sexual contact. Secondary HSV generalization (in patients with atopic dermatitis) Secondary bacterial infection Dehydration (gingivostomatitis – in children with HSV1) Cervical carcinoma (HSV 2 associated infections) Death (mucocutaneous herpes infection in immunocompromised patients (including neonates!) can become generalized and then disseminated to internal organs) Recommended treatment for a first clinical episode of genital herpes is with acyclovir, famciclovir (...) Hunt syndrome is felt generally to be more severe than Bell’s palsy attributed to HSV, with increased rates of late neural denervation and a decreased probability of complete recovery (UTD) [24] What is the treatment of herpes zoster? Antiviral medications are indicated, especially within <72 hours of onset of rash, to decrease the duration of symptoms and associated pain. Antiviral therapy may be initiated with acyclovir, famciclovir, or valacyclovir. [Uptodate recommends continuing administration

2017 CandiEM

37. CRACKCast E071 – Ophthalmology Part A

and recognized immediately, herpes zoster of the eye may result in acute necrotizing retinitis and vision loss.” – Rosen’s 7th Ed. Involvement of the nasociliary branch —> Hutchinson’s sign Vesicles on the tip of the nose 75% risk of ocular involvement *** If not recognized leads to acute necrotizing retinitis and vision loss*** Treatment: Antivirals: acyclovir/valacyclovir/famciclovir ideally within 72 hrs Topical steroid agents Topical antibiotics (prevent secondary infection) Analgesia Cool compresses

2017 CandiEM

38. Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes

Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies (...) before adding more. Safety and Efficacy of Famciclovir in HIV1 Positive Adults With Recurrent Genital Herpes The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT01154543 Recruitment Status : Completed First Posted : July 1, 2010 Last Update Posted : March 20, 2013 Sponsor: Holdsworth House Medical

2010 Clinical Trials

39. One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients. (Abstract)

One-day famciclovir vs. placebo in patient-initiated episodic treatment of recurrent genital herpes in immunocompetent Black patients. There are no known racial differences in genital herpes disease pathogenesis or response to therapy. Despite high herpes simplex virus (HSV) seroprevalence in Black persons, clinical trials investigating the treatment of recurrent genital herpes (RGH) have typically enrolled a small proportion of Black patients.This multicenter, double-blind, placebo-controlled (...) study evaluated the efficacy and safety of patient-initiated, 1-day famciclovir 1000 mg twice-daily in immunocompetent Black adults (USA and South Africa) with RGH. Eligible patients were randomized (2:1) to famciclovir or placebo. The primary endpoint was time to healing of non-aborted genital herpes lesions (i.e., lesions that progressed beyond papule stage). Secondary endpoints included proportion of patients with aborted genital herpes lesions, time to resolution of associated symptoms

2010 Current medical research and opinion Controlled trial quality: predicted high

40. Safety and effectiveness of the herpes zoster vaccine to prevent postherpetic neuralgia: 2014 update and consensus statement from the Canadian Pain Society

it be given to individuals who are taking high doses of corticosteroids (>20 mg/day of prednisone) or other immunosuppressive drugs. POSITION 3 Drug treatment (eg, antivirals, corticosteroids) of active shingles has not been shown to decrease the risk of PHN Rationale: Shingles can be treated with antiviral drugs such as acyclovir, famciclovir and valacyclovir. However, these drugs are effective only if given within 72 h of the first signs of the initial pain or rash. Antivirals have been shown

2015 CPG Infobase

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