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Failure to Thrive Causes

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1. Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions. (PubMed)

Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions. Desmoplakin (DSP) and Desmoglein 1 (DSG1) variants result in skin barrier defects leading to erythroderma, palmoplantar keratoderma and variable [AQ4] other features. Some DSG1 variant carriers present with SAM syndrome (Severe dermatitis, multiple Allergies, Metabolic wasting) and a SAM-like phenotype has been reported in 4 subjects with different

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2019 Acta Dermato-Venereologica

2. Cricopharyngeal achalasia associated with laryngomalacia as a cause of failure to thrive. (PubMed)

Cricopharyngeal achalasia associated with laryngomalacia as a cause of failure to thrive. To describe a case of concurrent cricopharyngeal achalasia with laryngomalacia as a cause of failure to thrive, and to review the literature and management options of cricopharyngeal achalasia in the paediatric population.A chart review was performed on a four-month-old male, referred for failure to thrive, and diagnosed with cricopharyngeal achalasia and laryngomalacia. A PubMed and Embase search (...) and resolution of failure to thrive. The literature review revealed no reported case of the combined pathologies as a cause of failure to thrive.Functional endoscopic evaluation of swallowing and videofluoroscopic evaluation of swallowing are complimentary in the evaluation of paediatric patients with failure to thrive and suspected oropharyngeal dysphagia. Both supraglottoplasty and botulinum toxin injection are effective for definitive management in cases of combined pathology, and can be safely performed

2018 Journal of Laryngology & Otology

3. Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death (PubMed)

Homozygous EEF1A2 mutation causes dilated cardiomyopathy, failure to thrive, global developmental delay, epilepsy and early death Eukaryotic elongation factor 1A (EEF1A), is encoded by two distinct isoforms, EEF1A1 and EEF1A2; whereas EEF1A1 is expressed almost ubiquitously, EEF1A2 expression is limited such that it is only detectable in skeletal muscle, heart, brain and spinal cord. Currently, the role of EEF1A2 in normal cardiac development and function is unclear. There have been several (...) reports linking de novo dominant EEF1A2 mutations to neurological issues in humans. We report a pair of siblings carrying a homozygous missense mutation p.P333L in EEF1A2 who exhibited global developmental delay, failure to thrive, dilated cardiomyopathy and epilepsy, ultimately leading to death in early childhood. A third sibling also died of a similar presentation, but DNA was unavailable to confirm the mutation. Functional genomic analysis was performed in S. cerevisiae and zebrafish. In S

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2017 Human molecular genetics

4. Failure to Thrive Causes

Failure to Thrive Causes Failure to Thrive Causes Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Failure to Thrive Causes Failure (...) to Thrive Causes Aka: Failure to Thrive Causes II. Precautions First define if growth is truly abnormal (See ) suggest organic cause III. Causes: Normal Physiologic Half of infants under age 2 shift weight, height by 25% (Short Parents) Most common reason for in children IV. Causes: Nonorganic (80% of cases, no Failure to Thrive Red Flags) Accidental error in formula preparation or Improper feeding technique Misconception about nutrition needs fed infants with insufficient (e.g. poor latching

2018 FP Notebook

5. De Novo Truncating Variants in SON Cause Intellectual Disability, Congenital Malformations, and Failure to Thrive. (PubMed)

De Novo Truncating Variants in SON Cause Intellectual Disability, Congenital Malformations, and Failure to Thrive. SON is a key component of the spliceosomal complex and a critical mediator of constitutive and alternative splicing. Additionally, SON has been shown to influence cell-cycle progression, genomic integrity, and maintenance of pluripotency in stem cell populations. The clear functional relevance of SON in coordinating essential cellular processes and its presence in diverse human

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2016 American Journal of Human Genetics

6. Severe Hiatal Hernia as a Cause of Failure to Thrive Discovered by Transthoracic Echocardiogram (PubMed)

Severe Hiatal Hernia as a Cause of Failure to Thrive Discovered by Transthoracic Echocardiogram A newborn infant with failure to thrive presented for murmur evaluation on day of life three due to a harsh 3/6 murmur. During the evaluation, a retrocardiac fluid filled mass was seen by transthoracic echocardiogram. The infant was also found to have a ventricular septal defect and partial anomalous pulmonary venous return. Eventually, a large hiatal hernia was diagnosed on subsequent imaging

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2016 Case reports in pediatrics

7. PYCR2 mutations cause a lethal syndrome of microcephaly and failure to thrive. (PubMed)

PYCR2 mutations cause a lethal syndrome of microcephaly and failure to thrive. A study was undertaken to characterize the clinical features of the newly described hypomyelinating leukodystrophy type 10 with microcephaly. This is an autosomal recessive disorder mapped to chromosome 1q42.12 due to mutations in the PYCR2 gene, encoding an enzyme involved in proline synthesis in mitochondria.From several international clinics, 11 consanguineous families were identified with PYCR2 mutations by whole (...) exome or targeted sequencing, with detailed clinical and radiological phenotyping. Selective mutations from patients were tested for effect on protein function.The characteristic clinical presentation of patients with PYCR2 mutations included failure to thrive, microcephaly, craniofacial dysmorphism, progressive psychomotor disability, hyperkinetic movements, and axial hypotonia with variable appendicular spasticity. Patients did not survive beyond the first decade of life. Brain magnetic resonance

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2016 Annals of Neurology

8. The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study

The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before (...) adding more. The Heart Failure Readmission Intervention by Variable Early Follow-up (THRIVE) Study (THRIVE) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT03524534 Recruitment Status : Completed First Posted : May 15, 2018 Last Update Posted : January 9, 2019 Sponsor: Kaiser Permanente Collaborator

2018 Clinical Trials

9. Retroperitoneal Mass Masquerading as Failure to Thrive in a 91-year-old Woman (PubMed)

Retroperitoneal Mass Masquerading as Failure to Thrive in a 91-year-old Woman Failure to thrive (FTT) is a state of overall decline. Patients often present with weight loss, poor appetite, malnutrition, and decreased physical functioning. The etiology is multifactorial including chronic diseases, functional impairments, and acute illnesses. Evaluation for reversible causes is paramount, and treatment is aimed at maintaining or improving functional status. We present a case of a 91-year-old (...) woman with a retroperitoneal mass that was found on workup for failure to thrive.

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2017 Cureus

10. Parent-Infant Interaction for Non-Organic Failure to Thrive

is a diagnosis of impaired growth, particularly related to weight gain in young children without any underlying medical cause. It is a complex condition that requires a multidisciplinary approach for evaluation and management. Team members may include physicians, bedside nurses, speech pathologists, occupational therapists, social workers, and nutritionists. The incidence of failure to thrive is between 1-5% of tertiary hospital admissions in children under 1 year of age. It is estimated that up to 10 (...) Parent-Infant Interaction for Non-Organic Failure to Thrive Copyright © 2011 Cincinnati Children's Hospital Medical Center; all rights reserved. Page 1 of 7 Patient Services/Non-Organic Failure to Thrive/Parent-infant Interaction / BESt 099 Best Evidence Statement (BESt) Date: June 28, 2011 Parent-Infant Interaction and Non-Organic Failure to Thrive Topic and/or question as originally asked How do parent-child interactions in the context of feeding support or inhibit child acceptance of oral

2011 Cincinnati Children's Hospital Medical Center

11. Developmental delay and failure to thrive in a 7-month-old baby boy with spontaneous transient Graves’ thyrotoxicosis: a case report (PubMed)

Developmental delay and failure to thrive in a 7-month-old baby boy with spontaneous transient Graves’ thyrotoxicosis: a case report Thyroid dysfunction can induce developmental delay and failure to thrive in infancy. Congenital hypothyroidism is one of the common causes of these symptoms in infancy. By contrast, hyperthyroidism is a rare cause of these symptoms in infancy.A 7-month-old Japanese baby boy was examined for developmental delay and failure to thrive. Blood tests were performed (...) of developmental delay and fail to thrive.

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2016 Journal of medical case reports

12. Investigating Transitional Care to Decrease Post-pancreatectomy 30-Day Hospital Readmissions for Dehydration or Failure to Thrive. (PubMed)

Investigating Transitional Care to Decrease Post-pancreatectomy 30-Day Hospital Readmissions for Dehydration or Failure to Thrive. Current literature emphasizes post-operative complications as a leading cause of post-pancreatectomy readmissions. Transitional care factors associated with potentially preventable conditions such as dehydration and failure to thrive (FTT) may play a significant role in readmission after pancreatectomy and have not been studied.Thirty-one post-pancreatectomy (...) ), the absence of family during the delivery of discharge instructions (P = 0.0098), episodic intermittent nausea at discharge (P = 0.0019), uncertainty about quantity, quality, or frequency of fluid intake (P = 0.0137), and the inability or failure to adhere to the clinician's instructions in the outpatient setting (P = 0.0048).Transitional-care-related factors are found to be associated with post-pancreatectomy readmission for dehydration and FTT. Using these results to identify high-risk patients

2016 Journal of Gastrointestinal Surgery

13. Hematological Indices in Children with Non-organic Failure to Thrive: a Case-Control Study (PubMed)

Hematological Indices in Children with Non-organic Failure to Thrive: a Case-Control Study Non-organic failure to thrive (NFTT) is the most common cause of failure to thrive (FTT) which is attributed to inadequate nutrition due to economic factors or parental neglect . NFTT can lead to a vicious cycle of poor and inadequate eating and severity of anemia. The aim of this study was to determine the hematological indices in children with NFTT.In a cross sectional case control study, iron status

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2016 Iranian journal of pediatric hematology and oncology

14. Failure to Thrive in the Elderly

in the Elderly Failure to Thrive in the Elderly Aka: Failure to Thrive in the Elderly II. Epidemiology: Incidence Community adults: >5% : >25% Hosptalized: >50% III. Pathophysiology: Contributing Factors Physical function decline: Weakness, falls, ADL decline : Weight loss, , decreased immunity Depression Cognitive ( , ) IV. Causes Medications See See Most common medication culprits Psychotropic medications s Recently added medications Consider non-prescription drug use, Missed dose and non-compliance (...) Failure to Thrive in the Elderly Failure to Thrive in the Elderly Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Failure to Thrive

2018 FP Notebook

15. Failure to Thrive in the Elderly

in the Elderly Failure to Thrive in the Elderly Aka: Failure to Thrive in the Elderly From Related Chapters II. Epidemiology: Incidence Community adults: >5% : >25% Hosptalized: >50% III. Pathophysiology: Contributing Factors Physical function decline: Weakness, falls, ADL decline : Weight loss, , decreased immunity Depression Cognitive ( , ) IV. Causes Medications See See Most common medication culprits Psychotropic medications s Recently added medications Consider non-prescription drug use, Missed dose (...) Failure to Thrive in the Elderly Failure to Thrive in the Elderly Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Failure to Thrive

2018 FP Notebook

16. Failure to Thrive

to Thrive , Failure to Thrive in Children , Pediatric Failure to Thrive , Weight Faltering , FTT II. Definition Inadequate weight gain (or Weight Faltering) over time due to inadequate or absorption or excessive caloric expendature III. Epidemiology Hospitalized children <2 years: 1-5% Families with Medical, Psychosocial problems: 10% IV. Causes V. Signs Weight is affected first by Length and affected in severe cases Cognition and failure to meet s may occur in very severe cases VI. Diagnosis: Failure (...) Failure to Thrive Failure to Thrive Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Failure to Thrive Failure to Thrive Aka: Failure

2018 FP Notebook

17. Failure to Thrive Red Flags

Failure to Thrive Red Flags Aka: Failure to Thrive Red Flags II. Indications III. Red Flags Cardiac findings (suggesting. ) Extremity edema See refractory to adequate caloric replacement or Abnormal Recurrent infections (e.g. recurrent respiratory infections, ) Recurrent or with dehydration IV. Interpretation Positive findings suggest organic cause of and warrant diagnostic evaluation Negative findings (no red flags) are reassuring for non-organic cause and empiric caloric management can be instituted (...) Failure to Thrive Red Flags Failure to Thrive Red Flags Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Failure to Thrive Red Flags

2018 FP Notebook

18. Failure to thrive in babies and toddlers (PubMed)

, the most common cause of failure to thrive in children is malnutrition secondary to psychosocial and caregiver factors. 'Picky eating' is common in the local setting and best managed with an authoritative feeding style from caregivers. Other causes are malabsorption and existing congenital or chronic medical conditions. Child neglect or abuse should always be ruled out. Iron deficiency is the most common complication. The family doctor plays a pivotal role in early detection, timely treatment (...) Failure to thrive in babies and toddlers Failure to thrive in a child is defined as 'lack of expected normal physical growth' or 'failure to gain weight'. Diagnosis requires repeated growth measurements over time using local, age-appropriate growth centile charts. Premature babies with appropriate growth velocity and children with 'catch-down' growth, constitutional growth delay or familial short stature show normal growth variants, and usually do not require further evaluation. In Singapore

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2016 Singapore medical journal

19. Idiopathic Pulmonary Hemosiderosis Presenting as Anemia, Failure to Thrive, and Jaundice in a Toddler. (PubMed)

and intravascular causes of hemolysis. Systemic treatment of IPH with glucocorticoids has been shown to decrease morbidity, mortality, and disease progression to pulmonary fibrosis. Thus, diagnostic delays can impact prognosis. Here, we present a case of a 15-month-old boy with IPH who presented with anemia, jaundice, and failure to thrive, as well as a history of hemoptysis that was not initially elicited. (...) Idiopathic Pulmonary Hemosiderosis Presenting as Anemia, Failure to Thrive, and Jaundice in a Toddler. Idiopathic pulmonary hemosiderosis (IPH) is a rare disease characterized by the triad of hemoptysis, pulmonary infiltrates on chest radiograph, and anemia. Its diagnosis should be considered in any child presenting with moderate to severe anemia and failure to thrive of unclear etiology. Consideration of the differential diagnosis in such a child should include the review of both extravascular

2015 Pediatric Emergency Care

20. An Infant with Nasal Regurgitation Since Birth and Failure to Thrive (PubMed)

An Infant with Nasal Regurgitation Since Birth and Failure to Thrive The condition achalasia cardia is rare in paediatric age group, especially in infants. An 11-month-old female infant presented with complaints of oronasal regurgitation since birth and failure to thrive. Upper GI contrast study was conducted which demonstrated massive dilatation of lower 2/3(rd) of oesophagus with abrupt narrowing at lower oesophageal sphincter and positive 'bird beak sign'. On the basis of radiological (...) findings infantile achalasia cardia was diagnosed and patient underwent modified Heller's Oesophagocardiomyotomy with anti reflux procedure. Post operatively the symptoms subsided and weight gain was noted after six month follow up. Although functional infant regurgitation and Gastro-oesophageal reflux (GER) is common in infancy, uncommon causes like achalasia cardia should also be considered as a differential when symptoms are persisting.

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2015 Journal of clinical and diagnostic research : JCDR

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