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Factor IX Deficiency

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161. Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex. Full Text available with Trip Pro

Gla-domainless factor Xa: molecular bait to bypass a blocked tenase complex. Hemophilia is caused by deficiencies in coagulation factor VIII or IX, resulting in direct blockade of the intrinsic tenase complex and indirect blockade of the extrinsic tenase complex which is rapidly inhibited upon binding of factor Xa to tissue factor pathway inhibitor. We evaluated the ability of Gla-domainless factor Xa, a truncated form of factor Xa devoid of procoagulant properties, to bind to tissue factor (...) pathway inhibitor and to alleviate the physiological inhibition of the extrinsic tenase.Using a thrombin generation assay triggered by a low concentration of tissue factor, we evaluated the ability of Gla-domainless factor Xa to restore blood coagulation in plasma from hemophilia A and B patients without and with inhibitors. We then compared its efficacy to generate thrombin to depletion of antithrombin or tissue factor pathway inhibitor by specific antibodies. Finally, we compared the kinetics

2012 Haematologica

162. Coagulation factors in chronic liver disease Full Text available with Trip Pro

Coagulation factors in chronic liver disease Coagulation studies were carried out on 30 patients with chronic liver disease. The clotting defect was complex and involved factors V, VII, IX (Christmas factor), and prothrombin. Some patients showed a significant depression of factor IX in the presence of a normal one-stage prothrombin time. Thrombotest was found to be a good indicator of factor IX deficiency in this group of patients and may be of use as an additional liver function test (...) . The screening of patients with liver disease for surgery or liver biopsy should assess the coagulation factors involved in both intrinsic and extrinsic thromboplastin generation.

1969 Journal of Clinical Pathology

163. Coagulation factor concentrate in the treatment of the haemorrhagic diathesis of fulminant hepatic failure. Full Text available with Trip Pro

patients, fell subsequently, particularly in those given concentrate alone. There was some improvement in the prothrombin ratio in both groups of patients but not complete correction, and serial assays of clotting factors showed that although factor II rose to high levels during treatment, factors IX and X showed little response. Thus, the use of concentrate of factor IX in this trial, as well as potentiating intravascular coagulation, was inadequate as replacement for the clotting factor deficiencies. (...) Coagulation factor concentrate in the treatment of the haemorrhagic diathesis of fulminant hepatic failure. To assess the value of clotting factor concentrate infusions in fulminant hepatic failure, a controlled trial was performed in which nine patients were randomly allocated to treatment with either concentrate alone or concentrate plus heparin. The five patients receiving concentrate alone all died, with major bleeding as the direct cause of death in three, whereas in the four receiving

1974 Gut Controlled trial quality: uncertain

164. Canadian Stroke Best Practice recommendations: rehabilitation, recovery, and community participation following stroke. Part one: rehabilitation and recovery following stroke; 6th edition update 2019

, essential for helping patients to regain lost skills, relearn tasks, and regain independence. Following a stroke, many people typically require rehabilitation for persisting deficits related to hemiparesis, upper-limb dysfunction, pain, impaired balance, swallowing, and vision, neglect, and limitations with mobility, activities of daily living, and communication. This module addresses interventions related to these issues as well as the structure in which they are provided, since rehabilitation can (...) , and communication) and to identify potential discharge needs. Admission to an interprofessional program should be limited to patients who have more than one type of disability and who require the services of two or more rehabilitation dis- ciplines. Three important factors in?uencing the deci- sion to accept a patient for inpatient rehabilitation include pre-morbid cognition, pre-morbid mobility, and pre-morbid communication. 11 Patients with a single disability can usually bene?t from outpatient or community

2020 CPG Infobase

165. 5-Aminolevulinic Acid Hydrochloride (5-ALA)–Guided Surgical Resection of High-Grade Gliomas

and neurological adverse events, with an observed increase in neurological deficits 48 hours after surgery with 5-ALA (GRADE: Very low). The economic literature search identified five studies that met our inclusion criteria because they evaluated the cost- effectiveness of 5-ALA–guided surgical resection as compared with surgery with a standard operating microscope under white light (“white-light microscopy”). Most of these studies found 5-ALA–guided surgical resection was cost-effective compared to white (...) that are malignant, highly invasive, and infiltrative of surrounding brain tissue. Among these, the most common subtypes are glioblastoma multiforme (or glioblastoma, Grade IV), anaplastic astrocytoma (Grade III) and anaplastic oligodendroglioma (Grade III). 1 Glioblastomas are the most common and most aggressive form of the disease, accounting for approximately 57% of all gliomas 1 and 60% to 70% of all high-grade gliomas. 8 Most high-grade gliomas are not linked to any specific risk factor and have no clear

2020 Health Quality Ontario

166. Clinical care of severe acute respiratory infections – Tool kit

, Toronto, Canada); Edgar Bautista (Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico); Satish Bhagwanjee (University of Washington, Seattle, WA, United States of America); Niranjan Bhat (Johns Hopkins University, Baltimore, MD, United States of America); ix Acknowledgements Hillary Cohen (Maimonides Medical Center, Brooklyn, NY, United States of America); Shelly Dev and Gordon Rubenfeld (Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Wes Ely (Vanderbilt

2020 WHO Coronavirus disease (COVID-19) Pandemic

167. Interventions for anxiety in mainstream school-aged children with autism spectrum disorder (ASD) Full Text available with Trip Pro

significant functional impairment. This study tested a modular cognitive behavioral therapy (CBT) program for children with this profile. A standard CBT program was augmented with multiple treatment components designed to accommodate or remediate the social and adaptive skill deficits of children with ASD that could pose barriers to anxiety reduction. Method: Forty children (7‐11 years old) were randomly assigned to 16 sessions of CBT or a 3‐month waitlist (36 completed treatment or waitlist). Therapists

2020 Campbell Collaboration

168. Allogeneic stem cell transplantation in aggressive B-cell non-Hodgkin lymphoma and in T-cell non-Hodgkin lymphoma

studies. To obtain reliable data for future use, all patients with NHL should be registered in a disease- specific registry from the date of diagnosis. Extract of final report N17-02 Version 1.0 Allogeneic stem cell transplantation in aggressive B-NHL and T-NHL 26 March 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - vii - Table of contents Page Key statement iv List of tables ix List of figures x List of abbreviations xi 1 Background 1 2 Research question 4 3 Methods 5 4 Results 8 (...) – Searches in bibliographic databases 71 A.1.1 Search strategies in bibliographic databases for comprehensive information retrieval 71 A.1.2 Search strategies in bibliographic databases for focused information retrieval (fateful course of disease) 74 A.2 – Searches in study registries 75 Extract of final report N17-02 Version 1.0 Allogeneic stem cell transplantation in aggressive B-NHL and T-NHL 26 March 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - ix - List of tables Page Table 1

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

169. Benefit assessment of biotechnologically produced drugs for the treatment of rheumatoid arthritis

necrosis factor Based on the approval of the biologics and the recommendations of EULAR [5], there are 7 subquestions for the present benefit assessment (see Figure 1). Extract of final report A16-70 Version 1.0 Biologics for rheumatoid arthritis 23 July 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - v - Without MTX pre-treatment After MTX failure a After biologic failure Severe, active progressive rheumatoid arthritis? Biologic + MTX Yes Unfavourable prognostic factors? Biologic (...) (IQWiG) - ix - 7 References for English extract 55 Appendix A – Search strategies 119 A.1 – Searches in bibliographic databases 119 A.2 – Searches in study registries 122 Extract of final report A16-70 Version 1.0 Biologics for rheumatoid arthritis 23 July 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - x - List of tables Page Table 1: Overview of the biologics considered in the present benefit assessment for the treatment of rheumatoid arthritis in the respective approved

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

170. Relationship between volume of services and quality of treatment outcome for lung cancer - rapid report

for lung carcinoma 8 October 2019 Institute for Quality and Efficiency in Health Care (IQWiG) - v - Table of contents Page Key statement iii List of tables vii List of figures viii List of abbreviations ix 1 Background 1 2 Research question 5 3 Course of the project 6 4 Methods 7 4.1 Criteria for study inclusion in the investigation 7 4.1.1 Population 7 4.1.2 Volume of services 7 4.1.3 Outcomes 7 4.1.4 Study types 8 4.1.5 Adjustment 8 4.1.6 Study duration 8 4.1.7 Publication period 8 4.1.8 (...) criteria of studies for research questions 1a and 1b 9 Table 2: Overview of inclusion and exclusion criteria of studies for research question 2 10 Table 3: Study pool for research question 1a 16 Table 4: Characteristics of the studies included for research question 1a 17 Table 5: Informative value of results 31 Table 6: Risk factors at the patient level for which an adjustment was performed 35 Table 7: Risk factors at the physician and hospital level for which an adjustment was performed 38 Table 8

2019 Institute for Quality and Efficiency in Healthcare (IQWiG)

171. Effects of bystander programs on the prevention of sexual assault among adolescents and college students: A systematic review Full Text available with Trip Pro

States 2013 Campus SaVE Act requires postsecondary educational institutions participating in Title IX financial aid programs to provide incoming college students with primary prevention and awareness programs addressing sexual violence. The Campus SaVE Act mandates that these programs include a component on bystander intervention. Currently, there is no comparable legislation regarding sexual assault among adolescents (e.g., mandating bystander programs in secondary schools). Findings from (...) area). The strength of the bystander model lies in its emphasis on the role of peers in the prevention of violence. Peers are a salient influence on young people's intimate relationships (Adelman & Kil, ; Giordano, ). In some respects, this influence can be detrimental, as having friends involved in violent intimate relationships (i.e., characterized by sexual or physical violence) is a risk factor for becoming both a perpetrator and victim of violence (Arriaga & Foshee, ; Foshee, Benefield, Ennett

2019 Campbell Collaboration

172. Diagnosis and Treatment of Low Back Pain

of a neurological deficit or leg pain experienced below the knee, among others. Given the exclusion criteria, these guideline rec- ommendations address a subset of low back pain care as opposed to low back pain in its entirety. This clinical guideline is not intended to be a fixed treatment protocol; it is anticipated that there will be patients who require more or less treatment than what is outlined. This clinical guideline should not be construed as including all proper methods of care or excluding other (...) . Gilbert, MD Joseph Gjolaj, MD Matthew Smuck, MD, Stakeholder Representative, American Academy of Physical Medicine and Rehabilitation (AAPM&R)Diagnosis & Treatment of Low Back Pain | Preface Recommendations were developed based on a specific definition, inclusion/exclusion criteria, and the resulting literature which excluded conditions such as presence of a neurological deficit or leg pain experienced below the knee, among others. Given the exclusion criteria, these guideline rec- ommendations

2020 North American Spine Society

173. New Direct-acting Antiviral for Hepatitis C (Epclusa?

. It interferes with vitamin K reductase, inhibiting vitamin K cycle and activation of vitamin K-dependent coagulation factors II (fibrinogen), VII, IX, and X, and works as an anticoagulant. Note2:An enzyme which hydrolyzes ester. There are various kinds of esterase. Hemorrhage could be predicted based on the results of animal tests: The package insert explains that mechanism of onset and risk factors of hemorrhage due to interaction with warfarin are unknown [3,8]. However, at least vitamin K deficiency (...) K, which activates factors II, VII, IX and X, and prolongs PT and skin. It should be noted that there are cases in which bleeding occurred on the day of the treatment (cases 3 and 4) and those in which bleeding occurred and abnormality in coagulation factors was detected several days after the treatment (cases 1 and 2). In the latter, PT and PT-INR were immeasurable and there were increased potential risks of irreversible hemorrhage and death. Xofluza is metabolized by esterase (Note 2

2019 Med Check - The Informed Prescriber

174. Critical Assessment of Diabetes Guidelines

. It interferes with vitamin K reductase, inhibiting vitamin K cycle and activation of vitamin K-dependent coagulation factors II (fibrinogen), VII, IX, and X, and works as an anticoagulant. Note2:An enzyme which hydrolyzes ester. There are various kinds of esterase. Hemorrhage could be predicted based on the results of animal tests: The package insert explains that mechanism of onset and risk factors of hemorrhage due to interaction with warfarin are unknown [3,8]. However, at least vitamin K deficiency (...) K, which activates factors II, VII, IX and X, and prolongs PT and skin. It should be noted that there are cases in which bleeding occurred on the day of the treatment (cases 3 and 4) and those in which bleeding occurred and abnormality in coagulation factors was detected several days after the treatment (cases 1 and 2). In the latter, PT and PT-INR were immeasurable and there were increased potential risks of irreversible hemorrhage and death. Xofluza is metabolized by esterase (Note 2

2019 Med Check - The Informed Prescriber

175. KDOQI Clinical Practice Guidelines for Nutrition in CKD

dietitian nutritionist REE Resting energy expenditure R-NST Renal-Nutrition Screening Tool RRT Renal Replacement Therapy Guideline on Nutrition in CKD Page 7 SBP Systolic blood pressure SGA Subjective Global Assessment SKF Skinfold thickness SR Systematic review TBF Total body fat TG Triglycerides TNF-a Tumor Necrosis Factor alpha TSF Triceps skinfold thickness VPD Vegetable proteindiet VLPD Very low protein diet vs. Versus Guideline on Nutrition in CKD Page 8 WORK GROUP MEMBERSHIP Work Group Co-Chairs (...) the level for the strength of the recommendation, a number of factors besides the quality of evidence are taken into consideration, including patient values and preferences, quality of evidence, benefits and harms, cost/resources to implement the recommendation, acceptability, feasibility, and health equity. In addition to evidence-based recommendations, in certain scenarios “Opinion” statements were developed. These statements were developed when there was not enough evidence or evidence had too low

2020 National Kidney Foundation

176. Public health guidance on prevention and control of blood-borne viruses in prison settings

treatment in prison settings 27 Table 11. Evidence for the effectiveness of interventions to prevent BBVs post-release 29 Table 12. Evidence for the effectiveness of interventions to increase linkage to care post-release 30 Public health guidance on prevention and control of blood-borne viruses in prison settings SCIENTIFIC ADVICE iv Abbreviations AIDS Acquired immune deficiency syndrome ALT Alanine aminotransferase ART Antiretroviral therapy BBV Blood-borne virus CD4 Cluster of differentiation 4 DAAs (...) . transmission of infectious diseases) associated with drug use disorders Jail Locally-operated, short term facilities that hold adults awaiting trial or sentencing or both, and people sentenced mostly to a term of less than one year Mandatory testing Testing which is offered to all eligible individuals, and the person is obliged to be tested Opt-in Testing which is voluntary and offered to all eligible individuals, often on the basis of identified risk factors, and the person chooses whether or not to have

2019 European Centre for Disease Prevention and Control - Public Health Guidance

177. Impact of Community Health Worker Certification on Workforce and Service Delivery for Asthma and Other Selected Chronic Diseases

is a Technical Brief. A Technical Brief is a rapid report, typically on an emerging medical technology, strategy or intervention. It provides an overview of key issues related to the intervention—for example, current indications, relevant patient populations and subgroups of interest, outcomes measured, and contextual factors that may affect decisions regarding the intervention. Although Technical Briefs generally focus on interventions for which there are limited published data and too few completed (...) . Further viii research is needed to determine if certification is linked to improved outcomes for people with asthma and other chronic illness outcomes. ix Contents Introduction 1 Background 1 Guiding Questions 2 Methods 4 Published Literature 4 Grey Literature 5 Discussions With Key Informants 5 Peer Review and Public Commentary 6 Results 7 Results of the Published Literature Search 7 Results of the Grey Literature Search 7 Results of the Key Informant Interviews 8 Guiding Question 1: Effects

2020 Effective Health Care Program (AHRQ)

178. Acute Treatments for Migraine

Migraine Disability Assessment mITT Modified intention-to-treat MQoLQ Migraine Quality of Life Questionnaire LCD Local Coverage Determinations LY Life year n Number of participants N Total number of participants N/A Not applicable ©Institute for Clinical and Economic Review, 2020 Page ix Final Evidence Report- Acute Treatments for Migraine Return to Table of Contents NCD National Coverage Determinations NICE National Institute for Health and Care Excellence NMA Network meta-analysis NR Not reported n.s (...) work productivity, increased disability claims and account for $11-50 billion in total costs. 4-6,7,8,9 The precise cause of migraine is not known and there is no specific test to confirm the diagnosis. 10-12 Migraine often starts in early adulthood, is more common in women, runs in families, and attacks can be triggered by a variety of predisposing factors such as stress and certain stimuli, activities and foods. 2,3,13,14 Treatment broadly includes acute therapies to quickly abort episodic

2020 California Technology Assessment Forum

179. Treatment of Depression in Children and Adolescents

of suicidal ideation or behavior for other SSRIs for adolescents and children with MDD or other DD (7–18 years) (10 RCTs [n = 2,368]; relative risk, 1.14 [95% CI, 0.89 to 1.45]; I 2 , 8%). However, this report excluded data on inpatients and those without depressive disorders, whom the Food and Drug Administration included in finding an increased risk of suicidality for all antidepressants across all indications. ix Conclusions. Efficacious treatments exist for adolescents with MDD. SSRIs may

2020 Effective Health Care Program (AHRQ)

180. Evidence-Based Clinical Guidelines for Multidisciplinary Spine Care: Diagnosis and Treatment of Low Back Pain

literature which excluded conditions such as presence of a neurological deficit or leg pain experienced below the knee, among others. Given the exclusion criteria, these guideline rec- ommendations address a subset of low back pain care as opposed to low back pain in its entirety. This clinical guideline is not intended to be a fixed treatment protocol; it is anticipated that there will be patients who require more or less treatment than what is outlined. This clinical guideline should not be construed (...) Society (SIS) Contributors: Michael P. Dohm, MD Thomas J. Gilbert, MD Joseph Gjolaj, MD Matthew Smuck, MD, Stakeholder Representative, American Academy of Physical Medicine and Rehabilitation (AAPM&R)Diagnosis & Treatment of Low Back Pain | Preface Recommendations were developed based on a specific definition, inclusion/exclusion criteria, and the resulting literature which excluded conditions such as presence of a neurological deficit or leg pain experienced below the knee, among others. Given

2020 American Academy of Pain Medicine

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