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Factor IX Deficiency

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181. Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis

, respectively. 6 National data on HIV incidence among sex workers and their cli- ents are scarce, perhaps in part because sex work is criminalized in Canada; as such, this guideline should be applied to these indi- viduals based on the presence of other risk factors. We adopted a client perspective, as our primary intended audi- ence is clinicians working in primary care, infectious diseases, emergency medicine, nursing, pharmacy and related disciplines. GUIDELINE Canadian guideline on HIV pre-exposure (...) and industrialized country guidelines. The World Health Orga- nization recommends PrEP for any risk group with HIV incidence higher than 3%. 34 More granular recommendations are made for MSM, PWID and heterosexual populations in guidelines from Europe, the United Kingdom, United States and Australia, based on addi- tional risk factors. 35–38 For MSM, most recommend PrEP for those with a previous STI, and previous nPEP is also included by the Interna- tional Antiviral Society–USA guideline. In contrast, no other

2017 CPG Infobase

182. Screen-based activities and children and young people’s mental health and psychosocial wellbeing: a systematic map of reviews

). - Fewer reviews attempted to explore the risk factors (n=6) or consequences (n=11) of screen- based activities by conducting syntheses of longitudinal data. - Even fewer reviews explored CYP’s experience of engagement with screen-based activities by conducting a qualitative evidence synthesis (n=4). Outcomes A wide spectrum of mental health and psychosocial outcomes were investigated across the reviews. These included commonly recognised mental health outcomes such as depression and anxiety (...) , in addition to outcomes such as self-esteem, loneliness, social connectedness and life satisfaction. Population focus Fifty-seven reviews focused solely on CYP populations (i.e. people up to the age of 25 years), while the remaining twenty-five reviews included populations of any age. Overall, there was greater ix emphasis on CYP populations in the context of screen time, gaming, social media, cyberbullying, and sexting compared to internet use and problematic internet use. Size and analysis

2018 EPPI Centre

183. Interventions to improve the labour market outcomes of youth: a systematic review of training, entrepreneurship promotion, employment services and subsidized employment interventions

” and, in this regard, targeting disadvantaged youth may act as a key factor for success. 14 The Campbell Collaboration | www.campbellcollaboration.org There is a need to strengthen the evidence base with more studies of promising programmes, especially in sub-Saharan Africa. Further research should investigate intermediate outcomes and soft skills, and should collect cost data. How up-to-date is this review? The review authors searched for studies published up to January 2015. This Campbell systematic review (...) to assess factors associated with the magnitude of reported effect size estimates. RESULTS The primary and complementary searches identified 32,117 records, of which a total of 1,141 records were selected for full text screening. The subsequent selection process led to a sample of 113 reports, which were considered to be of adequate content and methodological rigour for inclusion in the meta-analysis. The 113 reports represented 107 interventions. The evidence base spanned 31 countries and covered 55

2017 Campbell Collaboration

184. An evaluation protocol for NIHDI conventions

– Overview of the votes related to the proposed interventions 51 Table 14 – Overview of the votes related to the suggested questions to be included in the meta-evaluation protocol 52 Table 15 – Overview of the votes related to the ‘burden of proof’ questions 54 KCE Report 299 An evaluation protocol for NIHDI conventions 5 LIST OF ABBREVIATIONS ABBREVIATION DEFINITION AIDS Acquired Immune Deficiency Syndrome ARS Agence Régionale de Santé (FR) Regional Health Agency AZ Algemeen Ziekenhuis (BE) General (...) with the patient and the patient's family. Individual, patient- specific treatment plans are developed, and delivery of care becomes a shared responsibility 9, 10 . ? Rehabilitation is an active process oriented towards a repertoire of multidisciplinary, goal-oriented and sensible activities, in interaction with personal and environmental factors, to reach and maintain an 12 An evaluation protocol for NIHDI conventions KCE Report 299 optimal level of independence and functioning for people with a functional

2018 Belgian Health Care Knowledge Centre

185. Bruising

disorders are caused by a reduction or inhibition of circulating clotting factors, and may be inherited or acquired. Be aware that a negative family history does not exclude a genetically inherited disorder. Haemophilia A (factor VIII deficiency) and haemophilia B (factor IX deficiency) There are X-linked conditions, affecting 1 in 5000 males and 1 in 30,000 males respectively. The most severe forms occur almost exclusively in males. One third of cases arise secondary to new genetic mutations, where (...) . Liver disease can cause impaired synthesis of clotting factors. Vitamin K deficiency This can result in functional deficiencies of factors II, VII, IX, and X, and proteins C and S, and can cause bleeding in an infant in the first weeks of life, when it is known as Haemorrhagic Disease of the Newborn (HDN). HDN is more prevalent in exclusively breastfed babies, and those with an inadequate or omitted dose of prophylactic vitamin K after birth. Bleeding can vary from bruising or petechiae in the first

2017 Prodigy

186. Antiocoagulation - oral

ischaemia. How do anticoagulants work? Warfarin is a coumarin derivative that acts by inhibiting vitamin K dependent clotting factors (II, VII, IX, X) as well as the anticoagulant proteins C and S [ ]. Warfarin had been used for decades to treat and prevent venous thromboembolism. Apixaban, dabigatran, edoxaban and rivaroxaban are newer anticoagulants with a novel mode of action: Apixaban, edoxaban and rivaroxaban are direct and reversible inhibitors of factor Xa. Inhibition of factor Xa prevents (...) No NICE quality standards were found during the review of this topic. Background information Licensed indications What are the indications for apixaban? Apixaban is licensed for the [ ] : Prevention of stroke and systemic embolism in adults with non-valvular atrial fibrillation (NVAF), with one or more of the following risk factors: Previous stroke or transient ischaemic attack. Age 75 years or more. Hypertension. Diabetes mellitus. Symptomatic heart failure, New York Heart Association (NYHA) Class 2

2017 Prodigy

187. Palliative Care for the Patient with Incurable Cancer or Advanced Disease: Part 3: Grief and Bereavement

grieving, but it is helpful to provide a listening ear, to be supportive, and to provide information. • Distinguish grief from depression and treat grief-related major depression once you are confident it is pathological. • In the case of Prolonged Grief Disorder (complicated grief), assess and take note of any risk factors or concerns. • Primary care providers play a key role in the continued monitoring of patients’ grief responses and may refer the patient to grief counselling and treatment options (...) for hastened death. If present, assess for suicide risk. • Focus on personal strengths and coping mechanisms: what has worked in the past? • Protective factors / resiliency for a patient or caregiver: o Has an internalized belief in his / her own ability to cope effectively. o Perceives the need for AND is willing to access social support. o Is predisposed to a high level of optimism / positive state of mind. o Has spiritual / religious beliefs that assist in coping with the death. All of us grieve

2017 Clinical Practice Guidelines and Protocols in British Columbia

188. Stroke in childhood - clinical guideline for diagnosis, management and rehabilitation

. The most important factor in stroke care in adults is being managed on a stroke unit by staff with specific expertise and interest in the disease. Stroke units have never been tested for childhood stroke and as a result are not even mentioned in these guidelines. Clot busting treatment for ischemic stroke, or clot removal, are becoming mainstays of care in adults, yet there is very little evidence for these treatments in children because research has not been done. These guidelines are the first stage (...) those who have been involved in producing such an important clinical guideline. Professor Anne Greenough Professor of Clinical Respiratory Physiology, King’s College London RCPCH Vice President for Science & Research v Contents Endorsement i Foreword ii Preface iv Acknowledgments vii Funding vii Guideline development group (GDG) vii RCPCH team ix Guideline preparation ix Parent and young people representation x Delphi panellists* x Stakeholders xi Intellectual property xi Acronyms and abbreviations

2017 Royal College of Paediatrics and Child Health

189. Effects of Dietary Sodium and Potassium Intake on Chronic Disease Outcomes and Risks

No. 18-EHC009-EF June 2018ii Key Messages Purpose of Review To synthesize the evidence regarding the effects of dietary sodium reduction and increased potassium intake on blood pressure and risk for cardiovascular diseases (CVD) and renal disease outcomes and related risk factors. Key Messages • Decreasing dietary sodium intake most likely reduces blood pressure in normotensive adults and more so in those with hypertension. • Higher sodium intake may be associated with greater risk for developing (...) Heart and Vascular Center Lebanon, NH Stephen R. Daniels, M.D., Ph.D. Chairman, Department of Pediatrics University of Colorado School of Medicine Pediatrician-in-Chief L. Joseph Butterfield Chair in Pediatrics Children's Hospital Colorado Aurora, CO Bonita Faulkner, M.D., FAHA, FASH Professor Emeritus of Medicine and Pediatrics Thomas Jefferson University Philadelphia, PA Joachim Ix, M.D., M.A.S., FASN Chief, Division of Nephrology Professor of Medicine, UC San Diego La Jolla, CA Jens Marc Titze

2018 Effective Health Care Program (AHRQ)

190. Emicizumab for Hemophilia A with Inhibitors: Effectiveness and Value

WTP Willingness to pay ©Institute for Clinical and Economic Review, 2018 Page ES1 Evidence Report: Emicizumab for Hemophilia A with Inhibitors Return to Table of Contents Executive Summary Background Hemophilia A Hemophilia A is a condition of increased tendency to bleed due to an inherited deficiency of factor VIII, which disrupts the clotting cascade (Figure ES1). Hemophilia A has X-linked recessive inheritance, and so predominantly affects males. It is the most common form of hemophilia (...) to as “emicizumab” in this report) is a monoclonal antibody with dual targets (“bispecific”) that allow it to bridge activated factor IX and factor X, the role normally played by activated factor VIII in the clotting cascade (see Figure 1.1 in main report). 13 Emicizumab was approved by the United States (US) Food and Drug Administration (FDA) on November 16, 2017 as a prophylactic treatment for hemophilia A in patients who have inhibitors to factor VIII. 16 Emicizumab is administered subcutaneously

2018 California Technology Assessment Forum

191. Physiologic Predictors of Severe Injury: Systematic Review

Compromise 49 Respiratory Rate 50 Oxygen Saturation 53 Airway/Ventilatory Support 56 Other Respiratory Measures 57 Key Question 3: Combination Measures 59 Combinations of Physiologic Measures and Glasgow Coma Scale 64 Combinations of Physiologic Measures Without Glasgow Coma Scale 77 Key Questions 1a, 2a, and 3a: Differences Across Age Groups 80 Pediatrics 80 Older Individuals 84 Discussion 90 ix Key Findings 90 Findings in Relationship to What Is Already Known 92 Applicability 92 Limitations (...) support. 5 If steps 1 and 2 do not specify the patient as requiring transport to a major trauma center, steps 3 and 4 consider the mechanism of injury and additional factors such as age and comorbidities. The purpose of this systematic review is to identify and summarize the research evidence evaluating measures of circulatory and respiratory compromise, focusing on measures that can be used in the field to triage trauma patients. This review is designed to help inform decisions about what measures

2018 Effective Health Care Program (AHRQ)

192. Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy

problem and a significant source of morbidity and mortality. Nearly all hospitalized patients have at least 1 risk factor for thromboembolism; approximately 40% have 3 or more risk factors ( ). Consequently, the majority of hospitalized patients are candidates for thromboprophylaxis. The agent, dosing regimen, and duration of thromboprophylaxis are based on identification of risk factors, both individual (eg, age, sex, previous history of thromboembolism) and group-specific (eg, primary reason (...) for hospitalization, surgery, medical illness) ( and ). Depending on the risks of thromboembolism and bleeding, thromboprophylaxis may be achieved with compression stockings, intermittent compression devices, with medications (chemoprophylaxis), or a combination of both. Because an individualized approach to thromboprophylaxis is complex, most recommendations are group specific, with modifications based on the presence/absence of additional risk factors. Guidelines for antithrombotic therapy including appropriate

2018 American Society of Regional Anesthesia and Pain Medicine

193. Cancer Treatment Pathways

and drug schedules (i.e. the interval between doses) in selection of a Pathway regimen. Selecting a Pathway depends upon a number of factors – the type of cancer, the stage of disease, and the biomarkers or specific genetic profile of the cancer. Within each cancer type, separate Pathways are usually available for early stage and advanced cancer, sub-types of cancer (e.g. HER2 positive) and different lines of therapy. Pathways are not available for every medical condition, but are intended (...) to be applicable for individuals with the most common cancer types. Selecting the best cancer treatment depends upon a number of factors – the type of cancer, the stage, the biomarkers or specific genetic profile of the cancer, and unique aspects of each individual’s medical condition. Given the complexity of cancer and all of the unique individual circumstances, it would not be possible to have a Pathway option available for every specific situation. The treating oncologist will determine if, in his/her

2018 AIM Specialty Health

194. Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries

(with no additional breastfeeding support services) may not be effective for increasing breastfeeding initiation rates. • For women enrolled in the WIC Program, peer-support interventions offered by WIC agencies may improve rates of breastfeeding initiation and duration. • Breastfeeding is associated with reduced maternal risk of breast and ovarian cancer, hypertension, and type 2 diabetes. • Workplace, school-based, and community-based interventions and underlying socioeconomic factors need further research.iii (...) , Switzerland Laurie Nommsen-Rivers, Ph.D., R.D., IBCLC University of Cincinnati Cincinnati, OH Leanne Redman, Ph.D. Pennington Biomedical Research Center Baton Rouge, LA ix Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries Structured Abstract Objectives. To summarize the effectiveness of community, workplace, and health care system– based programs and policies aimed at supporting and promoting breastfeeding and determine the association between

2018 Effective Health Care Program (AHRQ)

195. Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications

Procite Reference Manager Save my selection doi: 10.1097/AAP.0000000000000700 CHRONIC AND INTERVENTIONAL PAIN: SPECIAL ARTICLE Free The American Society of Regional Anesthesia and Pain Medicine (ASRA) 2012 survey of meeting attendees showed that existing ASRA anticoagulation guidelines for regional anesthesia were insufficient for their needs. Those surveyed agreed that procedure-specific and patient-specific factors required separate guidelines for pain and spine procedures. In response, a guidelines (...) outcomes. As with any clinical guideline recommendation, these are subject to revision as knowledge of specific complications advances. | DISCUSSION Pain-specific procedural guidelines are important because the technical and anatomical considerations for pain interventions are significantly different than for peripheral regional anesthesia technique. These factors can be divided into procedure-specific factors and patient-specific factors. The spectrum of interventional spine and pain procedures is far

2018 American Society of Regional Anesthesia and Pain Medicine

196. Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks

-EHC009-EF June 2018ii Key Messages Purpose of Review To synthesize the evidence regarding the effects of dietary sodium reduction and increased potassium intake on blood pressure and risk for cardiovascular diseases (CVD) and renal disease outcomes and related risk factors. Key Messages • Decreasing dietary sodium intake most likely reduces blood pressure in normotensive adults and more so in those with hypertension. • Higher sodium intake may be associated with greater risk for developing (...) Heart and Vascular Center Lebanon, NH Stephen R. Daniels, M.D., Ph.D. Chairman, Department of Pediatrics University of Colorado School of Medicine Pediatrician-in-Chief L. Joseph Butterfield Chair in Pediatrics Children's Hospital Colorado Aurora, CO Bonita Faulkner, M.D., FAHA, FASH Professor Emeritus of Medicine and Pediatrics Thomas Jefferson University Philadelphia, PA Joachim Ix, M.D., M.A.S., FASN Chief, Division of Nephrology Professor of Medicine, UC San Diego La Jolla, CA Jens Marc Titze

2018 Effective Health Care Program (AHRQ)

197. A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology

. Ocular Infections IV. Soft Tissue Infections of the Head and Neck V. Upper Respiratory Tract Bacterial and Fungal Infections VI. Lower Respiratory Tract Infections VII. Infections of the Gastrointestinal Tract VIII. Intra-abdominal Infections IX. Bone and Joint Infections X. Urinary Tract Infections XI. Genital Infections XII. Skin and Soft Tissue Infections XIII. Arthropod-Borne Infections XIV. Viral Syndromes XV. Blood and Tissue Parasite Infections Contents Introduction and Executive Summary I (...) . Bloodstream Infections and Infections of the Cardiovascular System II. Central Nervous System Infections III. Ocular Infections IV. Soft Tissue Infections of the Head and Neck V. Upper Respiratory Tract Bacterial and Fungal Infections VI. Lower Respiratory Tract Infections VII. Infections of the Gastrointestinal Tract VIII. Intra-abdominal Infections IX. Bone and Joint Infections X. Urinary Tract Infections XI. Genital Infections XII. Skin and Soft Tissue Infections XIII. Arthropod-Borne Infections XIV

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2018 Infectious Diseases Society of America

198. Guideline for the management of knee and hip osteoarthritis

tomography DALYs disability-adjusted life-years DHA docosahexaenoic acid DMOADs disease-modifying osteoarthritis drugs DMSO dimethylsulfoxide EMA European Medicines Agency EPA eicosapentaenoic acid ESR erythrocyte sedimentation rate FGF fibroblast growth factor GP general practitioner GRADE Grading of Recommendations Assessment, Development and Evaluation HANDI Handbook of non-drug interventions HOOS Hip Disability and Osteoarthritis Outcome Score ICTRP International Clinical Trials Registry Platform (...) IgG2 immunoglobulin G2 IL-1 interleukin-1 IPDAS International Patient Decision Aids Standards KOOS Knee Injury and Osteoarthritis Outcome Score MBS Medicare Benefits Schedule MD mean difference MRI magnetic resonance imaging MSC mesenchymal stem cell MSM methylsulfonylmethane NATSIHS National Aboriginal and Torres Strait Islander Health Survey NGF nerve growth factor NHMRC National Health and Medical Research Council NICE National Institute for Health and Care Excellence NPRS Numeric Pain Rating

2018 Clinical Practice Guidelines Portal

199. Improving Quality of Life: Substance Use and Aging

physical or mental health, we are quick to assume it’s the result of “getting older” and might not consider the possibility of substance use as a contributing factor. To find a path forward that recognizes the needs of this growing population and responds effectively, we need to set our assumptions aside and look to the evidence. We need to build a more thorough understanding of what’s happening to people during this stage of life and why they might be more susceptible to experiencing harms associated (...) (SUD) or experiencing harmful interactions between prescription and non-prescription medications. This chapter presents evidence on the prevalence of and contributing factors behind some of the psychiatric disorders that commonly co-occur with SUDs, including schizophrenia, mood and anxiety disorders, post-traumatic stress disorder, and Alzheimer’s and Parkinson’s diseases. It also looks at how SUDs (and their lack of treatment) can worsen physical health issues such as coronary heart disease

2018 Canadian Centre on Substance Abuse

200. European Society of Endocrinology Clinical Practice Guidelines for the management of aggressive pituitary tumours and carcinomas

at presentation to identify secretory tumours that may indicate specific therapies or endocrine deficiencies, which if left untreated would contribute to patient morbidity. Assessment of pituitary endocrine function should be performed, at appropriate intervals (3–6 months on an individualised basis), both to characterise potential biomarkers of disease progression to monitor in parallel with imaging studies, and to manage endocrine deficiencies. R 2.1.4 In patients with aggressive pituitary tumours (...) -67 proliferative index evaluation. The p53 immunodetection and the mitotic count should be evaluated at least, when the Ki-67 index is ≥3% (+000). Reasoning Based on immunohistochemistry (IHC), pituitary tumours are classified into somatotroph (GH, Pit 1 positive), lactotroph (PRL, Pit1 and ER positive), corticotroph (ACTH, Tpit positive), thyrotroph (TSH, Pit1 positive), gonadotroph (FSH/LH, SF1 positive), null cell (negative for hormones and transcription factors) tumours and plurihormonal

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2018 European Society of Endocrinology

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