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101. Salivary Gland Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

102. Pleuropulmonary Blastoma, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

103. Pancreatic Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

104. Oral Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

105. Bladder Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

106. Squamous Cell Carcinoma (Skin Cancer), Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

107. Adrenocortical Carcinoma, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

108. Ovarian Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

109. Psychosocial and Environmental Pregnancy Risks (Treatment)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

110. Psychosocial and Environmental Pregnancy Risks (Overview)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

111. Psychosocial and Environmental Pregnancy Risks (Follow-up)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

112. Psychosocial and Environmental Pregnancy Risks (Diagnosis)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

114. Ezogabine (Potiga)

spontaneously and one after a fall at a “rest home”. Following a craniotomy for the second subdural hematoma the patient remained poorly responsive (Glasgow coma scale 3-4 non sedated) and a decision was made to withdrawal ventilator support. The record indicates ezogabine was among the discharge medications to the “rest home”. Death #2- Study VRX-RET-E22-303 (subject 15201): A 33 year old Hispanic male was treated with ezogabine for approximately 4 years at the time of death. The patient apparently had (...) frequency) 6 (0.4) 7 (0.5) 6 (0.4)b Dizziness 5 (0.4) 5 (0.4) 6 (0.4) Chest pain 5 (0.4) 5 (0.4) 5 (0.4) Grand mal convulsion 5 (0.4) 6 (0.4) 8 (0.6) Somnolence 4 (0.3) 4 (0.3) 4 (0.3) Headache 4 (0.3) 4 (0.3) 4 (0.3) Conversion disorder 4 (0.3) 4 (0.3) 4 (0.3) Pneumonia 4 (0.3) 5 (0.4) 5 (0.4) Urinary retention 4 (0.3) 4 (0.3) 4 (0.3) Hyponatremia 4 (0.3) 5 (0.4) 5 (0.4) Pregnancy 4 (0.3) 4 (0.3) 2 (0.1)c Coma 3 (0.2) 3 (0.2) 3 (0.2) Reference ID: 2957637Clinical Review Steven T. Dinsmore NDA 22345

2011 FDA - Drug Approval Package

115. Guidelines for the management of aneurysmal subarachnoid hemorrhage

by early treatment of the ruptured aneurysm, the risk of rebleeding is not increased by the ventriculostomy. 148 Numerous systems have been reported for grading the clinical outcome in patients with SAH from a ruptured intracranial aneurysm, but the current literature remains substantially deficient with respect to intraobserver and in- terobserver uniformity or consistency. 9,149–151 Recent reports have tended to use the Glasgow Coma Scale or Glasgow Outcome Scale. 149,150,152–178 It should be noted (...) that the Glasgow Coma Scale was designed to predict outcome after head injury and has not been fully assessed in outcome after SAH. In addition, patients who have no grossly evident neurological deficits after SAH frequently have subtle cog- nitive or neurobehavioral difficulties that impair their social adjustment and ability to return to their previous occupa- tions. 179–183 At least 1 study has suggested that these neu- robehavioral deficits are not correlated with tissue loss as seen on recent MRI 184

2009 American Academy of Neurology

116. Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. (PubMed)

performance category (CPC), and modified Rankin scale (mRS). We compared characteristics and outcomes to a control cohort matched on TH and 72 h FOUR score ± 1.Of 588 patients, 8 received methylphenidate, 6 received amantadine, and 2 both. Most were female suffering OHCA with median age 61 years. All received TH and a multi-modal neurological evaluation. Initial exam revealed median GCS 6 and FOUR 7, which was unchanged at 72 h. Six patients (38%) followed commands prior to discharge at median 2.5 days (...) Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. Despite critical-care packages including therapeutic hypothermia (TH), neurologic injury is common after cardiac arrest (CA) resuscitation. Methylphenidate and amantadine have treated coma in traumatically-brain-injured patients with mixed success, but have not been explored in post-arrest patients.Compare the outcome of comatose post-arrest patients treated with neurostimulants

2013 Resuscitation

117. The Vermont Oxford Neonatal Encephalopathy Registry: rationale, methods, and initial results. (PubMed)

(stupor, coma) during the first 72 hours of life, a 5 minute Apgar score of ≤ 3, or receiving HT. Infants with central nervous system birth defects were excluded.From 2006-2010, 95 centers registered 4232 infants. Of those, 59% suffered a seizure, 50% had a 5 minute Apgar score of ≤ 3, 38% received HT, and 18% had stupor/coma documented on neurologic exam. Some infants experienced more than one eligibility criterion. Only 53% had a cord gas obtained and only 63% had a blood gas obtained within 24 (...) hours of birth, important components for determining HT eligibility. Sixty-four percent received ventilator support, 65% received anticonvulsants, 66% had a head MRI, 23% had a cranial CT, 67% had a full channel encephalogram (EEG) and 33% amplitude integrated EEG. Of all infants, 87% survived.The VON NER describes the heterogeneous population of infants with NE, the subset that received HT, their patterns of care, and outcomes. The optimal routine care of infants with neonatal encephalopathy

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2012 BMC Pediatrics

118. Buprenorphine Transdermal System (Butrans)

of the cases were consistent with allergic contact dermatitis. The applicant also identified four articles describing a total of nine case reports of allergic contact dermatitis, confirmed by patch testing. Of the 1335 cases, 183 cases contained latency information. Approximately 45% of the cases with latency data had skin reactions within the first 10 days and 36% within the first day. However, 55% of patch site reactions occurred after 10 days and approximately 24% occurred after 100 days (...) electronic ECG data was to have been transmitted to for cardiologist interpretation. A copy of these and all subsequent ECGs were to have been saved in the subject’s file • Blood, urine and pregnancy testing If and when subjects met all eligibility criteria (with exception of the daily pain scores), the Investigator or site staff were to have immediately contacted the subjects by telephone and instructed them to discontinue all analgesic medications and other medications used for chronic pain. Subjects

2010 FDA - Drug Approval Package

119. Concussion

are associated with . It is not unusual for symptoms to last up to four weeks. Common causes include , , and . Risk factors include drinking . The mechanism may involve either a direct blow to the head or forces elsewhere on the body that are transmitted to the head. This is believed to result in dysfunction, as there is increased requirements but insufficient supply. Diagnosis requires less than 30 minutes of loss of consciousness, memory loss of less than 24 hours and a score of 13 to 15. Otherwise (...) –48 hours. A brain CT or brain MRI should be avoided unless there are progressive neurological symptoms, focal neurological findings or concern of skull fracture on exam. Diagnosis of MTBI is based on physical and neurological examination findings, duration of unconsciousness (usually less than 30 minutes) and post-traumatic amnesia (PTA; usually less than 24 hours), and the (MTBI sufferers have scores of 13 to 15). exist to measure cognitive function and the international consensus meeting

2012 Wikipedia

120. Phase IIb Study of MP4OX in Traumatic Hemorrhagic Shock Patients

to dosing (≤ 2.2 mmol/L) Patients with evidence of severe traumatic brain injury as defined by ANY one of the following: Known non-survivable head injury or open brain injury; Glasgow Coma Score (GCS) = 3, 4 or 5; Known AIS (head region) ≥ 4 shown by an appropriate imaging methodology; Contemplated CNS surgery; or Abnormal physical exam indicative of severe CNS or any spinal cord injury above T5 level Cardiac arrest prior to randomization Age below the legal age for consenting Estimated time from injury (...) alone is not sufficient to achieve resuscitation, and that the effects of MP4OX are additional to those of blood. Additional support comes from a recently completed phase IIa trauma study in 51 patients with lactic acidosis due to severe hemorrhage. MP4OX treatment was associated with a more rapid and sustained reduction of high lactate levels, and a greater proportion of MP4OX-treated patients who normalized lactate by four hours after dosing. There was also a trend toward shorter median hospital

2010 Clinical Trials

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