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81. Vaginal Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

82. Unknown Primary, Childhood Carcinoma of

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

83. Heart Tumors, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

84. Bronchial Tumors, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

85. Carcinoid Tumors, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

86. Breast Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

87. Unusual Cancers of Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

88. Thyroid Tumors, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

89. Thymoma and Thymic Carcinoma, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

90. Testicular Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

91. Salivary Gland Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

92. Pleuropulmonary Blastoma, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

93. Pancreatic Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

94. Oral Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

95. Bladder Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

96. Squamous Cell Carcinoma (Skin Cancer), Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

97. Adrenocortical Carcinoma, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

98. Ovarian Cancer, Childhood

with nasopharyngeal carcinoma present with advanced disease (stage III/IV or T3/T4).[ , ] Population-based studies have reported that patients younger than 20 years had a higher incidence of advanced-stage disease than did adult patients.[ , ] However, less than 10% of children and adolescents with nasopharyngeal carcinoma presented with distant metastases at diagnosis.[ - ] Prognosis The overall survival of children and adolescents with nasopharyngeal carcinoma has improved over the last four decades; with state (...) cytokeratin expression.[ ] Sixty-six samples of olfactory neuroblastoma and tumor samples from other cancers, including alveolar rhabdomyosarcoma and sinonasal adenocarcinoma, were obtained from nine medical centers and analyzed by genome-wide DNA methylation profiling, copy number analysis, immunohistochemistry, and next-generation panel sequencing. Unsupervised hierarchal clustering analysis of DNA methylation data identified the following four distinct clusters:[ ] The largest cluster, which comprised

2012 PDQ - NCI's Comprehensive Cancer Database

99. Psychosocial and Environmental Pregnancy Risks (Treatment)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

100. Psychosocial and Environmental Pregnancy Risks (Overview)

for pulsed Doppler, color flow, first trimester ultrasonography with a long transvesical path (>5 cm), second or third trimester exams when bone is in the focal zone, when scanning tissue with minimal perfusion (ie, embryonic), or in patients who are febrile. Operators can minimize risk by limiting dwell time, limiting exposure to critical structures, and following equipment-generated exposure information. Current equipment approved for use typically includes monitoring for application-specific intensity (...) is 20-25 mcg/mL, levels as low as 10 mcg/mL in maternal or cord blood are associated with transient cognitive defects in children. One article assessed the neurocognitive status of 6-month-old infants whose mothers were exposed to low but varying amounts of lead during pregnancy. Lead levels in cord blood were then compared to performance on infant intelligence and visual recognition tests. Infants scored lower if the lead concentration in blood was higher. [ ] Studies have also reported

2014 eMedicine.com

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