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Eyelid Swelling

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125. Baricitinib (Olumiant) - rheumatoid arthritis

reduced significantly the magnitude of the swelling by 48%, suggesting that baricitinib is able to inhibit delayed type hypersensitivity cellular responses which may contribute to the overall efficacy observed in the rodent models which reflect certain aspects of rheumatoid arthritis. In the murine collagen-induced arthritis (CIA) model, oral baricitinib =3 mg/kg bid showed efficacy which may be dependent on the impact of both T and B cell function by modulating the signalling of cytokines involved (...) in the adaptive immune response. In a murine anti-collagen antibody induced arthritis model, baricitinib at 10 mg/kg bid improved clinical and histological signs without inhibiting the generation of autoantibodies and without a detectable reduction in peripheral leukocyte or erythroid cellular components. In a rat adjuvant arthritis (rAIA) model, baricitinib (IV, 1 – 6 mg/kg/day for 2 weeks) reduced inflammation 50 – 100% as measured by redness and swelling of the paws, and histological comparison. Plasma

2017 European Medicines Agency - EPARs

127. Mycophenolate plus methylprednisolone versus methylprednisolone alone in active, moderate-to-severe Graves' orbitopathy (MINGO): a randomised, observer-masked, multicentre trial. (PubMed)

day for 24 weeks). The prespecified primary endpoints were rate of response (reduction of at least two parameters of a composite ophthalmic index [eyelid swelling, clinical activity score, proptosis, lid width, diplopia, and eye muscle motility] without deterioration in any other parameter) at 12 weeks and rate of relapse (a worsening of symptoms that occurred after a response) at 24 and 36 weeks. Rates of response at week 24 and sustained response at week 36 were added as post-hoc outcomes

2018 The lancet. Diabetes & endocrinology

128. Aerosolized Fibrin Sealant Is Effective for Postoperative Edema and Ecchymosis in Open Rhinoplasty Without Osteotomy. (PubMed)

of 2 groups: those treated with aerosolized FS (FS group) and those not treated (control group). The effect of FS on edema of the eyelid, edema of the dorsum and tip of the nose, and periorbital ecchymosis was separately rated postoperatively using a scale of 0 to 4 or 0 to 3. Postoperative pain was evaluated using questionnaires quantified with a visual analog scale. The Mann-Whitney U and Wilcoxon tests were used to compare parameters between the groups.A total of 41 patients were included (...) in this study. The FS group (n = 20) consisted of 13 male and 7 female patients with a mean age of 34.8 ± 5.8 years. The control group (n = 21) consisted of 15 male and 6 female patients with a mean age of 32.4 ± 4.8 years. There were no statistically significant differences between the 2 groups with respect to age, gender, or combined surgical techniques (P > .05). Aerosolized FS significantly reduced not only ecchymosis and swelling in the periorbital area but also edema of the nasal dorsum (P < .05

2018 Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

129. Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy. (PubMed)

delivery, with suspected Graves' orbitopathy. She has had bronchial asthma and recurrent skin rashes of unknown aetiology for the last 10 years and was treated for dacryoadenitis with steroid containing eye drops 5 years ago. During pregnancy she developed eyelid swelling. After delivery, eyelid redness and retrobulbar pain evolved. Proptosis was demonstrated by Hertel's exophthalmometry. Orbital magnetic resonance imaging showed enlarged lateral and superior rectus muscles in both orbits. Thyroid

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2018 BMC Ophthalmology

130. A case report of lupus erythematosus tumidus converted from discoid lupus erythematosus. (PubMed)

, including prominent swelling of the eyelids, a few erythematous, edematous plaques on the left forehead, face, and neck, and 2 hairless macules. The histopathologic findings reveal liquefaction degeneration of the basal cells, perivascular, and periadnexal infiltration of lymphocytes, and interstitial mucin deposition in the superficial, and deep dermis.A diagnosis of LET was made on clinical and histological features.The patient started treatment with prednisolone (1 mg/kg. d), combined

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2018 Medicine

131. Adult-Onset Orbital Sinus Pericranii with T2 Hyperintensity Lesion: A Case Report (PubMed)

Adult-Onset Orbital Sinus Pericranii with T2 Hyperintensity Lesion: A Case Report Sinus pericranii is a rare vascular anomaly, and most cases occur in children and develop at the midline. In previous reports of sinus pericranii, T2 hyperintensity lesion has not been regarded as a common sequela. We report an extremely rare case of orbital sinus pericranii with associated T2 hyperintensity lesion. A 50-year-old man was admitted to our hospital with a history of right upper eyelid swelling (...) in patients with a soft compressible swelling on the head, even if the lesion is located off the midline.

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2018 Case reports in neurology

132. Calvarial Tuberculosis in a Preschool-Aged Child: An uncommon entity (PubMed)

Calvarial Tuberculosis in a Preschool-Aged Child: An uncommon entity Calvarial tuberculosis is a rare manifestation of tuberculosis, especially in children under five years of age. We report a two-and-a-half-year-old male child who presented to the Nilratan Sircar Medical College, Kolkata, India, in 2015 with frontoparietal fluctuant swelling of three months' duration. He had also had chronic sinus discharge from the left lower eyelid over the previous six months. Computed tomography (...) of the head revealed a frontal swelling along with erosion of both the outer and inner plates of the left frontal bone. Fine needle aspiration of the pus indicated the presence of acid-fast bacilli. Unfortunately, no primary focus of tuberculosis could be established. The patient improved after one year of antitubercular therapy without requiring any surgical intervention and with no sign of subsequent disease recurrence.

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2018 Sultan Qaboos University medical journal

133. Intraorbital hemorrhage following a secondary intervention at integrated zygomatic implants: A case report (PubMed)

with proptosis and diffuse swelling of the eyelids. Emergency surgery was performed to drain the intraorbital hemorrhage. The patient healed uneventfully without loss of visual acuity.Scarce prior reports describe trauma to the orbit during zygomatic implant surgery, mostly involving orbital penetration during zygoma implant placement. To our knowledge, the present case report is the first to describe an intraorbital hemorrhage that led to an orbital compression syndrome necessitating emergency surgery.In

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2018 International journal of surgery case reports

134. Bilateral orbital isolated (solitary) neurofibroma in the absence of neurofibromatosis – A case report (PubMed)

of neurofibromatosis who presented with right upper eyelid swelling. Radiological studies revealed bilateral identical masses in the superior orbits. The patient underwent surgical excision of the lesion on the right side and it was proved to be neurofibroma. She did not have a recurrence with a follow up period of 2 years but developed sensory deficit. This is the fifth reported case of bilateral isolated neurofibroma. (...) Bilateral orbital isolated (solitary) neurofibroma in the absence of neurofibromatosis – A case report Isolated neurofibroma is a slowly progressive tumor rarely found in the orbit accounting for less than 1% of the space occupying lesions of the orbit. It usually presents in the 2nd to 5th decades of life with proptosis, swelling, visual changes, ptosis, diplopia or pain. Almost all cases reported are unilateral. We report a 23-year-old female with no systemic features or family history

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2018 Saudi Journal of Ophthalmology

135. Orbital solitary fibrous tumor: a clinicopathologic study from a Chinese tertiary hospital with a literature review (PubMed)

, and immunohistochemical features as well as the management and disease outcomes of patients with orbital SFT was conducted along with a review of orbital SFT cases in the literature.This study includes two male and two female patients, with an average age of 53 years. Common presentations among these patients included a palpable subcutaneous mass, swelling of the eyelid, proptosis, diplopia, and vision disturbance. Three patients (cases 2-4) underwent imaging scans. All patients had complete surgical excisions

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2018 Cancer management and research

136. Spontaneous subconjunctival abscess in congenital lamellar ichthyosis (PubMed)

Spontaneous subconjunctival abscess in congenital lamellar ichthyosis Congenital lamellar ichthyosis is an autosomal recessive, heterogeneous disorder presenting at birth with generalized skin involvement. The most common ophthalmic manifestation noted is bilateral ectropion of the lower eyelids. A 1-month-old female neonate, the second born of a nonconsanguineous marriage, presented with 4 days' history of redness, discharge, and swelling in the right eye. There was severe right upper eyelid (...) ectropion, conjunctival injection, chemosis, a subconjunctival mass on the temporal bulbar conjunctiva spontaneously draining pus and corneal haze. The anterior chamber, iris, lens and fundus appeared normal. Congenital lamellar ichthyosis was suspected because of scaling and excessive dryness of the entire body. The occurrence of a spontaneous subconjunctival abscess is not known in lamellar ichthyosis. We thus report the management of a rare case of unilateral upper eyelid ectropion, subconjunctival

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2018 Indian journal of ophthalmology

137. Delayed formation of sterile abscess after zygomaticomaxillary complex fracture treatment with bioabsorbable plates (PubMed)

Delayed formation of sterile abscess after zygomaticomaxillary complex fracture treatment with bioabsorbable plates We present a patient who showed a sterile abscess after facial bone fixation with bioabsorbable plates and screws. He had zygomaticomaxillary complex and periorbital fracture due to falling down. The displaced bones were treated by open reduction and internal fixation successfully using bioabsorbable plate system. However, at postoperative 11 months, abrupt painless swelling (...) was noted on the previous operation sites, left lateral eyebrow and lower eyelid. By surgical exploration, pus-like discharge and degraded materials were observed and debrided. The pathologic analysis revealed foreign body reaction with sterile abscess. This complication followed by bioabsorbable device implantation on maxillofacial bone surgery has been rarely reported in which we call attention to the maxillofacial plastic surgeons.

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2018 Archives of Craniofacial Surgery

138. Diagnosis of Acquired Punctal Stenosis Using Anterior Segment Optical Coherence Tomography

: (B)Examination: External examination: should be done to rule out causes of watering other than punctal stenosis (facial palsy, lacrimal pump failure, swelling in lacrimal sac area and regurge test) Slit lamp examination: for tear meniscus, lid margin, conjunctiva and punctual orifice Fluorescein dye disappearance test: performed with a drop of 2% fluorescein in lower conjunctival sac, patient is instructed not to wipe the eyes. After 5 minutes, presence of staining in the tear film is assessed (...) , Layout table for eligibility information Ages Eligible for Study: 40 Years to 60 Years (Adult) Sexes Eligible for Study: All Accepts Healthy Volunteers: Yes Sampling Method: Probability Sample Study Population Adults with acquired punctal stenosis Criteria Inclusion Criteria: Patients with acquired punctal stenosis Exclusion Criteria: Punctal agenesis Congenital punctal stenosis Allergic occlusion Lid malposition Canalicular, nasolacrimal, sac and duct obstruction Previous eyelid or lacrimal drainage

2018 Clinical Trials

139. Arnica Montana and Bromelain in Rhinoplasty

to reduce swelling, inflammation, and pain and may help to reduce wound healing time. Outcome Measures Go to Primary Outcome Measures : Ecchymosis extent 7 days post rhinoplasty [ Time Frame: 7 days ] Blinded facial plastic surgeons will review 4 photographs of participants (1frontal, 2 oblique, and 1 nasal base view) and using the photo analysis scale by Totonchi and Guyuron assign each participant an average score based on the extent of the ecchymosis from 0-5 where 0= no ecchymosis, 1= up to medial (...) one third of the lower and or upper eyelid, 2=medial half of the upper and or lower eyelid, 3=entire upper and lower eyelid, 4= entire lower and upper eyelid and or conjunctive, 5= extension of ecchymosis below the molar bone. Lower scores are more favorable. Ecchymosis extent 14 days post rhinoplasty [ Time Frame: 14 days ] Blinded facial plastic surgeons will review 4 photographs of participants (1frontal, 2 oblique, and 1 nasal base view) and using the photo analysis scale by Totonchi

2018 Clinical Trials

140. Adapting LFI for Melioidosis

glands involvement such as tender swelling over medial aspect of the lower eyelid of the lacrimal glands; submandibular glands, parotic glands Bedside scan with splenic or liver hypoechoic lesion (less than 2cm in diameter) Pneumonia not responding to 48 hours of first line antibiotics One or more joint pain with swelling Purplish vesicle or bullae mainly over the lower limbs, may resulting in ulcer after rupture Deep seated abscess or brain abscess or genitourinary abscess or osteomyelitis Severe

2018 Clinical Trials

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