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Exercise in the Elderly

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61. Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice Full Text available with Trip Pro

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by the Fe2+, and 2-oxoglutarate-dependent, 10-11 translocation methylcytosine dioxygenases (TET1, TET2, and TET3). Recent evidence suggests that, in addition to being an intermediate in active demethylation, 5hmC may also (...) have an epigenetic role. 5hmC is enriched in the adult brain, where it has been implicated in regulating neurogenesis. The rate of adult neurogenesis decreases with age, however physical exercise has been shown to counteract this deficit. Here, we investigated the impact of voluntary exercise on the age-related changes of TET1, TET2, expression and 5hmC content in the hippocampus and hypothalamus. For this purpose, we used voluntary exercise in young adult (3 months) and aged (18 months) mice

2018 Frontiers in Cell and Developmental Biology

62. Post-Exercise Appetite and Ad Libitum Energy Intake in Response to High-Intensity Interval Training versus Moderate- or Vigorous-Intensity Continuous Training among Physically Inactive Middle-Aged Adults Full Text available with Trip Pro

Post-Exercise Appetite and Ad Libitum Energy Intake in Response to High-Intensity Interval Training versus Moderate- or Vigorous-Intensity Continuous Training among Physically Inactive Middle-Aged Adults High-intensity interval training (HIIT) is considered a time-efficient exercise strategy for weight management. However, data regarding the acute appetite and energy intake responses to HIIT versus continuous training remain inconclusive. This study investigated the ad libitum energy intake (...) and appetite responses to a single session of HIIT versus moderate-intensity continuous training (MICT) and vigorous-intensity continuous training (VICT). Using a randomized crossover design, 11 middle-aged physically inactive men (45.7 ± 7.4 years, 23.5 ± 2.1 kg m-2) participated in three treadmill trials at 7-day intervals. HIIT comprised 10 1-min periods at 100% VO2max interspersed with 1-min periods of active recovery. MICT comprised a 40-min session at 65% VO2max, while VICT comprised a 20-min session

2018 Nutrients Controlled trial quality: uncertain

63. Aging Hallmarks: The Benefits of Physical Exercise Full Text available with Trip Pro

Aging Hallmarks: The Benefits of Physical Exercise World population has been continuously increasing and progressively aging. Aging is characterized by a complex and intraindividual process associated with nine major cellular and molecular hallmarks, namely, genomic instability, telomere attrition, epigenetic alterations, a loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication (...) . This review exposes the positive antiaging impact of physical exercise at the cellular level, highlighting its specific role in attenuating the aging effects of each hallmark. Exercise should be seen as a polypill, which improves the health-related quality of life and functional capabilities while mitigating physiological changes and comorbidities associated with aging. To achieve a framework of effective physical exercise interventions on aging, further research on its benefits and the most effective

2018 Frontiers in endocrinology

64. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging Full Text available with Trip Pro

both in the adulthood and in aging, since capable to promote fitness. Regular exercise alleviates the negative effects caused by free radicals and offers many health benefits, including reduced risk of all-cause mortality, sarcopenia in the skeletal muscle, chronic disease, and premature death in elderly people. However, physical performance is also known to induce oxidative stress, inflammation, and muscle fatigue. Many efforts have been carried out to identify micronutrients and natural compounds (...) Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging Physical exercise is considered to be one of the beneficial factors of a proper lifestyle and is nowadays seen as an indispensable element for good health, able to lower the risk of disorders of the cardiovascular, endocrine and osteomuscular apparatus, immune system diseases and the onset of potential neoplasms. A moderate and programmed physical exercise has often been reported to be therapeutic

2018 Oncotarget

65. Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases Full Text available with Trip Pro

Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases Skeletal muscle is a dynamic tissue with remarkable plasticity and its growth and regeneration are highly organized, with the activation of specific transcription factors, proliferative pathways and cytokines. The decline of skeletal muscle tissue with age, is one of the most important causes of functional loss of independence in older adults. Maintaining skeletal muscle function throughout (...) of different physical exercise training modalities in the skeletal muscle miRNA profile, their regulation under pathological conditions and the role of miRNAs in age-related muscle wasting. Specific miRNAs appear to be involved in response to different types of exercise and therefore to play an important role in muscle fiber identity and myofiber gene expression in adults and elder population. Understanding the roles and regulation of skeletal muscle miRNAs during muscle regeneration may result in new

2018 Oncotarget

66. Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT 1, SIRT3 and VEGF in the Substantia Nigra. Full Text available with Trip Pro

Physical Exercise Improves Aging-Related Changes in Angiotensin, IGF-1, SIRT 1, SIRT3 and VEGF in the Substantia Nigra. Dysregulation of tissue renin-angiotensin system (RAS) is involved in oxidative and inflammatory processes observed in major aging-related diseases, including neurodegenerative diseases such as Parkinson's disease (PD). Physical exercise has beneficial effects against aging-related changes, dopaminergic neuron vulnerability, and PD progression. The present study indicates (...) as an increase in expression of the protective Ang 1-7/Mas axis and inhibition of the Ang II/AT1 axis. The exercise-induced increase in IGF-1 and sirtuins may mediate the effects of exercise on the nigral RAS. However, exercise may induce the increase in VEGF and modulation of RAS activity by different pathways. Exercise, via RAS, contributes to inhibition of the pro-oxidative and proinflammatory state that increase dopaminergic neuron vulnerability and risk of PD with aging.

2018 Biological Sciences and Medical Sciences

67. Effects of age and sex on epigenetic modification induced by an acute physical exercise: Retraction Full Text available with Trip Pro

Effects of age and sex on epigenetic modification induced by an acute physical exercise: Retraction 29505027 2019 01 03 1536-5964 97 3 2018 01 Medicine Medicine (Baltimore) Effects of age and sex on epigenetic modification induced by an acute physical exercise: Retraction. e9706 10.1097/MD.0000000000009706 eng Journal Article Retraction of Publication United States Medicine (Baltimore) 2985248R 0025-7974 Medicine (Baltimore). 2017 Nov;96(44):e8325 29095264 2018 3 6 6 0 2018 3 6 6 0 2018 3 6 6 1

2018 Medicine

68. The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions

and physical fitness. Condition or disease Intervention/treatment Phase Physical Activity Age-related Cognitive Decline Behavioral: Aerobic Exercise Behavioral: Watching television Not Applicable Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Estimated Enrollment : 120 participants Allocation: Randomized Intervention Model: Single Group Assignment Masking: None (Open Label) Primary Purpose: Treatment Official Title: The Effect of Age, Physical Fitness (...) The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions The Effect of Age, Physical Fitness and a Single Bout of Aerobic Exercise on Motor and Cognitive Functions - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100

2018 Clinical Trials

69. Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression Full Text available with Trip Pro

with a host of age-related conditions, and is predictive of lifespan. Employing these clocks to measure epigenetic age in vitro, we interrogated the relationship between epigenetic ageing and telomerase activity. Although hTERT did not induce any perceptible change to the rate of epigenetic ageing, hTERT-expressing cells, which bypassed senescence, continued to age epigenetically. Employment of hTERT mutants revealed that neither telomere synthesis nor immortalisation is necessary for the continued (...) increase in epigenetic age by these cells. Instead, the extension of their lifespan is sufficient to support continued epigenetic ageing of the cell. These characteristics, observed in cells from numerous donors and cell types, reveal epigenetic ageing to be distinct from replicative senescence. Hence, while re-activation of hTERT may stave off physical manifestation of ageing through avoidance of replicative senescence, it would have little impact on epigenetic ageing which continues in spite

2018 Aging (Albany NY)

70. Home-based interactive e-health educational intervention for middle-aged adults to improve total exercise, adherence rate, exercise efficacy, and outcome: a randomised controlled trial. (Abstract)

Home-based interactive e-health educational intervention for middle-aged adults to improve total exercise, adherence rate, exercise efficacy, and outcome: a randomised controlled trial. 29938656 2018 12 11 2018 12 11 1024-2708 24 Suppl 2 1 2018 02 Hong Kong medical journal = Xianggang yi xue za zhi Hong Kong Med J Home-based interactive e-health educational intervention for middle-aged adults to improve total exercise, adherence rate, exercise efficacy, and outcome: a randomised controlled (...) Kong Med J 9512509 1024-2708 IM Adult Coronary Disease psychology rehabilitation Exercise Female Health Status Hong Kong Humans Male Middle Aged Patient Compliance statistics & numerical data Patient Education as Topic methods Prospective Studies Telemedicine 2018 6 26 6 0 2018 6 26 6 0 2018 12 12 6 0 ppublish 29938656

2018 Hong Kong medical journal = Xianggang yi xue za zhi Controlled trial quality: predicted high

71. Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years. Full Text available with Trip Pro

Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years. Child and adolescent overweight and obesity has increased globally, and can be associated with significant short- and long-term health consequences. This is an update of a Cochrane review published first in 2003, and updated previously in 2009. However, the update has now been split into six reviews addressing different childhood obesity treatments at different (...) ages.To assess the effects of diet, physical activity and behavioural interventions (behaviour-changing interventions) for the treatment of overweight or obese children aged 6 to 11 years.We searched CENTRAL, MEDLINE, Embase, PsycINFO, CINAHL, LILACS as well as trial registers ClinicalTrials.gov and ICTRP Search Portal. We checked references of studies and systematic reviews. We did not apply any language restrictions. The date of the last search was July 2016 for all databases.We selected randomised

2017 Cochrane

72. Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years. Full Text available with Trip Pro

Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years. Adolescent overweight and obesity has increased globally, and can be associated with short- and long-term health consequences. Modifying known dietary and behavioural risk factors through behaviour changing interventions (BCI) may help to reduce childhood overweight and obesity. This is an update of a review published in 2009.To assess the effects of diet, physical (...) , physical activity and behavioural interventions for treating overweight or obesity in adolescents aged 12 to 17 years.Two review authors independently assessed risk of bias, evaluated the overall quality of the evidence using the GRADE instrument and extracted data following the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions. We contacted trial authors for additional information.We included 44 completed RCTs (4781 participants) and 50 ongoing studies. The number

2017 Cochrane

73. Obesity prevention and beyond..highlights from the Faculty of Sports and Exercise Medicine Annual Scientific Conference 2017 “Exercise Medicine and Physical Activity for Health”

if we could increase physical activity levels by 25%, 1.3 million deaths would be avoided worldwide due to a direct reduction in conditions such as T2DM, cardiac disease, breast and colon cancer. Simply sit less, move more, the more the better! These are just a snippet of highlights from the entire conference. There were numerous other intriguing talks on a wide variety of topics including Exercise Medicine, Exercise and Population Health, Exercise in Rehabilitation and Treatment and Sports (...) Obesity prevention and beyond..highlights from the Faculty of Sports and Exercise Medicine Annual Scientific Conference 2017 “Exercise Medicine and Physical Activity for Health” Obesity prevention and beyond..highlights from the Faculty of Sports and Exercise Medicine Annual Scientific Conference 2017 “Exercise Medicine and Physical Activity for Health” | BJSM blog - social media's leading SEM voice by By Dr Ronan Brady and Dr Ronan Kearney This years Irish FSEM 14 th annual scientific

2017 British Journal of Sports Medicine Blog

74. Age is just a number: Views among people aged 50 and over in the English Longitudinal Study of Ageing

and discriminatory practices. Ageism is real: it is manifest in the way older people are portrayed in the media and it plays out with people not getting jobs because they’re perceived to be too old. Ageism even has serious health consequences, including lowered levels of self-efficacy and physical function as well as cardiovascular stress and memory loss (Levy, 1996). Data presented recently at the launch of Wave 8 of the English Longitudinal Study of Ageing (ELSA) showed that perceived age discrimination (...) that it has been very or mainly positive and just 7% very or mainly negative. This varies by marital status: 47% of single people and 53% of divorced people have found growing older very or mainly positive compared with 66% of married people. Also indicative of a broadly positive outlook is the fact that more than half (52%) of people aged 50+ say that growing old doesn’t bother them and nearly half of respondents (49%) say they are more tolerant as they age. About four-fifths (81%) of respondents do

2018 The Centre for Ageing Better

75. Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI)

Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI) Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI) - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100 (...) ). Please remove one or more studies before adding more. Physical Fitness, Exercise Self-efficacy, Physical Activity Level in People With Spinal Cord Injury (SCI) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before participating. Read our for details. ClinicalTrials.gov Identifier: NCT03420170

2018 Clinical Trials

76. Exercise training increases skeletal muscle strength independent of hypertrophy in older adults aged 75 years and older. (Abstract)

-intervention testing visits (young-old n = 73, old-old n = 63). Older adults in exercise groups were subjected to a series of programmed elastic band and free exercises twice per week at three to five sets of 15-20 repetitions. Body composition, skeletal muscle mass, knee strength (extensors and flexors) and gait-related physical function were evaluated as main variables.As expected, muscular mass and knee strength (both extensors and flexors) were inversely correlated with age in the old-old group (all P (...) Exercise training increases skeletal muscle strength independent of hypertrophy in older adults aged 75 years and older. We investigated whether exercise-mediated acquisition of muscle mass and strength would occur in a concurrent manner in older adults.A total of 152 community-dwelling older adults (young-old aged 65-74 years, old-old aged >75 years) were allocated into either 8-week comprehensive exercise training or the control group. Participants (n = 136) completed all pre- and post

2019 Geriatrics & gerontology international

77. Does prescribing an exercise program which meets physical activity guidelines for people with stroke, improve mobility and physical activity levels of stroke survivors compared to usual care or compared to exercise programs which do not meet these guideli

Does prescribing an exercise program which meets physical activity guidelines for people with stroke, improve mobility and physical activity levels of stroke survivors compared to usual care or compared to exercise programs which do not meet these guideli Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. CRD bears no responsibility or liability for the content (...) ruler software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac

2018 PROSPERO

78. Measuring ageing: An introduction to the Ageing Better Measures Framework

The ABMF is a non-exhaustive compendium of 63 measures, survey scales and their associated data sources looking at outcomes at the individual level related to ageing and later life. It is split into 12 broad topics: Finance Health and wellbeing Social connections Major life transitions Plans for the future Recreation and leisure Fulfilling work Community contributions Relationships Physical and mental health activity Home and neighbourhood Care and support services5 © Centre for Ageing Better 2019 How (...) Better 2019 Local monitoring and evaluation We are also making use of the ABMF at a local level. We are working with the Greater Manchester Combined Authority, Leeds City Council and Leeds Older People’s Forum, supporting them, as well as other members of the UK Network of Age-Friendly Communities, in their use of data and measures to understand local experiences of ageing and monitor progress. We look forward to continuing to work with these and other partners interested in measuring what matters

2020 The Centre for Ageing Better

79. Long term effects of manual lymphatic drainage and active exercises on physical morbidities, lymphoscintigraphy parameters and lymphedema formation in patients operated due to breast cancer: A clinical trial. Full Text available with Trip Pro

Long term effects of manual lymphatic drainage and active exercises on physical morbidities, lymphoscintigraphy parameters and lymphedema formation in patients operated due to breast cancer: A clinical trial. evaluate whether manual lymphatic drainage (MLD) or active exercise (AE) is associated with shoulder range of motion (ROM), wound complication and changes in the lymphatic parameters after breast cancer (BC) surgery and whether these parameters have an association with lymphedema formation (...) marker uptake before or after surgery predicted lymphedema formation in the long run (>2 years). None of the lymphoscintigraphy parameters were shown to be associated with the study group. Age ≤39 years was the factor with the greatest association with lymphedema (p = 0.009). In women with age ≤39 years, BMI >24Kg/m2 was significantly associated with lymphedema (p = 0.017). In women over 39 years old, women treated with MLD were at a significantly higher risk of developing lymphedema (p = 0.011

2018 PLoS ONE

80. Exercise electrocardiogram in middle-aged and older leisure time sportsmen: 100 exercise tests would be enough to identify one silent myocardial ischemia at risk for cardiac event. (Abstract)

and potentially preventable cardiac events.This prospective cohort study included leisure time asymptomatic sportsmen over 35years old, referred from 2011 to 2014 in the Sports Medicine Unit of the University Hospital of Saint-Etienne.Of the cohort of 1500 sportsmen (1205 men; mean age 50.7±9.4years; physical activity level 32.8±26.8MET-h/week), 951 (63%) had at least one cardiovascular disease (CVD) risk factor. Family history, medical examination and standard resting 12-lead were collected. A total of 163 (...) Exercise electrocardiogram in middle-aged and older leisure time sportsmen: 100 exercise tests would be enough to identify one silent myocardial ischemia at risk for cardiac event. The importance of exercise electrocardiogram (ECG) has been controversial in the prevention of cardiac events among sportsmen. The aim of this study was to determine the frequency of silent myocardial ischemia (SMI) from an exercise ECG and its relationship with induced coronary angiographic assessment

2018 International journal of cardiology

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