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Exercise in the Elderly

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6981. Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly. (Full text)

Exercise training enhances in vivo tuberculosis purified protein derivative response in the elderly. We investigated the effect of 25 wk of exercise training on in vivo immune measures that depend on T helper 1 (Th1) and T helper 2 (Th2) immune responses in the elderly as a substudy of a randomized controlled trial to investigate health benefits of regular exercise training for the elderly. Sixty-five healthy elderly volunteers were randomly assigned to either an exercise training group (n = 32 (...) . Repeated-measures ANOVA revealed a significant interaction between time and exercise intervention, which appeared as an enhanced skin reaction to tuberculin PPD (P < 0.05) and a reduced serum IgG4 concentration, the production of which depends on Th2-dependent class switching (P < 0.05), in the exercise group after 25 wk. No immune variables changed in the control group. These result supports the hypothesis that exercise training favors in vivo Th1 immune response in elderly persons.

2008 Journal of applied physiology (Bethesda, Md. : 1985) Controlled trial quality: uncertain PubMed abstract

6982. Developing a qigong intervention and an exercise therapy for elderly patients with chronic neck pain and the study protocol. (Abstract)

Developing a qigong intervention and an exercise therapy for elderly patients with chronic neck pain and the study protocol. In the so far published trials on qigong and exercise therapies, the methods and especially the interventions applied are rarely described in detail. Therefore, we report on the development of the interventions, the study design and protocols of a randomised controlled multi-centre trial.The aim of the study was to develop a qigong intervention and an exercise therapy (...) for elderly patients and to evaluate whether qigong is more effective than (1) no treatment or (2) the exercise therapy. DEVELOPMENT OF THE INTERVENTIONS: In a consensus process with qigong experts and physiotherapists special interventions for elderly patients were developed allowing most exercises to be performed in a sitting position. Both interventions will be held by qualified therapists for a period of 3 months twice per week for 45 min. In addition, patients will be encouraged to exercise

2008 Forschende Komplementärmedizin (2006)

6983. Effect of Water-Exercise on Balance Function of Healthy Elderly Individuals

Effect of Water-Exercise on Balance Function of Healthy Elderly Individuals Effect of Water-Exercise on Balance Function of Healthy Elderly Individuals - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Water-Exercise on Balance Function of Healthy Elderly Individuals (EWEB) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00708136 Recruitment Status : Completed First Posted : July 2, 2008 Last Update Posted : July 2, 2008 Sponsor: Soroka University Medical Center Information provided by: Soroka

2008 Clinical Trials

6984. Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly

Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly Effect of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Effect (...) of Weight Loss and Exercise on Liver and Muscle Fat in Obese Elderly The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our for details. ClinicalTrials.gov Identifier: NCT00779207 Recruitment Status : Completed First Posted : October 24, 2008 Last Update Posted : October 24, 2008 Sponsor: Washington University School of Medicine Information provided

2008 Clinical Trials

6985. Exercise and Testosterone Therapy in Elderly Men With Physical Frailty

Exercise and Testosterone Therapy in Elderly Men With Physical Frailty Exercise and Testosterone Therapy in Elderly Men With Physical Frailty - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Exercise (...) + supervised exercise training for six months. Study Design Go to Layout table for study information Study Type : Interventional (Clinical Trial) Actual Enrollment : 25 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: Exercise and Testosterone Therapy in Elderly Men With Physical Frailty Study Start Date : November 2004 Actual Primary Completion Date

2006 Clinical Trials

6986. Randomized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japanese women. (Abstract)

Randomized controlled trial of exercise intervention for the prevention of falls in community-dwelling elderly Japanese women. Falls are common in elderly people. Possible consequences include serious injuries and the post-fall syndrome, with functional decline and limitation of physical activity. The present randomized controlled study sought to clarify the benefits of a combined long-term and home-based fall prevention program for elderly Japanese women. The subjects were individuals aged (...) over 73 years, living at home in a western suburb of Tokyo, who had attended a comprehensive geriatric health check. Persons with a marked decline in the basic activities of daily living (ADL), hemiplegia, or those missing baseline data were excluded. Fifty-two subjects who expressed a wish to participate in the trial were randomized, 28 to an exercise-intervention group and 24 to a control group. Baseline data for age, handgrip force, walking speed, total serum cholesterol, serum albumin, basic

2004 Journal of bone and mineral metabolism Controlled trial quality: uncertain

6987. A specific arm-interval exercise program could improve the health status and walking ability of elderly patients after total hip arthroplasty: a pilot study. (Abstract)

A specific arm-interval exercise program could improve the health status and walking ability of elderly patients after total hip arthroplasty: a pilot study. To investigate the influence of an arm-interval exercise program for the upper limbs on health status and walking ability in elderly patients after total hip arthroplasty.A randomized controlled investigation. After surgery, a control group started a general rehabilitation program, and a training group combined it with an arm-interval (...) exercise program.Fourteen patients (age 75.1 +/- 4.8 years) were randomly assigned to the control group (n = 7) and the training group (n = 7).A Western Ontario and MacMaster University (WOMAC) Osteoarthritis Index was completed and an incremental exercise test on an arm crank ergometer was also performed 1 month before (T(-1)) and 2 months after surgery (T2). Moreover, a 6-minute walk test was performed at T2.Both groups significantly improved all dimensions of WOMAC, except in WOMAC physical function

2004 Journal of rehabilitation medicine : official journal of the UEMS European Board of Physical and Rehabilitation Medicine Controlled trial quality: uncertain

6988. The effects of multidimensional home-based exercise on functional performance in elderly people. (Abstract)

The effects of multidimensional home-based exercise on functional performance in elderly people. This study tested the hypothesis that a home-based exercise program would improve functional performance in elderly people.We conducted a 6-month, single-blinded, randomized controlled trial. 72 community dwelling men and women (aged >/=70 years) with self-reported and laboratory-based functional impairment were recruited for the study. Participants were randomly assigned to either a home-based (...) no differences between groups in the change in strength, gait speed, or cardiovascular endurance.Minimally supervised exercise is safe and can improve functional performance in elderly individuals. The improvements in functional performance occurred along with improvements in balance but without a significant change in muscle strength or endurance.

2004 The journals of gerontology. Series A, Biological sciences and medical sciences Controlled trial quality: uncertain

6989. The effect of a 5-week wobble-board exercise intervention on ability to discriminate different degrees of ankle inversion, barefoot and wearing shoes: a study in healthy elderly. (Abstract)

The effect of a 5-week wobble-board exercise intervention on ability to discriminate different degrees of ankle inversion, barefoot and wearing shoes: a study in healthy elderly. There is some evidence of an improvement in falls risk in the elderly after completing a wobble-board training program. This study examined the effects of wobble-board training on ability to discriminate between different extents of ankle inversion movements in a group of older subjects, tested wearing shoes

2004 Journal of the American Geriatrics Society Controlled trial quality: uncertain

6990. Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. (Abstract)

Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. Intermittent hypoxia has been suggested to increase exercise tolerance by enhancing stress resistance and improving oxygen delivery. Because the improvement of exercise tolerance reduces mortality in the elderly with and without coronary artery disease intermittent hypoxia might be a valuable preventive and therapeutic tool. However, controlled studies are lacking.Sixteen males (50-70 (...) of perceived exertion were diminished after intermittent hypoxia compared to control conditions (all p < 0.05). Changes in responses to exercise after intermittent hypoxia were similar in subjects with and without prior myocardial infarction.Three weeks of passive short-term intermittent hypoxic exposures increased aerobic capacity and exercise tolerance in elderly men with and without coronary artery disease.Copyright 2003 Elsevier Ireland Ltd.

2004 International journal of cardiology Controlled trial quality: uncertain

6991. Balance disorders in the elderly and the benefit of balance exercise. (Abstract)

Balance disorders in the elderly and the benefit of balance exercise. Symptoms of balance disorders including 'unsteadiness', 'dizziness and vertigo' are common in the elderly and commonly found in general practice in medicine. There are many causes of balance disorders and vary from one person to another. Disorder of the internal ear or vestibular end-organ type is one cause. Unsteadiness of somato-sensory or proprioception is common in the elderly so is degenerative disorder of central (...) control in brain. The elderly are prone to many chronic illnesses or disorders which are causes of balance disorder or give rise to more rapid degeneration of the central nervous system i.e. high blood pressure, diabetes mellitus, heart disease, proprioception and joint problems, arthritis and muscular weakness due to lack of good health and exercise. The objectives of this research study were to find the etiologies of balance disorders and how Balance Exercises and the 'National Health Service' can

2004 Journal of the Medical Association of Thailand = Chotmaihet thangphaet Controlled trial quality: uncertain

6992. An exercise program to improve fall-related outcomes in elderly nursing home residents. (Abstract)

An exercise program to improve fall-related outcomes in elderly nursing home residents. This study tested a 3-month ankle-strengthening and walking program designed to improve or maintain the fall-related outcomes of balance, ankle strength, walking speed, risk of falling, fear of falling, and confidence to perform daily activities without falling (falls efficacy) in elderly nursing home residents. Nursing home residents (N = 81) between the ages of 64 and 100 years participated in the study (...) . Two of the fall-related outcomes, balance and fear of falling, were maintained or improved for the exercise group in comparison to the control group.

2004 Applied nursing research : ANR Controlled trial quality: uncertain

6993. New intervention program for preventing falls among frail elderly people: the effects of perturbed walking exercise using a bilateral separated treadmill. (Abstract)

New intervention program for preventing falls among frail elderly people: the effects of perturbed walking exercise using a bilateral separated treadmill. To determine the effects of a perturbed walking exercise using a bilateral separated treadmill in physically disabled elderly.Participants of the study were 32 long-term care facility residents and outpatients aged 66-98 yrs. Participants were randomly assigned to a usual exercise group or to a treadmill exercise group. Perturbed gait (...) were seen in time to first fall.Gait training with unexpected perturbation seems to have a beneficial impact on physical function in disabled elderly individuals. The results suggest that this program may be used as an exercise intervention to reduce falls in institutional settings.

2004 American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Controlled trial quality: uncertain

6994. The effects of GH replacement therapy on cardiac morphology and function, exercise capacity and serum lipids in elderly patients with GH deficiency. (Full text)

The effects of GH replacement therapy on cardiac morphology and function, exercise capacity and serum lipids in elderly patients with GH deficiency. To assess effects of GH replacement therapy on cardiac structure and function, exercise capacity as well as serum lipids in elderly patients with GH deficiency (GHD).Thirty-one patients (six females, 25 males), aged 60-79 years (mean 68 years) with GHD on stable cortisone and thyroxine substitution were studied. All men with gonadotropin deficiency (...) had testosterone and one woman had oestrogen replacement. They were randomized in a double-blind manner to GH or placebo treatment for 6 months, followed by another 12 months GH (Humatrope, Eli Lilly & Co, Uppsala, Sweden). GH dose was 0.017 mg/kg/week for 1 month and then 0.033 mg/kg/week divided into daily subcutaneous injections at bedtime. Echocardiography, exercise capacity tests and serum lipid measurements were performed at 0, 6, 12 and 18 months.During the 6-month placebo-controlled period

2004 Clinical endocrinology Controlled trial quality: uncertain PubMed abstract

6995. Moderate regular exercise increases basal production of nitric oxide in elderly women. (Abstract)

Moderate regular exercise increases basal production of nitric oxide in elderly women. Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and is thought to have antiatherosclerotic properties. Therefore, it has also been proposed that NO may be useful to regulate vascular tonus and prevent progression of atherosclerosis. On the other hand, NO activity reduces with aging. We previously reported that the plasma nitrite/nitrate (NOx: the stable end (...) product of NO) concentration was significantly increased by intense aerobic exercise training in healthy young humans. We hypothesized that lifestyle modification (e.g., even mild regular exercise training) can increase NO production in previously sedentary older humans. We measured the plasma NOx concentration before and after a mild aerobic exercise training regimen (cycling on a leg ergometer at 80% ventilatory threshold for 30 min, 5 days/week) for 3 months in elderly women. In addition, we

2004 Hypertension research : official journal of the Japanese Society of Hypertension Controlled trial quality: uncertain

6996. Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. (Abstract)

Effect of impact exercise on bone mineral density in elderly women with low BMD: a population-based randomized controlled 30-month intervention. Evidence of the effect of exercise on bone loss comes mainly from studies in voluntary postmenopausal women, and no population-based, long-term interventions have been performed. The purpose of this population-based, randomized, controlled trial was to determine the effect of long-term impact exercise on bone mass at various skeletal sites in elderly (...) in both groups at the radius and calcaneum. In multivariate analysis, weight gain was associated with increased BMD and BMC at all femur sites both in the exercise group and in the pooled groups. In conclusion, impact exercise had no effect on BMD, while there was a positive effect on BMC at the trochanter. Exercise may prevent fall-related fractures in elderly women with low bone mass.

2006 Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Controlled trial quality: predicted high

6997. Can elderly patients who have had a hip fracture perform moderate- to high-intensity exercise at home? (Abstract)

Can elderly patients who have had a hip fracture perform moderate- to high-intensity exercise at home? The majority of patients after a hip fracture do not return to prefracture functional status. Depression has been shown to affect recovery. Although exercise can reduce impairments, access issues limit elderly people from participating in facility-based programs. The primary purpose of this study was to determine the effects and feasibility of a home exercise program of moderate- or high (...) -intensity exercise. A secondary purpose was to explore the relationship of depression and physical recovery.Thirty-three elderly people (24 women, 9 men; mean = 78.6 years of age, SD = 6.8, range = 64-89) who had completed a regimen of physical therapy following hip fracture participated in the study. Subjects were randomly assigned to a resistance training group, an aerobic training group, or a control group.Subjects were tested before and upon completion of the exercise trial. Isometric lower

2005 Physical therapy Controlled trial quality: uncertain

6998. Balance, mobility, and falls among community-dwelling elderly persons: effects of a rehabilitation exercise program. (Abstract)

Balance, mobility, and falls among community-dwelling elderly persons: effects of a rehabilitation exercise program. To assess the short-term effect of an exercise-based rehabilitation intervention on balance, mobility, falls and injuries.This randomized, controlled trial with repeated measures was performed at an outpatient rehabilitation center. Elderly, ambulatory, community-dwelling volunteers underwent 6 wks of supervised stretching, balance, endurance, coordination, and strengthening (...) exercises. Controls attended seminars. Data were recorded for time and quality performance on a functional obstacle course and for self-reported falls and injuries.From baseline through 6-mo follow-up, participants in the exercise group (n = 122) significantly outperformed those in the control group (n = 83). The exercise group's functional obstacle course quality improved 2.3% postintervention and 1.57% at follow-up compared with 0.3% for the control group for each time period (P = 0.001). Functional

2005 American journal of physical medicine & rehabilitation / Association of Academic Physiatrists Controlled trial quality: uncertain

6999. Changes in pulmonary function response to a 10-week controlled exercise program in sedentary elderly adults. (Abstract)

Changes in pulmonary function response to a 10-week controlled exercise program in sedentary elderly adults. This randomized clinical trial was aimed to assess whether pulmonary function would change in sedentary elderly people after a controlled exercise program. 45 participants over 75 yr. of age (M age 83.7 +/- 3.0) were assigned randomly to a control and two aerobic exercise groups of moderate and high intensity. In 10 wk. the program sessions were 40 min. in duration 3 days per week (...) . Forced vital capacity (FVC) and forced expiratory volume in 1 sec. (FEV1.0) were measured pre- and post-intervention. After the training, the Moderate intensity group experienced significant mean change in FVC. In the High intensity group, significant changes were observed in both FVC and FEV1.0, but no change was noted for the Control group. The 10-wk. aerobic training of moderate or high intensity showed positive effects on pulmonary function in these elderly individuals. These exercise-induced

2005 Perceptual and motor skills Controlled trial quality: uncertain

7000. Effect of exercise on extraskeletal risk factors for hip fractures in elderly women with low BMD: a population-based randomized controlled trial. (Full text)

Effect of exercise on extraskeletal risk factors for hip fractures in elderly women with low BMD: a population-based randomized controlled trial. We conducted a 30-month population-based, randomized, controlled trial in 160 elderly women at risk for fractures on the basis of a low baseline BMD. Mainly home-based weight-bearing exercise was effective in improving strength, balance, and gait.Evidence on the effect of exercise on extraskeletal risk factors for hip fractures comes mainly from (...) studies in voluntary low-risk women, and no population-based, long-term interventions have been performed in elderly women with low bone mass. The aim of this study was to determine the effect of long-term weight-bearing exercise on balance, muscle strength, and gait in elderly women at risk for fractures on the basis of a low baseline BMD.A birth cohort of 1690 women 70-73 years of age were invited to the radius and hip BMD measurements; 96 women were excluded because of medical reasons; 160 women

2006 Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Controlled trial quality: predicted high PubMed abstract

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