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Exercise in the Elderly

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181. Repeated sit-to-stand exercise enhances muscle strength and reduces lower body muscular demands in physically frail elders. (Abstract)

Repeated sit-to-stand exercise enhances muscle strength and reduces lower body muscular demands in physically frail elders. To examine the effect of a conditioning program consisting of repeated sit-to-stand exercise on knee extensor strength and muscular activities during body mass-based squat movement in physically frail elders.Fourteen men and women aged 75 to 88 years who used the long-term care insurance system participated in the 12-week training program (48 reps/session, 3 sessions/week (...) /kg at week 4 and 1.31 ± 0.28 Nm/kg at week 12 (P < 0.001), and QF %EMGmax decreased from 67.2 ± 17.2% to 49.3% at week 4 (P < 0.001) and 43.5 ± 7.7% at week 12 (P = 0.016). At each of the three measurement time points KET/BM was inversely correlated with QF %EMGmax (r = -0.78 to -0.86, P ≤ 0.001).For physically frail elders, a short-term conditioning program consisting of repeated sit-to-stand exercise is effective in increasing knee extensor strength and reducing the muscular effort required

2018 Experimental Gerontology

182. Gender and age differences in the association between living arrangement and physical activity levels among youth aged 9-19 years in Shanghai, China: a cross-sectional questionnaire study. Full Text available with Trip Pro

Gender and age differences in the association between living arrangement and physical activity levels among youth aged 9-19 years in Shanghai, China: a cross-sectional questionnaire study. We examined the correlations between living arrangement and the physical activity (PA) levels of youth aged 9-19 years while accounting for demographic factors such as age, sex, and socioeconomic status in Shanghai, China.Cross-sectional analyses of data from the 2014 Physical Activity and Fitness in Shanghai (...) China-The Youth Study was conducted. Participants were 33,213 primary (9-11-year-olds; n = 13,237), junior middle (12-14-year-olds; n = 11,157), and junior high school students (15-19-year-olds; n = 8819). Youth (boys = 49%) and their guardians were randomly sampled from 17 districts in Shanghai, China. Youths' moderate-to-vigorous PA (MVPA) levels, information about living arrangement, and guardians' sociodemographic factors were collected via questionnaires.Only 17.8% of school-aged youths

2019 BMC Public Health

183. Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults: The FIT-AGEING study. (Abstract)

Association of physical activity and fitness with S-Klotho plasma levels in middle-aged sedentary adults: The FIT-AGEING study. To determine the association between physical activity and physical fitness levels (i.e. cardiorespiratory fitness and muscular strength) and the shed form of the α-Klotho gene (S-Klotho plasma levels) in middle-aged sedentary adults.A total of 74 middle-aged sedentary adults (52.7% women; 53.7 ± 5.1 years old) were enrolled in the FIT-AGEING study. Physical activity (...) of the cumulative variance in S-Klotho plasma level explained was 28.9%s; this reached 33.0% of cumulative variance when sex was included in the model.In summary, our results indicate that physical activity and physical fitness levels are associated with S-Klotho plasma levels in middle-aged sedentary adults. Therefore, the S-Klotho protein could be a key factor in the relationship between physical activity and physical fitness and health improvements during the ageing process.Copyright © 2019 Elsevier B.V. All

2019 Maturitas

184. The Effect of Leisure Activity Diversity and Exercise Time on the Prevention of Depression in the Middle-Aged and Elderly Residents of Taiwan Full Text available with Trip Pro

The Effect of Leisure Activity Diversity and Exercise Time on the Prevention of Depression in the Middle-Aged and Elderly Residents of Taiwan Previous studies have confirmed that activity participation is beneficial to mental health, but few studies focus on older adults' depression. Based on the theory of social integration, this study examined the effects of leisure activity diversity and exercise time on depression in late adulthood. Subjects in the 2011 Survey of Health and Living Status (...) of the Middle-Aged and Elderly in Taiwan were extracted. A series of logistic regressions were conducted to discern factors related to the odds of having depression. Among study subjects (N = 3727; age ≥ 58), 20.9% indicated an inclination of having depression (CESD-10 score ≥ 8). This study found that participating in diverse leisure activities and longer exercise time decreases older adults' risk of having depression. Additionally, the results confirmed that depression is positively correlated

2018 International journal of environmental research and public health

185. Combined exercise is a modality for improving insulin resistance and aging-related hormone biomarkers in elderly Korean women. (Abstract)

Combined exercise is a modality for improving insulin resistance and aging-related hormone biomarkers in elderly Korean women. The functional decline of the endocrine and immune systems with aging causes changes in the regulation of the body's metabolism and defense functions. Although it is impossible to stop aging artificially, regular exercises reportedly delay aging and have positive effects on senile diseases. The improvements in insulin resistance values and aging-related hormones (...) in elderly women after combined exercises have not been effectively elucidated.In this study, we aimed to examine the impact of combined exercise on insulin resistance and aging-related hormones in elderly women.Twenty elderly Korean women were randomly assigned to a "non-exercise" (n = 10) or combined exercise group (n = 10). The exercise group performed both anaerobic and aerobic exercises for 12 weeks, three times per week. Exercise intensity was increased gradually, from 40% to 70% of the heart rate

2018 Experimental Gerontology Controlled trial quality: uncertain

186. Do age and the amount of exercises matter in cognitive games training in the elderly? A systematic review and meta-analysis

Do age and the amount of exercises matter in cognitive games training in the elderly? A systematic review and meta-analysis Print | PDF PROSPERO This information has been provided by the named contact for this review. CRD has accepted this information in good faith and registered the review in PROSPERO. The registrant confirms that the information supplied for this submission is accurate and complete. CRD bears no responsibility or liability for the content of this registration record, any (...) ruler software. In case data are not reported or unclear, we will attempt to contact authors by e-mail (max. 2 attempts). In case an outcome is measured at multiple time points, data from the time point where efficacy is highest will be included. ">Methods for data extraction Example: Experimental groups, control group(s) and number of animals per group. ">Data to be extracted: study design Example: Species, sex, weight, age, co‐morbidity, anaesthetic agent used, method of induction of cardiac

2020 PROSPERO

187. Timeline of functional recovery after hip fracture in seniors aged 65 and older: a prospective observational analysis. (Abstract)

Timeline of functional recovery after hip fracture in seniors aged 65 and older: a prospective observational analysis. We investigated the timeline of functional recovery after hip fracture over 12 months in adults age ≥ 65 years using objective lower extremity function tests and subjective physical functioning. Objective functional recovery was largely complete in the first 6 months, whereas subjective recovery improved up to 9 months after hip fracture.Hip fractures are a major cause of loss (...) of function among seniors. We assessed the timeline of objective and subjective functional recovery after hip fracture.We conducted a prospective observational secondary analysis of a 1-year clinical trial on vitamin D and home exercise treatment and complications after hip fracture among 173 patients age ≥ 65 years (mean age 84 years; 79.2% women; 77.4% community-dwelling) conducted from January 2005 through December 2007. Lower extremity function (Timed Up and Go test (TUG), knee extensor and flexor

2019 Osteoporosis International

188. Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly. Full Text available with Trip Pro

Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly. Animal research indicates that a combination of physical activity and sensory enrichment has the largest and the only sustaining effect on adult neuroplasticity. Dancing has been suggested as a human homologue to this combined intervention as it poses demands on both physical and cognitive functions. For the present exploratory study, we designed an especially challenging dance program (...) of voxel-based morphometry (VBM) designed specifically for pairwise longitudinal group comparisons was employed. Both interventions increased physical fitness to the same extent. Pronounced differences were seen in the effects on brain volumes: Dancing compared to conventional fitness activity led to larger volume increases in more brain areas, including the cingulate cortex, insula, corpus callosum and sensorimotor cortex. Only dancing was associated with an increase in plasma BDNF levels. Regarding

2018 PLoS ONE

189. Does attending an exercise class with a spouse improve long-term exercise adherence among people aged 65 years and older: a 6-month prospective follow-up study. Full Text available with Trip Pro

Does attending an exercise class with a spouse improve long-term exercise adherence among people aged 65 years and older: a 6-month prospective follow-up study. Family support can help older adults better adhere to exercise routine, but it remains unclear whether an exercise program targeting older married couples would have stronger effects on exercise adherence than would a program for individuals. The purpose of this study was to determine the effects of an exercise program on the exercise (...) adherence of older married couples over a 24-week follow-up period.Thirty-four older married couples and 59 older adults participated in this study as couple and non-couple groups (CG and NCG, respectively). All participants attended an 8-week supervised program (once a week and a home-based exercise program comprising walking and strength exercises) and then participated in a follow-up measurement (24 weeks after post-intervention measurement). Exercise adherence was prospectively measured via

2017 BMC Geriatrics

190. Acute effect of different exercise intensities and differences related to age on muscle performance in young and older women. (Abstract)

Acute effect of different exercise intensities and differences related to age on muscle performance in young and older women. The aim of this study was to compare the acute effect of different exercise intensities on the number of repetitions and total volume and differences related to age on the fatigue index.Twelve young women (19.0 ± 1.6 years) and ten older women (66.6 ± 5.8 years) performed two experimental sessions for the elbow flexor muscles in a balanced cross-over design. In one (...) % of 10-12 RM for both young and older women (all P<0.05). However, significant no differences were observed in the fatigue index between the young and older women for the sessions performed at 90% or 100% of 10-12 RM (P>0.05).These findings suggest that a 10% load reduction promotes a greater number of repetitions and higher total volume in young and older adults. Moreover, the results indicate that young and older women present the same fatigue index for the elbow flexor muscles.

2018 The Journal of sports medicine and physical fitness Controlled trial quality: uncertain

191. Aging and Thermoregulatory Control: The Clinical Implications of Exercising under Heat Stress in Older Individuals Full Text available with Trip Pro

Aging and Thermoregulatory Control: The Clinical Implications of Exercising under Heat Stress in Older Individuals Climate change is predicted to bring about a greater variability in weather patterns with an increase in extreme weather events such as sustained heat waves. This change may have a direct impact on population health since heat waves can exceed the physiological limit of compensability of vulnerable individuals. Indeed, many clinical reports suggest that individuals over the age (...) of 60 years are consistently the most vulnerable, experiencing significantly greater adverse heat-related health outcomes than any other age cohort during environmental heat exposure. There is now evidence that aging is associated with an attenuated physiological ability to dissipate heat and that the risk of heat-related illness in these individuals is elevated, particularly when performing physical activity in the heat. The purpose of this review is to discuss mechanisms of thermoregulatory

2018 BioMed research international

192. Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-aged and older women Full Text available with Trip Pro

Habitual exercise decreases plasma xanthine oxidoreductase activity in middle-aged and older women The aim of present study was to investigate the association between plasma xanthine oxidoreductase activity, which has gained attention as a novel preventive target of cardiovascular disease, and various physiological parameters and was to determine the effects of habitual exercise on plasma xanthine oxidoreductase activity in middle-aged and older women. In the cross-sectional study, we (...) investigated the association between plasma xanthine oxidoreductase activity and various physiological parameters in 94 middle-aged and older women. In the interventional study, subjects (n = 22) were divided into two groups: exercise (n = 12) or the control group (n = 10), whereby we examined the effect of 12-week aerobic exercise training on plasma xanthine oxidoreductase activity in middle-aged and older women. The cross-sectional study demonstrated that plasma xanthine oxidoreductase activity

2018 Journal of clinical biochemistry and nutrition

193. Tiotropium (Spiriva Respimat) - as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year

Tiotropium (Spiriva Respimat) - as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year Published 14 January 2019 www.scottishmedicines.org.uk Product update SMC2118 tiotropium 2.5 microgram solution for inhalation (Spiriva® Respimat®) Boehringer Ingelheim Limited 7 December 2018 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product (...) and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated submission tiotropium (Spiriva® Respimat®) is accepted for use within NHSScotland. Indication under review: as add-on maintenance bronchodilator treatment in patients aged 6 years and older with severe asthma who experienced one or more severe asthma exacerbations in the preceding year. Tiotropium has previously been accepted for use

2019 Scottish Medicines Consortium

194. Mepolizumab (Nucala) - as an add-on treatment for severe refractory eosinophilic asthma in adolescents and children aged 6 years and older

Mepolizumab (Nucala) - as an add-on treatment for severe refractory eosinophilic asthma in adolescents and children aged 6 years and older Published 08 April 2019 1 Product update SMC2139 mepolizumab 100mg powder for solution for injection (Nucala®) GlaxoSmithKline UK Limited 8 March 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic Committees (ADTCs) on its use in NHSScotland. The advice (...) is summarised as follows: ADVICE: following an abbreviated submission mepolizumab (Nucala®) is accepted for restricted use within NHSScotland. Indication under review: as an add-on treatment for severe refractory eosinophilic asthma in adolescents and children aged 6 years and older. SMC restriction: patients who have eosinophils of at least 150 cells per microlitre (0.15 x 10 9 /L) at initiation of treatment and have had at least four asthma exacerbations in the preceding year or are receiving maintenance

2019 Scottish Medicines Consortium

195. Blinatumomab (Blincyto) - for the treatment of paediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-cell precursor acute lymphoblastic leukaemia

Blinatumomab (Blincyto) - for the treatment of paediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-cell precursor acute lymphoblastic leukaemia Published 08 April 2019 1 Product update SMC2148 blinatumomab 38.5 micrograms powder for concentrate and solution for infusion (Blincyto®) Amgen Europe B.V. 8 March 2019 The Scottish Medicines Consortium (SMC) has completed its assessment of the above product and advises NHS Boards and Area Drug and Therapeutic (...) Committees (ADTCs) on its use in NHSScotland. The advice is summarised as follows: ADVICE: following an abbreviated submission blinatumomab (Blincyto®) is accepted for use within NHSScotland. Indication under review: As monotherapy for the treatment of paediatric patients aged 1 year or older with Philadelphia chromosome negative CD19 positive B-cell precursor acute lymphoblastic leukaemia which is refractory or in relapse after receiving at least two prior therapies or in relapse after receiving prior

2019 Scottish Medicines Consortium

196. [Role of age chronotropic criterion in the increase motor activity on an inpatient stage of rehabilitation of geriatric patients with myocardial infarction]. (Abstract)

[Role of age chronotropic criterion in the increase motor activity on an inpatient stage of rehabilitation of geriatric patients with myocardial infarction]. We studied the efficiency of the age chronotropic criterion inpatient rehabilitation of geriatric patients with myocardial infarction, provides for an increase in heart rate when the motor activity to submaximal values for the particular age of the patients. It was found that the inclusion of this criterion provides patients an optimal (...) heart rate during exercise, the passage of the individual stages / riser activity, prevents the formation of cardiomyopathy induced tachycardia.

2018 Advances in gerontology = Uspekhi gerontologii Controlled trial quality: uncertain

197. Age and the effect of exercise, nutrition and cognitive training on oxidative stress - The Vienna Active Aging Study (VAAS), a randomized controlled trial. (Abstract)

Age and the effect of exercise, nutrition and cognitive training on oxidative stress - The Vienna Active Aging Study (VAAS), a randomized controlled trial. The purpose of this study was to investigated the effect of age - over or under life-expectancy (LE) - on six months resistance training alone or combined with a nutritional supplement, and cognitive training by analyzing markers for oxidative stress and antioxidant defense in institutionalized elderly, living in Vienna. Three groups (n  (...) = 117, age = 83.1 ± 6.1 years) - resistance training (RT), RT combined with protein and vitamin supplementation (RTS) or cognitive training (CT) - performed two guided training sessions per week for six months. Oxidative stress, antioxidant defense and DNA strand breaks were analyzed and transformed into an "antioxidant factor" to compare the total effect of the intervention. Physical fitness was assessed by the 6-min-walking, the chair-rise and the handgrip strength tests. We observed significant

2018 Free radical biology & medicine Controlled trial quality: uncertain

198. Age-specific affective responses and self-efficacy to acute high-intensity interval training and continuous exercise in insufficiently active young and middle-aged men. Full Text available with Trip Pro

Age-specific affective responses and self-efficacy to acute high-intensity interval training and continuous exercise in insufficiently active young and middle-aged men. High-intensity interval training (HIIT) has been recognized as an emerging trend in public health promotion, but its age-specific differences in psycho-perceptual responses have yet to be investigated. This study compared the psycho-perceptual responses after a single session of HIIT versus moderate-intensity continuous exercise (...) (MICE) and vigorous-intensity continuous exercise (VICE) in twelve young and twelve middle-aged insufficiently active males respectively.Using a randomized cross-over design, participants undertook three main trials consisting of: HIIT (10 x 1-min run at 100% VO2max interspersed with 1-min active recovery), MICE (40-min run at 65% VO2max) and VICE (20-min run at 80% VO2max). Affective responses, self-efficacy and exercise preference were assessed for each trial.Both HIIT and VICE showed more

2018 Journal of exercise science and fitness Controlled trial quality: uncertain

199. Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. (Abstract)

Voluntary exercise reverses immune aging induced by oxidative stress in aging mice. Excessive oxidative stress leads to aging due to persistent damage to the cells, tissues, and the entire organism. Immunosenescence is also a devastating consequence of oxidative stress, but there is a lack of research on effective ways to overcome it. In this study, we used physiologic and immunological aging mouse models that had sustained oxidative stress to investigate whether voluntary exercise (...) and/or antioxidant treatment could overcome oxidative damage as well as aging. We established an aging model induced by continuously administering d-galactose (d-gal) to 6-week-old female C57BL/6J mice. We also assessed reversal of immunosenescence by providing free-wheel running and vitamin E (vit E) supplementation to this aging model. As an aging index, the level of advanced glycation end products (AGEs) in the blood was measured. Phenotypes of T cells in the thymus and spleen were examined as an index

2018 Experimental Gerontology

200. Exercise, Arterial Crosstalk-Modulation, and Inflammation in an Aging Population: The ExAMIN AGE Study Full Text available with Trip Pro

aims at examining the association of physical fitness and cardiovascular risk with large and small artery function in healthy older active (HOA, n = 40) and sedentary (HOS, n = 40) persons as well as older sedentary individuals with increased cardiovascular risk (OSR, n = 80) aged 50-80 years. In the interventional approach, the OSR group is randomized into a 12-week walking-based high intensity interval training (HIIT) group or a control condition, aiming at examining the effects of HIIT (...) Exercise, Arterial Crosstalk-Modulation, and Inflammation in an Aging Population: The ExAMIN AGE Study Background: Age is a key determinant for the development of cardiovascular disease and higher age coincides with an increased prevalence of obesity and physical inactivity. The study examines the influence of physical activity on aging processes of physiological systems focusing on the mechanisms of vascular aging. Methods/Design: The study consists of two parts. The cross-sectional approach

2018 Frontiers in physiology

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