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Esophageal Rupture

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181. Secukinumab (Cosentyx)

Amy S. Woitach, DO BLA 125-504 Cosentyx (secukinumab) 52 Palpitations 2 (0.18) 0 (0.00) 2 (0.07) 0 (0.00) 0 (0.00) Pulmonary edema 2 (0.18) 0 (0.00) 2 (0.07) 0 (0.00) 0 (0.00) Rib fracture 0 (0.00) 2 (0.17) 2 (0.07) 0 (0.00) 0 (0.00) Tendon rupture 0 (0.00) 2 (0.17) 2 (0.07) 0 (0.00) 0 (0.00) Vomiting 2 (0.18) 0 (0.00) 2 (0.07) 0 (0.00) 0 (0.00) Infections, including pneumonia and bacterial abscess, were reported more frequently with secukinumab treatment, but not reported for either placebo (...) treatment periods. Infections related to Candida did appear to show a dose response as shown in section 7.5.1. All Candida infections on secukinumab were mild or moderate in severity. 4 cases of esophageal candidiasis were reported (1 on 150 mg and 3 on 300 mg). Two of these cases were mild and two were moderate in severity. All were managed successfully with antifungal treatment and did not result in any interruption or discontinuation of study treatment. There was 1 additional case of esophageal

2014 FDA - Drug Approval Package

182. Eating Disorders

,suchashypokalemia. 141 Theseproblemsmayleadto orthostatic hypotension and syncope. Esophageal tears from excessive erosion of throat tissue can lead to serious and dif?cult-to-control bleeding. Binge eating can cause both gastric and esophageal rupture. 142 The mortality rate is estimated to be about 1% in BN patients, but more recent studies suggest that this may be an underestimate. 143,144 Indications for medical hospitalization of children and adolescents have been published by the American Academy

2015 American Academy of Child and Adolescent Psychiatry

183. Aortic Diseases

ulcer (PAU) and traumatic aortic injury (TAI), pseudoaneurysm, aortic rupture, atherosclerotic and in?ammatory affections, as well asgeneticdiseases(e.g.Marfansyndrome)andcongenitalabnormal- itiesincludingthecoarctationoftheaorta(CoA). Similarly to other arterial diseases, aortic diseases may be diag- nosed after a long period of subclinical development or they may have an acute presentation. Acute aortic syndrome is often the ?rst sign of the disease, which needs rapid diagnosis and decision (...) by guest on 02 April 2019patients undergoing urgent or emergent repair of acute Type A AD. 13 A similar relationship has been reported for the thoraco-abdominal aortic aneurysm repair, demonstrating a near doublingofin-hospitalmortalityatlow-(medianvolume1proced- ure/year) in comparison with high-volume hospitals (median volume 12 procedures/year; 27 vs. 15% mortality; P, 0.001) 14 and intact and ruptured open descending thoracic aneurysm repair. 15 Likewise, several reports have demonstrated

2014 European Society of Cardiology

184. Vascular Rings in Adults: Outcome of Surgical Management. (Abstract)

-SA and KD (n=20, 31%), double aortic arch (n=12, 18%), right arch with mirror imaging and persistent ligamentum off KD (n=7, 11%), and others (n=4, 6%). Indications for operation included dysphagia (n=43, 63%), respiratory symptoms (n=28, 43%), aneurysmal KD (n=12, 18%) and dissection/rupture (n=7, 11%).Kommerell's diverticulum was found in 51(78%) patients. Surgical approach included left-thoracotomy (n=50, 77%), right-thoracotomy (n=7, 11%), sternotomy (n=5, 8%) and hybrid-repair (n=3, 5%). A 2 (...) -stage repair with carotid-SA transposition followed by transthoracic KD excision was done in 51% of aberrant-SA (n=23). There was 1 early death. Morbidity included recurrent laryngeal nerve injury (n=5, 8%) and chylothorax (n=3, 5%). Symptomatic improvement occurred in 97%. Survival was 96.1%, 85.0%, and 73.4% at 1, 5, and 10years respectively. Dysphagia recurred in 9(14%) which included 7(11%) with esophageal dysmotility.Repair of VR in adults can be performed safely. Dysphagia is the most common

2019 Annals of Thoracic Surgery

185. Effect of local retropharyngeal steroids on fusion rate after anterior cervical discectomy and fusion. (Abstract)

levels treated, and smoking status. The case group had an overall fusion rate of 64.7%, whereas the control group had a fusion rate of 91%. When analyzed at each level of attempted fusion, the case group had a fusion rate of 81% compared to 93% in the control group. There was a single patient in the case group that developed esophageal rupture and retropharygeal abscess requiring surgical intervention with irrigation, debridement and repair at 8 months after index operation.The use of retropharyngeal

2019 The Spine Journal

186. Partial Splenic Embolization is a Safe and Effective Alternative in the Management of Portal Hypertension in Children. (Abstract)

patients (80.8%). Children with prior esophageal varices showed improvement after PSE with only nine (34.6%) requiring further endoscopic therapy. After PSE, patients developed transient abdominal pain, distention, fever, and peri-splenic fluid collections. Serious complications such as splenic abscess, splenic rupture, bleeding, pancreatic infarction, opportunistic infection or death were not observed. One patient experienced thrombotic complications following PSE and was later diagnosed

2019 Journal of Pediatric Gastroenterology and Nutrition

189. Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding.

pressure > 70 mmHg and heart rate < 100 bpm) could be achieved. Exclusion Criteria: Age < 18 years. Esophageal rupture. Esophageal, gastric or upper respiratory tract tumor. Esophageal stenosis. Recent esophageal surgery. Previous esophageal tamponade to treat the index bleed. Big hiatal hernia precluding the correct placement of the esophageal devices. Known hepatocellular carcinoma surpassing Milan criteria. Terminal disease. No written consent to participate in the study. Contacts and Locations Go (...) Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding. Self-expandable Esophageal Stent Versus Balloon Tamponade in Refractory Esophageal Variceal Bleeding. - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please

2010 Clinical Trials

191. Management and Outcomes of Congenital Anomalies in Low-, Middle- and High-Income Countries

, chylothorax, haemothorax, anastomotic leak, anastomotic stricture, recurrent TOF, other. CDH: air leak, chylothorax, recurrence, adhesional obstruction. IA: anastomotic leak/ stenosis, short-gut, missed additional atresia, adhesive bowel obstruction. Gastroschisis: ischaemic bowel, abdominal compartment syndrome, necrotising enterocolitis. Exomphalos: ruptured sac. ARM: electrolyte disturbance, high stoma output (over 20mls/kg/day), stoma prolapse/ retraction/ herniation, peri-stoma skin breakdown (...) Time Frame: Following publication of the main results. Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Congenital Abnormalities Hernia, Diaphragmatic Hernias, Diaphragmatic, Congenital Gastroschisis Hirschsprung Disease Anorectal Malformations Esophageal Atresia Intestinal Atresia Hernia Pathological Conditions, Anatomical Musculoskeletal Abnormalities

2018 Clinical Trials

192. The Compliance and Prognosis of NSBB Secondary Prevention of Cirrhosis With Gastroesophageal Varices Bleeding

. For general information, Layout table for eligibility information Ages Eligible for Study: Child, Adult, Older Adult Sexes Eligible for Study: All Accepts Healthy Volunteers: No Sampling Method: Probability Sample Study Population The patient was diagnosed with liver cirrhosis in the investigator's hospital or the outer court and had a history of esophageal variceal rupture and bleeding before into the group Criteria Inclusion Criteria: Signed informed consent All cases met the diagnostic criteria (...) for cirrhosis All patients were confirmed to be combined with esophageal and gastric varices through endoscopy or portal vein CTA or abdominal CT, and had at least one history of esophageal and gastric varices rupture and bleeding. Child-pugh was graded as A/B. All patients had basal heart rate greater than 60 beats/min and systolic pressure greater than 90mmhg. Exclusion Criteria: Patients with liver cancer or other gastrointestinal tumors Patients with splenomegaly due to extrahepatic portal hypertension

2018 Clinical Trials

193. Trophic Nutrition in Patients Submitted to High Flow Oxygen Therapy and / or Non Invasive Mechanical Ventilation

under spontaneous ventilation, with better oxygenation figures than conventional oxygen therapy methods. This positive pressure increase could be a facilitator of digestive intolerance either by air swallowing and gastric distension, or by promoting incontinence of the esophageal sphincters and thereby facilitating regurgitation and bronchoaspiration of the gastric contents. NIMV consists of a ventilatory support applied without placement of endotracheal or pharyngeal devices, achieving increased (...) of nutrients in the lumen of the intestine can trigger a loss of the anatomical and functional integrity of the intestinal epithelium, with a rupture of the intestinal barrier that can favor, through a pro-inflammatory immune response, the evolution towards the multiple organ dysfunction syndrome. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 310 participants Observational Model: Cohort Time Perspective: Prospective Official Title: Trophic Nutrition

2018 Clinical Trials

194. Gastric Variceal Ligation Versus Gastric Variceal Obturation for Secondary Prophylaxis of Gastric Varices

hypertension, with an incidence of 20%. Though the bleeding rate of GVs (25%) is lower than that of Esophageal varices (EVs), the mortality rate is higher due to greater GVs rupture and less space for endoscopic intervention. In addition, in 30% of patients with GVs, the possibility of treatment failure exists. Guidelines differ on endoscopic treatment for secondary prevention of GVs.Current studies suggest that EVL, due to its low incidence of complications, is suitable for GOV1, while it is still (...) for additonal information Responsible Party: Shanghai Zhongshan Hospital ClinicalTrials.gov Identifier: Other Study ID Numbers: CSY-GVL&GVO First Posted: November 5, 2018 Last Update Posted: November 5, 2018 Last Verified: November 2018 Layout table for additional information Studies a U.S. FDA-regulated Drug Product: No Studies a U.S. FDA-regulated Device Product: No Additional relevant MeSH terms: Layout table for MeSH terms Liver Cirrhosis Varicose Veins Esophageal and Gastric Varices Liver Diseases

2018 Clinical Trials

195. ADPKD Alterations in Hepatic Transporter Function

is the formation of liver cysts, which can vary from minor to extensive. Hepatic cysts can develop from medium-sized bile ducts and complications (i.e., cyst rupture, infection, obstruction of bile ducts, and compromised portal venous flow) can arise from increasing cystic burden. Previous studies have shown that elevated levels of endogenous molecules such as bile acids in ADPKD may indicate altered transporter function. Other endogenous molecules such as coproporphyrin (CP) I and III may be used as probes (...) normalized ratio (INR) > 1.3 times normal at screening, or history or presence of ascites, encephalopathy, or bleeding from esophageal varices Estimated glomerular filtration rate (GFR)< 15 mL/min per 1.73 m2, or on dialysis, at screening Subjects with a condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalent) or other immunosuppressive medications (including inhaled) within 14 days of study visit. Corticosteroids with minimal systemic absorption

2018 Clinical Trials

196. Irradiation Stent Placement Plus TACE for HCC and PVTT

%. PVTT can accompany intrahepatic tumor spread, liver function deterioration, and portal vein hypertension, and can lead to intractable ascites, variceal rupture, hepatic encephalopathy and/or death. As recommended by the Barcelona Clinic Liver Cancer (BCLC) group, the current standard treatment of HCC with PVTT is sorafenib only. However, sorafenib monotherapy does not achieve satisfactory outcomes, yielding a median survival time of 5.6 to 8.1 months. To improve the prognosis, transarterial (...) , mainly limited by rapid tumor infiltration and/or subsequent thrombosis formation. An irradiation stent has been developed and confirmed to be safe and effective in treating unresectable esophageal cancer. A modified irradiation stent designed for biliary tract obstruction was subsequently developed and resulted in significantly improved outcomes in a single-institute randomized, controlled study of patients with malignant biliary obstruction. This study aims to demonstrate that overall survival

2018 Clinical Trials

197. Role of Branched-chain Amino Acids Infusion as Adjunct Therapy Post Liver Surgery for Patients in Intensive Care Unit

infectious morbidity Infectious morbidity [ Time Frame: 30 days post surgery ] occurrence of infections post surgery non infectious morbidity [ Time Frame: 30 days ] occurrence of hepatic encephalopathy, ruptured esophageal varices, ascites requiring diuretic agent for control, wound dehiscence, intra-abdominal bleeding, intestinal obstruction, renal failure, pleural effusion, need mechanical ventilation, blood sugar control & nutritional status change. ICU stay. length of ICU stay, length of hospital

2018 Clinical Trials

198. Impact of Anesthesia on the Dimension of the Ascending Aorta

Center Information provided by (Responsible Party): Sheba Medical Center Study Details Study Description Go to Brief Summary: The aim of this study is to evaluate the accuracy and reliability of intra-operative TEE after the induction of anesthesia when assessing proximal thoracic aorta diameters in a cohort of aortic aneurysm patients. Condition or disease Intervention/treatment Phase Aortic Aneurysm, Thoracic Other: Trans-esophageal echocardiography Not Applicable Detailed Description: Dilatation (...) of the ascending aorta often progresses silently in an asymptomatic patient, until an acute complication occurs (such as a dissection or rupture), which is directly related to the diameter of the aortic. To prevent these extremely harmful situations, aortic replacement surgery, as indicated by significant dilatation of the ascending aorta, could be the option of choice (1). The decision to perform elective surgery depends on the measurement of the thoracic aorta diameter, which would rely on the largest aortic

2018 Clinical Trials

199. Perioperative Metabolic and Hormonal Aspects in Major Emergency Surgery

complications requiring resection Ruptured ectopic pregnancy, or pelvic abscesses due to pelvic inflammatory disease Laparotomy/laparoscopy for pathology caused by blunt or penetrating trauma, esophageal pathology, pathology of the spleen, renal tract, kidneys, liver, gall bladder and biliary tree, pancreas or urinary tract Contacts and Locations Go to Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact

2018 Clinical Trials

200. Randomized Controlled Trial of Psychoeducational and Hypnosis Interventions on the Fatigue Associated With PBC in Women

arguments (elastometry> 16 kPa), or on signs of portal hypertension based on echographic, endoscopic or biological (platelets <150000) approaches, Presence of disabling pruritus (permanent, or EVA> 5/10, or objectivable scratching skin lesions), Patient on liver transplantation waiting list or total bilirubin> 50 μmol / L (3 mg / dL), or MELD score ≥ 15 or recent complication (<6 months) of cirrhosis (ascites, hepatic encephalopathy, rupture bleeding) of esophageal varices), Untreated depressive

2018 Clinical Trials

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