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Eslicarbazepine

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121. Partial-onset seizures in epilepsy: zonisamide as monotherapy

effective than other cost-effective treatment alternatives. The Guideline Development Group concluded that eslicarbazepine acetate, lacosamide, pregabalin, tiagabine and zonisamide should be considered only when initial adjunctive therapy options are contraindicated, ineffective or not tolerated. See the introduction for more details. A NICE Pathway on epilepsy brings together all NICE guidance and associated products on epilepsy. Introduction Introduction Epilepsy is a common neurological condition (...) clinical guideline on epilepsy recommends that advice should be sought from a tertiary epilepsy specialist. Anti-epileptic drugs that may be considered are eslicarbazepine acetate, lacosamide, phenobarbital, phenytoin, pregabalin, tiagabine, vigabatrin and zonisamide. The NICE technology appraisal on retigabine for the adjunctive treatment of partial onset seizures in epilepsy (NICE technology appraisal guidance 232) recommends retigabine as an option at this point. Product o Product ov verview erview

2013 National Institute for Health and Clinical Excellence - Advice

123. Contraception - emergency

-inducing drugs or who have taken them within the past 28 days. Table 1 lists some drugs that induce liver enzymes, and may decrease the efficacy of emergency hormonal contraception. Table 1. Drugs that induce liver enzymes. Drug class Drug Antiepileptics Carbamazepine, eslicarbazepine, oxcarbazepine, phenytoin, phenobarbital, primidone, rufinamide, topiramate (weak inducer) Antibiotics Rifampicin (potent inducer), rifabutin Antiretrovirals Protease inhibitors: ritonavir, atazanavir, darunavir

2019 NICE Clinical Knowledge Summaries

124. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and th Full Text available with Trip Pro

-quality studies suggest clobazam, eslicarbazepine, ezogabine, felbamate, GBP, lacosamide, LEV, LTG, oxcarbazepine, perampanel, pregabalin, rufinamide, tiagabine, topiramate, vigabatrin, or ZNS is effective in treating new-onset epilepsy because no high-quality studies exist in adults of various ages. A recent Food and Drug Administration (FDA) strategy allows extrapolation of efficacy across populations; therefore, for focal epilepsy, eslicarbazepine and lacosamide (oral only for pediatric use) as add

2018 EvidenceUpdates

125. Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the Full Text available with Trip Pro

(Level B): lacosamide, eslicarbazepine, and extended-release topiramate for TRAFE (ezogabine production discontinued); immediate- and extended-release lamotrigine for generalized epilepsy with TR generalized tonic-clonic (GTC) seizures in adults; levetiracetam (add-on therapy) for TR childhood focal epilepsy (TRCFE) (1 month-16 years), TR GTC seizures, and TR juvenile myoclonic epilepsy; clobazam for LGS (add-on therapy); zonisamide for TRCFE (6-17 years); oxcarbazepine for TRCFE (1 month-4 years (...) ). The text presents Level C recommendations. AED selection depends on seizure/syndrome type, patient age, concomitant medications, and AED tolerability, safety, and efficacy. This evidence-based assessment informs AED prescription guidelines for TR epilepsy and indicates seizure types and syndromes needing more evidence. A recent Food and Drug Administration (FDA) strategy allows extrapolation of efficacy across populations; therefore, for focal epilepsy, eslicarbazepine and lacosamide (oral only

2018 EvidenceUpdates

126. Partial-onset seizures in epilepsy: perampanel as adjunctive treatment

) recommends carbamazepine, clobazam, gabapentin, lamotrigine, levetiracetam, oxcarbazepine, sodium valproate or topiramate as adjunctive treatment if monotherapy is ineffective or not tolerated. If adjunctive treatment is ineffective or not tolerated, the guideline recommends that advice should be sought from a tertiary epilepsy specialist. Anti-epileptic drugs that may be considered by the specialist at this point in the care pathway are eslicarbazepine acetate, lacosamide, phenobarbital, phenytoin (...) or not tolerated, advice should be sought from a tertiary epilepsy specialist. Anti-epileptic drugs that may be considered by the tertiary epilepsy specialist are eslicarbazepine acetate, lacosamide, phenobarbital, phenytoin, pregabalin, tiagabine, vigabatrin and zonisamide [1][3] Partial-onset seizures in epilepsy: perampanel as adjunctive treatment (ESNM7) © NICE 2018. All rights reserved. Subject to Notice of rights (https://www.nice.org.uk/terms-and- conditions#notice-of-rights). Page 3 of 15The NICE

2012 National Institute for Health and Clinical Excellence - Advice

127. Perampanel (epilepsy and seizures) ? Benefit assessment according to §35a Social Code Book V

and older in comparison with the appropriate comparator therapy (ACT). The G-BA specified the following ACT: ? an individual antiepileptic add-on therapy, if medically indicated and if no pharmacoresistance/intolerance and contraindications are known yet, with one of the following drugs: eslicarbazepine (for adults) or gabapentin or lacosamide (for patients aged 16 years and older) or lamotrigine or levetiracetam or oxcarbazepine or pregabalin (for adults) or topiramate or valproic acid or zonisamide (...) Appropriate comparator therapy Extent and probability of added benefit As add-on therapy of partial-onset seizures with or without secondarily generalized seizures in patients with epilepsy aged 12 years and older An individual antiepileptic add-on therapy, if medically indicated and if no pharmacoresistance/intolerance and contraindications are known yet, with one of the following drugs: eslicarbazepine a or gabapentin or lacosamide b or lamotrigine or levetiracetam or oxcarbazepine or pregabalin

2014 Institute for Quality and Efficiency in Healthcare (IQWiG)

128. Drug-drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program. (Abstract)

Drug-drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program. We have previously shown that cannabidiol (CBD; Epidiolex®) significantly affects levels of clobazam/N-desmethylclobazam, rufinamide, topiramate, zonisamide, and eslicarbazepine. In the present study, we tested whether the presence of concomitant clobazam affected seizure frequency and severity (treatment response) 12 weeks after initiation of therapy with CBD

2019 Epilepsy & behavior : E&B Controlled trial quality: uncertain

129. Use of Newer Anticonvulsants for the Treatment of Status Epilepticus. (Abstract)

status epilepticus (SRSE). The PubMed database was searched for clinical trials published between January 2000 and July 2018 using the search terms status epilepticus, refractory status epilepticus, super refractory status epilepticus, brivaracetam, clobazam, cannabidiol, eslicarbazepine, lacosamide, perampanel, rufinamide, stiripentol, and zonisamide. Trials that evaluated these agents in adults with SE, RSE, and SRSE were included. Brivaracetam use was identified in two retrospective reviews (...) with success rates of 27% and 57%. One unsuccessful case report of cannabidiol use in SE was found. Four clobazam studies were identified in SE and RSE with success rates ranging from 25-100%. No evidence for the use of eslicarbazepine and zonisamide was found. Using the search terms for lacosamide identified 38 articles: 1 systematic review, 5 prospective studies, 15 retrospective reviews, and 17 case reports. Success rates and dosing varied, but studies that included focal or partial types of SE showed

2019 Pharmacotherapy

131. Cannabidiol for Drug Resistant Pediatric Epilepsy (Expanded Access Use)

, Eslicarbazepine Acetate, Ethosuximide, Felbamate, Gabapentin, Lacosamide, Lamotrigine, Levetiracetam, Lorazepam, Oxcarbazepine, Perampanel, Phenobarbital, Phenytoin, Pregabalin, Rufinamide, Valproic Acid, Vigabatrin, Zonisamide. Documentation must include the diagnosis of epilepsy type or epilepsy syndrome (if possible), as well as the underlying case, when known. Between 1-3 baseline anti-epileptic drugs at stable doses for a minimum of 4 weeks prior to enrollment. Vagus nerve stimulator, and dietary

2018 Clinical Trials

132. Recurrent epileptiform discharges in the medial entorhinal cortex of kainate-treated rats are differentially sensitive to antiseizure drugs. Full Text available with Trip Pro

-7-nitroquinoxaline-2,3-dione, (2R)-amino-5-phosphonovaleric acid, tetrodotoxin, or ASDs were bath applied for 20 minutes. Concentration-dependent effects and half maximal effective concentration values were determined for RED duration, frequency, and amplitude.ASDs targeting sodium and potassium channels (carbamazepine, eslicarbazepine, ezogabine, lamotrigine, lacosamide, phenytoin, and rufinamide) attenuated REDs at concentrations near their average therapeutic plasma concentrations. γ

2018 Epilepsia

133. Reference ranges for antiepileptic drugs revisited: a practical approach to establish national guidelines Full Text available with Trip Pro

databases.Reference ranges varied between laboratories for four of 23 available AEDs (lamotrigine, valproate, eslicarbazepine and oxcarbazepine). For four AEDs (brivaracetam, perampanel, stiripentol and sulthiame), reference ranges had not previously been established. In total, 13 reference ranges were either harmonized, updated or newly established. No changes were applied to the remaining 10 AEDs.Updated and harmonized reference ranges are now available for 22 of the 23 AEDs available in Norway. The exception

2018 Drug design, development and therapy

135. Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B Genotype and Phenytoin Dosing

, eslicarbazepine acetate, and lamotrigine have some evidence linking SJS/TEN with the HLA-B*15:02 allele, and thus caution should be used in choosing alternatives to phenytoin (see Supplementary Material online for details). d Recommended maintenance dose based on patient’s clinical characteristics. 544 VOLUME 96 NUMBER 5 | NOVEMBER 2014 | www.nature.com/cptCPIC GuIdelInes HLA-B*15:02 with phenytoin-induced SJS/TEN (P < 3? ×? 10 –4 ; odds ratio = 4.26; 95% confidence interval (CI) = 1.93–9.39) under a fixed (...) carbamazepine and phenytoin, unless the benefits of treating the underlying disease clearly outweigh the risks (see Table 2). Some evidence exists linking SJS/TEN with the HLA-B*15:02 allele in association with the use of alternative medications such as oxcarbazepine, eslicarbazepine acetate, and lamotrigine, and thus caution should be used in choos- ing alternatives to phenytoin (see Supplementary Material online for details). CYP2C9 recommendations. Phenytoin and fosphenytoin dose should first be adjusted

2014 Clinical Pharmacogenetics Implementation Consortium

136. Antiepileptic drugs: new advice on switching between different manufacturers? products for a particular drug

For these drugs, doctors are advised to ensure that their patient is maintained on a specific manufacturer’s product Category 2 – valproate, lamotrigine, perampanel, retigabine, rufinamide, clobazam, clonazepam, oxcarbazepine, eslicarbazepine, zonisamide, topiramate For these drugs, the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history

2013 MHRA Drug Safety Update

137. Efficacy and safety of antiepileptic drugs for refractory partial-onset epilepsy: a network meta-analysis. (Abstract)

RCTs with 17 AEDs and 20,711 patients were included in the NMAs, which showed that Brivaracetam (BRV), Levetiracetam (LEV), Oxcarbazepine (OXC), Topiramate, Vigabatrin (VGB), and Valproate (VPA) had a greater likelihood of allowing patients to achieve seizure freedom. We also found that LEV was associated with a lower withdrawal rate due to adverse effects than Lacosamide, Eslicarbazepine acetate, OXC, Pregabalin, and Retigabine. LEV, VGB, VPA, and BRV emerged as the agents with the best

2017 Journal of neurology

138. Interactions between cannabidiol and commonly used antiepileptic drugs. Full Text available with Trip Pro

to determine if the frequency of sedation in participants was related to the mean serum N-desmethylclobazam level, and if aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were different in participants taking concomitant valproate.Increases in topiramate, rufinamide, and N-desmethylclobazam and decrease in clobazam (all p < 0.01) serum levels were seen with increasing CBD dose. Increases in serum levels of zonisamide (p = 0.02) and eslicarbazepine (p = 0.04) with increasing CBD (...) dose were seen in adults. Except for clobazam and desmethylclobazam, all noted mean level changes were within the accepted therapeutic range. Sedation was more frequent with higher N-desmethylclobazam levels in adults (p = 0.02), and AST/ALT levels were significantly higher in participants taking concomitant valproate (p < 0.01).Significantly changed serum levels of clobazam, rufinamide, topiramate, zonisamide, and eslicarbazepine were seen. Abnormal liver function test results were noted

2017 Epilepsia

139. The Risk of Specific Congenital Anomalies in Relation to Newer Antiepileptic Drugs: A Literature Review Full Text available with Trip Pro

The Risk of Specific Congenital Anomalies in Relation to Newer Antiepileptic Drugs: A Literature Review More information is needed about possible associations between the newer anti-epileptic drugs (AEDs) in the first trimester of pregnancy and specific congenital anomalies of the fetus.We performed a literature review to find signals for potential associations between newer AEDs (lamotrigine, topiramate, levetiracetam, gabapentin, oxcarbazepine, eslicarbazepine, felbamate, lacosamide

2016 Drugs - real world outcomes

140. Systematic Adverse Drug Reaction Monitoring of Patients Under Newer Antiepileptic Drugs Using Routine Clinical Data of Inpatients Full Text available with Trip Pro

, lacosamide and eslicarbazepine, under real-life conditions by means of an assessment of routine clinical data of inpatients.Over 2.75 years data of all inpatients receiving one of the newer AEDs were documented. Occurring adverse drug reactions (ADRs) were classified according to the WHO-UMC Causality Assessment concerning their likely relationship to the prescribed AEDs. For each AED, the total number of patients without and with ADRs, assessed as at least possibly related to the particular drug

2016 Drugs - real world outcomes

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