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Erythema Toxicum Neonatorum

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21. The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa. (PubMed)

The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin and vernix caseosa. Peptide antibiotics are part of the surface defences against microbial intruders. However, the presence and significance of these innate immune effectors in the skin barrier of the newborn infant have not yet been appreciated. Erythema toxicum neonatorum is an inflammatory skin reaction of unknown aetiology and significance, commonly present in the healthy newborn (...) infant.As peptide antibiotics are upregulated in inflammatory skin disorders, we hypothesized that this also could be the case in erythema toxicum. We also investigated if the vernix caseosa, a cream-like white substance present on the skin of the infant at birth, might contribute to host defences.The presence of the human antibacterial peptide LL-37 was investigated by immunohistochemistry and confocal imaging of skin biopsies from four 1-day-old infants with an erythema toxicum rash and four matched

2002 British Journal of Dermatology

22. Erythema Toxicum Neonatorum in Newborns and the Development of Asthma

Erythema Toxicum Neonatorum in Newborns and the Development of Asthma Erythema Toxicum Neonatorum in Newborns and the Development of Asthma - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Erythema Toxicum (...) Study Description Go to Brief Summary: Erythema Toxicum Neonatorum (ETN) is a common skin finding that affects healthy full-term babies. Several authors have commented on the possible relationship between ETN and the development of atopic conditions, such as atopic dermatitis or respiratory disease later in life. There is a paucity of research addressing this issue. Condition or disease Asthma Erythema Toxicum Neonatorum Study Design Go to Layout table for study information Study Type

2005 Clinical Trials

23. Erythema toxicum neonatorum is an innate immune response to commensal microbes penetrated into the skin of the newborn infant. (PubMed)

Erythema toxicum neonatorum is an innate immune response to commensal microbes penetrated into the skin of the newborn infant. Erythema toxicum neonatorum is a common rash of unknown etiology affecting healthy newborn infants. In this study, we postulated that the rash reflects a response to microbial colonization of the skin at birth, and that the hair follicle constitutes an "easily opened door" for microbes into the skin of the newborn. We collected microbial cultures from the skin of 69 (...) healthy, 1-d-old infants with and without erythema toxicum to identify the colonizing flora and correlate culture results with clinical findings. We also analyzed biopsies from lesions of erythema toxicum with scanning and transmission electron microscopy in the search for microbes. Finally, each infant's body temperature was measured as a sign of acute phase response. We found that 84% of 1-d-old healthy infants, with and without erythema toxicum were colonized with coagulase-negative staphylococci

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2005 Pediatric Research

24. Urticaria Neonatorum: Accumulation of tryptase-expressing mast cells in the skin lesions of newborns with Erythema Toxicum. (PubMed)

Urticaria Neonatorum: Accumulation of tryptase-expressing mast cells in the skin lesions of newborns with Erythema Toxicum. Erythema Toxicum, a rash frequently present in the healthy newborn infant is an innate, immune response to the first commensal micro flora. Flushing and urtication are seen in this manifestation suggesting mast cell (MC) activation and MC derived mediator release. It has recently become evident that MCs participate in the protective, innate immune response against microbes (...) also by secreting products toxic to pathogens such as cathelicidin peptide antibiotics. We hypothesized that MCs contribute to the process of inflammation in Erythema Toxicum and that skin MCs of human newborns express the cathelicidin peptide antibiotic LL-37. Skin sections were immunostained for MC tryptase. Double immunofluorescence was performed by staining LL-37 in combination with tryptase. We studied ultra structure of skin MCs with transmission (TEM) and immunoelectron microscopy (IEM

2007 Pediatric Allergy and Immunology

25. Erythema neonatorum toxicum. (PubMed)

Erythema neonatorum toxicum. 3592724 1987 07 09 2018 11 13 1468-2044 62 4 1987 Apr Archives of disease in childhood Arch. Dis. Child. Erythema neonatorum toxicum. 327-8 Berg F J FJ Solomon L M LM eng Journal Article England Arch Dis Child 0372434 0003-9888 AIM IM Erythema diagnosis etiology Folliculitis complications Humans Infant, Newborn Melanosis complications Pigmentation Disorders complications 1987 4 1 1987 4 1 0 1 1987 4 1 0 0 ppublish 3592724 PMC1778345 Am J Dis Child. 1966 Aug;112(2

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1987 Archives of Disease in Childhood

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