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Erythema Multiforme Differential Diagnosis

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1. Current Perspectives on Erythema Multiforme. (Abstract)

Current Perspectives on Erythema Multiforme. Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions (...) with predominant acral localization as well as histological findings. Clinically, erythema multiforme can be differentiated into isolated cutaneous and combined mucocutaneous forms. Atypical erythema multiforme manifestations include lichenoid or granulomatous lesions as well as lesional infiltrates of T cell lymphoma and histiocytes. Herpes simplex virus infection being the most common cause, other infectious agents like-especially in children-Mycoplasma pneumoniae, hepatitis C virus, Coxsackie virus

2018 Clinical Reviews in Allergy & Immunology

2. Erythema Multiforme

Central necrosis Some lesions may coalesce into annular s Healing Scarring Alternative presentations Non-transient l s s or bullae form in prior or wheal VIII. Labs: None are necessary (use for differential diagnosis) Skin Biopsy (if diagnosis unclear) Evaluate underlying etiology of skin lesion Complement fixation Cold agglutinins IX. Differential Diagnosis Severe illnesses with Erythema Multiforme type lesions ( ) l lesions persist <24 hours, then migrate Figurate erythema Toxic erythema Viral (...) Erythema Multiforme Erythema Multiforme Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Erythema Multiforme Erythema Multiforme Aka

2018 FP Notebook

3. Rash Week! Briefs: Serum sickness like reaction & erythema multiforme

patients and like palpable purpura, maculopapular lesions or erythema multiforme-type exanthema in others. There is no involvement of the mucous membranes or eyes. Most patients develop remittent fever without temporal spikes. Two out of three have arthralgias, most commonly seen in the hands, wrists, feet, ankles and shoulders. The differential diagnosis includes: Viral exanthems (roseola) Hypersensitivity vasculitis Scarlet fever Acute rheumatic fever Meningococcemia Disseminated gonococcemia (...) Rash Week! Briefs: Serum sickness like reaction & erythema multiforme Rash Week! Briefs: Serum sickness like reaction & erythema multiforme – PEMBlog Search for: Search for: Rash Week! Briefs: Serum sickness like reaction & erythema multiforme You are seeing a child who is well appearing but has a dramatic rash. The rash appeared this morning and seemed to begin on her torso, later spreading to her limbs. The daycare thought that it was an allergy and was going to give her another child’s

2018 PEM Blog

4. Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report Full Text available with Trip Pro

. Target lesions may or may not be present in EM cases. When target lesions are not present on the skin, it is very difficult to make a differential diagnosis of EM. Herpes associated erythema multiforme (HAEM) is an uncommon lesion caused by herpes simplex virus infection. A case of severe painful lesions in a 28-year-old pregnant patient with HAEM is presented here. HAEM is rarely found in pregnant women, and its clinical findings, diagnosis and treatment have not previously been reported. (...) Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report Erythema Multiforme, (EM) is an uncommon, acute inflammatory disease of the skin and mucous membranes characterized by ulcerations caused by hypersensitivity to drugs, microbial agents or other allergens. An EM outbreak can result in more severe forms of EM involving the skin, and there are several types of EM manifestations. A hemorrhagic crust on the lip is a pathognomonic sign of this disease

2016 Acta Stomatologica Croatica

5. Mucosal erosions as the presenting symptom in erythema multiforme: a case report Full Text available with Trip Pro

Department of Dermatology; Gayed Sedki S Department of Genitourinary Medicine, East Lancashire Hospitals NHS Trust, Blackburn. eng Case Reports Journal Article England Br J Gen Pract 9005323 0960-1643 IM Adult Diagnosis, Differential Erythema Multiforme diagnosis etiology microbiology Humans Lip Diseases diagnosis microbiology Male Mouth Diseases diagnosis microbiology Mouth Mucosa microbiology pathology Mycoplasma pneumoniae Penile Diseases diagnosis microbiology Pneumonia, Mycoplasma complications (...) Mucosal erosions as the presenting symptom in erythema multiforme: a case report 26917662 2017 05 19 2018 11 13 1478-5242 66 644 2016 Mar The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract Mucosal erosions as the presenting symptom in erythema multiforme: a case report. e222-4 10.3399/bjgp16X684205 Spencer Stephen S Foundation year 2 doctor. Buhary Thajunnisha T Specialist registrar in genitourinary medicine; Coulson Ian I

2016 The British Journal of General Practice

6. Erythema Multiforme

Central necrosis Some lesions may coalesce into annular s Healing Scarring Alternative presentations Non-transient l s s or bullae form in prior or wheal VIII. Labs: None are necessary (use for differential diagnosis) Skin Biopsy (if diagnosis unclear) Evaluate underlying etiology of skin lesion Complement fixation Cold agglutinins IX. Differential Diagnosis Severe illnesses with Erythema Multiforme type lesions ( ) l lesions persist <24 hours, then migrate Figurate erythema Toxic erythema Viral (...) Erythema Multiforme Erythema Multiforme Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Erythema Multiforme Erythema Multiforme Aka

2015 FP Notebook

7. Erythema multiforme. Full Text available with Trip Pro

Erythema multiforme. 5007067 1972 03 06 2018 11 13 0007-1447 1 5792 1972 Jan 08 British medical journal Br Med J Erythema multiforme. 63-4 eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Diagnosis, Differential Erythema Multiforme diagnosis drug therapy etiology pathology Humans 1972 1 8 1972 1 8 0 1 1972 1 8 0 0 ppublish 5007067 PMC1789254 Lancet. 1967 Nov 25;2(7526):1116-8 4168557 JAMA. 1966 Feb 21;195(8):691-3 5951775 Lancet. 1951 May 19;1(6664):1091-5 14832975 Br J Dermatol

1972 British medical journal

8. Erythema Multiforme and Nodosum-like Eruption as the Presenting Sign of Monoblastic Leukæmia Full Text available with Trip Pro

Erythema Multiforme and Nodosum-like Eruption as the Presenting Sign of Monoblastic Leukæmia 14226779 1996 12 01 2018 12 01 0035-9157 57 1964 Nov Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. ERYTHEMA MULTIFORME AND NODOSUM-LIKE ERUPTION AS THE PRESENTING SIGN OF MONOBLASTIC LEUKAEMIA. 1097-8 FORMAN L L eng Journal Article England Proc R Soc Med 7505890 0035-9157 OM Diagnosis, Differential Erythema Multiforme Erythema Nodosum Exanthema Humans Leukemia, Monocytic, Acute (...) Leukemia, Myeloid Lupus Erythematosus, Systemic Pathology Skin Manifestations DIAGNOSIS, DIFFERENTIAL ERYTHEMA MULTIFORME ERYTHEMA NODOSUM LEUKEMIA, MONOCYTIC LUPUS ERYTHEMATOSUS, SYSTEMIC PATHOLOGY SKIN MANIFESTATIONS 1964 11 1 1964 11 1 0 1 1964 11 1 0 0 ppublish 14226779 PMC1898203 Arch Dermatol. 1964 Mar;89(3):339-41 5297315

1964 Proceedings of the Royal Society of Medicine

9. Urticaria Multiforme. (Abstract)

Urticaria Multiforme. 27518665 2016 08 18 2016 08 13 1533-4406 375 5 2016 Aug 04 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Urticaria Multiforme. 470 10.1056/NEJMicm1508654 Kotlyar Simon S Telluride Medical Center, Telluride, CO simonkotlyar@mac.com. eng Case Reports Journal Article United States N Engl J Med 0255562 0028-4793 AIM IM Child, Preschool Diagnosis, Differential Erythema Multiforme diagnosis Female Humans Skin pathology Urticaria diagnosis 2016

2016 NEJM

10. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association Full Text available with Trip Pro

findings may be diagnosed with incomplete KD (also sometimes referred to as atypical KD). In the absence of a specific diagnostic test, other clinical, laboratory, and echocardiographic findings can support the diagnosis of incomplete KD in a patient whose clinical presentation suggests KD but whose clinical features do not meet the epidemiological case definition. Table 3. Diagnosis of Classic KD Classic KD is diagnosed in the presence of fever for at least 5 d (the day of fever onset is taken (...) , jaundice Gallbladder hydrops Pancreatitis Nervous system Extreme irritability Aseptic meningitis (pleocytosis of cerebrospinal fluid) Facial nerve palsy Sensorineural hearing loss Genitourinary Urethritis/meatitis, hydrocele Other Desquamating rash in groin Retropharyngeal phlegmon Anterior uveitis by slit lamp examination Erythema and induration at BCG inoculation site The differential diagnosis includes other infectious and noninfectious conditions, including the following: Measles Other viral

2017 American Heart Association

11. Selected presentations of lip enlargement: clinical manifestation and differentiation Full Text available with Trip Pro

Selected presentations of lip enlargement: clinical manifestation and differentiation Lip enlargement may be an important symptom of either systemic or local diseases. On the basis of selected age-matched clinical cases we present the possible causes of lip swelling. We describe the most representative symptoms and recommend treatment of these pathologies. We differentiate lip swelling in Miescher syndrome, monosymptomatic form of Melkersson-Rosenthal syndrome, lip swelling in erythema (...) multiforme and Stevens-Johnson syndrome and lip hemangioma and mucous extravasation cyst. We compare different causes of lip edema and indicate the most helpful diagnostic and treatment methods.

2018 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii

12. Erythema Multiforme

. Diagnosis Clinical evaluation Diagnosis of erythema multiforme is by clinical appearance; biopsy is rarely necessary. Differential diagnosis includes essential urticaria, vasculitis, bullous pemphigoid, pemphigus, linear IgA dermatosis, acute febrile neutrophilic dermatosis, and dermatitis herpetiformis. Oral lesions must be distinguished from aphthous stomatitis, pemphigus, herpetic stomatitis, and hand-foot-and-mouth disease. Patients with widely disseminated purpuric macules and blisters (...) Erythema Multiforme Erythema Multiforme - Dermatologic Disorders - MSD Manual Professional Edition Brought to you by The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases The trusted provider of medical information since 1899 SEARCH SEARCH MEDICAL TOPICS Common Health Topics Resources QUIZZES & CASES Quizzes Cases / / / / IN THIS TOPIC OTHER TOPICS IN THIS CHAPTER Test your knowledge Diagnostic Tests

2013 Merck Manual (19th Edition)

13. Cutaneous Lupus Erythematosus (CLE), Diagnosis and Monitoring

participants were included in this project and agreed on all recommendations. The diagnosis of CLE requires a specific approach based on patient´s history, clinical and laboratory findings, as well as histological analyses of skin biopsy specimens. In selected cases, direct immunofluorescence and photoprovocation using a standardized protocol may be applied to confirm the diagnosis or to exclude differential diagnoses. If the clinical picture and the laboratory signs are not in concordance, additional (...) autoimmune disease with a broad spectrum of clinical manifestations. To our knowledge, no standardized, consensus- based diagnostic and monitoring procedures have been developed up to date. Therefore, the aim of the present guideline was to achieve a broad consensus on diagnostic and monitoring approaches for the diagnosis of CLE by a European subcommittee, guided by the European Dermatology Forum (EDF) and supported by the European Academy of Dermatology and Venereology (EADV). In total, 15 European

2013 European Dermatology Forum

14. Erythema Multiforme-Oral Variant: Case Report and Review of Literature Full Text available with Trip Pro

for oral disease is immense. Therefore, an otolaryngologist or a dentist while treating such patients should have a differential diagnosis for all oral lesions. We report a case of erythema multiforme in which alcohol (ethanol) seems to be the precipitating factor and have also reviewed the English literature in the present context. (...) Erythema Multiforme-Oral Variant: Case Report and Review of Literature Erythema multiforme (EM) is an interesting dermatologic disease which has oral manifestations. EM is clinically characterized by a "minor" form and a "major" form. It presents a diagnostic dilemma because the oral cavity has the ability to produce varied manifestations. Infections (particularly herpes simplex and mycoplasma pneumonia) and drugs seem to predispose toward the development of EM. The range of possible etiologies

2011 Indian Journal of Otolaryngology and Head & Neck Surgery

15. Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)?

Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing (...) including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? Question and Answer supplied by Evidence Direct (a Royal Melbourne Hospital Health Sciences Library service) via the Centre for Evidence Based

2010 TRIP Answers

16. Toxic Epidermal Necrolysis (Diagnosis)

involvement can result in gastrointestinal hemorrhage, respiratory failure, ocular abnormalities, and genitourinary complications. Diffuse maculopapular rash in toxic epidermal necrolysis (TEN). TEN is most commonly drug induced. However, the disorder has other potential etiologies, including infection, malignancy, and vaccinations (see Etiology). TEN is idiosyncratic, and its occurrence is not easily predicted. Some authors believe that (SJS; also known as erythema multiforme major) is a manifestation (...) developed ocular complications. [ ] Patients treated with steroids fared no better than those treated without steroids. Therefore, TEN remains a common cause of visual loss in a significant number of patients. Ultimately, 5-9% of patients can become blind as a result of some of these complications. Previous References Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch

2014 eMedicine.com

17. Tularemia (Diagnosis)

, macular, or maculopapular and progress to pustular. Erythema nodosum and erythema multiforme are rare. More specific signs and symptoms are as follows: Ulceroglandular tularemia - Includes painful regional lymphadenopathy and an ulcerated skin lesion Glandular tularemia - Tender lymphadenopathy without evidence of local cutaneous lesions Oculoglandular tularemia - Unilateral conjunctivitis, corneal ulceration, lymphadenopathy, photophobia, lacrimation, lid edema, vision loss (rare) Oropharyngeal (...) Tularemia (Diagnosis) Tularemia: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjMwOTIzLW92ZXJ2aWV3 processing > Tularemia Updated: Sep 05, 2018 Author: Kerry O

2014 eMedicine.com

18. Histoplasmosis (Diagnosis)

, mediastinal fibrosis Physical examination: Uncommon findings include erythema nodosum and erythema multiforme CBC count: Thrombocytopenia in disseminated disease Serology: Useful in testing immunocompetent individuals with acute or subacute disease. Antigen testing: Useful in testing infiltrative or chronic disease in immunosuppressed; urine antigen has ~60% sensitivity; serum antigen has ~60% sensitivity; both combined have >80% sensitivity Acute/subacute presentation: Lung infiltrate, lobar pneumonia (...) Histoplasmosis (Diagnosis) Histoplasmosis: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjk5MDU0LW92ZXJ2aWV3 processing > Histoplasmosis Updated: Sep 21, 2018 Author

2014 eMedicine.com

19. Hepatitis C (Diagnosis)

Hepatitis C (Diagnosis) Hepatitis C: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTc3NzkyLW92ZXJ2aWV3 processing > Hepatitis C Updated: Jan 17, 2019 Author (...) changes ( ) Ankle edema and abdominal distention ( ) Hematemesis or melena ( ) Physical findings usually are not abnormal until portal hypertension or decompensated liver disease develops. Signs in patients with decompensated liver disease include the following: Hand signs: Palmar erythema, , asterixis, leukonychia, clubbing Head signs: Icteric sclera, temporal muscle wasting, enlarged parotid gland, cyanosis Fetor hepaticus Gynecomastia, small testes Abdominal signs: Paraumbilical hernia, ascites

2014 eMedicine.com

20. Nonneoplastic Epithelial Disorders of the Vulva (Diagnosis)

), a desmosomal cadherin that mediates cell-to-cell adhesion in the epidermis. The vulva is affected in approximately 10% of cases. Contact pemphigus induced by topical imiquimod may occur. [ ] Erythema multiforme (minor/major) Erythema multiforme is a cutaneous hypersensitivity reaction that may be triggered by herpesvirus infection or drug intake. Sulfonamides, beta-lactam antibiotics, and nonsteroidal anti-inflammatory drugs are the offending agents in most patients. Vulvar involvement is frequently (...) a pseudomembranous coating. Vulvar ulcers, ranging in diameter from a few millimeters to 3 cm, often appear as multiple crops of well-defined and very tender ulcers with fibrinous bases and considerable undermining. Fistulae, with partial or complete destruction of the labia, may develop. Other manifestations of the disease include fever, malaise, acneiform lesions or cutaneous nodules on the skin, arthritis, synovitis, and thrombophlebitis. Associated erythema nodosum and erythema multiforme have been reported

2014 eMedicine.com

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