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Erythema Multiforme Differential Diagnosis

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1. Current Perspectives on Erythema Multiforme. (PubMed)

Current Perspectives on Erythema Multiforme. Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions (...) with predominant acral localization as well as histological findings. Clinically, erythema multiforme can be differentiated into isolated cutaneous and combined mucocutaneous forms. Atypical erythema multiforme manifestations include lichenoid or granulomatous lesions as well as lesional infiltrates of T cell lymphoma and histiocytes. Herpes simplex virus infection being the most common cause, other infectious agents like-especially in children-Mycoplasma pneumoniae, hepatitis C virus, Coxsackie virus

2018 Clinical Reviews in Allergy & Immunology

2. Rash Week! Briefs: Serum sickness like reaction & erythema multiforme

patients and like palpable purpura, maculopapular lesions or erythema multiforme-type exanthema in others. There is no involvement of the mucous membranes or eyes. Most patients develop remittent fever without temporal spikes. Two out of three have arthralgias, most commonly seen in the hands, wrists, feet, ankles and shoulders. The differential diagnosis includes: Viral exanthems (roseola) Hypersensitivity vasculitis Scarlet fever Acute rheumatic fever Meningococcemia Disseminated gonococcemia (...) Rash Week! Briefs: Serum sickness like reaction & erythema multiforme Rash Week! Briefs: Serum sickness like reaction & erythema multiforme – PEMBlog Search for: Search for: Rash Week! Briefs: Serum sickness like reaction & erythema multiforme You are seeing a child who is well appearing but has a dramatic rash. The rash appeared this morning and seemed to begin on her torso, later spreading to her limbs. The daycare thought that it was an allergy and was going to give her another child’s

2018 PEM Blog

3. Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report (PubMed)

. Target lesions may or may not be present in EM cases. When target lesions are not present on the skin, it is very difficult to make a differential diagnosis of EM. Herpes associated erythema multiforme (HAEM) is an uncommon lesion caused by herpes simplex virus infection. A case of severe painful lesions in a 28-year-old pregnant patient with HAEM is presented here. HAEM is rarely found in pregnant women, and its clinical findings, diagnosis and treatment have not previously been reported. (...) Treatment of a Pregnant Patient with Herpes Associated Erythema Multiforme (HAEM): A case report Erythema Multiforme, (EM) is an uncommon, acute inflammatory disease of the skin and mucous membranes characterized by ulcerations caused by hypersensitivity to drugs, microbial agents or other allergens. An EM outbreak can result in more severe forms of EM involving the skin, and there are several types of EM manifestations. A hemorrhagic crust on the lip is a pathognomonic sign of this disease

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2016 Acta Stomatologica Croatica

4. Mucosal erosions as the presenting symptom in erythema multiforme: a case report (PubMed)

Department of Dermatology; Gayed Sedki S Department of Genitourinary Medicine, East Lancashire Hospitals NHS Trust, Blackburn. eng Case Reports Journal Article England Br J Gen Pract 9005323 0960-1643 IM Adult Diagnosis, Differential Erythema Multiforme diagnosis etiology microbiology Humans Lip Diseases diagnosis microbiology Male Mouth Diseases diagnosis microbiology Mouth Mucosa microbiology pathology Mycoplasma pneumoniae Penile Diseases diagnosis microbiology Pneumonia, Mycoplasma complications (...) Mucosal erosions as the presenting symptom in erythema multiforme: a case report 26917662 2017 05 19 2018 11 13 1478-5242 66 644 2016 Mar The British journal of general practice : the journal of the Royal College of General Practitioners Br J Gen Pract Mucosal erosions as the presenting symptom in erythema multiforme: a case report. e222-4 10.3399/bjgp16X684205 Spencer Stephen S Foundation year 2 doctor. Buhary Thajunnisha T Specialist registrar in genitourinary medicine; Coulson Ian I

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2016 The British Journal of General Practice

5. Erythema Multiforme

Central necrosis Some lesions may coalesce into annular s Healing Scarring Alternative presentations Non-transient l s s or bullae form in prior or wheal VIII. Labs: None are necessary (use for differential diagnosis) Skin Biopsy (if diagnosis unclear) Evaluate underlying etiology of skin lesion Complement fixation Cold agglutinins IX. Differential Diagnosis Severe illnesses with Erythema Multiforme type lesions ( ) l lesions persist <24 hours, then migrate Figurate erythema Toxic erythema Viral (...) . Concepts Disease or Syndrome ( T047 ) MSH ICD9 695.10, 695.1 ICD10 , SnomedCT 36715001 , 200919006 , 156362004 , 200928007 , 267848009 English ERYTHEMA MULTIFORME , Erythema multiforme, unspecified , erythema multiforme , erythema multiforme (diagnosis) , Erythema multiforme NOS , Erythema Multiforme [Disease/Finding] , erythema polymorphe , multiforme erythema , Erythema;multiforme , erythema multiformes , Target lesion , Multiforme - erythema , Erythema multiforme NOS (disorder) , Erythaema

2018 FP Notebook

6. Urticaria Multiforme. (PubMed)

Urticaria Multiforme. 27518665 2016 08 18 2016 08 13 1533-4406 375 5 2016 Aug 04 The New England journal of medicine N. Engl. J. Med. IMAGES IN CLINICAL MEDICINE. Urticaria Multiforme. 470 10.1056/NEJMicm1508654 Kotlyar Simon S Telluride Medical Center, Telluride, CO simonkotlyar@mac.com. eng Case Reports Journal Article United States N Engl J Med 0255562 0028-4793 AIM IM Child, Preschool Diagnosis, Differential Erythema Multiforme diagnosis Female Humans Skin pathology Urticaria diagnosis 2016

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2016 NEJM

7. Erythema Multiforme

Central necrosis Some lesions may coalesce into annular s Healing Scarring Alternative presentations Non-transient l s s or bullae form in prior or wheal VIII. Labs: None are necessary (use for differential diagnosis) Skin Biopsy (if diagnosis unclear) Evaluate underlying etiology of skin lesion Complement fixation Cold agglutinins IX. Differential Diagnosis Severe illnesses with Erythema Multiforme type lesions ( ) l lesions persist <24 hours, then migrate Figurate erythema Toxic erythema Viral (...) . Concepts Disease or Syndrome ( T047 ) MSH ICD9 695.10, 695.1 ICD10 , SnomedCT 36715001 , 200919006 , 156362004 , 200928007 , 267848009 English ERYTHEMA MULTIFORME , Erythema multiforme, unspecified , erythema multiforme , erythema multiforme (diagnosis) , Erythema multiforme NOS , Erythema Multiforme [Disease/Finding] , erythema polymorphe , multiforme erythema , Erythema;multiforme , erythema multiformes , Target lesion , Multiforme - erythema , Erythema multiforme NOS (disorder) , Erythaema

2015 FP Notebook

8. Erythema Multiforme-Oral Variant: Case Report and Review of Literature (PubMed)

for oral disease is immense. Therefore, an otolaryngologist or a dentist while treating such patients should have a differential diagnosis for all oral lesions. We report a case of erythema multiforme in which alcohol (ethanol) seems to be the precipitating factor and have also reviewed the English literature in the present context. (...) Erythema Multiforme-Oral Variant: Case Report and Review of Literature Erythema multiforme (EM) is an interesting dermatologic disease which has oral manifestations. EM is clinically characterized by a "minor" form and a "major" form. It presents a diagnostic dilemma because the oral cavity has the ability to produce varied manifestations. Infections (particularly herpes simplex and mycoplasma pneumonia) and drugs seem to predispose toward the development of EM. The range of possible etiologies

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2011 Indian Journal of Otolaryngology and Head & Neck Surgery

9. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association

, jaundice Gallbladder hydrops Pancreatitis Nervous system Extreme irritability Aseptic meningitis (pleocytosis of cerebrospinal fluid) Facial nerve palsy Sensorineural hearing loss Genitourinary Urethritis/meatitis, hydrocele Other Desquamating rash in groin Retropharyngeal phlegmon Anterior uveitis by slit lamp examination Erythema and induration at BCG inoculation site The differential diagnosis includes other infectious and noninfectious conditions, including the following: Measles Other viral (...) clinical presentation. Typically the clinical features are not all present at a single point in time, and it is generally not possible to establish the diagnosis very early in the course. Similarly, some clinical features may have abated in patients who present after 1 to 2 weeks of fever, and a careful review of prior signs and symptoms can help establish the diagnosis. Figure 2. Clinical features of classic Kawasaki disease. A , Rash: Maculopapular, diffuse erythroderma, or erythema multiforme-like

2017 American Heart Association

10. Erythema multiforme. (PubMed)

Erythema multiforme. 5007067 1972 03 06 2018 11 13 0007-1447 1 5792 1972 Jan 08 British medical journal Br Med J Erythema multiforme. 63-4 eng Journal Article England Br Med J 0372673 0007-1447 AIM IM Diagnosis, Differential Erythema Multiforme diagnosis drug therapy etiology pathology Humans 1972 1 8 1972 1 8 0 1 1972 1 8 0 0 ppublish 5007067 PMC1789254 Lancet. 1967 Nov 25;2(7526):1116-8 4168557 JAMA. 1966 Feb 21;195(8):691-3 5951775 Lancet. 1951 May 19;1(6664):1091-5 14832975 Br J Dermatol

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1972 British medical journal

11. Erythema Multiforme and Nodosum-like Eruption as the Presenting Sign of Monoblastic Leukæmia (PubMed)

Erythema Multiforme and Nodosum-like Eruption as the Presenting Sign of Monoblastic Leukæmia 14226779 1996 12 01 2018 12 01 0035-9157 57 1964 Nov Proceedings of the Royal Society of Medicine Proc. R. Soc. Med. ERYTHEMA MULTIFORME AND NODOSUM-LIKE ERUPTION AS THE PRESENTING SIGN OF MONOBLASTIC LEUKAEMIA. 1097-8 FORMAN L L eng Journal Article England Proc R Soc Med 7505890 0035-9157 OM Diagnosis, Differential Erythema Multiforme Erythema Nodosum Exanthema Humans Leukemia, Monocytic, Acute (...) Leukemia, Myeloid Lupus Erythematosus, Systemic Pathology Skin Manifestations DIAGNOSIS, DIFFERENTIAL ERYTHEMA MULTIFORME ERYTHEMA NODOSUM LEUKEMIA, MONOCYTIC LUPUS ERYTHEMATOSUS, SYSTEMIC PATHOLOGY SKIN MANIFESTATIONS 1964 11 1 1964 11 1 0 1 1964 11 1 0 0 ppublish 14226779 PMC1898203 Arch Dermatol. 1964 Mar;89(3):339-41 5297315

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1964 Proceedings of the Royal Society of Medicine

12. Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)?

Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? - Trip Database or use your Google+ account Liberating the literature ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing (...) including images, videos, patient information leaflets, educational courses and news. For further information on Trip click on any of the questions/sections on the left-hand side of this page. But if you still have questions please contact us via jon.brassey@tripdatabase.com Can deep radiation therapy lead to Erythema Multiforme (Stevens-Johnson Syndrome)? Question and Answer supplied by Evidence Direct (a Royal Melbourne Hospital Health Sciences Library service) via the Centre for Evidence Based

2010 TRIP Answers

13. Erythema Multiforme

. Diagnosis Clinical evaluation Diagnosis of erythema multiforme is by clinical appearance; biopsy is rarely necessary. Differential diagnosis includes essential urticaria, vasculitis, bullous pemphigoid, pemphigus, linear IgA dermatosis, acute febrile neutrophilic dermatosis, and dermatitis herpetiformis. Oral lesions must be distinguished from aphthous stomatitis, pemphigus, herpetic stomatitis, and hand-foot-and-mouth disease. Patients with widely disseminated purpuric macules and blisters (...) , characterized by target or iris skin lesions. Oral mucosa may be involved. Diagnosis is clinical. Lesions spontaneously resolve but frequently recur. Erythema multiforme usually occurs as a reaction to an infectious agent such as herpes simplex virus or mycoplasma but may be a reaction to a drug. Suppressive antiviral therapy may be indicated for patients with frequent or symptomatic recurrence due to herpes simplex virus. For years, erythema multiforme was thought to represent the milder end of a spectrum

2013 Merck Manual (19th Edition)

14. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections

Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections We use cookies to enhance your experience on our website. By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America | Clinical Infectious Diseases | Oxford Academic Search Account Menu Menu Navbar (...) Search Filter Mobile Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article navigation 15 July 2014 Article Contents Article Navigation Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America Dennis L. Stevens 1Division of Infectious Diseases, Department of Veterans Affairs, Boise, Idaho Search for other works by this author on: Alan L. Bisno 2Medical

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2014 Infectious Diseases Society of America

15. Tularemia (Diagnosis)

, macular, or maculopapular and progress to pustular. Erythema nodosum and erythema multiforme are rare. More specific signs and symptoms are as follows: Ulceroglandular tularemia - Includes painful regional lymphadenopathy and an ulcerated skin lesion Glandular tularemia - Tender lymphadenopathy without evidence of local cutaneous lesions Oculoglandular tularemia - Unilateral conjunctivitis, corneal ulceration, lymphadenopathy, photophobia, lacrimation, lid edema, vision loss (rare) Oropharyngeal (...) Tularemia (Diagnosis) Tularemia: Practice Essentials, Background, Pathophysiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMjMwOTIzLW92ZXJ2aWV3 processing > Tularemia Updated: Sep 05, 2018 Author: Kerry O

2014 eMedicine.com

16. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (Diagnosis)

macules, leading to epidermal detachment of 10-30% of the BSA. Classic toxic epidermal necrolysis has epidermal detachment of more than 30%. An uncommon form of toxic epidermal necrolysis (toxic epidermal necrolysis without spots) lacks targetoid lesions, and blisters form on confluent erythema. Greater than 10% epidermal detachment is required for diagnosis of these cases. In contrast, bullous erythema multiforme, which was previously grouped with Stevens-Johnson syndrome, may have epidermal (...) defined, erythematous macules with darker, purpuric centers. The lesions differ from classic target lesions of erythema multiforme by having only two zones of color: a central, dusky purpura or a central bulla, with a surrounding macular erythema. A classic target lesion has three zones of color: a central, dusky purpura or a central bulla; a surrounding pale, edematous zone; and a surrounding macular erythema. See the image below. Note the presence of both 2-zoned atypical targetoid lesions

2014 eMedicine.com

17. Stevens-Johnson Syndrome (Diagnosis)

the linking of Stevens-Johnson syndrome and toxic epidermal necrolysis together with their differentiation from erythema multiforme. Various etiologic factors (eg, infection, drugs, malignancies) have been implicated as causes of Stevens-Johnson syndrome. However, as many as half of cases are idiopathic. There is strong evidence for a genetic predisposition to Stevens-Johnson syndrome provoked by certain drugs. (See Etiology.) There are no specific laboratory studies (other than biopsy) that can (...) symmetrically on the face and the upper part of the torso. The cutaneous lesions are characterized as follows: The rash can begin as macules that develop into papules, vesicles, bullae, urticarial plaques, or confluent erythema The typical lesion has the appearance of a target; this is considered pathognomonic In contrast to the typical lesions of erythema multiforme, these lesions have only 2 zones of color The lesion’s core may be vesicular, purpuric, or necrotic; that zone is surrounded by macular

2014 eMedicine.com

18. Toxic Epidermal Necrolysis (Diagnosis)

involvement can result in gastrointestinal hemorrhage, respiratory failure, ocular abnormalities, and genitourinary complications. Diffuse maculopapular rash in toxic epidermal necrolysis (TEN). TEN is most commonly drug induced. However, the disorder has other potential etiologies, including infection, malignancy, and vaccinations (see Etiology). TEN is idiosyncratic, and its occurrence is not easily predicted. Some authors believe that (SJS; also known as erythema multiforme major) is a manifestation (...) developed ocular complications. [ ] Patients treated with steroids fared no better than those treated without steroids. Therefore, TEN remains a common cause of visual loss in a significant number of patients. Ultimately, 5-9% of patients can become blind as a result of some of these complications. Previous References Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch

2014 eMedicine.com

19. Cutaneous Manifestations of HIV Disease (Diagnosis)

and papules may be generalized and can become permanent after the discontinuation of the therapy. Sulfonamides may cause the following: Urticaria Erythema multiforme Toxic epidermal necrolysis Systemic reactions, including fever, leukopenia, thrombocytopenia, hepatitis, and nephritis Toxic epidermal necrolysis has been reported with the following agents in patients with HIV: Fluconazole Clindamycin and other antibiotics Phenobarbital Chlormezanone has been reported in 2 patients receiving saquinavir (...) occur primarily or as a drug eruption in HIV disease. Cold urticaria has also been associated with HIV disease. [ ] Previous Next: Differential Diagnosis The differential diagnosis includes the following: : Its exacerbation in association with HIV infection is likely a result of co-infection with the hepatitis C virus rather than with HIV [ ] Other problems to be considered in HIV-infected patients with dermatologic conditions include the following: Ashy dermatosis [ ] Normolipemic xanthomas

2014 eMedicine.com

20. Cutaneous Manifestations of Hepatitis C (Diagnosis)

or findings relevant to HCV infection manifest in 20-40% of patients presenting to dermatologists and in a significant percentage (15-20%) of general patients. HCV is suggested and must appear in the differential diagnosis of these patients to avoid missing this important but occult factor in clinical disease in the appropriate setting. Extrahepatic manifestations of HCV are numerous. [ ] The most prevalent and most closely linked with HCV is essential mixed cryoglobulins with dermatologic, neurologic (...) vasculitis). Courtesy of Walter Reed Army Medical Center Dermatology. Cutis marmorata. Courtesy of Walter Reed Army Medical Center Dermatology. Erythema multiforme, bull's-eye lesions. Courtesy of Walter Reed Army Medical Center Dermatology. Erythema dyschromicum perstans. Courtesy of Walter Reed Army Medical Center Dermatology. Erythema dyschromicum perstans. Courtesy of Walter Reed Army Medical Center Dermatology. Erythema nodosa. Courtesy of Walter Reed Army Medical Center Dermatology. Erythema nodosa

2014 eMedicine.com

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