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Ergotamine

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1. Contractile Response of Bovine Lateral Saphenous Vein to Ergotamine Tartrate Exposed to Different Concentrations of Molecularly Imprinted Polymer (PubMed)

Contractile Response of Bovine Lateral Saphenous Vein to Ergotamine Tartrate Exposed to Different Concentrations of Molecularly Imprinted Polymer Ergot alkaloids, in their active isomeric form, affect animal health and performance, and adsorbents are used to mitigate toxicities by reducing bioavailability. Adsorbents with high specificity (molecularly imprinted polymers: MIP) adsorb ergot alkaloids in vitro, but require evaluation for biological implications. Using ex vivo myography, synthetic (...) polymers were evaluated for effects on the bioactivity of ergotamine tartrate (ETA). Polymers were first evaluated using isotherms. Lateral saphenous veins were collected from 17 steers for four independent studies: dose response of ETA, adsorbent dose response, validation of pre-myograph incubation conditions and MIP/ non-molecularly imprinted polymer (NIP) comparison. Norepinephrine normalized percent contractile response to increasing ETA exhibited a sigmoidal dose response (max: 88.47 and log

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2018 Toxins

2. Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience. (PubMed)

Modulatory effect of the 5-HT1A agonist buspirone and the mixed non-hallucinogenic 5-HT1A/2A agonist ergotamine on psilocybin-induced psychedelic experience. The mixed serotonin (5-HT) 1A/2A/2B/2C/6/7 receptor agonist psilocybin dose-dependently induces an altered state of consciousness (ASC) that is characterized by changes in sensory perception, mood, thought, and the sense of self. The psychological effects of psilocybin are primarily mediated by 5-HT2A receptor activation. However (...) , accumulating evidence suggests that 5-HT1A or an interaction between 5-HT1A and 5-HT2A receptors may contribute to the overall effects of psilocybin. Therefore, we used a double-blind, counterbalanced, within-subject design to investigate the modulatory effects of the partial 5-HT1A agonist buspirone (20mg p.o.) and the non-hallucinogenic 5-HT2A/1A agonist ergotamine (3mg p.o.) on psilocybin-induced (170 µg/kg p.o.) psychological effects in two groups (n=19, n=17) of healthy human subjects. Psychological

2017 European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

3. Ergotamine Use and Overuse in Taiwan: A Retrospective Cohort Study. (PubMed)

Ergotamine Use and Overuse in Taiwan: A Retrospective Cohort Study. The aim of this study was to investigate the pattern of ergotamine prescription and overuse in Taiwan.Ergotamine is a frequently prescribed medication for the treatment of migraine, although excessive use may lead to medication-overuse headache.We conducted a retrospective cohort study by using the Longitudinal Health Insurance Database 2005 in Taiwan. Patients enrolled in the study were between the ages of 18 and 80 years (...) , received at least two prescriptions of ergotamine, and follow-up for more than 1 year at outpatient clinics during 1999 to 2013. Each ergotamine prescription was converted into a defined daily dose (DDD) and patients were sorted into two groups: occasional users, having fewer than 3 consecutive months of use, and regular users, with 3 consecutive months of use or more. Regular users were further divided into overusers (DDDs ≥ 10 per month) and non-overusers.A total of 41,023 migraine patients were

2017 Headache

4. Ergotamine

Ergotamine Ergotamine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ergotamine Ergotamine Aka: Ergotamine , Wigraine II. Indications (...) on the term "Ergotamine." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Ergotamine (C0014710) Definition (MSH) A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS. Definition (NCI) A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates

2018 FP Notebook

5. Adverse cardiovascular events associated with triptans and ergotamines for treatment of migraine: systematic review of observational studies. (PubMed)

Adverse cardiovascular events associated with triptans and ergotamines for treatment of migraine: systematic review of observational studies. Apart from the underlying cardiovascular (CV) risk associated with migraine, both triptans and ergotamines can induce vasoconstriction and potentially increase the risk of serious ischemic events. Because of the low frequency of such events in eligible patients, randomized controlled trials are not exhaustive to assess the drug-related CV risk (...) . Observational studies are, therefore, an essential source of information to clarify this matter of concern.The aim of this study was to systematically review the available published observational studies investigating the risk of serious CV events in triptan or ergotamine users, as compared to unexposed migraineur controls.We systematically searched MEDLINE and EMBASE electronic databases for cohort or case-control studies up to December 1, 2013. Studies retrieved from CDSR, DARE and HTA databases

2015 Cephalalgia : an international journal of headache

6. Ergotamine-induced tricuspid valvulopathy presenting as recurrent pleural effusions. (PubMed)

Ergotamine-induced tricuspid valvulopathy presenting as recurrent pleural effusions.

2014 Chest

7. Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. (PubMed)

Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure. Severely affected patients with autonomic failure require pressor agents to counteract the blood pressure fall and improve presyncopal symptoms upon standing. Previous studies suggest that combination ergotamine and caffeine may be effective in the treatment of autonomic failure, but the efficacy of this drug has not been evaluated in controlled trials. Therefore, we compared (...) the effects of ergotamine/caffeine on seated blood pressure and orthostatic tolerance and symptoms in 12 primary autonomic failure patients without history of coronary artery disease. Patients were randomized to receive a single oral dose of placebo, midodrine (5-10 mg), or ergotamine and caffeine (1 and 100 mg, respectively) in a single-blind, crossover study. Blood pressure was measured while patients were seated and after standing for up to 10 min, at baseline and at 1 h post-drug. Ergotamine/caffeine

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2014 Frontiers in physiology

8. Tolfenamic acid is as effective as ergotamine during migraine attacks. (PubMed)

Tolfenamic acid is as effective as ergotamine during migraine attacks. Tolfenamic acid (a potent inhibitor of prostaglandin biosynthesis), ergotamine tartrate, acetylsalicylic acid, or placebo was administered during 160 migraine attacks in twenty women in a double-blind, cross-over study. Tolfenamic acid and ergotamine were equally effective in reducing the duration and intensity of attacks, but side-effects, especially nausea, were less common with tolfenamic acid. This probably accounted

1979 Lancet

9. THE EFFECT OF DEMEROL, ERGOTAMINE, AND DIHYDRO-ERGOTAMINE ON MORTALITY AFTER CORONARY OCCLUSION IN DOGS (PubMed)

THE EFFECT OF DEMEROL, ERGOTAMINE, AND DIHYDRO-ERGOTAMINE ON MORTALITY AFTER CORONARY OCCLUSION IN DOGS 18610063 2008 08 22 2018 12 01 0007-0769 9 2 1947 Apr British heart journal Br Heart J THE EFFECT OF DEMEROL, ERGOTAMINE, AND DIHYDRO-ERGOTAMINE ON MORTALITY AFTER CORONARY OCCLUSION IN DOGS. 85-95 Manning G W GW Banting and Best Department of Medical Research, Banting Institute, Toronto, Canada. Caudwell G C GC eng Journal Article England Br Heart J 0370634 0007-0769 9E338QE28F Meperidine (...) PR834Q503T Ergotamine OM Animals Coronary Occlusion Coronary Vessels Dogs Ergotamine Heart Humans Meperidine Vascular Diseases 4713:976m CORONARY VESSELS/occlusion 1947 4 1 0 0 1947 4 1 0 1 1947 4 1 0 0 ppublish 18610063 PMC481012 Can Med Assoc J. 1944 Dec;51(6):509-17 20323279 Can Med Assoc J. 1946 Jul;55(1):43-6 20323839 Can Med Assoc J. 1933 Aug;29(2):122-4 20319191

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1947 British Heart Journal

10. An unusual cause of chest pain: Acute coronary syndrome following administration of ergotamine tartrate (PubMed)

An unusual cause of chest pain: Acute coronary syndrome following administration of ergotamine tartrate For many years, ergotamine has been used for the acute treatment of migraine. Ergotamine may produce coronary vasospasm, which is often associated with ischemic electrocardiography changes and angina pectoris. A 62-year-old woman who was admitted to the emergency department because of chest pain is described. She had a history of severe migraine attacks and started to use ergotamine tartrate (...) 0.75 mg daily the day before. Electrocardiography revealed sinus tachycardia with left anterior hemiblock and T wave inversion in the precordial leads. Cardiac biomarker levels were elevated. After discontinuation of the drug and initiation of vasodilator treatment, her chest pain resolved. Patients with migraine may have an underlying vasospastic disorder predisposing them to coronary artery spasm. Physicians should be alerted to potential cardiac vasospastic effects of low-dose ergotamine

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2012 Experimental & Clinical Cardiology

11. Ergotamine-Associated Valvulopathy with Recurrent Chylous Pleural Effusion (PubMed)

Ergotamine-Associated Valvulopathy with Recurrent Chylous Pleural Effusion We report a rare case of ergotamine-associated mitral stenosis in a 55-year-old woman who presented with recurrent chylous pleural effusion. Echocardiographic, gross, and microscopic features of the mitral valve were consistent with chronic ergotamine-induced valvulopathy. We conclude that medication-induced valvulopathy should be included in the differential diagnosis of valvular heart disease. In addition, cardiac (...) function should be monitored before and during long-term therapy with ergotamine or ergotamine-derived dopamine agonists.

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2012 Texas Heart Institute Journal

12. Ergotamine

Ergotamine Ergotamine Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Ergotamine Ergotamine Aka: Ergotamine , Wigraine II. Indications (...) on the term "Ergotamine." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Ontology: Ergotamine (C0014710) Definition (MSH) A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS. Definition (NCI) A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates

2015 FP Notebook

13. Ischemic Colitis Secondary to Ergotamine Use: A Case Study (PubMed)

Ischemic Colitis Secondary to Ergotamine Use: A Case Study A 48-year-old woman with a history of chronic migraines, initially admitted for inpatient management of intractable migraine headaches, developed new onset abdominal pain, hypotension, and diarrhea on hospital day number ten. In our institution's headache unit, patients are treated by a multidisciplinary approach, including individualized drug therapy based on diagnosis and previous response to therapy. Given the patient's hypotension (...) and clinical appearance, she was transferred to the intensive care unit and treated for septic shock and metabolic acidosis. A bedside colonscopy revealed diffuse ischemic colitis. Final pathology after colon resection showed widespread, transmural necrosis of the colonic wall. We review the pathophysiology of ergotamine use and its potential association with ischemic colitis.

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2011 Case reports in gastroenterology

14. Upper limb artery segmental occlusions due to chronic use of ergotamine combined with itraconazole, treated by thrombolysis (PubMed)

Upper limb artery segmental occlusions due to chronic use of ergotamine combined with itraconazole, treated by thrombolysis The ergotamine tartrate associated with certain categories of drugs can lead to critical ischemia of the extremities. Discontinuation of taking ergotamine is usually sufficient for the total regression of ischemia, but in some cases it could be necessary thrombolytic and anticoagulant therapy to avoid amputation.A woman of 62 years presented with a severe pain left forearm (...) (equivalent to 3.2 mg of ergotamine).From about ten days had begun therapy with itraconazole for vaginal candidiasis. The Color-Doppler ultrasound shown arterial thrombosis of the upper limbs (humeral and radial bilateral), with minimal residual flow to the right and no signal on the humeral and radial left artery.Angiography revealed progressive reduction in size of the axillary artery and right humeral artery stenosis with right segmental occlusions and multiple hypertrophic collateral circulations

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2011 Thrombosis journal

15. The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache. (PubMed)

The analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine for the treatment of postdural puncture headache. We investigated the analgesic and antiemetic efficacy of gabapentin or ergotamine/caffeine (Cafergot), in addition to conservative treatment consisting of bed rest and adequate fluid intake, for the treatment of postdural puncture headache (PDPH).In this randomized, prospective, controlled study, gabapentin or Cafergot was administered to 42 adult patients suffering from

2011 Advances in medical sciences

16. A randomized controlled trial of ergotamine tartrate. (PubMed)

A randomized controlled trial of ergotamine tartrate. 4908199 1970 05 13 2015 11 19 0007-1242 24 1 1970 Feb British journal of preventive & social medicine Br J Prev Soc Med A randomized controlled trial of ergotamine tartrate. 65 Waters W E WE eng Clinical Trial Journal Article Randomized Controlled Trial England Br J Prev Soc Med 0372672 0007-1242 0 Placebos PR834Q503T Ergotamine IM Clinical Trials as Topic Ergotamine adverse effects therapeutic use Female Headache diagnosis Humans Migraine

1970 British journal of preventive & social medicine

17. A double-blind crossover trial of isometheptene mucate compound and ergotamine in migraine. (PubMed)

A double-blind crossover trial of isometheptene mucate compound and ergotamine in migraine. 4552744 1972 06 15 2013 11 21 0007-0947 26 2 1972 Feb The British journal of clinical practice Br J Clin Pract A double-blind crossover trial of isometheptene mucate compound and ergotamine in migraine. 76-9 Yuill G M GM Swinburn W R WR Liversedge L A LA eng Clinical Trial Comparative Study Journal Article Randomized Controlled Trial England Br J Clin Pract 0372546 0007-0947 0 Amines 0 Methylamines 0 (...) Sympathomimetics PR834Q503T Ergotamine Y7L24THH6T isometheptene IM Amines adverse effects therapeutic use Diarrhea chemically induced Ergotamine adverse effects therapeutic use Female Humans Male Methylamines adverse effects therapeutic use Migraine Disorders drug therapy Sympathomimetics adverse effects therapeutic use Wakefulness drug effects 1972 2 1 1972 2 1 0 1 1972 2 1 0 0 ppublish 4552744

1972 The British journal of clinical practice

18. Letter: Ergotamine tartrate overdose. (PubMed)

Letter: Ergotamine tartrate overdose. 1252836 1976 06 02 2008 11 20 0007-1447 1 6008 1976 Feb 28 British medical journal Br Med J Letter: Ergotamine tartrate overdose. 525 Rose F C FC Wilkinson M M eng Journal Article England Br Med J 0372673 0007-1447 0 Ergotamines AIM IM Ergotamines adverse effects Migraine Disorders drug therapy 1976 2 28 1976 2 28 0 1 1976 2 28 0 0 ppublish 1252836 PMC1638819

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1976 British medical journal

19. Letter: Hazards of ergotamine tartrate. (PubMed)

Letter: Hazards of ergotamine tartrate. 1260365 1976 07 06 2018 11 13 0007-1447 1 6013 1976 Apr 03 British medical journal Br Med J Letter: Hazards of ergotamine tartrate. 834-5 Pearce J J eng Journal Article England Br Med J 0372673 0007-1447 PR834Q503T Ergotamine AIM IM Ergotamine adverse effects Headache chemically induced Humans Migraine Disorders drug therapy Substance-Related Disorders 1976 4 3 1976 4 3 0 1 1976 4 3 0 0 ppublish 1260365 PMC1639502 Practitioner. 1973 Sep;211(263):316-20

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1976 British medical journal

20. Unilateral arm ischemia due to ergotamine tartrate. (PubMed)

Unilateral arm ischemia due to ergotamine tartrate. 5928531 1967 02 25 2018 11 13 0008-4409 95 25 1966 Dec 17 Canadian Medical Association journal Can Med Assoc J Unilateral arm ischemia due to ergotamine tartrate. 1319-21 Tator C H CH Heimbecker R O RO eng Case Reports Journal Article Canada Can Med Assoc J 0414110 0008-4409 0 Dextrans 9005-49-6 Heparin B6E06QE59J Mepivacaine CHH9H12AQ3 Tolazoline PR834Q503T Ergotamine AIM IM Angiography Arm blood supply Dextrans therapeutic use Ergotamine

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1966 Canadian Medical Association Journal

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