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Epilepsy Resources

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1. Seizure frequency, healthcare resource utilisation and mortality in childhood epilepsy: a retrospective cohort study using the THIN database. (PubMed)

Seizure frequency, healthcare resource utilisation and mortality in childhood epilepsy: a retrospective cohort study using the THIN database. To understand the association of seizure frequency with healthcare resource utilisation (HCRU) and mortality in UK children with epilepsy (CWE).Retrospective cohort study.Routinely collected data in primary care from The Health Improvement Network UK database.CWE ≥1 and<18 years of age with a record of seizure frequency were included in mortality analyses

2019 Archives of Disease in Childhood

2. Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study. (PubMed)

Obstetric outcomes and effects on babies born to women treated for epilepsy during pregnancy in a resource limited setting: a comparative cohort study. Management of epilepsy during pregnancy in a resource-limited setting (RLS) is challenging. This study aimed to assess obstetric outcomes and effects on babies of women with epilepsy (WWE) exposed to Anti-epileptic drugs (AEDs) compared to non-exposed controls in a RLS.Pregnant WWE were recruited from antenatal and neurology clinics

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2018 BMC Pregnancy and Childbirth

3. Health care resource utilization before and after perampanel initiation among patients with epilepsy in the United States. (PubMed)

Health care resource utilization before and after perampanel initiation among patients with epilepsy in the United States. The purpose of this study was to evaluate changes in health care resource utilization following the initiation of perampanel for the treatment of epilepsy in the United States.Health care claims from Symphony Health's Integrated Dataverse database between December 2012 and November 2015 were analyzed. Patients newly initiated on perampanel, having ≥1 epilepsy (International (...) ) observation duration was 459.8 [462] (±146.3) days in the postperampanel period. The postperampanel period was associated with significantly lower rates of all health care resource utilization outcomes than the pre-period. For the post- versus pre-period, perampanel users had 42.3 versus 53.8 overall hospitalizations per 100 person-years (rate ratio [RR] = 0.80, p < 0.001) and 1,240.2 versus 1,343.8 outpatient visits per 100 person-years (RR = 0.91, p < 0.001). Epilepsy-related hospitalizations

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2017 Epilepsia

4. The Burden of Severely Drug-Refractory Epilepsy: A Comparative Longitudinal Evaluation of Mortality, Morbidity, Resource Use, and Cost Using German Health Insurance Data (PubMed)

The Burden of Severely Drug-Refractory Epilepsy: A Comparative Longitudinal Evaluation of Mortality, Morbidity, Resource Use, and Cost Using German Health Insurance Data To evaluate long-term outcome of three years and treatment patterns of patients suffering from severely drug-refractory epilepsy (SDRE).This analysis was population-based and retrospective, with data collected from four million individuals insured by statutory German health insurance. ICD-10 codes for epilepsy (G40*) and intake (...) AEDs per patient was prescribed during the first follow-up year. The AEDs most commonly prescribed were: levetiracetam (53.5%), lamotrigine (41.4%), valproate (41.3%), lacosamide (20.4%), and topiramate (17.8%). During 3-year follow-up, there was an annual rate of hospitalization in the range 42.7 to 55%, which was significantly higher than the 11.6-12.8% (p < 0.001) for the matched controls. Admissions to hospital because of epilepsy ranged between 1.7 and 1.9 per year, with an average duration

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2017 Frontiers in neurology

5. Epilepsy Resources

Epilepsy Resources Epilepsy Resources Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Epilepsy Resources Epilepsy Resources Aka (...) : Epilepsy Resources , Seizure Disorder Resources From Related Chapters II. Resources: Organizations CDC Foundation of America NINDS Information III. Resources: Books Freeman (2002) s and in Childhood Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Epilepsy Resources." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Seizure Disorders About

2018 FP Notebook

6. The influence of socioeconomic status on health resource utilization in pediatric epilepsy in a universal health insurance system. (PubMed)

The influence of socioeconomic status on health resource utilization in pediatric epilepsy in a universal health insurance system. It is unknown if there is a disparity in health resource utilization (HRU) among children with epilepsy in a universal health insurance system. The aims of this study were to evaluate whether socioeconomic status (SES) influenced the pattern of HRU among children with epilepsy, and to determine if neurology visits were associated with emergency department (ED (...) visits and hospitalizations after adjusting for SES, probably related to epilepsy severity. Our study identified an at-risk population for high resource use that may require additional support to reduce ED visits and hospitalizations.Wiley Periodicals, Inc. © 2016 International League Against Epilepsy.

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2016 Epilepsia

7. Diagnosis and management of epilepsy in adults

in epilepsy 55 9 Models of care 57 9.1 Models of primary care for epilepsy 57 9.2 Models of secondary and tertiary care for epilepsy 59 9.3 Role of the epilepsy specialist nurse 61 9.4 Self management 62 10 Provision of information 63 10.1 Advice and information on epilepsy 63 10.2 Checklist for provision of information 64 10.3 Sources of further information 65 11 Implementing the guideline 69 11.1 Implementation strategy 69 11.2 Resource implications of key recommendations 69 11.3 Auditing current (...) Diagnosis and management of epilepsy in adults SIGN 143 • Diagnosis and management of epilepsy in adults A national clinical guideline Evidence May 2015 · Revised 2018KEY TO EVIDENCE STATEMENTS AND GRADES OF RECOMMENDATIONS LEVELS OF EVIDENCE 1 ++ High-quality meta-analyses, systematic reviews of RCTs, or RCTs with a very low risk of bias 1 + Well-conducted meta-analyses, systematic reviews, or RCTs with a low risk of bias 1 - Meta-analyses, systematic reviews, or RCTs with a high risk of bias

2018 SIGN

8. Epilepsy

) Loading history... Population: Intervention: Comparison: Outcome: Population: Intervention: Latest & greatest articles for epilepsy The Trip Database is a leading resource to help health professionals find trustworthy answers to their clinical questions. Users can access the latest research evidence and guidance to answer their clinical questions. We have a large collection of systematic reviews, clinical guidelines, regulatory guidance, clinical trials and many other forms of evidence. If you wanted (...) Epilepsy Top results for epilepsy - Trip Database or use your Google+ account Find evidence fast ALL of these words: Title only Anywhere in the document ANY of these words: Title only Anywhere in the document This EXACT phrase: Title only Anywhere in the document EXCLUDING words: Title only Anywhere in the document Timeframe: to: Combine searches by placing the search numbers in the top search box and pressing the search button. An example search might look like (#1 or #2) and (#3 or #4

2018 Trip Latest and Greatest

9. Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. (PubMed)

Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data. Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National (...) AEDs (carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine, gabapentin, topiramate, levetiracetam, zonisamide) currently used as monotherapy in children and adults with partial onset seizures (simple partial, complex partial or secondary generalised) or generalised tonic-clonic seizures with or without other generalised seizure types (absence, myoclonus).We searched the following databases: Cochrane Epilepsy's Specialised Register, CENTRAL, MEDLINE and SCOPUS

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2017 Cochrane

10. Using natural language processing to extract structured epilepsy data from unstructured clinic letters: development and validation of the ExECT (extraction of epilepsy clinical text) system. (PubMed)

Using natural language processing to extract structured epilepsy data from unstructured clinic letters: development and validation of the ExECT (extraction of epilepsy clinical text) system. Routinely collected healthcare data are a powerful research resource but often lack detailed disease-specific information that is collected in clinical free text, for example, clinic letters. We aim to use natural language processing techniques to extract detailed clinical information from epilepsy clinic (...) letters to enrich routinely collected data.We used the general architecture for text engineering (GATE) framework to build an information extraction system, ExECT (extraction of epilepsy clinical text), combining rule-based and statistical techniques. We extracted nine categories of epilepsy information in addition to clinic date and date of birth across 200 clinic letters. We compared the results of our algorithm with a manual review of the letters by an epilepsy clinician.De-identified

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2019 BMJ open

11. Disclosure strategies in adults with epilepsy when telling, "I have epilepsy": The How2tell study. (PubMed)

) opportunities for telling; (4) moment of disclosure-how to construct the message; (5) tailoring the message to audience needs-altering the message when telling family members, partner, friends, children, or employer and workplace colleagues; and (6) managing reactions by making it ordinary.People with epilepsy use a range of different strategies during the process of disclosing their epilepsy. These strategies were used to inform the development of the How2tell multimedia self-management resource for PWEs (...) Disclosure strategies in adults with epilepsy when telling, "I have epilepsy": The How2tell study. To generate evidence-based knowledge about the strategies that adult people with epilepsy (PWEs) use in the process of telling others about their epilepsy.In-depth, one-to-one interviews explored PWEs' first-hand experiences of self-disclosure (or not), and grounded theory methods of inductive-deductive analysis were used to identify strategies used in disclosing. Interviews were audio-recorded

2019 Epilepsia

12. What is the most appropriate antidepressant to use in people with epilepsy?

to antidepressants, resources suggest that SSRIs are an appropriate first-line choice for treating depression in people with epilepsy. This updated Medicines Q&A evaluates the published information available on the most appropriate choice of antidepressant for people with epilepsy. Attachments · Word · 313 KB Regional Medicines Information Manager, London Medicines Information Service · · Copyright © 2019 SPS - Specialist Pharmacy Service. All Rights Reserved. (...) What is the most appropriate antidepressant to use in people with epilepsy? What is the most appropriate antidepressant to use in people with epilepsy? – SPS - Specialist Pharmacy Service – The first stop for professional medicines advice Menu · · Published 29th January 2019, updated 29th January 2019 · UKMi NICE recommend that non-pharmacological interventions such as CBT should be considered in people presenting with depression, in addition to the use of antidepressants. With respect

2019 Specialist Pharmacy Services

13. Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). (PubMed)

Treatments for the prevention of Sudden Unexpected Death in Epilepsy (SUDEP). Sudden Unexpected Death in Epilepsy (SUDEP) is defined as sudden, unexpected, witnessed or unwitnessed, non-traumatic or non-drowning death of people with epilepsy, with or without evidence of a seizure, excluding documented status epilepticus and in whom postmortem examination does not reveal a structural or toxicological cause for death. SUDEP has a reported incidence of 1 to 2 per 1000 patient years and represents (...) the most common epilepsy-related cause of death. The presence and frequency of generalised tonic-clonic seizures (GTCS), male sex, early age of seizure onset, duration of epilepsy, and polytherapy are all predictors of risk of SUDEP. The exact pathophysiology of SUDEP is currently unknown, although GTCS-induced cardiac, respiratory, and brainstem dysfunction appears likely. Appropriately chosen antiepileptic drug treatment can render around 70% of patients free of all seizures. However, around one

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2016 Cochrane

14. A range of anti-epilepsy drugs are effective as first-line treatment

A range of anti-epilepsy drugs are effective as first-line treatment A range of anti-epilepsy drugs are effective as first-line treatment Discover Portal Discover Portal A range of anti-epilepsy drugs are effective as first-line treatment Published on 12 September 2017 doi: Lamotrigine and levetiracetam are emerging as first-line treatments for epilepsy, which people may be more likely to keep taking than carbamazepine. Reducing the risk of adverse events and treatment withdrawal is important (...) when selecting an anti-epilepsy drug as it usually will need to be taken long-term. This study reviewed evidence on anti-epilepsy drugs in adults and children. The drugs were compared directly or indirectly with each other. The main outcome of interest was time to withdrawal from treatment, which indicates effectiveness and tolerability. The findings support NICE recommendations to use carbamazepine or lamotrigine as first-line therapies for epilepsy with partial seizures, with levetiracetam

2019 NIHR Dissemination Centre

15. Epilepsy in Pregnancy

of an integrated antenatal care pathway and take into consideration the local resources. Local guidelines and clear mechanisms of communication need to be in place for the care of WWE at all stages of their pregnancy until the postnatal period. There are no studies on the evaluation of clinical effectiveness of joint obstetrics and neurology clinics on maternal and fetal outcomes in WWE. In women with an unplanned pregnancy, an individualised management plan should be agreed between the woman with epilepsy (...) Epilepsy in Pregnancy Epilepsy in Pregnancy Green-top Guideline No. 68 June 2016 Endorsed by:Epilepsy in Pregnancy This is the first edition of this guideline, produced by the Royal College of Obstetricians and Gynaecologists (RCOG) and endorsed by the following organisations: Association of British Neurologists, Epilepsy Action, Royal College of General Practitioners, Royal College of Midwives and the Royal College of Physicians. Executive summary of recommendations Diagnosis of epilepsy What

2016 Royal College of Obstetricians and Gynaecologists

16. The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy. (PubMed)

for repurposing from the database.The PDE3 database is an important new resource for drug repurposing research in epilepsy.Wiley Periodicals, Inc. © 2018 International League Against Epilepsy. (...) The prescribable drugs with efficacy in experimental epilepsies (PDE3) database for drug repurposing research in epilepsy. Current antiepileptic drugs (AEDs) have several shortcomings. For example, they fail to control seizures in 30% of patients. Hence, there is a need to identify new AEDs. Drug repurposing is the discovery of new indications for approved drugs. This drug "recycling" offers the potential of significant savings in the time and cost of drug development. Many drugs licensed

2018 Epilepsia

17. Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel (PubMed)

of time and resources expended to reach a diagnosis. Furthermore, a genetic diagnosis can provide accurate prognostic information and, in certain cases, enable targeted therapy. Here, several early infantile epilepsy syndromes with strong genetic associations are briefly reviewed, and their genotype-phenotype correlations are summarized. Because the clinical presentations of these disorders frequently overlap and have heterogeneous genetic causes, next-generation sequencing (NGS)-based gene panel (...) Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel Recent advances in genetics have determined that a number of epilepsy syndromes that occur in the first year of life are associated with genetic etiologies. These syndromes range from benign familial epilepsy syndromes to early-onset epileptic encephalopathies that lead to poor prognoses and severe psychomotor retardation. An early genetic diagnosis can save time and overall cost by reducing the amount

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2018 Korean journal of pediatrics

18. An estimation of global volume of surgically treatable epilepsy based on a systematic review and meta-analysis of epilepsy. (PubMed)

is crucial for future policy efforts and resource allocation.METHODSThe authors performed a systematic literature review and meta-analysis to determine the global incidence, lifetime prevalence, and active prevalence of epilepsy; to estimate surgically treatable epilepsy volume; and to evaluate regional trends by WHO regions and World Bank income levels. Data were extracted from all population-based studies with prespecified methodological quality across all countries and demographics, performed between (...) comprehensive overview of current epidemiological trends. The disproportionate burden of epilepsy on low- and middle-income countries will require targeted diagnostic and treatment efforts to reduce the global disparities in care and cost. Quantifying global epilepsy provides the first step toward restructuring the allocation of healthcare resources as part of global healthcare system strengthening.

2018 Journal of Neurosurgery

19. Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy

Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Cost-effectiveness of pediatric epilepsy surgery compared to medical treatment in children with intractable epilepsy Widjaja E, Li B, Schinkel CD, Ritchie LP, Weaver J, Snead OC, Rutka JT, Coyte PC Record Status This is a critical abstract of an economic evaluation (...) that meets the criteria for inclusion on NHS EED. Each abstract contains a brief summary of the methods, the results and conclusions followed by a detailed critical assessment on the reliability of the study and the conclusions drawn. CRD summary This study assessed the cost-effectiveness of epilepsy surgery in children with intractable epilepsy. The authors concluded that surgical treatment was cost-effective compared with medical therapy, but larger samples and longer follow-up were required

2011 NHS Economic Evaluation Database.

20. A range of anti-epilepsy drugs are effective as first-line treatment

A range of anti-epilepsy drugs are effective as first-line treatment A range of anti-epilepsy drugs are effective as first-line treatment Discover Portal Discover Portal A range of anti-epilepsy drugs are effective as first-line treatment Published on 12 September 2017 doi: Lamotrigine and levetiracetam are emerging as first-line treatments for epilepsy, which people may be more likely to keep taking than carbamazepine. Reducing the risk of adverse events and treatment withdrawal is important (...) when selecting an anti-epilepsy drug as it usually will need to be taken long-term. This study reviewed evidence on anti-epilepsy drugs in adults and children. The drugs were compared directly or indirectly with each other. The main outcome of interest was time to withdrawal from treatment, which indicates effectiveness and tolerability. The findings support NICE recommendations to use carbamazepine or lamotrigine as first-line therapies for epilepsy with partial seizures, with levetiracetam

2018 NIHR Dissemination Centre

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