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Eosinophilic Cellulitis

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161. Hashimoto's Thyroiditis

tyreoiditt , Hashimotos syndrom , Hashimotos sykdom Derived from the NIH UMLS ( ) Ontology: Hurthle Cells (C0949667) Definition (NCI) A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria Definition (MSH) Oxyphil cells in the thyroid gland are known as Hurthle cells and Askenazy cells. Concepts Cell ( T025 ) MSH English Hurthle Cell , Oxyphil cell of thyroid , Thyroid gland oxyphil cell , hurthle cells , hurthle cell , cells hurthles , Askenazy (...) Cells , Cells, Askenazy , Cells, Hurthle , Thyroid Gland Oxyphil Cell , Thyroid Gland Oxyphilic Cell , Hurthle Cells French Cellule de Hürthle , Cellules de Hürthle Czech Hürthleovy buňky , Askenazyho buňky Portuguese Células de Hürthle German Hürthle-Zellen Spanish Células de Hürthle Italian Cellule di Hurthle Norwegian Ashkenazy-celler , Hürthle-celler Dutch Hurthle-cellen Derived from the NIH UMLS ( ) Related Topics in Thyroid Disease About is a rapid access, point-of-care medical

2015 FP Notebook

162. Chronic Leukemia

differentiated, usually B-lymphocytes, but immunologically incompetent; types distinguished include chronic granulocytic, chronic lymphocytic, chronic myelomonocytic, eosinophilic and hairy cell leukemia. Concepts Neoplastic Process ( T191 ) ICD9 208.1 ICD10 , , SnomedCT 92812005 , 2557004 , 128933000 , 190027002 , 188764001 , 154600002 English Leukemia of unspecified cell type, chronic , Chronic leukaemia NOS , Chronic leukemia NOS , Chronic leukaemia of unspecified cell type , Chronic leukemia (...) Leucémie chronique SAI , Leucémie à cellules de type non précisé, chronique , Leucémie chronique de type cellulaire non précisé , Leucémie chronique à cellules de type non précisé , Leucémie chronique German Leukaemie, chronisch , chronische Leukaemie eines unspezifischen Zelltyps , chronische Leukaemie NNB , Leukaemie eines unspezifischen Zelltyps, chronisch , Chronische Leukaemie nicht naeher bezeichneten Zelltyps , chronische Leukaemie Portuguese Leucemia crónica NE , Leucemia crónica de tipo

2015 FP Notebook

163. Hand-Schuller-Christian Syndrome

gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. Definition (NCI) A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs (...) affected at presentation. (WHO, 2001) Definition (NCI) A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions. Definition (CSP) group of disorders of histiocyte proliferation which includes Letterer-Siwe disease; Hand-Schueller-Christian syndrome; and eosinophilic granuloma; Langerhans cells are components of the lesions

2015 FP Notebook

164. Persistent hypereosinophilia with Wells syndrome. (PubMed)

Persistent hypereosinophilia with Wells syndrome. Since Wells and Smith first described cases of eosinophilic cellulitis (Wells syndrome; WS) in 1979, it has been noted that some but not all patients with WS present with eosinophilia. In the face of idiopathic persistent eosinophilia patients will also then fall within the hypereosinophilic syndrome (HES), which represents a multifarious spectrum of disorders of varying severity, causes and outcomes. In this article we propose that patients who

2012 Clinical & Experimental Dermatology

166. Ceftaroline fosamil for injection (Teflaro)

. For the indication of ABSSSI, as part of a multi-day AIDAC meeting on November 8, 2008, the use of a non-inferiority trial design and justification for an NI margin in patients with severe cellulitis or wound infections was supported by adequate evidence in the historical literature. However, the treatment effect of antibacterials following primary incision and drainage in patients with abscesses could not be estimated. Hence, major abscesses lacking significant inflammatory components should be excluded in NI

2010 FDA - Drug Approval Package

167. Sinusitis

between/behind the eyes, the sides of the upper part of the nose (the ), and headaches (J01.2/J32.2) – can cause pain or pressure behind the eyes, but is often in the , over the , or the back of the head. Complications [ ] Stage Description I Preseptal cellulitis II Orbital cellulitis III Subperiosteal abscess IV Orbital abscess V Cavernous sinus septic thrombosis The proximity of the brain to the sinuses makes the most dangerous complication of sinusitis, particularly involving the frontal (...) spread to the orbit may result in periorbital , subperiosteal , orbital cellulitis, and abscess. Orbital cellulitis can complicate acute if anterior and posterior enables the spread of the infection to the lateral or orbital side of the . Sinusitis may extend to the , where it may cause cavernous sinus , retrograde , and epidural, subdural, and brain abscesses. Orbital symptoms frequently precede intracranial spread of the infection . Other complications include sinobronchitis, maxillary

2012 Wikipedia

168. List of cutaneous conditions

, vascular rosacea) ( acne excoriée des jeunes filles , Picker's acne) (acne inversa, pyoderma fistulans significa, Verneuil's disease) (granulomatous rosacea, micropapular tuberculid, rosacea-like tuberculid of Lewandowsky) (acne infantum, acne neonatorum, neonatal cephalic pustulosis) (ophthalmic rosacea, ophthalmorosacea) (chronic upper facial erythematous edema, Morbihan's disease, rosaceous lymphedema) (inflammatory rosacea) (dissecting cellulitis of the scalp, dissecting folliculitis (...) , generalized eczema) (diaper dermatitis, napkin dermatitis) (atopic winter feet, dermatitis plantaris sicca, forefoot dermatitis, moon-boot foot syndrome, sweaty sock dermatitis) (discoid eczema, microbial eczema, nummular eczema, nummular neurodermatitis) (oid-oid disease) (asteatotic eczema, desiccation dermatitis, eczema craquelé , pruritus hiemalis, winter eczema, winter itch) Pustular [ ] See also: Pustular dermatitis is an of the skin that presents with . (Ofuji's disease, sterile eosinophilic

2012 Wikipedia

169. Wells syndrome associated with Churg-Strauss syndrome. (PubMed)

Wells syndrome associated with Churg-Strauss syndrome. Churg–Strauss syndrome (CSS) is a systemic vasculitis occurring in patients with a history of asthma. Wells' syndrome (WS) is a rare inflammatory dermatosis that clinically resembles cellulitis, and is histologically characterized by eosinophilic infiltration and flame figures. We report a case of WS associated with CSS. There have been three previous reports of WS associated with CSS; ours is the fourth. All cases had bullous lesions

2010 Clinical & Experimental Dermatology

170. Investigating Re-Dosing With Otelixizumab in Adults With Newly-Diagnosed Type 1 Diabetes Mellitus

Baseline value. Mean Change From Baseline in Value of Estradiol [ Time Frame: Baseline and up to Month 24 ] Clinical chemistry parameters were planned to be analyzed from Baseline to Month 24. Day 1 value was considered to be Baseline value. Change from Baseline was planned to be calculated as any post-Baseline value minus Baseline value. Mean Change From Baseline in Basophils, Eosinophils, Lymphocytes, Monocytes, Platelet Count and White Blood Cell Count [ Time Frame: Baseline and up to Month 24 (...) antigen (HBsAg), positive hepatitis C test result within 3 months of screening Significant systemic infection during the 6 weeks before the first dose of study drug (e.g., infection requiring hospitalisation, major surgery, or IV antibiotics to resolve; other infections, e.g., bronchitis, sinusitis, localised cellulitis, candidiasis, or urinary tract infections, must be assessed on a case-by-case basis by the investigator regarding whether they are serious enough to warrant exclusion). History

2010 Clinical Trials

171. GSK1322322 Versus Linezolid in the Treatment of Acute Bacterial Skin and Skin Structure Infection

on Day 1. Mean Hematology Parameters of Basophils, Eosinophils, Lymphocytes, Monocytes, Total Neutrophils, White Blood Cells (WBC) and Platelet Count at Indicated Time Points [ Time Frame: Up to Follow-up (28 Day Follow-up, Day 40) ] Blood samples were obtained for analysis of basophils, eosinophils, lymphocytes, monocytes, total neutrophils, WBC and platelet count at Day 1, Day 4, Day 8, Day 11, 7 Day Follow-up and 28 Day Follow-up. Baseline value was defined as the assessment done on Day 1. Mean (...) -dose). Data is reported for number of participants with abnormal transition from Baseline 'to high' or 'to low' relative to normal range. Only those parameters for which at least one value of abnormal transition was reported are summarized. Number of Participants With Abnormal Transition From Baseline in Hematology Values Relative to Normal Range [ Time Frame: Day 1 (pre-dose, Baseline) up Follow-up (28 Day Follow-up, Day 40) ] The parameters of clinical chemistry included basophils, eosinophils

2010 Clinical Trials

172. Fampridine Sustained Release (4-aminopyridine)

SAEs were Nervous system disorders (5.4%) and Infections and Infestations (4.3%). No other SOC grouping included > 1% of subjects. Dr. Boehm has provided a list of SAEs reported by at least 3 fampridine subjects in the pooled MS and SCI trials. The most frequent were MS relapse (n= 38, 2.5%), convulsion (n=19, 1.3%), urinary tract infection (n=18, 1.2%), and cellulitis (n=16, 1.1%). There was 1 SAE of pancytopenia and 1 SAE of pancreatitis, both described below. No subjects experienced SAEs

2009 FDA - Drug Approval Package

173. Rilutek - riluzole

. * = AE frequency = to placebo Body as a Whole: Frequent: Hostility*. Infrequent: Abscess*, sepsis*, photosensitivity reaction*, cellulitis, face edema*, hernia, peritonitis, attempted suicide, injection site reaction, chills*, flu syndrome, intentional injury, enlarged abdomen, neoplasm. Rare: Acrodynia, hypothermia, moniliasis*, rheumatoid arthritis. Digestive System: Infrequent: Increased appetite, intestinal obstruction*, fecal impaction, gastrointestinal hemorrhage, gastrointestinal ulceration (...) pulmonary fibrosis. Am J Respir Crit Care Med 2001; 164:193-196.) 8 MedDRA = the Medical Dictionary for Regulatory Activities 8 one or more) (n= 16) ILD Diagnoses Interstitial pneumonia (8 a ) alveolitis (2 b ) ‘hypersensitivity pneumonitis’ (1), pulmonary fibrosis (1), serum sickness/hypersensitivity reaction (1), ‘drug related pneumonia’ (1), ‘drug induced pulmonary disease’ (1), eosinophilic pneumonia (1), NR (1) Diagnostic findings (may have more than one) Chest X-Ray (n=16): pulmonary interstitium

2009 FDA - Drug Approval Package

174. Dermatitis cruris pustulosa et atrophicans--a frequent but poorly understood tropical skin condition--a case report from Burkina Faso. (PubMed)

. A bacterial origin has not been demonstrated in this case. Histology showed an intraepidermal neutrophilic pustule with dermal and subcutaneous infiltration by neutrophils and eosinophils forming flame figures. Different pathogenic hypotheses are discussed with special regard to a potential relationship between DCPA and eosinophilic cellulitis.

2008 International Journal of Dermatology

175. Hypereosinophilic syndrome with various skin lesions and juvenile temporal arteritis. (PubMed)

Hypereosinophilic syndrome with various skin lesions and juvenile temporal arteritis. Hypereosinophilic syndrome (HES) is a multisystem disease with a high mortality rate. It is characterized by peripheral blood eosinophilia and eosinophilic infiltration of the skin and many other organs. The commonest cutaneous features include erythematous pruritic maculopapules and nodules, angio-oedema or urticarial plaques. However, some case reports have indicated that eosinophilic cellulitis, cutaneous (...) with eosinophilic cellulitis, Raynaud's phenomenon, digital gangrene and JTA. JTA may also be one of the features of HES.

2008 Clinical & Experimental Dermatology

176. Nasal Polyps

) of the nasopharynx. Histological examination reveals that in most polyps there are sac-like entities with an eosinophil-rich oedematous wall; their poor blood supply gives them a pale appearance. Over time, they may become fleshy and reddened due to squamous metaplasia. Benign and malignant nasal tumours can mimic or co-exist with nasal polyps. Nasal polyps can be classified as eosinophil-rich (the most common type in the UK), infective, or due to other causes. Recent research has identified differences (...) of intracranial infections (eg, meningitis); cavernous sinus thrombosis, orbital complications (periorbital and orbital cellulitis, orbital abscess); subperiosteal abscess. Sleep disruption. May contribute to symptoms of asthma. Rarely, massive polyps (such as those occurring in cystic fibrosis or with allergic fungal sinusitis) can lead to craniofacial structural abnormalities with resulting proptosis, hypertelorism (increased interorbital distance) and diplopia. Prognosis There is no single curative

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2008 Mentor

177. Aspergillosis

Segmental or lobar collapse Progressive respiratory failure Differential diagnosis of pulmonary aspergillosis The differentials of the various clinical syndromes are wide, depending on the presenting symptoms, radiological findings and clinical course. Conditions to consider include: . . . Eosinophilic pneumonia. . . Other opportunistic infections in the immunocompromised. . . Cutaneous aspergillosis This occurs most commonly as a result of disseminated (or invasive) infection with Aspergillus spp (...) . [ ] Primary cutaneous aspergillosis : this is less common. Infection tends to occur on the background of previous trauma, including wound infections at cannula and catheter sites and after venepuncture. A. flavus or Aspergillus terreus are the most frequent causes of primary infection. Localised cellulitis is usually followed by development of a necrotic ulcer. Onychomycosis due to infection with Aspergillus spp. can also occur. [ ] Primary skin infection can lead to invasive aspergillosis, particularly

2008 Mentor

178. Cholesterol Emboli

causes of acute abdomen. or . De novo . Multisystem organ failure due to other causes, eg sepsis, cardiogenic shock. De novo myocardial infarction (MI). Other causes of renal impairment, eg , glomerulonephritis, renal vascular disease. Severe atheroma of aorto-iliac vessels. Cardiogenic shock. Secondary hypertension. Other causes of . Vasculitides, eg . Cellulitis. Deep vein thrombosis. Causes of acute neurological dysfunction or delirium. Diabetic vascular disease and leg ulcers. . Investigations (...) FBC reveals leukocytosis in some cases but is nonspecific. Eosinophilia (found in early days in 80% patients). [ ] U&Es nearly always show varying degrees of elevated urea and creatinine. Creatine kinase, cardiac enzymes, LFTs and amylase may be elevated. Urine microscopy shows hyaline casts and eosinophils (strongly suggestive of the diagnosis). Urinalysis may show microscopic haematuria and proteinuria. Elevated CRP before arterial instrumentation is a useful predictive factor with an odds ratio

2008 Mentor

179. Chronic Granulomatous Disease

, UK and European Guidelines. You may find one of our more useful. In this article In This Article Chronic Granulomatous Disease In this article Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder of phagocytes (neutrophils, monocytes, macrophages and eosinophils) resulting from impaired killing of bacteria and fungi [ ] . Epidemiology CGD is rare (prevalence approximately 1 in 250,000) [ ] . CGD is caused by pathogenic variants in one of five genes that encode the subunits (...) . Infections typically include pneumonia, lymphadenitis, liver abscess, osteomyelitis and skin abscesses or cellulitis. Granulomas typically involve the bladder and gastrointestinal tract (often initially the pylorus and later the oesophagus, jejunum, ileum, caecum, rectum and perirectal area). Initial features often involve the skin - eg, recurrent pyodermas causing perianal, axillary or scalp abscesses. Other features include fever, diarrhoea, osteomyelitis, pulmonary abscesses and granulomas, spleen

2008 Mentor

180. Incontinentia pigmenti

methods Typical skin lesions and genetic testing are sufficient for diagnosis. Leukocytosis and eosinophilia may be noted. Skin histology shows eosinophilic spongisostic bulles (stage I); hyperkeratotic and acanthotic epidermis with dyskeratotic keratinocytes (stage II) and loose dermal melanine deposits (stage III). Differential diagnosis Stage I may be misdiagnosed as bullous impetigo, inherited epidermolysis bullosa, herpes or varicella. Differential diagnosis of stage II includes warts, molluscum (...) -linked dominantly. An affected woman has a 50% risk of having affected children. Live-born affected males should be checked for a 47,XXY karyotype. Management and treatment Treatment is symptomatic, including standard management of blisters (not opening them and avoidance of trauma), topical treatment (medication, oatmeal baths) and addressing infections (as in cellulitis). Dental abnormalities should be managed by a pedodontist in combination with speech therapy and a pediatric nutritional program

2005 Orphanet

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