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Eosinophilic Cellulitis

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61. Renal Cell Carcinoma

; renal cell , renal cell; adenocarcinoma , renal cell; carcinoma , Renal Cell Carcinoma , Renal Cell Adenocarcinoma , Adenocarcinoma of Kidney , Adenocarcinoma of the Kidney , Kidney Adenocarcinoma , Renal Cell Carcinoma, Stage Unspecified , renal carcinoma Swedish Njurcellskarcinom Finnish Munuaissolukarsinooma Italian Adenocarcinoma a cellule renali , Carcinoma renale , Cancro a cellule renali , Carcinoma a cellule renali NAS , Adenocarcinoma del rene , Carcinoma a cellule renali, stadio non (...) specificato , Tumore di Grawitz , Carcinoma a cellule renali Russian GIPERNEFROMA , KARTSINOMA POCHECHNO-KLETOCHNAIA , GRAVITTSA OPUKHOL' , KARTSINOMA GIPERNEFROIDNAIA , ADENOKARTSINOMA POCHECHNO-KLETOCHNAIA , АДЕНОКАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ , ГИПЕРНЕФРОМА , ГРАВИТЦА ОПУХОЛЬ , КАРЦИНОМА ГИПЕРНЕФРОИДНАЯ , КАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ Spanish Adenocarcinoma de riñón , Adenocarcinoma de células renales , Cáncer de células renales , Carcinoma de células renales, estadio no especificado , Carcinoma de células

2018 FP Notebook

62. Hand-Schuller-Christian Syndrome

gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. Definition (NCI) A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs (...) affected at presentation. (WHO, 2001) Definition (NCI) A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions. Definition (CSP) group of disorders of histiocyte proliferation which includes Letterer-Siwe disease; Hand-Schueller-Christian syndrome; and eosinophilic granuloma; Langerhans cells are components of the lesions

2018 FP Notebook

63. Hashimoto's Thyroiditis

tyreoiditt , Hashimotos syndrom , Hashimotos sykdom Derived from the NIH UMLS ( ) Ontology: Hurthle Cells (C0949667) Definition (NCI) A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria Definition (MSH) Oxyphil cells in the thyroid gland are known as Hurthle cells and Askenazy cells. Concepts Cell ( T025 ) MSH English Hurthle Cell , Oxyphil cell of thyroid , Thyroid gland oxyphil cell , hurthle cells , hurthle cell , cells hurthles , Askenazy (...) Cells , Cells, Askenazy , Cells, Hurthle , Thyroid Gland Oxyphil Cell , Thyroid Gland Oxyphilic Cell , Hurthle Cells French Cellule de Hürthle , Cellules de Hürthle Czech Hürthleovy buňky , Askenazyho buňky Portuguese Células de Hürthle German Hürthle-Zellen Spanish Células de Hürthle Italian Cellule di Hurthle Norwegian Ashkenazy-celler , Hürthle-celler Dutch Hurthle-cellen Derived from the NIH UMLS ( ) Related Topics in Thyroid Disease About is a rapid access, point-of-care medical

2018 FP Notebook

64. Richard Lehman’s journal review—30 May 2017

gain either. It’s hard to know how this drug may or may not fit into the future treatment of people with severe eosinophilic asthma: you could call it an example of uncertain benralizability. JAMA 23/30 May 2017 Vol 317 Combining antibiotics for cellulitis Between-country variations in drug availability are a complete mystery to me. In the UK we use flucloxacillin as first-line treatment for most skin infections, but when I mentioned this agent to US doctor friends, they looked blankly. It isn’t (...) better at maintaining blood pressure in this group than placebo. This often allowed doses of catecholamines to be reduced, but the trial was not powered to measure effects on mortality or organ failure. Benralizumab for asthma requiring oral steroids Some people have terrible asthma with lots of eosinophils in their airways, and cannot get by without continuous oral steroids. Benralizumab is an antibody designed to kill eosinophils, or, to put it more amply, a humanized, afucosylated (engineered

2017 The BMJ Blog

65. Retinoblastoma Treatment (PDQ®): Health Professional Version

tumors present with pain, orbital cellulitis, glaucoma, or buphthalmos. As the tumor progresses, patients may present with orbital or metastatic disease. Metastases occur in the preauricular and laterocervical lymph nodes, in the CNS, or systemically (commonly in the bones, bone marrow, and liver). In the United States, children of Hispanic origin and children living in lower socioeconomic conditions have been noted to present with more advanced disease.[ ] Diagnostic and Staging Evaluation (...) , round, densely packed cells with hypochromatic nuclei and scant cytoplasm. Several degrees of photoreceptor differentiation have been described and are characterized by distinctive arrangements of tumor cells, as follows: Flexner-Wintersteiner rosettes are specific to retinoblastoma; these structures consist of a cluster of low columnar cells arranged around a central lumen that is bounded by an eosinophilic membrane analogous to the external membrane of the normal retina. The lumen contains

2015 PDQ - NCI's Comprehensive Cancer Database

68. Management of Patients with Infections Caused by Methicillin-Resistant Staphylococcus Aureus Full Text available with Trip Pro

sites of infection) or rapid progression in presence of associated cellulitis, signs and symptoms of systemic illness, associated comorbidities or immunosuppression, extremes of age, abscess in an area difficult to drain (eg, face, hand, and genitalia), associated septic phlebitis, and lack of response to incision and drainage alone (A-III) . For outpatients with purulent cellulitis (eg, cellulitis associated with purulent drainage or exudate in the absence of a drainable abscess), empirical therapy (...) for CA-MRSA is recommended pending culture results. Empirical therapy for infection due to β-hemolytic streptococci is likely to be unnecessary (A-II) . Five to 10 days of therapy is recommended but should be individualized on the basis of the patient's clinical response. For outpatients with nonpurulent cellulitis (eg, cellulitis with no purulent drainage or exudate and no associated abscess), empirical therapy for infection due to β-hemolytic streptococci is recommended (A-II). The role of CA-MRSA

2011 Infectious Diseases Society of America

69. Ceftaroline fosamil for injection (Teflaro)

. For the indication of ABSSSI, as part of a multi-day AIDAC meeting on November 8, 2008, the use of a non-inferiority trial design and justification for an NI margin in patients with severe cellulitis or wound infections was supported by adequate evidence in the historical literature. However, the treatment effect of antibacterials following primary incision and drainage in patients with abscesses could not be estimated. Hence, major abscesses lacking significant inflammatory components should be excluded in NI

2010 FDA - Drug Approval Package

71. Vesiculobullous and hemorrhagic erythema migrans: uncommon variants of a common disease. (Abstract)

Vesiculobullous and hemorrhagic erythema migrans: uncommon variants of a common disease. The diagnosis of Lyme disease relies on the accurate diagnosis of erythema chronicum migrans (ECM) because serologic tests, culture, and polymerase chain reactions are often inaccurate. Although ECM is classically associated with a targetoid rash, there are many variants of this lesion. These variants of ECM are often initially diagnosed as cellulitis or spider bite reactions and treated with oral (...) case, microscopic examination of a skin biopsy showed epidermal spongiosis with parakeratosis, focal necrosis, papillary dermal edema, erythrocyte extravasation, and a superficial and deep perivascular lymphocytic infiltrate with neutrophils and eosinophils of the dermis. No fungal organisms or bacteria were identified. All four patients were treated with doxycycline with complete resolution of symptoms.It is important to recognize the vesiculobullous and hemorrhagic variants of ECM in order

2015 International Journal of Dermatology

72. Mass Spectrometry of Flame Figure. Full Text available with Trip Pro

eng Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Actins 0 Histones 0 Proteoglycans 147016-17-9 PRG2 protein, human EC 1.11.1.- Eosinophil Peroxidase EC 3.1.27.- Eosinophil Major Basic Protein EC Tyrosine-tRNA Ligase Wells syndrome IM Actins analysis Adult Biopsy Cellulitis metabolism pathology Eosinophil Major Basic Protein analysis Eosinophil Peroxidase analysis Eosinophilia metabolism pathology Eosinophils Female Histiocytes Histones analysis Humans Insect Bites

2015 Acta Dermato-Venereologica

73. Retinoblastoma

that they do not have an RB1 gene mutation. Clinical Presentation Age at presentation correlates with laterality; patients with bilateral disease present at a younger age, usually in the first 12 months of life. Most cases present with leukocoria, which is occasionally first noticed after a flash photograph is taken. Strabismus is the second most common presenting sign and usually correlates with macular involvement. Very advanced intraocular tumors present with pain, orbital cellulitis, glaucoma (...) of a cluster of low columnar cells arranged around a central lumen that is bounded by an eosinophilic membrane analogous to the external membrane of the normal retina. The lumen contains rosettes that are seen in 70% of tumors. Homer Wright rosettes are composed of irregular circlets of tumor cells arranged around a tangle of fibrils with no lumen or internal-limiting membrane. Horner Wright rosettes are infrequently seen in retinoblastoma and are most often seen in other neuroblastic tumors

2012 PDQ - NCI's Comprehensive Cancer Database

74. Fampridine Sustained Release (4-aminopyridine)

SAEs were Nervous system disorders (5.4%) and Infections and Infestations (4.3%). No other SOC grouping included > 1% of subjects. Dr. Boehm has provided a list of SAEs reported by at least 3 fampridine subjects in the pooled MS and SCI trials. The most frequent were MS relapse (n= 38, 2.5%), convulsion (n=19, 1.3%), urinary tract infection (n=18, 1.2%), and cellulitis (n=16, 1.1%). There was 1 SAE of pancytopenia and 1 SAE of pancreatitis, both described below. No subjects experienced SAEs

2009 FDA - Drug Approval Package

75. Rilutek - riluzole

. * = AE frequency = to placebo Body as a Whole: Frequent: Hostility*. Infrequent: Abscess*, sepsis*, photosensitivity reaction*, cellulitis, face edema*, hernia, peritonitis, attempted suicide, injection site reaction, chills*, flu syndrome, intentional injury, enlarged abdomen, neoplasm. Rare: Acrodynia, hypothermia, moniliasis*, rheumatoid arthritis. Digestive System: Infrequent: Increased appetite, intestinal obstruction*, fecal impaction, gastrointestinal hemorrhage, gastrointestinal ulceration (...) pulmonary fibrosis. Am J Respir Crit Care Med 2001; 164:193-196.) 8 MedDRA = the Medical Dictionary for Regulatory Activities 8 one or more) (n= 16) ILD Diagnoses Interstitial pneumonia (8 a ) alveolitis (2 b ) ‘hypersensitivity pneumonitis’ (1), pulmonary fibrosis (1), serum sickness/hypersensitivity reaction (1), ‘drug related pneumonia’ (1), ‘drug induced pulmonary disease’ (1), eosinophilic pneumonia (1), NR (1) Diagnostic findings (may have more than one) Chest X-Ray (n=16): pulmonary interstitium

2009 FDA - Drug Approval Package

76. Dose-Ranging Study of GSK2140944 in the Treatment of Subjects With Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections

(Day 1). No post-baseline values were reported. Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils and Platelets [ Time Frame: Baseline (Day 1) up to Day 28 ] Blood samples for assessment of hematology parameters of basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets was collected at Baseline (Day 1), Day 2, Day 7 to 10, Day 12 to 21 and Day 21 to Day 28. Baseline was defined at Day 1. Change from (...) characterized by a collection of pus within the dermis or deeper that is accompanied by redness, edema, and/or induration of a minimum surface area of 75 cm^2 (e.g., the shortest distance of redness, edema, and/or induration extending at least 5 cm from the peripheral margin of the abscess). Cellulitis: a diffuse skin infection characterized by a spreading area of redness, edema, and/or induration of a minimum surface area of 75 cm^2 Note: For subjects with more than one type of eligible lesion/wound

2014 Clinical Trials

77. Traction Alopecia (Diagnosis)

a clinically noninflammatory patchy alopecia. The most common condition to produce this appearance is lichen planopilaris. The term “idiopathic pseudopelade” refers to a distinct fibrosing alopecia characterized by a thin dermis, with dense eosinophilic dermal collagen and thick recoiled elastic fibers. The fibrous tracts are broad and may contain granulomas, but the surrounding elastic sheath is preserved. Traction alopecia As the name implies, traction alopecia is alopecia secondary to physical traction (...) predominate are as follows: Folliculitis decalvans: Folliculitis decalvans presents with recurrent crops of follicular pustules that result in permanent epilation. Staphylococci are often cultured from pustules, but this condition does not respond the standard antibiotic regimens. The best results are obtained by long-term use of topical corticosteroids together with an oral tetracycline. Perifolliculitis capitis abscedens et suffodiens: Other terms used for include dissecting cellulitis and Hoffman


78. Toxicity, Cocaine (Diagnosis)

aspiration pneumonitis or after an intravenous injection of bacteria or toxic organic or inorganic materials Aneurysm or pseudoaneurysm: May be noted with mainlining (ie, directly injecting into a central artery or vein); this finding is an indication for further imaging studies In addition, radiography may be useful for evaluating cellulitis, an abscess, or a nonhealing wound in an intravenous drug user; it may reveal a foreign body or subcutaneous emphysema produced by gas-forming organisms (...) producing these effects are unknown, but hypotheses include a direct effect on lymphocyte activity, myocardial cell cytotoxicity secondary to an increase in the activity of natural killer cells, hypersensitivity reactions (suggested by eosinophilic infiltrate), and induction of focal myocarditis from catecholamine administration. Cocaine causes a direct negative inotropic effect on cardiac muscle, resulting in transient toxic cardiomyopathy. In one small series, 8 of 10 subjects who used cocaine long


79. Bedbug Bites (Follow-up)

. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction


80. Upper Respiratory Tract Infection (Diagnosis)

that respond to pathogens. Humoral immunity (immunoglobulin A) and cellular immunity act to reduce infections throughout the entire respiratory tract. Resident and recruited macrophages, monocytes, neutrophils, and eosinophils coordinate to engulf and destroy invaders. A host of inflammatory cytokines mediates the immune response to invading pathogens. Normal nasopharyngeal flora, including various staphylococcal and streptococcal species, help to defend against potential pathogens. Patients (...) , but immunocompromised persons may have a more severe course. Untreated group A streptococcal pharyngitis can result in the following: Acute rheumatic fever Acute glomerulonephritis Peritonsillar abscess Toxic shock syndrome Impetigo Cellulitis or abscess Otitis Sinusitis Conjunctivitis Bronchitis Mortality from group A streptococcal pharyngitis is rare, but serious morbidity or death may result from one of its complications. Streptococcal pharyngitis without complications rarely poses significant risk for morbidity


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