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Eosinophilic Cellulitis

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61. Vesiculobullous and hemorrhagic erythema migrans: uncommon variants of a common disease. (PubMed)

Vesiculobullous and hemorrhagic erythema migrans: uncommon variants of a common disease. The diagnosis of Lyme disease relies on the accurate diagnosis of erythema chronicum migrans (ECM) because serologic tests, culture, and polymerase chain reactions are often inaccurate. Although ECM is classically associated with a targetoid rash, there are many variants of this lesion. These variants of ECM are often initially diagnosed as cellulitis or spider bite reactions and treated with oral (...) case, microscopic examination of a skin biopsy showed epidermal spongiosis with parakeratosis, focal necrosis, papillary dermal edema, erythrocyte extravasation, and a superficial and deep perivascular lymphocytic infiltrate with neutrophils and eosinophils of the dermis. No fungal organisms or bacteria were identified. All four patients were treated with doxycycline with complete resolution of symptoms.It is important to recognize the vesiculobullous and hemorrhagic variants of ECM in order

2015 International Journal of Dermatology

62. Mass Spectrometry of Flame Figure. (PubMed)

eng Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Actins 0 Histones 0 Proteoglycans 147016-17-9 PRG2 protein, human EC 1.11.1.- Eosinophil Peroxidase EC 3.1.27.- Eosinophil Major Basic Protein EC 6.1.1.1 Tyrosine-tRNA Ligase Wells syndrome IM Actins analysis Adult Biopsy Cellulitis metabolism pathology Eosinophil Major Basic Protein analysis Eosinophil Peroxidase analysis Eosinophilia metabolism pathology Eosinophils Female Histiocytes Histones analysis Humans Insect Bites

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2015 Acta Dermato-Venereologica

64. Dalbavancin hydrochloride (HCl) (Dalvance)

of therapy At 42-72 hours after initiation of treatment Primary efficacy endpoint population Clinically evaluable Intent-to-treat Area of cellulitis of >75cm 2 for all subtypes of infection Not required as an inclusion criterion Required as an inclusion criterion Subjects with urine output of 2x the upper limit of normal Excluded Allowed Reference ID: 3481080Clinical Review Dmitri Iarikov, MD, PhD NDA 21883, 505 (b)(1) DALVANCE (dalbavancin hydrochloride) 36 Table 8: Key differences in the design (...) enrolled in a North American study center, and 24 (3.7%) were enrolled in an Asian- Pacific study center. The distribution of the subjects by infection type in the ITT population in DUR001-301 and -302 trials as well as infection area baseline measurements are presented in the table on the following page. Cellulitis was the most common type of infection, diagnosed in more than 50% of dalbavancin- and comparator-treated subjects in both trials. There were somewhat more subjects with abscesses

2013 FDA - Drug Approval Package

65. Dose-Ranging Study of GSK2140944 in the Treatment of Subjects With Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections

(Day 1). No post-baseline values were reported. Change From Baseline in Hematology Parameters: Basophils, Eosinophils, Leukocytes, Lymphocytes, Monocytes, Neutrophils and Platelets [ Time Frame: Baseline (Day 1) up to Day 28 ] Blood samples for assessment of hematology parameters of basophils, eosinophils, leukocytes, lymphocytes, monocytes, neutrophils and platelets was collected at Baseline (Day 1), Day 2, Day 7 to 10, Day 12 to 21 and Day 21 to Day 28. Baseline was defined at Day 1. Change from (...) characterized by a collection of pus within the dermis or deeper that is accompanied by redness, edema, and/or induration of a minimum surface area of 75 cm^2 (e.g., the shortest distance of redness, edema, and/or induration extending at least 5 cm from the peripheral margin of the abscess). Cellulitis: a diffuse skin infection characterized by a spreading area of redness, edema, and/or induration of a minimum surface area of 75 cm^2 Note: For subjects with more than one type of eligible lesion/wound

2014 Clinical Trials

66. Retinoblastoma

that they do not have an RB1 gene mutation. Clinical Presentation Age at presentation correlates with laterality; patients with bilateral disease present at a younger age, usually in the first 12 months of life. Most cases present with leukocoria, which is occasionally first noticed after a flash photograph is taken. Strabismus is the second most common presenting sign and usually correlates with macular involvement. Very advanced intraocular tumors present with pain, orbital cellulitis, glaucoma (...) of a cluster of low columnar cells arranged around a central lumen that is bounded by an eosinophilic membrane analogous to the external membrane of the normal retina. The lumen contains rosettes that are seen in 70% of tumors. Homer Wright rosettes are composed of irregular circlets of tumor cells arranged around a tangle of fibrils with no lumen or internal-limiting membrane. Horner Wright rosettes are infrequently seen in retinoblastoma and are most often seen in other neuroblastic tumors

2012 PDQ - NCI's Comprehensive Cancer Database

68. Neutropenia (Overview)

, namely neutrophils, eosinophils, and basophils. However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. The risk of serious infection increases as the absolute neutrophil count (ANC) falls to the severely neutropenic range (< 500/µL). The duration and severity of neutropenia directly correlate with the total incidence of all infections and of those infections that are life threatening. Tuberculosis (see (...) ). [ , ] Granulocytopenia is defined as a reduced number of blood granulocytes, namely neutrophils, eosinophils, and basophils. However, the term granulocytopenia is often used synonymously with neutropenia and, in that sense, is again confined to the neutrophil lineage alone. Neutropenia is defined in terms of the absolute neutrophil count (ANC). The ANC is calculated by multiplying the total white blood cell (WBC) count by the percentage of neutrophils (segmented neutrophils or granulocytes) plus the band forms

2014 eMedicine.com

69. Angioimmunoblastic Lymphadenopathy With Dysproteinemia (Follow-up)

in an elderly patient who presented with generalized pruritic maculopapular eruption and fever after taking doxycycline. [ ] Renner et al described eosinophilic cellulitis (Wells syndrome) in association with angioimmunoblastic lymphadenopathy. [ ] Physical examination All organ systems can be affected by AILD. Typical findings at presentation include the following: Rash (50% of cases) Pruritus (30%) Edema (40%) Pleural effusion (40%) Arthritis (20%) Ascites (25%) Skin involvement in AILD manifests (...) with angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis. Ann Hematol . 2004 Jul. 83(7):455-9. . Batinac T, Zamolo G, Jonjic N, Gruber F, Nacinovic A, Seili-Bekafigo I, et al. Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration. Tumori . 2003 Jan-Feb. 89(1):91-5. . Renner R, Kauer F, Treudler R, Niederwieser D, Simon JC. Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. Acta Derm Venereol . 2007. 87(6):525-8

2014 eMedicine.com

70. Angioedema (Follow-up)

angioedema with eosinophilia (Gleich's Syndrome). Immunol Allergy Clin North Am . 2006 Nov. 26(4):769-81. . Ferreli C, Pinna AL, Atzori L, Aste N. Eosinophilic cellulitis (Well's syndrome): a new case description. J Eur Acad Dermatol Venereol . 1999 Jul. 13(1):41-5. . Brown AF, McKinnon D, Chu K. Emergency department anaphylaxis: A review of 142 patients in a single year. J Allergy Clin Immunol . 2001 Nov. 108(5):861-6. . Yang MS, Lee SH, Kim TW, et al. Epidemiologic and clinical features of anaphylaxis

2014 eMedicine.com

71. Bedbug Bites (Follow-up)

. Repeated bites may sensitize individuals, leading to more pronounced cutaneous manifestations or systemic hypersensitivity reactions. The local trauma from bedbug bites can lead to secondary bacterial infection, causing ecthyma, cellulitis, or lymphangitis. There is some evidence that bedbugs may also be a vector for hepatitis B and Chagas disease. Histologic findings from bite-site biopsy specimens typically show eosinophilic infiltrates, which are indicative of the allergic nature of the reaction

2014 eMedicine.com

72. Upper Respiratory Tract Infection (Diagnosis)

that respond to pathogens. Humoral immunity (immunoglobulin A) and cellular immunity act to reduce infections throughout the entire respiratory tract. Resident and recruited macrophages, monocytes, neutrophils, and eosinophils coordinate to engulf and destroy invaders. A host of inflammatory cytokines mediates the immune response to invading pathogens. Normal nasopharyngeal flora, including various staphylococcal and streptococcal species, help to defend against potential pathogens. Patients (...) , but immunocompromised persons may have a more severe course. Untreated group A streptococcal pharyngitis can result in the following: Acute rheumatic fever Acute glomerulonephritis Peritonsillar abscess Toxic shock syndrome Impetigo Cellulitis or abscess Otitis Sinusitis Conjunctivitis Bronchitis Mortality from group A streptococcal pharyngitis is rare, but serious morbidity or death may result from one of its complications. Streptococcal pharyngitis without complications rarely poses significant risk for morbidity

2014 eMedicine.com

73. Traction Alopecia (Overview)

a clinically noninflammatory patchy alopecia. The most common condition to produce this appearance is lichen planopilaris. The term “idiopathic pseudopelade” refers to a distinct fibrosing alopecia characterized by a thin dermis, with dense eosinophilic dermal collagen and thick recoiled elastic fibers. The fibrous tracts are broad and may contain granulomas, but the surrounding elastic sheath is preserved. Traction alopecia As the name implies, traction alopecia is alopecia secondary to physical traction (...) predominate are as follows: Folliculitis decalvans: Folliculitis decalvans presents with recurrent crops of follicular pustules that result in permanent epilation. Staphylococci are often cultured from pustules, but this condition does not respond the standard antibiotic regimens. The best results are obtained by long-term use of topical corticosteroids together with an oral tetracycline. Perifolliculitis capitis abscedens et suffodiens: Other terms used for include dissecting cellulitis and Hoffman

2014 eMedicine.com

74. Toxicity, Cocaine (Overview)

aspiration pneumonitis or after an intravenous injection of bacteria or toxic organic or inorganic materials Aneurysm or pseudoaneurysm: May be noted with mainlining (ie, directly injecting into a central artery or vein); this finding is an indication for further imaging studies In addition, radiography may be useful for evaluating cellulitis, an abscess, or a nonhealing wound in an intravenous drug user; it may reveal a foreign body or subcutaneous emphysema produced by gas-forming organisms (...) producing these effects are unknown, but hypotheses include a direct effect on lymphocyte activity, myocardial cell cytotoxicity secondary to an increase in the activity of natural killer cells, hypersensitivity reactions (suggested by eosinophilic infiltrate), and induction of focal myocarditis from catecholamine administration. Cocaine causes a direct negative inotropic effect on cardiac muscle, resulting in transient toxic cardiomyopathy. In one small series, 8 of 10 subjects who used cocaine long

2014 eMedicine.com

75. Campylobacter Infections (Overview)

. Such adherence would promote gut colonization. PEB 1 is a superficial antigen that appears to be a major adhesin and is conserved among C jejuni strains. Some strains of C jejuni produce a heat-labile, choleralike enterotoxin, which is important in the watery diarrhea observed in infections. Infection with the organism produces diffuse, bloody, edematous, and exudative enteritis. The inflammatory infiltrate consists of neutrophils, mononuclear cells, and eosinophils. Crypt abscesses develop in the epithelial (...) in Campylobacter jejuni. Antimicrob Agents Chemother . 2008 Nov. 52(11):3947-54. . Carbone KM, Heinrich MC, Quinn TC. Thrombophlebitis and cellulitis due to Campylobacter fetus ssp. fetus. Report of four cases and a review of the literature. Medicine (Baltimore) . 1985 Jul. 64(4):244-50. . Crushell E, Harty S, Sharif F, Bourke B. Enteric campylobacter: purging its secrets?. Pediatr Res . 2004 Jan. 55(1):3-12. . Drake AA, Gilchrist MJ, Washington JA 2nd, et al. Diarrhea due to Campylobacter fetus subspecies

2014 eMedicine.com

76. Angioimmunoblastic Lymphadenopathy With Dysproteinemia (Overview)

in an elderly patient who presented with generalized pruritic maculopapular eruption and fever after taking doxycycline. [ ] Renner et al described eosinophilic cellulitis (Wells syndrome) in association with angioimmunoblastic lymphadenopathy. [ ] Physical examination All organ systems can be affected by AILD. Typical findings at presentation include the following: Rash (50% of cases) Pruritus (30%) Edema (40%) Pleural effusion (40%) Arthritis (20%) Ascites (25%) Skin involvement in AILD manifests (...) with angioimmunoblastic T-cell lymphoma and proliferative glomerulonephritis. Ann Hematol . 2004 Jul. 83(7):455-9. . Batinac T, Zamolo G, Jonjic N, Gruber F, Nacinovic A, Seili-Bekafigo I, et al. Angioimmunoblastic lymphadenopathy with dysproteinemia following doxycycline administration. Tumori . 2003 Jan-Feb. 89(1):91-5. . Renner R, Kauer F, Treudler R, Niederwieser D, Simon JC. Eosinophilic cellulitis (Wells' syndrome) in association with angioimmunoblastic lymphadenopathy. Acta Derm Venereol . 2007. 87(6):525-8

2014 eMedicine.com

77. Angioedema (Overview)

also been associated with certain conditions or syndromes, such as the following: Cytokine-associated angioedema syndrome (ie, Gleich syndrome or episodic angioedema with eosinophilia) [ ] Well syndrome or eosinophilic cellulitis (ie, granulomatous dermatitis with eosinophilia) [ ] Hypersensitivity angioedema Hypersensitivity (allergic) angioedema is often associated with urticaria. It is typically observed within 30 minutes to 2 hours after exposure to the allergen. Mast cell–mediated angioedema (...) episodic angioedema with eosinophilia (Gleich's Syndrome). Immunol Allergy Clin North Am . 2006 Nov. 26(4):769-81. . Ferreli C, Pinna AL, Atzori L, Aste N. Eosinophilic cellulitis (Well's syndrome): a new case description. J Eur Acad Dermatol Venereol . 1999 Jul. 13(1):41-5. . Brown AF, McKinnon D, Chu K. Emergency department anaphylaxis: A review of 142 patients in a single year. J Allergy Clin Immunol . 2001 Nov. 108(5):861-6. . Yang MS, Lee SH, Kim TW, et al. Epidemiologic and clinical features

2014 eMedicine.com

78. Dirofilariasis (Diagnosis)

Thighs Abdominal wall Male genitalia Ophthalmic involvement may be periorbital, [ , ] subconjunctival, [ ] subtenon, [ ] or intraocular. [ ] See for more detail. Diagnosis Studies used in the diagnosis and evaluation of dirofilariasis include the following: Complete blood count (CBC) - Using a CBC, eosinophilia may be detected in up to 20% of cases of HPD Sputum cytology - The presence of eosinophils may support a diagnosis of HPD in patients with a coin lesion observed on radiography, although (...) in endemic areas of northeastern Italy indicated that the mosquito host Culex pipiens fed on dogs 70% of the time and on humans 26% of the time. [ ] D immitis is most often associated with coin lesions of the lung (human pulmonary dirofilariasis, or HPD), but isolated reports exist of D immitis or D immitis –like worms causing cutaneous or conjunctival disease. Extrapulmonary D immitis infections described in the literature include a hepatic nodule, [ ] eosinophilic meningitis, [ ] intraocular infection

2014 eMedicine Pediatrics

79. Cutaneous Manifestations of HIV Disease (Diagnosis)

. The most common cutaneous infections in children with HIV disease are impetigo and cellulitis caused by Staphylococcus aureus . Other cutaneous manifestations of HIV infection in the pediatric age group are as follows: Recurrent herpetic gingivostomatitis Scabies Severe atopic dermatitis Drug eruptions Leukocytoclastic vasculitis Previous Next: Malignancies (KS) was the first reported malignancy associated with HIV infection and was first documented in 1981 from reports in New York, Los Angeles (...) suggest HIV infection. Bournerias et al reported tinea capitis from Microsporum canis in 2 patients infected with HIV. [ ] Pityriasis versicolor may be persistent and recurrent in patients with HIV infection. Previous Next: Deep Fungal Infections Rarely, cutaneous cryptococcosis may be observed in patients with HIV infection. [ ] Clinical manifestations include the following: Cellulitis Papules Plaques Ulcers Translucent dome-shaped papules with central umbilication, resembling MC Cutaneous

2014 eMedicine.com

80. Dirofilariasis (Diagnosis)

Thighs Abdominal wall Male genitalia Ophthalmic involvement may be periorbital, [ , ] subconjunctival, [ ] subtenon, [ ] or intraocular. [ ] See for more detail. Diagnosis Studies used in the diagnosis and evaluation of dirofilariasis include the following: Complete blood count (CBC) - Using a CBC, eosinophilia may be detected in up to 20% of cases of HPD Sputum cytology - The presence of eosinophils may support a diagnosis of HPD in patients with a coin lesion observed on radiography, although (...) in endemic areas of northeastern Italy indicated that the mosquito host Culex pipiens fed on dogs 70% of the time and on humans 26% of the time. [ ] D immitis is most often associated with coin lesions of the lung (human pulmonary dirofilariasis, or HPD), but isolated reports exist of D immitis or D immitis –like worms causing cutaneous or conjunctival disease. Extrapulmonary D immitis infections described in the literature include a hepatic nodule, [ ] eosinophilic meningitis, [ ] intraocular infection

2014 eMedicine.com

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