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Eosinophilic Cellulitis

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42. Literature review - Twitter summary from #ACAAI18 meeting

of IgG level. Many of the links are via NFKb. Decreased NFKB1 phenotypes (AD, 60% penetrant): aphthous ulcers, Behcet-like and hypog (H67R); inflammatory GI tract disease and hypogam (I553M); NO hypogam, decreased switched B cells, necrotizing cellulitis (R157X). APDS1: sinopulmonary infections, LAN/splenomegaly, bronchiectasis/bronchitis/tracheal nodules, EBV/CMV, HSV, VZV infections; High IgM, IgM+ but not IgG+ B cells in tissue. CGD carriers can get disease like CGD lite, especially if DHR (...) improve survival in scleroderma. Asthma Dr. Li on asthma and lower respiratory diseases. Dupilumab was more effective for asthma if eosinophils were greater than 300. Eosinophilia can occur in 4.1% and hypereosinophilia 1.2% on dupilumab for asthma. Increased FeNO predicted better response to dupilumab. Dupilumab recently approved for moderate-severe asthma: if eosinophils are higher than 300 or FeNO is elevated, see better response to treatment with this biologic. Hypereosinophilia complication

2019 Allergy Notes blog

44. British Association of Dermatologists' guidelines for the management of bullous pemphigoid

alone or associated with erythema and/or urti- cated plaques may precede formation of bullae by weeks or months;insomecasesbullaemaynotbecomeclinicallyapparent. 7.0 Diagnosis 7.1 Laboratory diagnosis of bullous pemphigoid A skin biopsy from a fresh blister stained with haematoxylin and eosin shows subepidermal clefting and an in?ammatory in?ltrate mainly consisting of eosinophils; however, the diag- nosis is con?rmed with immuno?uorescence studies (IF). A biopsy for direct IF (DIF) is taken from (...) also be caused by insect bites, burns, oedema, cellulitis, erythema multiforme and con- tact dermatitis. Viral and bacterial skin infections should be recognized and treated before treatment with immunosuppres- sant therapy is initiated. 8.0 Management BP is usually a self-limiting disease with a clinical course that may last from months to years. During the active stage, the disease is associated with signi?cant morbidity and a mortality twice that of the general elderly population. 3 Older age

2012 British Association of Dermatologists

45. IDIOPATHIC EOSINOPHILIC MENINGOENCEPHALOMYELITIS FOLLOWING WELL SYNDROME (PubMed)

IDIOPATHIC EOSINOPHILIC MENINGOENCEPHALOMYELITIS FOLLOWING WELL SYNDROME 19996079 2009 12 30 2018 11 13 1526-632X 73 23 2009 Dec 08 Neurology Neurology Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome. 2037-9 10.1212/WNL.0b013e3181c55ee7 Turkeltaub Peter E PE Department of Neurology, University of Pennsylvania Health System, Philadelphia, PA 19104, USA. peter.turkeltaub@uphs.upenn.edu Guzman Miguel A MA Lee Edward B EB Galetta Steven L SL eng Case Reports Journal Article (...) United States Neurology 0401060 0028-3878 AIM IM Cellulitis complications diagnosis Encephalomyelitis diagnosis etiology Eosinophilia complications diagnosis Female Humans Meningoencephalitis diagnosis etiology Middle Aged Syndrome 2009 12 10 6 0 2009 12 10 6 0 2009 12 31 6 0 ppublish 19996079 73/23/2037 10.1212/WNL.0b013e3181c55ee7 PMC2790232 Curr Opin Pulm Med. 2007 Sep;13(5):422-7 17940488 Intern Med. 2003 May;42(5):424-7 12793714 Int J Dermatol. 2003 Jan;42(1):62-7 12581147 Proc Natl Acad Sci U S

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2009 Neurology

46. Management of Patients with Infections Caused by Methicillin-Resistant Staphylococcus Aureus

sites of infection) or rapid progression in presence of associated cellulitis, signs and symptoms of systemic illness, associated comorbidities or immunosuppression, extremes of age, abscess in an area difficult to drain (eg, face, hand, and genitalia), associated septic phlebitis, and lack of response to incision and drainage alone (A-III) . For outpatients with purulent cellulitis (eg, cellulitis associated with purulent drainage or exudate in the absence of a drainable abscess), empirical therapy (...) for CA-MRSA is recommended pending culture results. Empirical therapy for infection due to β-hemolytic streptococci is likely to be unnecessary (A-II) . Five to 10 days of therapy is recommended but should be individualized on the basis of the patient's clinical response. For outpatients with nonpurulent cellulitis (eg, cellulitis with no purulent drainage or exudate and no associated abscess), empirical therapy for infection due to β-hemolytic streptococci is recommended (A-II). The role of CA-MRSA

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2011 Infectious Diseases Society of America

47. Hashimoto's Thyroiditis

tyreoiditt , Hashimotos syndrom , Hashimotos sykdom Derived from the NIH UMLS ( ) Ontology: Hurthle Cells (C0949667) Definition (NCI) A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria Definition (MSH) Oxyphil cells in the thyroid gland are known as Hurthle cells and Askenazy cells. Concepts Cell ( T025 ) MSH English Hurthle Cell , Oxyphil cell of thyroid , Thyroid gland oxyphil cell , hurthle cells , hurthle cell , cells hurthles , Askenazy (...) Cells , Cells, Askenazy , Cells, Hurthle , Thyroid Gland Oxyphil Cell , Thyroid Gland Oxyphilic Cell , Hurthle Cells French Cellule de Hürthle , Cellules de Hürthle Czech Hürthleovy buňky , Askenazyho buňky Portuguese Células de Hürthle German Hürthle-Zellen Spanish Células de Hürthle Italian Cellule di Hurthle Norwegian Ashkenazy-celler , Hürthle-celler Dutch Hurthle-cellen Derived from the NIH UMLS ( ) Related Topics in Thyroid Disease About FPnotebook.com is a rapid access, point-of-care medical

2018 FP Notebook

48. Hand-Schuller-Christian Syndrome

gland (which makes hormones that control other glands and many body functions, especially growth). Langerhans cell histiocytosis is most common in children and young adults. Definition (NCI) A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination. Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease. The clinical course is generally related to the number of organs (...) affected at presentation. (WHO, 2001) Definition (NCI) A multifocal, unisystem form of Langerhans-cell histiocytosis. There is involvement of multiple sites in one organ system, most frequently the bone. Patients are usually young children presenting with multiple destructive bone lesions. Definition (CSP) group of disorders of histiocyte proliferation which includes Letterer-Siwe disease; Hand-Schueller-Christian syndrome; and eosinophilic granuloma; Langerhans cells are components of the lesions

2018 FP Notebook

49. Renal Cell Carcinoma

; renal cell , renal cell; adenocarcinoma , renal cell; carcinoma , Renal Cell Carcinoma , Renal Cell Adenocarcinoma , Adenocarcinoma of Kidney , Adenocarcinoma of the Kidney , Kidney Adenocarcinoma , Renal Cell Carcinoma, Stage Unspecified , renal carcinoma Swedish Njurcellskarcinom Finnish Munuaissolukarsinooma Italian Adenocarcinoma a cellule renali , Carcinoma renale , Cancro a cellule renali , Carcinoma a cellule renali NAS , Adenocarcinoma del rene , Carcinoma a cellule renali, stadio non (...) specificato , Tumore di Grawitz , Carcinoma a cellule renali Russian GIPERNEFROMA , KARTSINOMA POCHECHNO-KLETOCHNAIA , GRAVITTSA OPUKHOL' , KARTSINOMA GIPERNEFROIDNAIA , ADENOKARTSINOMA POCHECHNO-KLETOCHNAIA , АДЕНОКАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ , ГИПЕРНЕФРОМА , ГРАВИТЦА ОПУХОЛЬ , КАРЦИНОМА ГИПЕРНЕФРОИДНАЯ , КАРЦИНОМА ПОЧЕЧНО-КЛЕТОЧНАЯ Spanish Adenocarcinoma de riñón , Adenocarcinoma de células renales , Cáncer de células renales , Carcinoma de células renales, estadio no especificado , Carcinoma de células

2018 FP Notebook

50. Chronic Leukemia

differentiated, usually B-lymphocytes, but immunologically incompetent; types distinguished include chronic granulocytic, chronic lymphocytic, chronic myelomonocytic, eosinophilic and hairy cell leukemia. Concepts Neoplastic Process ( T191 ) ICD9 208.1 ICD10 , , SnomedCT 92812005 , 2557004 , 128933000 , 190027002 , 188764001 , 154600002 English Leukemia of unspecified cell type, chronic , Chronic leukaemia NOS , Chronic leukemia NOS , Chronic leukaemia of unspecified cell type , Chronic leukemia (...) Leucémie chronique SAI , Leucémie à cellules de type non précisé, chronique , Leucémie chronique de type cellulaire non précisé , Leucémie chronique à cellules de type non précisé , Leucémie chronique German Leukaemie, chronisch , chronische Leukaemie eines unspezifischen Zelltyps , chronische Leukaemie NNB , Leukaemie eines unspezifischen Zelltyps, chronisch , Chronische Leukaemie nicht naeher bezeichneten Zelltyps , chronische Leukaemie Portuguese Leucemia crónica NE , Leucemia crónica de tipo

2018 FP Notebook

53. Retinoblastoma Treatment (PDQ®): Health Professional Version

is the second most common presenting sign and usually correlates with macular involvement. Very advanced intraocular tumors present with pain, orbital cellulitis, glaucoma, or buphthalmos. As the tumor progresses, patients may present with orbital or metastatic disease. Metastases occur in the preauricular and laterocervical lymph nodes, in the CNS, or systemically (commonly in the bones, bone marrow, and liver). In the United States, children of Hispanic origin and children living in lower socioeconomic (...) ; these structures consist of a cluster of low columnar cells arranged around a central lumen that is bounded by an eosinophilic membrane analogous to the external membrane of the normal retina. The lumen contains rosettes that are seen in 70% of tumors. Homer Wright rosettes are composed of irregular circlets of tumor cells arranged around a tangle of fibrils with no lumen or internal-limiting membrane. Horner Wright rosettes are infrequently seen in retinoblastoma and are most often seen in other neuroblastic

2015 PDQ - NCI's Comprehensive Cancer Database

54. Farydak - panobinostat

Sal. Gland (f), ? foll. cell. hypertrophy thyroid, ? fatty atrophy sternum, ? heamosiderin spleen, trend of ? # of females in oestrus phase of cycle BoneMarrow smears: ? # erythroid cells & ? M:E, ? proportion of eosinophilic cells ± abnormal morphology, ? # of granulocytic cells show maturation arrest. (all effects are associated with each other) =30 ? FC (m), ? Hb (m), MCV, MCHC, WBC, L, N, Eos, B (m), LUC (m, f only wk 13))), Plat (wk13 & 26) ? MCH (f) ? ALT (m), ? TP (f), ?rT3 (f) ? rel. brain

2015 European Medicines Agency - EPARs

55. Orbactiv - oritavancin

severe or life-threatening, depending on the pathogen [Corey and Stryjewski, 2011; Elston, 2005]. ABSSSIs include cellulitis/erysipelas, wound infections, major cutaneous abscesses, and burn infections. They commonly involve at least a 75 cm 2 surface area of redness, oedema and/or induration accompanied by lymph node enlargement or systemic symptoms such as fever [FDA, 2010]. The morbidity associated with ABSSSI often requires rapid intervention with antibacterial therapy to minimise tissue damage (...) and dogs was a dose related accumulation of eosinophilic granules in tissue macrophages including hepatocytes, renal cortical epithelial cells, adrenal cells and macrophages of the reticulo endothelial system. The appearance of the eosinophilic granules did not occur following single dose administration and did not significantly affect innate macrophage function in vitro at intracellular levels anticipated from a single 1,200 mg dose. Assessment report EMA/183786/2015 Page 27/92 Moderate, dose-related

2015 European Medicines Agency - EPARs

56. Olodaterol inhalation solution (Striverdi Respimat)

(%) n (%) Number of patients 1134 (100.0) 1133 (100.0) 2267 (100.0) Total with serious adverse events 53 (4.7) 64 (5.6) 117 (5.2) Infections and infestations 8 (0.7) 10 (0.9) 18 (0.8) Pneumonia 5 (0.4) 3 (0.3) 8 (0.4) Cellulitis 0 (0.0) 2 (0.2) 2 (0.1) Gastroenteritis 1 (0.1) 1 (0.1) 2 (0.1) Metabolism and nutrition disorders 1 (0.1) 1 (0.1) 2 (0.1) Reference ID: 3540833NDA 203108, Boehringer-Ingelheim, Olodaterol Inhalation Solution (Striverdi Respimat) 5 Dehydration 1 (0.1) 1 (0.1) 2 (0.1

2014 FDA - Drug Approval Package

57. Tybost - cobicistat

Alternate Cause/Confounders Proposed Labeling 2434-8258 Diabetes mellitus (worsening) 2 No / Unlikely 10+ year history of DM; obesity None 0986-8285 Ovarian cyst Cervical dysplasia 1 2 No / No No / No Pre-existing conditions None None 4143-8442 Cervical dysplasia 3 No / No HPV None 2058-8335 Scrotal abscess Subcutaneous abscess 2 2 No / No No / No Circumcision None None 2734-8509 Perineal abscess/cellulitis Subcutaneous abscess 2 2 No / Unlikely No / Unlikely None None 3975-8443 Anal abscess 3 (...) initiating DRV/co and FTC/TDF. On Day 25 the reaction progressed to a diffuse erythematous rash, some angioedema, and pruritus at which time study drugs were discontinued. Liver enzymes, white blood cell count, and eosinophil count were normal. The next day, the subject had no oral lesions, blistering, or noticeable angioedema. The subject received antihistamines and prednisone, and the event resolved over a few days. The investigator assessed the event as Grade 3 and related to study medications

2014 FDA - Drug Approval Package

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