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Eosinophilic Cellulitis

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1. Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab (Full text)

Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab 29892672 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab. 548-550 10.1016/j.jdcr.2018.02.011 Herout Sandra S Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria. Bauer Wolfgang Michael WM Department of Dermatology, Division of Immunology (...) Wells syndrome eosinophilic cellulitis mepolizumab 2018 6 13 6 0 2018 6 13 6 0 2018 6 13 6 1 epublish 29892672 10.1016/j.jdcr.2018.02.011 S2352-5126(18)30052-3 PMC5991892 N Engl J Med. 2017 May 18;376(20):1921-1932 28514601 Eur J Dermatol. 2014 Sep-Oct;24(5):603-10 25115356 N Engl J Med. 2017 Oct 26;377(17 ):1613-1629 28893134 Nat Rev Drug Discov. 2013 Feb;12(2):117-29 23334207 Trans St Johns Hosp Dermatol Soc. 1971;57(1):46-56 5570262 Int J Dermatol. 2013 Aug;52(8):949-54 23786445 Lancet Respir Med

2018 JAAD Case Reports PubMed

2. Eosinophilic Cellulitis

Eosinophilic Cellulitis Eosinophilic Cellulitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Eosinophilic Cellulitis Eosinophilic (...) Cellulitis Aka: Eosinophilic Cellulitis From Related Chapters II. Pathophysiology Noninfectious III. Symptoms and Signs Moderate erythema or edema Rapid development over days Minimal tenderness, and lack of local heat No response to antibiotics IV. Diagnosis Biopsy of lesion ic infiltrate V. Course Resolves in weeks, but often recurs Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Eosinophilic Cellulitis." Click on the image (or right

2018 FP Notebook

3. Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. (PubMed)

Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective

2016 Journal of the European Academy of Dermatology and Venereology : JEADV

4. Eosinophilic cellulitis (Wells’ syndrome) caused by a temporary henna tattoo (Full text)

Eosinophilic cellulitis (Wells’ syndrome) caused by a temporary henna tattoo Eosinophilic cellulitis (Wells' syndrome) is an uncommon condition of unknown etiology. Wells' syndrome is usually seen in adulthood but very rare in childhood. Although pathogenesis of the disease is not very clear, it is a hypersensitivity reaction developing against a variety of exogenous and endogenous antigenic stimuli. Paraphenylenediamine is a strong allergen frequently used as a temporary henna tattoo, which

2014 Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii PubMed

5. Wells Syndrome (Eosinophilic Cellulitis) (Overview)

Wells Syndrome (Eosinophilic Cellulitis) (Overview) Wells Syndrome: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyNDg0NC1vdmVydmlldw== processing > Wells Syndrome Updated (...) : Mar 06, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Wells Syndrome Overview Background In 1971, George Wells first described this syndrome as a recurrent granulomatous dermatitis with eosinophilia. [ ] Wells and Smith renamed it eosinophilic cellulitis in 1979. [ ] Wells syndrome (eosinophilic cellulitis) is an uncommon condition of unknown etiology. The presentation usually involves a mildly pruritic or tender

2014 eMedicine.com

6. Wells Syndrome (Eosinophilic Cellulitis) (Diagnosis)

Wells Syndrome (Eosinophilic Cellulitis) (Diagnosis) Wells Syndrome: Background, Pathophysiology, Etiology Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyNDg0NC1vdmVydmlldw== processing > Wells Syndrome (...) Updated: Mar 06, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Wells Syndrome Overview Background In 1971, George Wells first described this syndrome as a recurrent granulomatous dermatitis with eosinophilia. [ ] Wells and Smith renamed it eosinophilic cellulitis in 1979. [ ] Wells syndrome (eosinophilic cellulitis) is an uncommon condition of unknown etiology. The presentation usually involves a mildly pruritic or tender

2014 eMedicine.com

7. Wells Syndrome (Eosinophilic Cellulitis) (Treatment)

Wells Syndrome (Eosinophilic Cellulitis) (Treatment) Wells Syndrome Treatment & Management: Approach Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyNDg0NC10cmVhdG1lbnQ= processing > Wells (...) Syndrome Treatment & Management Updated: Mar 06, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Wells Syndrome Treatment Approach Considerations There are numerous treatment options for Wells Syndrome (eosinophilic cellulitis), including the use of topical corticosteroids, calcineurin inhibitors, griseofulvin, H1 antihistamines, cyclosporine, dapsone, and systemic corticosteroids. [ ] Systemic corticosteroids are the most

2014 eMedicine.com

8. Wells Syndrome (Eosinophilic Cellulitis) (Follow-up)

Wells Syndrome (Eosinophilic Cellulitis) (Follow-up) Wells Syndrome Treatment & Management: Approach Considerations Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTEyNDg0NC10cmVhdG1lbnQ= processing > Wells (...) Syndrome Treatment & Management Updated: Mar 06, 2018 Author: Robert A Schwartz, MD, MPH; Chief Editor: Dirk M Elston, MD Share Email Print Feedback Close Sections Sections Wells Syndrome Treatment Approach Considerations There are numerous treatment options for Wells Syndrome (eosinophilic cellulitis), including the use of topical corticosteroids, calcineurin inhibitors, griseofulvin, H1 antihistamines, cyclosporine, dapsone, and systemic corticosteroids. [ ] Systemic corticosteroids are the most

2014 eMedicine.com

9. Wells Syndrome (Eosinophilic Cellulitis): A Clinical Imitator of Bacterial Cellulitis (Full text)

Wells Syndrome (Eosinophilic Cellulitis): A Clinical Imitator of Bacterial Cellulitis To report a case of Wells syndrome (eosinophilic cellulitis) in a patient who was previously hospitalized twice and received several antibiotic treatments.Inpatient hospital consultation.One patient diagnosed with Wells Syndrome based on supporting clinical history, histopathological examination, and other laboratory data.Change in signs and symptoms over time.Improvement of skin lesions after administration (...) of corticosteroids.Wells syndrome is a clinical condition that mimics bacterial cellulitis. It is characterized as an erythematous, edematous tender plaque with predilection for the lower extremity. The authors report this case to warn clinicians about other primary dermatological disorders that resemble infectious cellulitis in order to avoid misdiagnoses and delayed treatment.

2011 The Journal of clinical and aesthetic dermatology PubMed

10. Eosinophilic Cellulitis Induced by Subcutaneous Administration of Interferon-β (Full text)

Eosinophilic Cellulitis Induced by Subcutaneous Administration of Interferon-β 23604053 2014 06 18 2015 11 19 1651-2057 93 6 2013 Nov Acta dermato-venereologica Acta Derm. Venereol. Eosinophilic cellulitis induced by subcutaneous administration of interferon-β. 755-6 10.2340/00015555-1611 Kambayashi Yumi Y Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo-machi 1-1, Aoba-ku, Sendai, 980-8574, Japan. Fujimura Taku T Ishibashi Masaya M Haga Takahiro T Aiba Setsuya S (...) eng Case Reports Journal Article Sweden Acta Derm Venereol 0370310 0001-5555 0 Antineoplastic Agents 0 Biomarkers 0 STAT1 Transcription Factor 0 STAT1 protein, human 0 STAT6 Transcription Factor 0 STAT6 protein, human 77238-31-4 Interferon-beta Wells syndrome IM Aged Antineoplastic Agents administration & dosage adverse effects Biomarkers analysis Biopsy Cellulitis chemically induced diagnosis metabolism Drug Eruptions diagnosis etiology metabolism Eosinophilia chemically induced diagnosis

2013 Acta Dermato-Venereologica PubMed

11. Treatment of hypereosinophilic syndrome and eosinophilic dermatitis with reslizumab. (PubMed)

Treatment of hypereosinophilic syndrome and eosinophilic dermatitis with reslizumab. 29496465 2019 03 07 2019 03 07 1534-4436 120 6 2018 06 Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology Ann. Allergy Asthma Immunol. Treatment of hypereosinophilic syndrome and eosinophilic dermatitis with reslizumab. 670-671 S1081-1206(18)30144-3 10.1016/j.anai.2018.02.017 Kuruvilla Merin M Allergy/Immunology, Emory University, Atlanta (...) , Georgia. Electronic address: merin.ek1@gmail.com. eng Case Reports Journal Article 2018 02 26 United States Ann Allergy Asthma Immunol 9503580 1081-1206 0 Antibodies, Monoclonal, Humanized 0 Glucocorticoids 0 IL5 protein, human 0 Immunologic Factors 0 Interleukin-5 35A26E427H reslizumab VB0R961HZT Prednisone Wells syndrome IM Antibodies, Monoclonal, Humanized therapeutic use Cellulitis drug therapy genetics immunology pathology Dermatitis drug therapy genetics immunology pathology Eosinophilia drug

2018 Asthma & Immunology

12. Innate Immunity in Eosinophilic Esophagitis

shown below. All acquisitions and analyses will be achieved using a 13-colour NovoCyte cytometer (AACEA) and its associated software (NovoAxpressTM), which are available in the laboratory. Study Design Go to Layout table for study information Study Type : Observational Estimated Enrollment : 60 participants Observational Model: Case-Control Time Perspective: Prospective Official Title: Innate Lymphoid Cells in Eosinophilic Esophagitis (French Title : Cellules Lymphoïdes innées Dans l'Oesophagite à (...) Innate Immunity in Eosinophilic Esophagitis Innate Immunity in Eosinophilic Esophagitis - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Innate Immunity in Eosinophilic Esophagitis (CLOE) The safety

2018 Clinical Trials

13. Diagnosis and management of eosinophilic cellulitis (Wells’ syndrome): A case series and literature review (Full text)

Diagnosis and management of eosinophilic cellulitis (Wells’ syndrome): A case series and literature review Eosinophilic cellulitis (Wells' syndrome) is an inflammatory dermatitis that is often misdiagnosed as infectious cellulitis due to its similarity in presentation. Misdiagnosis leads to delay of correct treatment and inappropriate use of antibiotics.A case series of eosinophilic cellulitis and a literature review are presented.Patients with Wells' syndrome may present with a variety (...) of nonspecific symptoms, such as fever, arthralgia and malaise, as well as myriad cutaneous lesions with associated erythema, presenting as blisters, bullae, papules and/or nodules. Several treatment modalities have been used to treat eosinophilic cellulitis and have been met with variable success rates; these include systemic corticosteroids, topical corticosteroids and antihistamines, with success rates of 91.7%, 50% and 25%, respectively.A high degree of clinical suspicion must be exercised to diagnose

2012 The Canadian Journal of Plastic Surgery PubMed

14. Successful Treatment of Steroid-Dependent Eosinophilic Cellulitis With Cyclosporine (Full text)

Successful Treatment of Steroid-Dependent Eosinophilic Cellulitis With Cyclosporine Eosinophilic cellulitis (EC) is a rare idiopathic disorder, first described as a "recurrent granulomatous dermatitis with eosinophilia", that mimics cellulitis of infectious origin. We describe here a previously healthy 11-year-old girl who experienced fever and tender erythematous patch lesions after trauma to her knees. Because of the relapsing cellulitis-like skin lesions, skin biopsies were taken, resulting

2012 Allergy, asthma & immunology research PubMed

15. Eosinophilic Cellulitis

Eosinophilic Cellulitis Eosinophilic Cellulitis Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Eosinophilic Cellulitis Eosinophilic (...) Cellulitis Aka: Eosinophilic Cellulitis From Related Chapters II. Pathophysiology Noninfectious III. Symptoms and Signs Moderate erythema or edema Rapid development over days Minimal tenderness, and lack of local heat No response to antibiotics IV. Diagnosis Biopsy of lesion ic infiltrate V. Course Resolves in weeks, but often recurs Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "Eosinophilic Cellulitis." Click on the image (or right

2015 FP Notebook

16. Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature (Full text)

Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature A 53-year-old man was admitted to the hospital with a diagnosis of cellulitis and osteomyelitis. Twenty-four days after the initiation of daptomycin and sulbactam/ampicillin, he developed a fever and pulmonary infiltration. Bronchoalveolar lavage revealed a high number of eosinophils, while an intracutaneous test revealed positivity for daptomycin. The patient improved after discontinuing antimicrobial therapy (...) . The plasma daptomycin minimum concentration (Cmin) was elevated (27.4 μg/mL), but plasma protein binding of daptomycin was low (87.8%). Although the pathophysiology of eosinophilic pneumonia remains unclear, antigenic stimulation due to daptomycin accumulation in the alveoli may have caused continuous immune activation.

2017 Internal Medicine PubMed

17. Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases (Full text)

Wells’ Syndrome Mimicking Facial Cellulitis: A Report of Two Cases Wells' syndrome (WS), or eosinophilic cellulitis, is an uncommon inflammatory dermatosis of unknown etiology that typically presents with pruritic cellulitis-like plaques on the extremities. Therefore, WS is often misdiagnosed as bacterial cellulitis due to its similarity in presentation. Here, we report two cases of WS that masqueraded as bacterial facial cellulitis. Under treatment with oral prednisone and/or a combination (...) therapy with levocetirizine and hydroxyzine, both patients showed a dramatic improvement of the skin lesions. These cases highlight the need for clinicians to consider WS in the differential diagnosis when evaluating a patient with facial cellulitis that does not respond to an initial antimicrobial regimen. In addition, our cases suggest that combination therapy with levocetirizine and hydroxyzine may be successfully used as corticosteroid-sparing treatment or to prevent relapse after

2015 Case reports in dermatology PubMed

18. Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome (Full text)

Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations and Flame Figures: A Spectrum of Eosinophilic Dermatoses Whose Features Overlap With Wells' Syndrome Wells syndrome (WS) (eosinophilic cellulitis) is an uncommon eosinophilic dermatitis that has been rarely described in association with, but distinct from, hypereosinophilic syndrome (HES).We report a case of an eosinophilic dermatosis with flame figures in association with idiopathic HES, manifested by inflammatory myocarditis (...) , asthma, and peripheral blood eosinophilia.The diagnoses of WS and HES, rather than being distinct findings, may represent 2 entities on a spectrum of hypereosinophilic diseases. The diagnosis of WS should be made with caution and should prompt a thorough investigation that includes a work-up for a systemic eosinophilic disorder.

2015 The American Journal of dermatopathology PubMed

19. Eosinophilic Skin Diseases: A Comprehensive Review. (PubMed)

bites, and autoimmune blistering skin diseases such as bullous pemphigoid, are also common. Besides these, there are several rare types of eosinophilic dermatoses with unknown origin, in which eosinophil infiltration is a central component and affects specific tissue layers or adnexal structures of the skin, such as the dermis, subcutaneous fat, fascia, follicles, and cutaneous vessels. Some typical examples are eosinophilic cellulitis, granuloma faciale, eosinophilic pustular folliculitis (...) , recurrent cutaneous eosinophilic vasculitis, and eosinophilic fasciitis. Although tissue eosinophilia is a common feature shared by these disorders, their clinical and pathological properties differ dramatically. Among these rare entities, eosinophilic pustular folliculitis may be associated with human immunodeficiency virus (HIV) infection or malignancies, and some other diseases, like eosinophilic fasciitis and eosinophilic cellulitis, may be associated with an underlying hematological disorder, while

2015 Clinical Reviews in Allergy & Immunology

20. Distinguishing cellulitis from its mimics. (PubMed)

Distinguishing cellulitis from its mimics. Distinguishing true cellulitis from its many imitators is challenging but critical if we are to avoid unnecessary use of antibiotics and delays in treatment. Common imitators of cellulitis are stasis dermatitis, lipodermatosclerosis, contact dermatitis, lymphedema, eosinophilic cellulitis, and papular urticaria. Specific criteria do not exist for the diagnosis of cellulitis, but the alert physician can find clues in the history and physical examination (...) that point toward cellulitis.

2012 Cleveland Clinic Journal of Medicine

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