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Eosinophilia-Myalgia Syndrome

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2. Eosinophilia-Myalgia Syndrome

Eosinophilia-Myalgia Syndrome Eosinophilia-Myalgia Syndrome Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Eosinophilia-Myalgia (...) Syndrome Eosinophilia-Myalgia Syndrome Aka: Eosinophilia-Myalgia Syndrome From Related Chapters II. Associated Conditions III. Pathophysiology Linked to L-Tryptophan usage IV. Symptoms Myalgias (Uniformly present) Rapid onset with persistent pain Severe and incapacitating pain Associated with muscle spasms (esp. calves, ) Associated with perceived weakness Exacerbated by movement s (73%) Non-productive cough with (59%) (27%) or Hypesthesia (e.g. Burning sensation) V. Signs Rash (60%) (59%) Cutaneous

2018 FP Notebook

3. 34m with fever, headache and myalgias

sanitation worker with an acute onset febrile syndrome with headaches, myalgias, cholestatic liver injury, thrombocytopenia, and an AKI with microscopic hematuria. So really a multiorgan inflammatory state, in which the clinical scenario still seems most compelling and most pressing to look for infection. And I would go back to the infection category being broken down even more thoroughly by bacteria, viral, etc, and sort of force myself at this point to commit to what organisms I’m most worried about (...) 34m with fever, headache and myalgias Core IM Hoofbeats: 34M with Fever, Headache and Myalgias – Clinical Correlations Search Core IM Hoofbeats: 34M with Fever, Headache and Myalgias January 16, 2019 15 min read Podcast: | Subscribe: | By Shira Sachs MD, Stephanie Sherman MD, Cindy Fang MD and John Hwang MD || Audio Editing by Richard Chen || Graphic by Amy Ou MD Time Stamps Player three has entered the game! [0:15] Case presentation, part 1 [1:20] First impressions [3:24] Rethinking another

2019 Clinical Correlations

4. Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system. (Abstract)

Myalgia and chronic fatigue syndrome following immunization: macrophagic myofasciitis and animal studies support linkage to aluminum adjuvant persistency and diffusion in the immune system. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multifactorial and poorly undersood disabling disease. We present epidemiological, clinical and experimental evidence that ME/CFS constitutes a major type of adverse effect of vaccines, especially those containing poorly degradable particulate (...) and distinctive pattern of cerebral glucose hypometabolism. Deltoid muscle biopsy performed to investigate myalgia typically yields macrophagic myofasciitis (MMF), a histological biomarker assessing longstanding persistency of aluminum agglomerates within innate immune cells at site of previous immunization. MMF is seemingly linked to altered mineral particle detoxification by the xeno/autophagy machinery. Comparing toxicology of different forms of aluminum and different types of exposure is misleading

2019 Autoimmunity reviews

5. Assessment of eosinophilia

Assessment of eosinophilia Assessment of eosinophilia - Differential diagnosis of symptoms | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search  Assessment of eosinophilia Last reviewed: February 2019 Last updated: August 2018 Summary Eosinophilia is defined as an increase in the peripheral blood eosinophil count. The upper limit of normal is usually taken as about 0.6 × 10⁹/L (600/microlitre), but it is lower (about 0.4 × 10⁹/L [400/microlitre]) if people (...) with minor allergies are excluded. There is no ethnic variation in the normal eosinophil count and no physiological cause of an increased count. Bain BJ. Blood cells: a practical guide. 5th ed. Oxford: Wiley-Blackwell; 2015. Causes of eosinophilia The most common causes of eosinophilia depend on socioeconomic and geographical factors. In the developing world the most common cause is parasitic infection (and parasitic infections result in the greatest number of cases worldwide), whereas in the developed

2018 BMJ Best Practice

6. Imatinib-Associated Tumor Lysis Syndrome in a Patient With Myeloid Neoplasm With Eosinophilia and PDGFRA Rearrangement: A Case Report and Review of the Literature Full Text available with Trip Pro

Imatinib-Associated Tumor Lysis Syndrome in a Patient With Myeloid Neoplasm With Eosinophilia and PDGFRA Rearrangement: A Case Report and Review of the Literature 30241197 2019 03 04 2378-9506 4 2018 Sep Journal of global oncology J Glob Oncol Imatinib-Associated Tumor Lysis Syndrome in a Patient With Myeloid Neoplasm With Eosinophilia and PDGFRA Rearrangement: A Case Report and Review of the Literature. 1-4 10.1200/JGO.2016.007716 Socola Francisco F All authors: University of Arkansas

2017 Journal of global oncology

7. Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome Full Text available with Trip Pro

Aggressive treatment in paediatric or young patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is associated with future development of type III polyglandular autoimmune syndrome We experienced a 6-year-old case of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) with subsequent development autoimmune thyroiditis (Hashimoto's thyroiditis), type 1 diabetes (...) with antithyroglobulin, thyroid peroxidase, insulinoma-associated antigen and anti-insulin antibodies at 4 months, alopecia at 7 months, vitiligo, uveitis due to Vogt-Koyanagi-Harada disease at 8 months after clinical resolution of the DiHS/DRESS. He was diagnosed as type III polyglandular autoimmune syndrome (PASIII) after DiHS/DRESS. Prompted by this case, we sought to determine which triggering factors were responsible for later development of PASIII in previously published cases with autoimmune sequelae

2018 BMJ case reports

8. Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy

Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You (...) have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Prophylactic Gabapentin for Taxane-Induced Arthralgia and Myalgia Syndrome in Breast Cancer Patients Undergoing Adjuvant Chemotherapy The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. of clinical studies and talk to your health care provider before

2018 Clinical Trials

9. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculous drugs: two case reports and a review of the literature. (Abstract)

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculous drugs: two case reports and a review of the literature. Patients suffering from drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome caused by first-line antituberculous drugs often need to be re-treated rapidly. Patch tests prior to the re-introduction of antituberculosis drugs are rarely performed.We aim to highlight those drugs most often involved in DRESS from (...) antituberculosis drugs, illustrate the potential value of patch tests to identify these culprit(s), and provide insights in how to rapidly re-treat these patients.A detailed description of the work-up of two illustrative patients, together with a literature review of similar cases, is provided.All first-line antituberculosis drugs may cause DRESS syndrome, but rifampicin and isoniazid are most frequently involved. Patch tests can be performed sooner than usually advised in the context of DRESS syndrome

2019 Contact Dermatitis

10. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive Full Text available with Trip Pro

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive 29387775 2019 02 26 2352-5126 4 2 2018 Mar JAAD case reports JAAD Case Rep Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: Case report of severe multiorgan involvement to perindopril/amlodipine combination antihypertensive. 170-174 10.1016/j.jdcr.2017.10.007 Chan Linda L Concord Repatriation General (...) symptoms RegiSCAR, Registry of Severe Cutaneous Adverse Reactions amlodipine drug reaction drug reaction with eosinophilia and systemic symptoms syndrome perindopril renal impairment 2018 2 2 6 0 2018 2 2 6 0 2018 2 2 6 1 epublish 29387775 10.1016/j.jdcr.2017.10.007 S2352-5126(17)30259-X PMC5789762 Australas J Dermatol. 2014 Feb;55(1):15-23 23866082 J Eur Acad Dermatol Venereol. 2015 Nov;29(11):2199-205 26354734 Arch Dermatol. 2010 Dec;146(12):1373-9 20713773 Int J Dermatol. 2015;54(5):537-42 24738653

2018 JAAD Case Reports

11. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature Full Text available with Trip Pro

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome Secondary to Furosemide: Case Report and Review of Literature BACKGROUND DRESS is a rare, life threatening syndrome that occurs following exposure to certain medications, most commonly antibiotics and antiepileptics. While sulfonamide antibiotics are frequently implicated as causative agents for DRESS syndrome, furosemide, a nonantibiotic sulfonamide, has not been routinely reported as the causative agent despite its (...) widespread use. CASE REPORT A 63 year old male who started furosemide for lower extremity edema 10 weeks prior presented with diarrhea, fever of 39.4°C, dry cough and maculopapular rash involving >50% of his body. He self-discontinued furosemide due to concern for dehydration. The diarrhea spontaneously resolved, but he developed hypoxia requiring hospitalization. CT scan demonstrated mediastinal lymphadenopathy and interstitial infiltrates. Laboratory evaluation revealed leukocytosis, eosinophilia

2018 The American journal of case reports

12. Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms Full Text available with Trip Pro

Recent Advances in Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms Drug-induced hypersensitivity syndrome (DIHS), also termed as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multiorgan systemic reaction characterized by a close relationship with the reactivation of herpes virus. Published data has demonstrated that among patients with DIHS/DRESS, 75-95% have leukocytosis, 18.2-90% show atypical lymphocytes, 52-95% have (...) eosinophilia, and 75-100% have hepatic abnormalities. Histologically, eosinophils were observed less frequently than we expected (20%). The mainstay of DIHS/DRESS treatment is a moderate dose of systemic corticosteroids, followed by gradual dose reduction. In this review, we will emphasize that elevations in the levels of several cytokines/chemokines, including tumor necrosis factor- (TNF-) α and the thymus and activation-regulated chemokine (TARC/CCL17), during the early stage of disease, are good markers

2018 Journal of immunology research

13. Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome Full Text available with Trip Pro

Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome 30023418 2019 02 26 2352-5126 4 6 2018 Jul JAAD case reports JAAD Case Rep Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. 524-527 10.1016/j.jdcr.2018.05.002 Kerneuzet Ines I Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France. Blind Eline E Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France (...) reactions SJS, Stevens Johnson syndrome TEN, toxic epidermal necrolysis drug reaction drug reaction with eosinophilia and systemic symptoms ivermectin 2018 7 20 6 0 2018 7 20 6 0 2018 7 20 6 1 epublish 30023418 10.1016/j.jdcr.2018.05.002 S2352-5126(18)30118-8 PMC6047220 Ann Dermatol Venereol. 2018 Jun - Jul;145(6-7):454-464 29657073 J Invest Dermatol. 2003 Jul;121(1):215-6 12839588 Am J Emerg Med. 2018 May;36(5):887-889 28927997 Br J Dermatol. 2007 Mar;156(3):609-11 17300272 Arch Dermatol. 2012 Apr;148

2018 JAAD Case Reports

14. Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) severity score: A useful tool for assessing disease severity and predicting fatal cytomegalovirus disease. Full Text available with Trip Pro

Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) severity score: A useful tool for assessing disease severity and predicting fatal cytomegalovirus disease. The prognosis of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS) is highly unpredictable. Severe complications, either related or unrelated to cytomegalovirus (CMV) reactivation, are a highly probable cause of death.The aim

2018 Journal of American Academy of Dermatology

15. Successful treatment of drug reaction with eosinophilia and systemic symptoms syndrome relapse with oral pulsed dexamethasone Full Text available with Trip Pro

Successful treatment of drug reaction with eosinophilia and systemic symptoms syndrome relapse with oral pulsed dexamethasone 30364766 2019 02 26 2352-5126 4 9 2018 Oct JAAD case reports JAAD Case Rep Successful treatment of drug reaction with eosinophilia and systemic symptoms syndrome relapse with oral pulsed dexamethasone. 959-961 10.1016/j.jdcr.2018.07.015 Bayan Claire-Audrey Y CY Columbia University College of Physicians and Surgeons, New York, New York. Lopez Adriana A Columbia University (...) College of Physicians and Surgeons, New York, New York. Fontecilla Natalia M NM Columbia University College of Physicians and Surgeons, New York, New York. Geskin Larisa J LJ Department of Dermatology, Columbia University Medical Center, New York, New York. eng Case Reports 2018 10 13 United States JAAD Case Rep 101665210 2352-5126 DRESS syndrome DRESS, drug reaction with eosinophilia and systemic symptoms allopurinol dexamethasone oral pulse therapy steroids 2018 10 27 6 0 2018 10 27 6 0 2018 10 27 6

2018 JAAD Case Reports

16. Drug reaction with eosinophilia and systemic symptoms (DRESS) and multiple organ dysfunction syndrome (MODS): one more reason for a new effective treatment against leishmaniasis. (Abstract)

Drug reaction with eosinophilia and systemic symptoms (DRESS) and multiple organ dysfunction syndrome (MODS): one more reason for a new effective treatment against leishmaniasis. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a severe drug-induced reaction associated with eosinophilia and systemic manifestations. Anticonvulsants, sulfonamides, and antivirals are the most related and described drugs in DRESS syndrome.We present a case of severe multiple organ (...) dysfunction syndrome (MODS) with the risk of death associated with DRESS syndrome due to antileishmanial pentavalent antimonial drug and its simultaneous toxicity. Consequently, a comprehensive review of the main clinical problems and comparative discussion of both clinical conditions was made.The overlap of DRESS syndrome and antileishmanial pentavalent antimonial drug toxicity can be life-threatening. Both conditions represent a true clinical, diagnostic, and therapeutic challenge. We exposed specific

2018 International Journal of Dermatology

17. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in two young children: the importance of an early diagnosis Full Text available with Trip Pro

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome in two young children: the importance of an early diagnosis Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a serious life-treating condition characterized by skin eruption, fever, haematologic abnormalities, and multi-organ involvement that can be fatal if unrecognized, especially in patients with liver failure. Diagnosis may be difficult because it is rarely described in children and can mimic (...) many different conditions.We report two cases of DRESS syndrome due to prolonged antibiotic treatment in young children in whom recovery occurred following different therapeutic approaches. A previously healthy 5-year-old boy had been receiving intravenous vancomycin for right wrist and left elbow osteomyelitis and developed DRESS syndrome on day 30. The patient achieved a complete resolution of all symptoms with pulse methylprednisolone followed by oral prednisone. A 4-year-old girl with cystic

2018 Italian journal of pediatrics

18. Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: A clue to parvovirus B19 reactivation? Full Text available with Trip Pro

Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: A clue to parvovirus B19 reactivation? 30167447 2019 02 26 2352-5126 4 7 2018 Aug JAAD case reports JAAD Case Rep Reticular rash in drug reaction with eosinophilia and systemic symptoms syndrome: A clue to parvovirus B19 reactivation? 728-732 10.1016/j.jdcr.2018.03.024 Cura María Julia MJ Department of Dermatology, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. Torre Ana Clara AC Department

2018 JAAD Case Reports

19. Myocarditis Associated with Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report and Review of the Literature Full Text available with Trip Pro

Myocarditis Associated with Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: A Case Report and Review of the Literature BACKGROUND Drug reaction with eosinophilia and systemic symptoms (DRESS) is a clinical syndrome that can be life-threatening, depending on the organs involved. Although DRESS commonly presents with skin lesions, myocarditis and pericarditis associated with DRESS, although rare, can be fatal. A case of DRESS associated with myocarditis is presented (...) that required mechanical cardiac support. A diagnosis was made of myocarditis associated with DRESS syndrome. After treatment began with prednisolone, the skin rash, multi-organ dysfunction, and cardiogenic dysfunction resolved. CONCLUSIONS Myocarditis is a rare complication associated with DRESS, but when it is suspected, urgent echocardiography should be performed, particularly when hemodynamic instability occurs. Early diagnosis, removal of the causative agent, and treatment with corticosteroids

2018 The American journal of case reports

20. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. (Abstract)

Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. To describe key diagnostic considerations in patients with pulmonary infiltrates with eosinophilia, with a special emphasis on raising awareness of hypereosinophilic syndrome (HES), a disease that often involves the lungs and prompts investigation for clonal neoplastic processes that determine prognosis and treatment.Studies and review articles were selected from PubMed and Scopus for relevance (...) consideration in the differential diagnosis is pulmonary involvement by HES. HES is a rare syndrome that comprises a heterogeneous group of conditions characterized by persistent blood and/or tissue eosinophilia associated with organ dysfunction. Approximately one-third of HES cases are caused by neoplastic diseases, with the remaining cases classified as reactive or idiopathic. Lung involvement is seen in up to 67% of cases and may be the presenting manifestation of the disorder.The differential diagnosis

2018 Asthma & Immunology

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