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Endocrine Manifestations of HIV

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141. Infertility

been made to the recommendations. February 2012 — minor update. Broken table link fixed in the section on When to refer. Issued in March 2012. March 2011 — topic structure revised to ensure consistency across CKS topics. No changes to clinical recommendations have been made. June 2009 — minor typographical error corrected. Issued in June 2009. May 2009 — minor update. The Human Fertilisation and Embryology Association is now correctly referred to as the Human Fertilisation and Embryology Authority (...) ). In these men [ ; ]: There is no previous history of diseases affecting fertility, and physical findings, as well as endocrine, genetic, and biochemical laboratory testing (usually done in secondary care), are normal. However, semen analysis might reveal a decreased number of spermatozoa (oligozoospermia), decreased sperm motility (asthenozoospermia), and many abnormal sperm on morphological examination (teratozoospermia). Oligospermia, asthenozoospermia, and teratozoospermia usually occur together

2018 NICE Clinical Knowledge Summaries

142. Acne clinical guideline Full Text available with Trip Pro

updated and reviewed throughout guideline development. If a potential conflict was noted, the work group member recused him or herself from discussion and drafting of recommendations pertinent to the topic area of the disclosed interest. Table I Clinical questions used to structure the evidence review What systems are most commonly used for the grading and classification of adult acne and acne vulgaris in adolescents (11-21 years of age) to adults? What is the role of microbiologic and endocrine (...) . 2013 ; 19 : 176–182 | | , x 35 Kim, M.K., Choi, S.Y., Byun, H.J. et al. Comparison of sebum secretion, skin type, pH in humans with and without acne. Arch Dermatol Res . 2006 ; 298 : 113–119 | | | , x 36 Xhauflaire-Uhoda, E. and Pierard, G.E. Skin capacitance imaging of acne lesions. Skin Res Technol . 2007 ; 13 : 9–12 | | , x 37 Youn, S.H., Choi, C.W., Choi, J.W., and Youn, S.W. The skin surface pH and its different influence on the development of acne lesion according to gender and age. Skin Res

2016 American Academy of Dermatology

143. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

confined to heart muscle. Secondary cardiomyopathies had myocardial involvement as part of a large number and variety of generalized systemic (multiorgan) disorders, including systemic diseases such as amyloidosis, hemochromatosis, sarcoidosis, autoimmune/collagen vascular diseases, toxins, cancer therapy, and endocrine disorders such as diabetes mel- litus. 6 The European Society of Cardiology (ESC) Work- ing Group on Myocardial and Pericardial Diseases took a different approach based on a clinically (...) , peripartum cardiomyopathy, cardiac sarcoidosis, myocarditis, autoimmune cardiomy- opathy, endocrine and metabolic cardiomyopathies, and genetic cardiomyopathies will be reviewed. DIAGNoSTIC AND TrEATMENT STrATEGIES for C ArDIAC AMyLoIDoSIS Definition, p athogenesis, Epidemiology, and prognosis Cardiac amyloidosis usually starts as restrictive cardio- myopathy with mildly depressed LV systolic dysfunction Downloaded from http://ahajournals.org by on March 27, 2019Bozkurt et al December 6, 2016 Circulation

2016 American Heart Association

144. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association Full Text available with Trip Pro

and Cardiometabolic Health; and Council on Quality of Care and Outcomes Research Seema Mital , Kiran Musunuru , Vidu Garg , Mark W. Russell , David E. Lanfear , Rajat M. Gupta , Kathleen T. Hickey , Michael J. Ackerman , Marco V. Perez , Dan M. Roden , Daniel Woo , Caroline S. Fox *The input provided by Dr. Fox is from her own perspective, and the opinions expressed in this article do not reflect the view of the National Institutes of Health, US Department of Health and Human Services, or the United States (...) of this statement is to provide recommendations about requirements for core competencies in genetics that are relevant to cardiovascular and stroke health and to enable cardiovascular and stroke specialists to acquire these core competencies. This statement derives in part from the National Coalition for Health Professional Education in Genetics guidelines and the Secretary’s Advisory Committee on Genetics, Health, and Society report to the US Department of Health and Human Services in February 2011 titled

2016 American Heart Association

145. Will the growth spurt continue? Trends in child health economic evaluation: 1980 to 2013

analysis HIV human immunodeficiency virus HPV human papilloma virus ICD International Classification of Diseases QALY quality adjusted life year QOL quality of life RSV respiratory syncytial virus WHO World Health Organization viii SUMMARY Introduction Economic evaluations conducted as part of health technology assessments in pediatric populations have unique features compared to those conducted in adults. The Pediatric Economic Database Evaluation (PEDE) project includes a comprehensive database (...) to 21). Table 17. Publications by the ten most frequent target populations (1980-2013) Target population n % Universal 290 10.1% Pregnant 281 9.8% Children 160 5.6% Neonates 111 3.9% Vaccinated 84 2.9% Cancer 72 2.5% Asthma 70 2.4% HIV 62 2.2% Cardiac abnormality 53 1.8% Rotavirus 40 1.4% TOTAL 1223 42% Total number of categorized target populations reported in 1980-2013 = 410 Abbreviation: HIV = human immunodeficiency virus 32 Table 18. Publications by the most frequent target populations (1980

2016 SickKids Reports

146. Guidelines for Psychological Practice With Transgender and Gender Nonconforming People

for Transgender Health Standards of Care (Coleman et al., 2012) and the Endocrine Society (Hembree et al., 2009). 2 For the purposes of these guidelines, “youth” refers to both children and adolescents under the age of 18. This document is copyrighted by the American Psychological Association or one of its allied publishers. This article is intended solely for the personal use of the individual user and is not to be disseminated broadly. 833 December 2015 ? American PsychologistCompatibility These Guidelines (...) identities of TGNC people. Rationale. Gender identity and gender expression may have profound intersections with other aspects of identity (Collins, 2000; Warner, 2008). These aspects may include, but are not limited to, race/ethnicity, age, educa- tion, socioeconomic status, immigration status, occupation, disability status, HIV status, sexual orientation, relational status, and religion and/or spiritual af?liation. Whereas some of these aspects of identity may afford privilege, others may create stigma

2015 American Psychological Association

147. Nerventra - laquinimod

Gastrointestinal GLP Good Laboratory Practices GPRD General Practice Research Database HCT Hematocrit hERG human ether-a-go-go-related gene HIV Human Immunodeficiency Virus HPLC High Performance Liquid Chromatography HR Hazard Ratio I3C Indol-3-Carbinol ICH International Conference On Harmonization IFN Interferon Ig Immunoglobulin IHD Ischaemic Heart Disease IM or i.m Intramuscular IR Infrared ITT Intention to Treat IV or i.v Intravenous IVRS Centralised Interactive Voice Response System IWRS Interactive Web (...) Nerventra - laquinimod 7 Westferry Circus ? Canary Wharf ? London E14 4HB ? United Kingdom An agency of the European Union Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7455 E-mail info@ema.europa.eu Website www.ema.europa.eu 22 May 2014 EMA/451905/2014 Committee for Medicinal Products for Human Use (CHMP) Nerventra laquinimod Procedure No. EMEA/H/C/002546 Applicant: Teva Pharma GmbH Assessment report as adopted by the CHMP with all commercially confidential information deleted

2014 European Medicines Agency - EPARs

148. Ketoconazole HRA

Ketoconazole HRA 30 Churchill Place ? Canary Wharf ? London E14 5EU ? United Kingdom An agency of the European Union Telephone +44 (0)20 3660 6000 Facsimile +44 (0)20 3660 5520 Send a question via our website www.ema.europa.eu/contact 25 September 2014 EMA/CHMP/534845/2014 Committee for Medicinal Products for Human Use (CHMP) Assessment report Ketoconazole HRA International non-proprietary name: KETOCONAZOLE HRA Procedure No. EMEA/H/C/003906/0000 Note Assessment report as adopted by the CHMP (...) from milk from healthy animals in the same condition as those used to collect milk for human consumption and that the lactose has been prepared without the use of ruminant material other than calf rennet according to the Note for Guidance on Minimising the Risk of Transmitting Animal Spongiform Encephalopathy Agents Via Human and veterinary medicinal products. Ketoconazole HRA Assessment report EMA/CHMP/534845/2014 Page 14/115 2.2.4. Discussion on chemical, pharmaceutical and biological aspects

2014 European Medicines Agency - EPARs

149. Ledipasvir/Sofosbuvir

-0115, A Phase 3, Multicenter, Open-Label Study to Investigate the Safety and Efficacy of Sofosbuvir/Ledipasvir Fixed-Dose Combination for 12 Weeks in Subjects with Chronic Genotype 1 or 4 Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV)-1 Co Infections NIAID-13-I-0159, An Open Label Trial to Assess Safety, Tolerability, and Efficacy of the Fixed Dose Combination of GS-5885 and GS-7977 in HCV Genotype 1 Subjects Coinfected with HIV Summary interim safety data are available from (...) Ledipasvir/Sofosbuvir CENTER FOR DRUG EVALUATION AND RESEARCH APPLICATION NUMBER: 205834Orig1s000 MEDICAL REVIEW(S) MEMORANDUM DEPARTMENT OF HEALTH AND HUMAN SERVICES PUBLIC HEALTH SERVICE FOOD AND DRUG ADMINISTRATION CENTER FOR DRUG EVALUATION AND RESEARCH DIVISION OF ANTIVIRAL PRODUCTS DATE: September 25, 2014 TO: NDA 205834 SDN 32, received August 7, 2014 FROM: Medical Officer, Division of Antiviral Products SUBJECT: GS-US-337-0115 and NIAID-13-I-0159 Summary Interim Safety Data GS-US-337

2014 FDA - Drug Approval Package

150. Medical eligibility criteria for contraceptive use

delivered subcutaneously 61 Recommendations for safety of Sino-implant (II) 67 Recommendations for use of emergency contraceptive pills, including adding the condition of obesity and the new method, ulipristal acetate 72 Recommendations for intrauterine devices among women with increased risk for sexually transmitted infections 77 Recommendations for use of progesterone-releasing vaginal ring 79 Recommendations for use of hormonal contraception among women at high risk of HIV, women living with HIV (...) , and women living with HIV using antiretroviral therapy 82 PART II. USING THE RECOMMENDATIONS Background 99 How to use this document 104 Using the categories in practice 105 Programmatic implications 106 Clients with special needs 106 Summary of changes within the MEC fifth edition 107 TABLES Combined hormonal contraceptives 111 Progestogen-only contraceptives 157 Emergency contraceptive pills 186 Intrauterine devices 189 Copper-bearing IUD for emergency contraception 211 Barrier methods 214 Fertility

2015 World Health Organisation Guidelines

151. Systematic review of needs for medical devices for ageing populations

sites remain poorly defined. Lung cancer is the leading cause of mortality due to cancer among both men and women, and tobacco use is associated with the majority of all deaths from lung cancer. High body mass index, low fruit and vegetable intake, physical inactivity, tobacco use, alcohol use, unsafe sex, urban and indoor air pollution, and unsafe health care injections are risk factors attributing to 35% of all cancer mortality. Infections such as viral hepatitis, liver flukes, human (...) for pension schemes or retirement: this is usually between 60 and 65 years (11). Ageing is a diffuse biological process that can be described as the accumulation of deleterious changes in cells and tissues that occur with advancing age. Defining old age is challenging as its onset is not defined by a single physiological phenomenon and its manifestation varies across individuals. The process of ageing involves physical, physiological and social changes and is considered by many to be a stage of life

2015 Publication 80

152. Male Infertility

attempting to conceive a subsequent child. Three percent of women remain involuntarily childless, while 6% of parous women are not able to have as many children as they would wish [5]. Infertility affects both men and women. In 50% of involuntarily childless couples, a male-infertility-associated factor is found together with abnormal semen parameters. A fertile partner may compensate for the fertility problem of the man and thus infertility usually manifests if both partners have reduced fertility [4 (...) ]. Male fertility can be reduced as a result of [4]: • congenital or acquir ed ur ogenital abnormalities; • malignancies; • ur ogenital tract infections; • incr eased scr otal temperatur e (e.g. as a consequence of varicocele); • endocrine disturbances; • genetic abnormalities; • immunological factors. In 30-40% of cases, no male-infertility-associated factor is found (idiopathic male infertility). These men present with no previous history of diseases affecting fertility and have normal findings

2015 European Association of Urology

154. Congenital Heart Disease in the Older Adult Full Text available with Trip Pro

. It is likely that as the ACHD population ages and has more severe comorbid disease, the excess death risk for patients with moderate or severe disease will be manifest in many countries. , Survival to adulthood varies with severity of CHD, with 98% of patients with mild CHD, 96% of those with moderate CHD, but only 56% of those with severe forms surviving to adult ages. Survival of the population as a whole to adulthood was 81% in 1970 to 1974, increasing to 88.6% in 1990 to 1992. As far back as 1970, 36.4 (...) with diminished and with preserved systolic function; on occasion, there is no clear pathogenetic hemodynamic load. Diastolic dysfunction is present without the usual comorbidities of obesity or hypertension in many of these patients. Intra-atrial reentrant tachycardia (IART) is increasingly common in the ACHD population across diagnostic categories, with the estimate that 50% of all patients will manifest some atrial arrhythmia by 55 years of age. This reentry circuit often involves a prior atriotomy scar

2015 American Heart Association

156. Clinical Practice Guideline on management of patients with diabetes and chronic kidney disease stage 3b or higher (eGFR <45 mL/min) Full Text available with Trip Pro

questions, we included all studies that compared any of the pre-defined clinical or biochemical tests with a golden standard reference test. For intervention questions, we included all studies in which one of the pre-defined interventions was evaluated in humans. We excluded case series that reported on benefit if the number of participants was ≤5, but included even individual case reports if they reported an adverse event. No restriction was made based on language. We used the Early Reference (...) comment or suggestion, the guideline development group evaluated whether the statement needed to be adapted, again taking into account the balance between desirable and undesirable consequences of the alternative management strategies, the quality of the evidence, and the variability in values and preferences. 6.10.2. External review The guideline was sent to the Endocrine Society of Australia (ESA), the European Society of Endocrinology, Kidney Health Australia–Caring for Australasians with Renal

2015 European Renal Best Practice

157. The Society of Invasive Cardiovascular Professionals New 2015 Educational Guidelines for Invasive Cardiovascular Technology Personnel in the Cardiovascular Catheterization Laboratory

Environment and Safety Regulatory Compliance Procedure Room Preparation Body Mechanics a. Safely Moving Patients b. Safety Strategies for Staff 4. Electronics a. Biomedical Instrumentation b. Ohms Law, Resistance B. Aseptic Technique Pathogens a. Blood-borne, Air-borne, Bacteria, HIV, TB, Hepatitis, MRSA, C-Diff 2. OSHA Regulations 3. Universal Precautions 4. Hand Washing 5. PPE (Personal Protective Equipment) a. Accident Exposure Engineering Controls Workplace Controls 6. Gowning and Gloving a. Open (...) and Treatments A. Identification of Pathologies and Complications B. Evaluation of Statistical Data for Cardiovascular Diseases C. Etiology, Pathophysiology, Clinical Manifestations, and Treatment of: 1. Coronary Artery Disease – Atherosclerosis 2. Angina a. Stable, Unstable Variants (Printzmetal’s) 3. Acute Coronary Syndromes – Myocardial Infarction (STEMI, UA/NSTEMI) a. No-Reflow, Microvascular Obstruction 4. Heart Failure (Left Heart, Right Heart, Biventricular) 5. Shock (Cardiogenic, Hypovolemic, Septic

2015 Society for Cardiovascular Angiography and Interventions

158. Acute Pain Management: Scientific Evidence

and the development of chronic pain ( Reardon 2015). The transition of acute postoperative or post-traumatic pain to pathological chronic pain is a complex and poorly understood process (Shipton 2014a). Biological, psychological, and social- environmental factors and the known polymorphisms in human genes are all involved in perpetuating the pain ( Walsh 2011). Anaesthetists and other physicians treating acute trauma play a pivotal role in the identification of factors that may lead to suboptimal pain control (...) was the “Declaration of Montreal”, which called for “access to pain management as a fundamental human right” (Cousins 2011). This included the management of acute pain. This fourth edition sums up the evidence currently available to assist health professionals in the management of acute pain. Additional literature has been reviewed from August 2009 to August 2014. Levels of evidence have been documented according to the National Health and Medical Research Council (NHMRC) designation ( NHMRC 1999). The Jadad

2015 Clinical Practice Guidelines Portal

159. Diagnosis and Management of Aplastic Anaemia

, glycerophosphatidylinositol; AA, aplastic anaemia; PNH, paroxysmal nocturnal haemoglobinuria; FLAER, fluorescent aerolysin; EBV, Epstein‒Barr virus; CMV, cytomegalovirus; HIV, human immunodeficiency virus; SCT, stem cell transplantation; IBMFS, inherited bone marrow failure syndromes; MDS, myelodysplastic syndrome; AML, acute myeloid leukaemia; CT, computerized tomography; DC, dyskeratosis congenita; FA, Fanconi anaemia. See Table for the summary of investigations for the diagnosis and further evaluation of AA (...) to discussion of the case with a centre that has expertise in AA regarding the indications for HSCT and the choice of conditioning regimen. Grade 1C To inform the multi‐disciplinary team decision‐making regarding HSCT: All patients who are potential HSCT candidates should undergo human leucocyte antigen (HLA) typing at diagnosis, followed by related or UD searches as appropriate to assess the availability of potential donors. Grade 1B A careful reassessment should be made to confirm the precise diagnosis

2015 British Committee for Standards in Haematology

160. Canadian Diabetes Association 2013 clinical practice guidelines for the prevention and management of diabetes in Canada

“theirmoregeneralnaturerenders them insensitive to the particular circumstances of the individual cases.” Healthcare professionals must consider the needs, values and preferences of individual patients, use clinical judgement and work with available human and healthcare service resources in their settings. These guidelines were developed using the best available evidence. It is incumbent upon healthcare professionals to staycurrent in this rapidlychanging?eld. Unless otherwise speci?ed, these guidelines pertain tothe care

2013 CPG Infobase

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