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Endocrine Manifestations of HIV

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121. Developmental rheumatology in children. Scenario: Delayed walking in children

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

122. Developmental rheumatology in children. Scenario: Knock knees in children

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

123. Developmental rheumatology in children. Scenario: Out-toeing

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

124. Developmental rheumatology in children. Scenario: Clumsy child

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

125. Developmental rheumatology in children. Scenario: Tip-toe walking

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

126. Developmental rheumatology in children. Scenario: Bow legs in children

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

127. Developmental rheumatology in children. Scenario: Flat feet in children

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

128. Developmental rheumatology in children. Scenario: Curly toes in children

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

129. Developmental rheumatology in children. Scenario: Growing pains

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

130. Developmental rheumatology in children

, special shoes, and inserts) are not usually indicated [ ; ]. Referral The recommendation on when to consider referral is based on musculoskeletal triage guidance for children and young people [ ], an explanation of the pGALS (paediatric Gait, Arms, Legs, and Spine) examination [ ], and expert opinion in review articles [ ; ; ; ]. In a small number of children, bracing or surgical intervention may be indicated (for example infantile Blount disease, skeletal dysplasia, bony manifestation of endocrine (...) symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early diagnosis and appropriate referral to specialist

2019 NICE Clinical Knowledge Summaries

131. Acute pain management: scientific evidence (3rd Edition)

to be a fundamental human right and integral to the ethical, patient-centred and cost-effective practice of modern medicine. This progress is the result of dedicated efforts by health care professionals worldwide, including many in Australia and New Zealand who have contributed to past and present editions of Acute Pain: Scientific Evidence. The consistently high standards of Acute Pain: Scientific Evidence have established it as the foremost English-language resource of its type worldwide. Changes between (...) in every case, early recognition and treatment of incipient chronic pain by a vigilant healthcare system is necessary for cost- effective intervention. The National Pain Strategy document that underpins the 2010 Australian Pain Summit summarises the emerging literature on social, human and economic costs of undertreated acute and chronic pain — establishing pain as a major disease burden (www.painsummit.org.au) and proposing an integrated new framework for management of acute, chronic and cancer pain

2015 National Health and Medical Research Council

132. Autoimmune Hepatitis

delta - Chronic hepatitis C Cholangiopathy due to human immunodeficiency virus infection Alcoholic liver disease Drug-induced liver injury Granulomatous hepatitis Hemochromatosis Non-alcoholic steatohepatitis a1-antithrypsin deficiency Wilson’s disease Systemic lupus erythematosus Celiac disease JOURNAL OF HEPATOLOGY Journal of Hepatology 2015 vol. 63 j 971–1004 973proposed. Initially, two major types, AIH-1 and AIH-2, have been proposed(Table2).AIH-1ischaracterizedbythepresenceofANA and/or SMA (...) -cadidiasis ectodermal dystrophy; AS, acute severe autoimmune; CNI, Calcineurin inhibitor; CPG, Clinical Practice Guideline; DEXA, Dual energy x-ray absorptiometry; DILI, Drug-induced liver injury; HAI, Hepatitis activity index; HBV, Hepatitis B virus; HLA, Human leukocyte antigens; HRQoL, Health related quality of life; IBD, In?ammatory bowel disease; IgG, Immunoglobulin G; LBR, Live birth rate; LT, Liver transplantation; MMF, Mycophenolate mofetil; MRCP, Magnetic resonance cholangiopancreatography

2015 European Association for the Study of the Liver

133. Childhood Cancer Genomics (PDQ®): Health Professional Version

-haploid ALL, alterations targeting RTK signaling, RAS signaling, and IKZF3 are common.[ ] In low-hypodiploid ALL, genetic alterations involving TP53 , RB1 , and IKZF2 are common. Importantly, the TP53 alterations observed in low-hypodiploid ALL are also present in nontumor cells in approximately 40% of cases, suggesting that these mutations are germline and that low-hypodiploid ALL represents, in some cases, a manifestation of Li-Fraumeni syndrome.[ ] Approximately two-thirds of patients with ALL

2018 PDQ - NCI's Comprehensive Cancer Database

134. Late Effects of Treatment for Childhood Cancer (PDQ®): Health Professional Version

for Childhood Cancer During the past five decades, dramatic progress has been made in the development of curative therapy for pediatric malignancies. Long-term survival into adulthood is the expectation for more than 80% of children with access to contemporary therapies for pediatric malignancies.[ , ] The therapy responsible for this survival can also produce adverse long-term health-related outcomes, referred to as late effects , which manifest months to years after completion of cancer treatment (...) contemporary therapy in early follow-up (up to 10 years after diagnosis). However, survivors still frequently experience life-altering morbidity related to effects of cancer treatment on endocrine, reproductive, musculoskeletal, and neurologic function. A CCSS investigation examined temporal patterns in the cumulative incidence of severe to fatal chronic health conditions among survivors treated from 1970 to 1999. The 20-year cumulative incidence of at least one grade 3 to 5 chronic condition decreased

2018 PDQ - NCI's Comprehensive Cancer Database

135. Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

ethnic groups, such as inhabitants of some areas in North Africa and the Mediterranean basin, and, particularly, Southeast Asia. In the United States, the incidence of nasopharyngeal carcinoma is higher in black children and adolescents younger than 20 years.[ , ] Risk Factors Nasopharyngeal carcinoma is strongly associated with Epstein-Barr virus (EBV) infection. In addition to the serological evidence of infection in more than 98% of patients, EBV DNA is present as a monoclonal episome (...) regimens, the 3-year event-free survival was 34%, and the overall survival was 44%.[ ] Given the unique pathogenesis of nasopharyngeal carcinoma, immunotherapy has been explored for patients with refractory disease, as follows: The use of Epstein-Barr virus (EBV)–specific cytotoxic T-lymphocyte therapy has shown to be a very promising approach with minimal toxicity and evidence of significant antitumor activity in patients with relapsed or refractory nasopharyngeal carcinoma.[ ] In a phase I/II study

2018 PDQ - NCI's Comprehensive Cancer Database

136. Childhood Hematopoietic Cell Transplantation (PDQ®): Health Professional Version

(e.g., immunodeficiencies, metabolic disorders, and hemoglobinopathies). Allogeneic transplant approaches to cancer treatment also may involve high-dose therapy, but because of immunologic differences between the donor and recipient, an additional graft-versus-tumor (GVT) or graft-versus-leukemia (GVL) treatment effect can occur. Although autologous approaches are associated with less short-term mortality, many malignancies are resistant to even high doses of chemotherapy and/or involve the bone (...) overview Appropriate matching between donor and recipient HLA in the major histocompatibility complex located on chromosome 6 is essential to successful allogeneic HCT (refer to and ). Figure 1. HLA Complex. Human chromosome 6 with amplification of the HLA region. The locations of specific HLA loci for the class I B, C, and A alleles and the class II DP, DQ, and DR alleles are shown. HLA class I (A, B, C, etc.) and class II (DRB1, DQB1, DPB1, etc.) alleles are highly polymorphic; therefore, finding

2018 PDQ - NCI's Comprehensive Cancer Database

138. Childhood Vascular Tumors Treatment (PDQ®): Health Professional Version

compromise.[ ] This usually occurs with hemangiomas of the upper medial eyelid but any hemangioma around the eye that is large enough can obstruct the visual axis. The clinician should be aware of subcutaneous periocular hemangiomas, as these lesions can extend into the orbit, causing exophthalmos or globe displacement with only limited cutaneous manifestations. Issues with these lesions include astigmatism from direct pressure of the growing hemangioma, ptosis, proptosis, and strabismus. One (...) inhibitor, IFN-beta. Int J Oncol 14 (3): 401-8, 1999. [ ] North PE, Waner M, Mizeracki A, et al.: A unique microvascular phenotype shared by juvenile hemangiomas and human placenta. Arch Dermatol 137 (5): 559-70, 2001. [ ] Colonna V, Resta L, Napoli A, et al.: Placental hypoxia and neonatal haemangioma: clinical and histological observations. Br J Dermatol 162 (1): 208-9, 2010. [ ] de Jong S, Itinteang T, Withers AH, et al.: Does hypoxia play a role in infantile hemangioma? Arch Dermatol Res 308 (4

2018 PDQ - NCI's Comprehensive Cancer Database

139. Depression, anxiety, pain and quality of life in people living with chronic hepatitis C: a systematic review and meta-analysis

126 11.2 Metabolic disorders 127 11.3 Lymphoproliferative disorders 128 11.4 Integumentary conditions 129 11.5 Cardiovascular/circulatory conditions 131 11.6 Renal conditions 132 11.7 Haematological conditions 133 11.8 Musculoskeletal conditions 134 11.9 Autoimmune/immunodeficiency conditions 135 11.10 Gastrointestinal conditions 135 11.11 Cancers 136 11.12 Endocrine conditions 137 11.13 Cerebrovascular conditions 138 11.14 Pulmonary conditions 139 vi 11.15 Reproductive conditions 139 11.16 (...) Scale CWP Chronic widespread pain DASS Depression, Anxiety and Stress Scales DH Department of Health, UK EHC Extrahepatic condition FS Fibromyalgia syndrome HBV Hepatitis B virus HCSUS HIV Cost and Services Utilization Study (US) HCV Hepatitis C virus HADS Hospital Anxiety and Depression Scale HDRS Hamilton Depression Rating Scale HRQOL Health-Related Quality of Life IFN Interferon therapy MCS Mental component score of the SF36 HRQOL scale MD Mean difference MOS Medical Outcomes Study NAFLD Non

2015 EPPI Centre

140. Chronic prostatitis and chronic pelvic pain syndrome

. 6 CBP and CP/CPPS show heterogeneity in terms of clinical manifestations, which arise from a variety of possible underlying aetiologies. 7,8 These aetiological mechanisms include: 3 ? Infection ? Anatomical ? Genetic ? Endocrine ? Neuromuscular ? Immunological ? Psychological. The main four symptom domains of CBP and CP/CPPS are urogenital pain, lower urinary tract symptoms (LUTS), psychological issues and sexual dysfunction. 9 The most common presentation of CBP is recurrent urinary tract (...) to be in the ‘later stages’ of the disease if they have experienced persistent, recurrent symptoms for over six months and are refractory to initial lines of pharmacotherapy (Level 5). Signs and symptoms CBP and CP/CPPS show heterogeneity of clinical manifestations arising from the variety of possible underlying aetiologies (for example, bacterial infection and/or inflammation and/or neurological damage) and symptoms can vary between patients or fluctuate over time. 7,8 The four main symptom domains associated

2015 Prostate Cancer UK

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