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Endocrine Manifestations of HIV

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81. CRACKCast E128 – Thyroid and Adrenal Disorders

CRACKCast E128 – Thyroid and Adrenal Disorders CRACKCast E128 – Thyroid and Adrenal Disorders - CanadiEM CRACKCast E128 – Thyroid and Adrenal Disorders In , , by Chris Lipp November 20, 2017 This episode of CRACKCast covers Rosen’s Chapter 120, Thyroid and Adrenal disorders. This episode is going to have a nice breakdown of how each of these major endocrine glands can go haywire and what to do when the storm approaches. The shownotes also have some additional material worth checking out (...) event in patients with untreated or undertreated hypothyroidism. Treatment with thyroid hormone replacement must be initiated, often solely on clinical findings. Adrenal Insufficiency Clinical manifestations of primary and secondary adrenal insufficiency may be vague and nonspecific and require a high index of suspicion for diagnosis. Predominant complaints include fatigue, weakness, dizziness, nausea, vomiting, and other nonspecific GI symptoms. Patients with primary adrenal insufficiency

2017 CandiEM

82. CRACKCast E110 – Thought Disorders

erythematosus Temporal (giant cell) arteritis ORGAN FAILURE Hepatic encephalopathy Uremia NEUROLOGIC DISORDERS Alzheimer’s disease Cerebrovascular disease Encephalitis (including HIV infection) Encephalopathies Epilepsy Huntington’s disease Multiple sclerosis Neoplasms Normal-pressure hydrocephalus Parkinson’s disease Pick’s disease Wilson’s disease ENDOCRINE DISORDERS Addison’s disease Cushing’s disease Panhypopituitarism Parathyroid disease Postpartum psychosis Recurrent menstrual psychosis Sydenham’s (...) , corticosteroids Under the table hallucinogens Tranquilizers!!! (diazepam, clonazepam) ETOH Propranolol Sedatives phenYtoin Captopril Heavy metals Opioids SteroIdS [3] Describe the DSM V diagnostic criteria for schizophrenia “ Schizophrenia often manifests as a thought disorder or psychosis …..Although the etiology of schizophrenia is multifactorial, it has a substantial genetic component with 80% of the variation in the trait of the disease attributed to genetic factors. Definition from Rosens – 9th Edition

2017 CandiEM

83. Biologic therapy for psoriasis

to recommendations 112 9 Biologic therapy and cancer risk 116 9.1 Introduction 116 9.2 Review question 116 9.3 Clinical evidence 117 9.4 Link from evidence to recommendations 125 10 Biologic therapy and chronic viral infections: hepatitis B, hepatitis C or HIV 129 10.1 Introduction 129 10.2 Review question: 129 10.3 Clinical evidence 130 10.4 Link from evidence to recommendations 148 11 Additional safety aspects relating to screening, monitoring and contraindications to biologic therapy 151 11.1 Tuberculosis 151 (...) : Evidence tables clinical studies 227 Appendix F: Forest plots 296 Appendix G: Stakeholders 342 Appendix H: Study selection flow charts 343 Appendix I: GRADE tables 349 Appendix J: Choice of biologic treatment for psoriasis (decision aid) 385 Appendix K: Groups at increased risk of tuberculosis, hepatitis B, hepatitis C and HIV 389 British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017 1 Guideline Development Group members Name Role CLINICAL Ms Tracy Bale British

2017 British Association of Dermatologists

84. CRACKCast E124 – Acid-Base Disorders

alkalosis in addition to a metabolic acidosis is likely to be present. Patients who have a chronic respiratory acidosis (eg, in chronic obstructive pulmonary disease) are at risk for dangerous alkalemia if they are ventilated with routine parameters. Blood gas analysis in these cases should be performed frequently and settings titrated to the serum pH. Alcoholic ketoacidosis may be manifested similarly to diabetic ketoacidosis but is much less common; insulin is contraindicated in alcoholic ketoacidosis (...) by hypoxia High altitude Severe anemia Ventilation-perfusion mismatch Central hyperventilation Voluntary or psychogenic Cerebrovascular accident Increased intracranial pressure (tumor, hemorrhage, trauma) Toxic or pharmacologic Salicylates** Caffeine, nicotine Catecholamines Thyroxine Pulmonary Pulmonary embolism Pneumonia Pulmonary edema Asthma Mechanical hyperventilation (iatrogenic) Endocrine Pregnancy Paco2 between 31 and 35 mm Hg, serum pH between 7.46 and 7.50, and serum bicarbonate concentration

2017 CandiEM

86. Guideline for the Evaluation of Cholestatic Jaundice in Infants: Joint Recommendations of NASPGHAN and ESPGHAN

cholestasis, congenital infections Alloimmune hemolysis; glucose-6-P-dehydrogenase de?ciency; hydrops fetalis Increased risk of neonatal cholestasis Neonatal infection Urinary tract infection, sepsis related cholestasis, CMV, HIV, syphilis, etc Newborn screen Panhypopituitarism galactosemia, fatty acid oxidation defects, cystic ?brosis Source of nutrition: breast milk, formula, PN Galactosemia, hereditary fructose intolerance, PN-associated liver disease Growth Genetic and metabolic disease Vision Septo (...) , panhypopituitarism Abdominal surgery Necrotizing enterocolitis, intestinal atresia CF ¼ cystic ?brosis; CMV ¼ cytomegalovirus; HIV ¼ human immunode?ciency virus; PFIC¼ progressive familial intrahepatic cholestasis; PN ¼ parenteral nutrition; TJP ¼ tight-junction protein; TORCH ¼ Toxoplasma gondii, other viruses, rubella, cytomegalovirus, and herpes simplex virus. TABLE 3. Physical ?ndings in children with neonatal cholestasis Assessment of general health Ill appearance may indicate infection or metabolic disease

2017 North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition

87. American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease

American Association of Clinical Endocrinologists and American College of Endocrinology Guidelines for Management of Dyslipidemia and Prevention of Cardiovascular Disease ENDOCRINE PRACTICE Vol 23 (Suppl 2) April 2017 1 Copyright © 2017 AACE AACE 2017 Guidelines AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY GUIDELINES FOR MANAGEMENT OF DYSLIPIDEMIA AND PREVENTION OF CARDIOVASCULAR DISEASE Paul S. Jellinger, MD, MACE, Chair 1 ; Yehuda Handelsman MD, FACP (...) in light of local resources and individual circumstances. From the 1 Professor of Clinical Medicine, University of Miami, Miller School of Medicine, Miami, Florida, The Center for Diabetes & Endocrine Care, Hollywood, Florida; 2 Medical Director & Principal Investigator, Metabolic Institute of America, Chair, AACE Diabetes Scientific Committee, Tarzana, California; 3 Clinical Professor, University of Alabama, Director, Southside Endocrinology, Birmingham, Alabama; 4 Clinical Professor, Mount Sinai

2017 American Association of Clinical Endocrinologists

88. Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association

of the Fontan procedure, but its impact remains poorly defined in oth- er adults with CHD. 12 Genetic syndromes are commonly associated with CHD and may lead to unique endocrine and immunological complications. 13 Noncardiac causes of death in patients with Down syndrome include Al- zheimer disease, respiratory infections, stroke, DM, and seizures. 14 Cyanotic patients with CHD represent some of the most complex patients, with potential compli- cations affecting nearly all organ systems, including unique (...) liver disease IMMUNOLOGY/ INFECTIOUS DISEASE Protein-losing enteropathy Infective endocarditis Pneumonia Brain abscess HEMATOLOGY Secondary erythrocytosis/Iron (Cyanotic CHD) Thromboembolism Anemia ONCOLOGY Low-dose ionizing radiation and malignancy Hepatocellular carcinoma Age-appropriate cancer screening PSYCHOSOCIAL Depression Anxiety ENDOCRINE Thyroid Calcium hemostasis/Bone health Obesity/Metabolic syndrome Diabetes Dyslipidemia RENAL Chronic kidney disease Cardiorenal syndrome VASCULAR

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2017 American Heart Association

89. The International Glossary on Infertility and Fertility Care

, endocrine, genetic, functional or immunological abnormalities of the reproductive system; chronic illness; and sexual conditions incompatible with coitus. Fertility The capacity to establish a clinical pregnancy. Zegers-Hochschild. International Glossary on Infertility and Fertility Care. Fertil Steril 2017. VOL. 108 NO. 3 / SEPTEMBER 2017 399 Fertility and Sterility®Continued. Term Consensus de?nition Fertility awareness The understanding of reproduction, fecundity, fecundability, and related (...) repair of a defect, is a visually evident or life-threatening structural or functional defect, or causes death. Male infertility Infertility caused primarily by male factors encompassing: abnormal semen parameters or function; anatomical, endocrine, genetic, functional or immunological abnormalities of the reproductive system;chronicillness;andsexualconditionsincompatiblewiththeabilitytodepositsemeninthe vagina. Maternal spindle transfer Transfer of the maternal spindle (including maternal

2017 Society for Assisted Reproductive Technology

90. Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association (PubMed)

to influence health behavior change, as described in the AHA Community Guide for Prevention, may have greater potential to reach both African American women and men and to shift the health behaviors and consequent cardiovascular risk of the entire population. Comorbidities Certain health conditions that predispose to CVDs are more common among African Americans than whites. Below, we highlight chronic kidney disease, sickle cell disease/sickle cell trait, and HIV, given their relatively higher prevalence

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2017 American Heart Association

91. Identification and Symptom Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

disease ? Endocrine disorders such as diabetes, Addison’s disease, thyroid disease, menopause ? Infectious diseases such as tuberculosis, HIV/AIDS, chronic hepatitis, Lyme disease ? Intestinal diseases such as celiac or Crohn’s disease ? Malignancies ? Neurological disorders such as multiple sclerosis, Parkinson's disease, myasthenia gravis ? Primary psychiatric disorders and substance abuse (but not clinical depression) Identification & Symptom Management of ME/CFS | January 2016 Clinical Practice (...) and is accompanied by fatigue, which is often profound, is of new or definite onset (not lifelong), is not the result of ongoing excessive exertion, and is not substantially alleviated by rest 2. Post exertional malaise 3. Un-refreshing sleep At least one of the two following manifestations is also required: 1. Cognitive impairment* 2. Orthostatic intolerance *Frequency and severity of symptoms should be assessed. The diagnosis of ME/CFS should be questioned if patients do not have these symptoms at least half

2016 Toward Optimized Practice

92. Acute and Chronic Heart Failure

each), Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly (>65 years), Drugs/alcohol concomitantly (1 point each) HbA1c glycated haemoglobin HCM hypertrophic cardiomyopathy HES hypereosinophilic syndrome HF heart failure HFA Heart Failure Association HFmrEF heart failure with mid-range ejection fraction HFpEF heart failure with preserved ejection fraction HFrEF heart failure with reduced ejection fraction H-ISDN hydralazine and isosorbide dinitrate HIV/AIDS (...) of the diagnostic workup, as they may offer specific therapeutic opportunities. Table 3.4 Aetiologies of heart failure ARVC = arrhythmogenic right ventricular cardiomyopathy; DCM = dilated cardiomyopathy; EMF = endomyocardial fibrosis; GH = growth hormone; HCM = hypertrophic cardiomyopathy; HES = hypereosinophilic syndrome; HIV/AIDS = human immunodeficiency virus/acquired immune deficiency syndrome; LV = left ventricular. Table 3.4 Aetiologies of heart failure ARVC = arrhythmogenic right ventricular

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2016 European Society of Cardiology

93. Dyslipidaemias

glomerular filtration rate GISSI Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico GP general practitioner GWAS genome-wide association studies HAART highly active antiretroviral treatment HATS HDL-Atherosclerosis Treatment Study HbA1C glycated haemoglobin HeFH heterozygous familial hypercholesterolaemia HDL-C high-density lipoprotein cholesterol HF heart failure HHS Helsinki Heart Study HIV human immunodeficiency virus HMG-CoA hydroxymethylglutaryl-coenzyme A HPS Heart Protection (...) estimation CVD = cardiovascular disease; SCORE = Systemic Coronary Risk Estimation. a Class of recommendation. b Level of evidence. 3. Evaluation of laboratory lipid and apolipoprotein parameters Screening for dyslipidaemia is always indicated in subjects with clinical manifestations of CVD, in clinical conditions associated with increased risk for CVD and whenever risk factor screening is considered. In several clinical conditions, dyslipidaemia may contribute to an increased risk of developing CVD

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2016 European Society of Cardiology

94. Pregabalin Trial In HIV Neuropathic Pain

Pregabalin Trial In HIV Neuropathic Pain Pregabalin Trial In HIV Neuropathic Pain - Full Text View - ClinicalTrials.gov Hide glossary Glossary Study record managers: refer to the if submitting registration or results information. Search for terms x × Study Record Detail Saved Studies Save this study Warning You have reached the maximum number of saved studies (100). Please remove one or more studies before adding more. Pregabalin Trial In HIV Neuropathic Pain The safety and scientific validity (...) to Brief Summary: This study examines the safety of pregabalin over a 6 month period in patients with neuropathic pain associated with HIV infection as an extension of another trial that tests the efficacy of pregabalin. Condition or disease Intervention/treatment Phase HIV-1 Infection Neuropathic Pain Drug: pregabalin (Lyrica) Phase 3 Detailed Description: The parent double blind study was stopped at interim analysis due to lack of efficacy and therefore this open label extension study was also

2010 Clinical Trials

95. Current Diagnostic and Treatment Strategies for Specific Dilated Cardiomyopathies: A Scientific Statement From the American Heart Association

confined to heart muscle. Secondary cardiomyopathies had myocardial involvement as part of a large number and variety of generalized systemic (multiorgan) disorders, including systemic diseases such as amyloidosis, hemochromatosis, sarcoidosis, autoimmune/collagen vascular diseases, toxins, cancer therapy, and endocrine disorders such as diabetes mel- litus. 6 The European Society of Cardiology (ESC) Work- ing Group on Myocardial and Pericardial Diseases took a different approach based on a clinically (...) , peripartum cardiomyopathy, cardiac sarcoidosis, myocarditis, autoimmune cardiomy- opathy, endocrine and metabolic cardiomyopathies, and genetic cardiomyopathies will be reviewed. DIAGNoSTIC AND TrEATMENT STrATEGIES for C ArDIAC AMyLoIDoSIS Definition, p athogenesis, Epidemiology, and prognosis Cardiac amyloidosis usually starts as restrictive cardio- myopathy with mildly depressed LV systolic dysfunction Downloaded from http://ahajournals.org by on March 27, 2019Bozkurt et al December 6, 2016 Circulation

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2016 American Heart Association

96. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association

correlated with disease manifestation) Various factors that influence the client’s ability to use genetic information and services, for example, ethnicity, culture, related health beliefs, ability to pay, and health literacy The potential physical and psychosocial benefits, limitations, and risks of genetic information for individuals, family members, and communities Resources available to assist clients seeking genetic information or services, including the types of genetics professionals available (...) genetic syndrome with multisystem involvement: Syndrome diagnosis, care coordination, and implementation of health supervision guidelines Intellectual or learning disability; autism; other cognitive impairment Dysmorphic features Short stature Features of connective tissue disease Any congenital anomaly Endocrine abnormalities Sensory deficits such as hearing loss or visual impairment Neurological deficits or psychiatric illness Unexplained medical conditions Family history of heritable cardiac

2016 American Heart Association

97. Will the growth spurt continue? Trends in child health economic evaluation: 1980 to 2013

analysis HIV human immunodeficiency virus HPV human papilloma virus ICD International Classification of Diseases QALY quality adjusted life year QOL quality of life RSV respiratory syncytial virus WHO World Health Organization viii SUMMARY Introduction Economic evaluations conducted as part of health technology assessments in pediatric populations have unique features compared to those conducted in adults. The Pediatric Economic Database Evaluation (PEDE) project includes a comprehensive database (...) 2.1% 73.1% 52 2.0% Congenital anomalies 88 10.9% 46.8% 100 5.5% 53.2% 188 7.1% Dental 32 4.0% 97.0% 1 0.1% 3.0% 33 1.3% Digestive system 22 2.7% 30.1% 51 2.8% 69.9% 73 2.8% Nervous system and sensory organs 34 4.2% 22.1% 120 6.6% 77.9% 154 5.9% Genitourinary system 20 2.5% 24.7% 61 3.4% 75.3% 81 3.1% Musculoskeletal system 4 0.5% 16.0% 21 1.2% 84.0% 25 1.0% Skin and sub-cutaneous tissue 3 0.4% 11.5% 23 1.3% 88.5% 26 1.0% Respiratory system 31 3.8% 17.4% 147 8.1% 82.6% 178 6.8% Endocrine, nutrition

2016 SickKids Reports

98. Acne clinical guideline

updated and reviewed throughout guideline development. If a potential conflict was noted, the work group member recused him or herself from discussion and drafting of recommendations pertinent to the topic area of the disclosed interest. Table I Clinical questions used to structure the evidence review What systems are most commonly used for the grading and classification of adult acne and acne vulgaris in adolescents (11-21 years of age) to adults? What is the role of microbiologic and endocrine (...) , A. Hormonal profiles and prevalence of polycystic ovary syndrome in women with acne. J Dermatol . 1997 ; 24 : 223–229 | | , x 53 Lucky, A.W. Endocrine aspects of acne. Pediatr Clin North Am . 1983 ; 30 : 495–499 | , x 54 Lucky, A.W., McGuire, J., Rosenfield, R.L., Lucky, P.A., and Rich, B.H. Plasma androgens in women with acne vulgaris. J Invest Dermatol . 1983 ; 81 : 70–74 | | | , x 55 Abulnaja, K.O. Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris. Braz J Med

2016 American Academy of Dermatology

99. Developmental rheumatology in children. Scenario: Out-toeing

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

100. Developmental rheumatology in children. Scenario: Clumsy child

dysplasia, bony manifestation of endocrine or renal abnormalities) [ ]. There may be an association with pathologic bow legs and early osteoarthritis. Surgery may be necessary if the condition does not spontaneously resolve or there is extreme angulation [ ]. Scenario: Clumsy child Scenario: Clumsy child From birth to 16 years. Clumsy child When should I consider referring a clumsy child? Management in the community (for example by a physiotherapist with paediatric expertise) is usually appropriate (...) or young person with: Atypical symptoms. Worsening symptoms. Unremitting pain; night pain; thoracic pain. Non-mechanical pain. Abnormal loss or deterioration of function. Significant loss of movement. Gait disturbance. Significant lower limb asymmetry. TB, cancer, HIV/AIDS, steroid use, multiple fractures. Skin changes, for example, cafe au lait, psoriasis, bruising. Paediatric Musculoskeletal Matters ( ) is a resource for clinicians working with children and young people. It aims to facilitate early

2019 NICE Clinical Knowledge Summaries

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