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Endocrine Manifestations of HIV

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61. Assessment of hypocalcaemia

for the preceding image starts]: Carpopedal spasm (Trousseau's sign) occurred a few minutes after inflation of a sphygmomanometer cuff above systolic blood pressure Pedrazzini B et al. BMJ Case Reports 2010;2010:bcr.08.2009.2188 [Citation ends]. Papilloedema, cataracts, basal ganglia calcifications, and skin, hair, and dental changes may occur with chronic hypocalcaemia. Neuropsychiatric manifestations include dementia in adults, anxiety, depression, lethargy, and extrapyramidal symptoms (parkinsonism). Skin (...) Hyperventilation Isolated hypoparathyroidism Pseudohypoparathyroidism Autoimmune hypoparathyroidism HIV-related hypoparathyroidism Hypermagnesaemia Hyperphosphataemia Hypercalciuria Sepsis Burns Renal failure Acute pancreatitis Extensive osteoblastic skeletal metastasis Hungry bone syndrome Drug-induced hypocalcaemia Multiple transfusions Hypoalbuminaemia Drug interference with assay Infiltrative hypoparathyroidism DiGeorge syndrome and other developmental complexes Rhabdomyolysis Tumour lysis syndrome

2018 BMJ Best Practice

62. What helps to support people affected by Adverse Childhood Experiences? A Review of Evidence

brain development, especially in the early years, but also into adolescence (Keverne, 2014, Sethi et al., 2013). ACEs have been associated with lasting changes in nervous, endocrine and immune systems which are observable in childhood and persist into adult life (Danese and McEwen, 2012). These resulting significant biological changes in children can exert long-term effects on health across the life-course, such as long-term morbidity from non-communicable disease (Danese and McEwen, 2012). Through

2019 EPPI Centre

63. ESC/ESH Management of Arterial Hypertension (Full text)

in women) Autoimmune and other inflammatory disorders Major psychiatric disorders Treatment for infection with human immunodeficiency virus Atrial fibrillation LV hypertrophy CKD Obstructive sleep apnoea syndrome Social deprivation, the origin of many causes of CVD Obesity (measured by BMI) and central obesity (measured by waist circumference) Physical inactivity Psychosocial stress, including vital exhaustion Family history of premature CVD (occurring at age <55 years in men and <60 years in women (...) ) Autoimmune and other inflammatory disorders Major psychiatric disorders Treatment for infection with human immunodeficiency virus Atrial fibrillation LV hypertrophy CKD Obstructive sleep apnoea syndrome BMI = body mass index; CKD = chronic kidney disease; CVD = cardiovascular disease; LV = left ventricular. Table 6 Risk modifiers increasing cardiovascular risk estimated by the Systemic COronary Risk Evaluation (SCORE) system Social deprivation, the origin of many causes of CVD Obesity (measured by BMI

2018 European Society of Cardiology PubMed abstract

64. Letermovir (Prevymis) - to prevent illness caused by cytomegalovirus (CMV) in adults having an allogeneic haematopoietic stem cell transplant

Committee for Medicinal Products for Human Use (CHMP) Assessment report PREVYMIS International non-proprietary name: letermovir Procedure No. EMEA/H/C/004536/0000 Note Assessment report as adopted by the CHMP with all information of a commercially confidential nature deleted. Assessment report EMA/CHMP/490007/2017 Page 2/124 Table of contents 1. Background information on the procedure 5 1.1. Submission of the dossier 5 1.2. Steps taken for the assessment of the product 6 2. Scientific discussion 8 2.1 (...) Ganciclovir GV Genotypic variant GVHD Graft-versus-host disease HSCT Hematopoietic stem cell transplant HSV Herpes simplex virus LLoQ Lower limit of quantification LOTTR Last observed time point MDRD Modification of diet in renal disease PET Pre-emptive therapy QTcF Fridericia correction of the QT interval VGCV Valganciclovir VZV Varicella Zoster Virus Assessment report EMA/CHMP/490007/2017 Page 5/124 1. Background information on the procedure 1.1. Submission of the dossier The applicant Merck Sharp

2018 European Medicines Agency - EPARs

65. Darvadstrocel (Alofisel) - Rectal Fistula

is carried out in agreement with the principles laid down in Directive 2006/17/EC on donation, procurement and testing of human tissues and cells as well as Directive 2006/86/EC on traceability of human tissues and cells. Detailed information on which virus markers are tested on the donors of adipose tissue has been provided. Both immunological and NAT tests are used for all markers. It has been confirmed that only CE-marked test kits are used for donor testing. Information about the laboratory where (...) include the lipoaspirate starting material and the excipients Dulbecco’s Modified Eagle’s Medium (DMEM) as isotonic buffer and Human Serum Albumin (HSA) 20% as stabilizer. Virus safety A revised risk assessment has been provided upon request where more detailed information has been included on testing of donor, virus testing on MCS and active substance and any risk related to the type of tissue used. The revised adventitious agent risk assessment report is acceptable. Regarding the lipoaspirate donor

2018 European Medicines Agency - EPARs

66. Asylum seekers in Belgium: options for a more equitable access to health care. A stakeholder consultation

) Fedasil Agence Fédérale pour l’Accueil des Demandeurs d’Asile – Federaal Agentschap voor de Opvang van de Asielzoekers (Belgian Federal Agency for the Reception of Asylum Seekers) FGM Female Genital Mutilation FOD – SPF (FPS) Service public fédéral – Federale overheidsdienst (Federal public service, Belgium) FTE Full Time Equivalent GP Generalist practitioner HIV – AIDS Human Immunodeficiency Virus infection – Acquired Immune Deficiency Syndrome ILA – LOI Initiative Locale d’Accueil – Lokaal Opvang (...) , discrimination and violence, as well as to review policies related to restrictions on entry based on HIV status, with a view to eliminating such restrictions and the return of people on the basis of their HIV status, and to support their access to HIV prevention, treatment, care and support. We reaffirm our commitment to protect the human rights of migrant children, given their vulnerability, particularly unaccompanied migrant children, and to provide access to basic health, education and psychosocial

2019 Belgian Health Care Knowledge Centre

67. Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD

Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD: A Systematic Review Comparative Effectiveness Review Number 221 RComparative Effectiveness Review Number 221 Pharmacologic and Nonpharmacologic Therapies in Adult Patients With Exacerbation of COPD: A Systematic Review Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services (...) of the authors, who are responsible for its contents; the findings and conclusions do not necessarily represent the views of AHRQ. Therefore, no statement in this report should be construed as an official position of AHRQ or of the U.S. Department of Health and Human Services. None of the investigators have any affiliations or financial involvement that conflicts with the material presented in this report. The information in this report is intended to help healthcare decision makers—patients and clinicians

2019 Effective Health Care Program (AHRQ)

68. WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights

Grading of Recommendations Assessment, Development and Evaluation GRC Guidelines Review Committee GVPS Global Values and Preferences Survey HIVST HIV self-testing HPV human papillomavirus HPVSS HPV self-sampling HRP The UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction IPCHS Integrated People-Centred Health Services framework MEC Medical eligibility criteria for contraceptive use (WHO publication) OCP oral contraceptive pill OPK (...) 122 95 116 89 112 122 98 92 112 123 77 4.4 Combating sexually transmitted infections (including HIV), reproductive tract infections, cervical cancer and other gynaecological morbidities 4.3 Eliminating unsafe abortion 4.2 Providing high- quality services for family planning, including infertility services 4.1 Improving antenatal care, delivery, postpartum and newborn care 5.1 Overview 6.1 Research on self-care contributing to WHO’s “triple billion” goals 7.1 Dissemination 5.4 Training needs

2019 World Health Organisation Guidelines

69. What is the evidence on the role of the arts in improving health and well-being? A scoping review

that are cofinanced by different budgets; • considering the introduction, or strengthening, of lines of referral from health and social care to arts programmes, for example through the use of social prescribing schemes; and • supporting the inclusion of arts and humanities education within the training of health-care professionals to improve their clinical, personal and communication skills.1 1. INTRODUCTION 1.1 Background 1.1.1 Defining the arts While the arts have always been conceptually difficult to define (...) , highlights the importance of multisectoral collaboration for catalysing action (45). This strategic shift has been further underlined by the recently published WHO Thirteenth General Programme of Work 2019–2023 (46), which also promotes a greater focus on both well-being and increasing human capital throughout the life-course. Furthermore, the 2030 Agenda for Sustainable Development (47) includes supporting good health and well-being, providing quality education, building sustainable cities

2019 WHO Health Evidence Network

70. Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk (Full text)

Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk: An Endocrine Society* Clinical Practice Guideline | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic ') We use cookies to enhance your experience on our website.By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Search Account Menu Menu Navbar Search Filter Mobile (...) Microsite Search Term Close search filter search input Article Navigation Close mobile search navigation Article Navigation September 2019 Article Contents Article Navigation Primary Prevention of ASCVD and T2DM in Patients at Metabolic Risk: An Endocrine Society Clinical Practice Guideline James L Rosenzweig Hebrew Rehabilitation Hospital, Boston, Massachusetts Correspondence: James L. Rosenzweig, MD, Hebrew Rehabilitation Hospital, 1200 Centre Street, Boston, Massachusetts 02131. E-mail: . Search

2019 The Endocrine Society PubMed abstract

71. Sepsis Management

stream infection 2.3% Device-related 1.3% CNS 0.8% Others e.g. cellulitis, intra-articular 11.3% 1.2 Clinical impact of sepsis Sepsis claims more lives than lung cancer, and more than breast cancer, bowel cancer and HIV/ AIDS combined. Mortality in adults with severe sepsis/septic shock a decade ago was 37 – 53% with a mortality of approximately 10% in paediatric sepsis.(10, 11) Since then the Surviving Sepsis Campaign, The UK Sepsis Trust, the Australian Commission for Clinical Excellence

2019 National Clinical Guidelines (Ireland)

72. Oncologic imaging

-risk sexual behavior, tobacco use, and infection with human papillomavirus or human immunodeficiency virus. The most common presentation is rectal bleeding or pain. INITIAL TREATMENT STRATEGY Anal cancer is staged using the American Joint Committee on Cancer TNM system. The vast majority of patients with locoregional disease will undergo concurrent chemoradiation treatment regardless of tumor or nodal staging. PET/CT scan in initial staging and radiation planning allows for better assessment (...) is considered medically necessary when criteria are met and CT is contraindicated or expected to be suboptimal (due to contrast allergy or anticipated contrast nephrotoxicity). Rationale The incidence of gastric cancer has declined over the past 10 years, but it remains one of the leading causes of death worldwide. The most common histologic type is adenocarcinoma. Presenting symptoms may include weight loss, pain, bleeding, or dysphagia. More advanced disease can manifest as ascites and symptoms related

2019 AIM Specialty Health

73. Appropriate Use Criteria: Imaging of the Brain

and/or inflammatory conditions) ? Risk factors for venous thrombosis (see Vascular Imaging guidelines) Patient populations High-risk vascular patient ? Over age 50 with new onset of headache ? Known malignancy ? Increased genetic risk for intracranial neoplasms including basal cell nevus syndrome, Gorlin syndrome, Li-Fraumeni syndrome, neurofibromatosis type 1 and type 2, Turcot syndrome, and von Hippel-Lindau syndrome ? Immunodeficiency including HIV ? Personal or family history (at least one first- degree (...) or posture that manifests before age 2. 5 MRI has a high sensitivity (86%-89%) for the condition 6 with 70%-90% of patients having identifiable structural abnormalities. Neuroimaging in general and MRI in particular are recommended by the American Academy of Neurology to help establish the diagnosis. 7 MRI is the preferred imaging modality for evaluation of congenital and developmental abnormalities of the brain because it is more sensitive than CT for the detection of morphological abnormalities

2019 AIM Specialty Health

74. The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC) (Full text)

tract, including the lip and oral cavity, nasal cavity, paranasal sinuses, nasopharynx, oropharynx, larynx and hypopharynx [ , , , , ]. In addition to traditional risk factors including smoking and alcohol consumption, over the last two to three decades it has become apparent that the human papillomavirus (HPV) and Epstein Barr Virus (EBV) are associated with development of squamous cell carcinoma of the oropharynx and nasopharynx, respectively [ , , , , , , , ]. Most patients present with locally (...) the scientific literature for current therapies related to head and neck cancer and immunotherapy in humans. The final search encompassed articles published from 2012 to 2018 (conducted on December 17, 2018) and was limited to clinical trials, meta-analyses, practice guidelines, and research in humans, supplemented by major presentations at international meetings where abstracts were peer-reviewed. The search terms included “head and neck neoplasm OR HNSCC OR SCCHN” and “pembrolizumab”, “nivolumab

2019 Society for Immunotherapy of Cancer PubMed abstract

75. Pruritus

may occur in 4% of herpes zoster patients, which is termed post-herpetic itch (Weisshaar and Dalgard 2009). 13 Some generalised infections are accompanied by pruritus. Above all, patients infected with human immunodeficiency virus (HIV) may develop CP, which can be the initial presentation of HIV infection. The true prevalence is not known but could be as high as 45% according to cross-sectional study (Kaushik, Cerci et al. 2014). In a significant number of HIV patients itching has no detectable (...) pruritus) 10 4.1.4 Pruritus in metabolic and endocrine diseases 11 4.1.5 Pruritus in malignancy 11 4.1.6 Pruritus in infectious diseases 12 4.1.7 Pruritus in neurological diseases 13 4.1.8 Pruritus in psychiatric diseases 14 4.1.9 Drug-induced chronic pruritus 14 4.2 Specific patient populations 15 4.2.1 Chronic pruritus in the elderly 15 4.2.2 Chronic pruritus in pregnancy 15 4.2.3 Chronic pruritus in children 16 5 Diagnostic management 178 5.1 Patient history and clinical examination 178 5.2

2019 European Dermatology Forum

76. Male Infertility

partner may compensate for the fertility problem of the man and thus infertility usually manifests if both partners have reduced fertility [ ]. Male fertility can be impaired as a result of [ ]: congenital or acquired urogenital abnormalities; malignancies; urogenital tract infections; increased scrotal temperature (e.g. as a consequence of varicocele); endocrine disturbances; genetic abnormalities; immunological factors. In 30-40% of cases, no male-infertility-associated factor is found (idiopathic (...) . Ultrasound of the male genital tract in relation to male reproductive health. Human Reprod Update, 2015. 21: 56. 14. WHO, WHO Laboratory Manual for the Examination and Processing of Human Semen, in 5th edn. 2010. 15. Hauser, R., et al. Fertility in cases of hypergonadotropic azoospermia. Fertil Steril, 1995. 63: 631. 16. Martin-du-Pan, R.C., et al. Increased follicle stimulating hormone in infertile men. Is increased plasma FSH always due to damaged germinal epithelium? Hum Reprod, 1995. 10: 1940. 17

2019 European Association of Urology

77. Male Hypogonadism

, Nieschlag S (eds). Andrology - male reproductive health and dysfunction. 3rd edn., in Andrology - male reproductive health and dysfunction. 2010, Springer: Berlin. 41. Buchter, D., et al. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol, 1998. 139: 298. 42. Sykiotis, G.P., et al. Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus (...) , pituitary, and testes. J Clin Endocrinol Metab, 2010. 95: 3019. 43. Rohayem, J., et al. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine, 2017. 55: 914. 44. Huhtaniemi, I., et al. Gonadotrophin resistance. Best Pract Res Clin Endocrinol Metab, 2006. 20: 561. 45. El Osta, R., et al. Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. Basic & Clinical Andrology, 2017. 27: 13. 46. Bhasin, S., et al. Testosterone therapy in men with androgen

2019 European Association of Urology

78. An evaluation protocol for NIHDI conventions

. During the past decennia rehabilitations conventions have been developed for a large heterogeneity of medical conditions, transcending the field of rehabilitation. The list of conventions can be found in Appendix 1. Agreements are made for: ? Respiratory diseases: respiratory rehabilitation, respiration support, oxygen therapy at home and cardiorespiratory monitoring of babies ? Conditions of the blood- and immunity system: haemophilia, AIDS ? Chronic fatigue syndrome ? Endocrine and metabolic (...) with the Scientific Institute for Public Health (WIV/ISP) : ? Initiative for quality promotion and epidemiology relative to diabetes (IKED-study) ? Initiative for quality promotion and epidemiology relative to diabetic foot (IKED-voet) ? Initiative for quality promotion and epidemiology for diabetes in children and adolescents ? The Belgian neuromuscular disease registry ? Belgian cystic fibrosis registry ? HIV registry ? Haemophilia registry (under construction) For the registries the convention agreement

2018 Belgian Health Care Knowledge Centre

79. Male Hypogonadism

, Nieschlag S (eds). Andrology - male reproductive health and dysfunction. 3rd edn., in Andrology - male reproductive health and dysfunction. 2010, Springer: Berlin. 41. Buchter, D., et al. Pulsatile GnRH or human chorionic gonadotropin/human menopausal gonadotropin as effective treatment for men with hypogonadotropic hypogonadism: a review of 42 cases. Eur J Endocrinol, 1998. 139: 298. 42. Sykiotis, G.P., et al. Congenital idiopathic hypogonadotropic hypogonadism: evidence of defects in the hypothalamus (...) , pituitary, and testes. J Clin Endocrinol Metab, 2010. 95: 3019. 43. Rohayem, J., et al. Delayed treatment of undescended testes may promote hypogonadism and infertility. Endocrine, 2017. 55: 914. 44. Huhtaniemi, I., et al. Gonadotrophin resistance. Best Pract Res Clin Endocrinol Metab, 2006. 20: 561. 45. El Osta, R., et al. Hypogonadotropic hypogonadism in men with hereditary hemochromatosis. Basic & Clinical Andrology, 2017. 27: 13. 46. Bhasin, S., et al. Testosterone therapy in men with androgen

2018 European Association of Urology

80. Management of Pregnancy

(seasonal) for mother and family b ? Screen for infectious diseases (GC/CT, HIV, syphilis, rubella, hepatitis B, varicella [if unsure], asymptomatic bacteriuria, TB, history of HSV); treat or manage as indicated a ? Screen for Rh status and anemia/hemoglobinopathies ? Evaluate for nutritional deficiencies in women who have undergone bariatric surgery with intervention as needed (Recommendation 20) ? Consult with RDN for women who have undergone bariatric surgery and who are on a restrictive diet ? Refer

2018 VA/DoD Clinical Practice Guidelines

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