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Endocrine Manifestations of HIV

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41. Dermatologic Manifestations of Hematologic Disease (Follow-up)

Dermatologic Manifestations of Hematologic Disease (Follow-up) Dermatologic Manifestations of Hematologic Disease: Coagulation Disorders, Cutaneous Manifestations of Anemia, Plasma-Cell Disorders and Dysproteinemias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary

2014 eMedicine.com

42. Dermatologic Manifestations of Gastrointestinal Disease (Follow-up)

of the epidemic form of KS has risen dramatically in the United States over the past 20 years with the spread of AIDS. Human herpesvirus type 8 (HHV-8) has been implicated in the pathogenesis of KS in both HIV-infected and non-HIV–infected patients. [ , , , ] KS may in fact be a hyperplasia caused by infection with HHV-8, rather than a sarcoma. Supporting evidence includes lack of clonality, multifocality, symmetry, absence of metastasis, and spontaneous regression with immune reconstitution. Recent evidence (...) or familial, but, in either case, it is clear that extrinsic factors play an important role in producing a clinical manifestation of the disease. Endogenous and exogenous factors (eg, alcohol, iron, estrogen, porphyrins, chronic hepatitis C virus infection, polychlorinated biphenyls, polychlorinated cyclic hydrocarbons) produce oxidative stress on the liver, leading to inhibition or decreased production of UROD. The pathogenesis of iron in porphyria cutanea tarda also provides the link to hereditary

2014 eMedicine.com

43. Dermatologic Manifestations of Renal Disease (Follow-up)

as it was in the past. The remaining causes of ESRD included vasculitis from an infectious or rheumatologic disease, interstitial nephritis, tumors, cholesterol emboli, and systemic amyloidosis. Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). [ ] Systemic lupus erythematosus (SLE) has been the most commonly reported rheumatologic cause of ESRD. Polyarteritis nodosa (...) Glomerulonephritis Vasculitis Purpura Subcutaneous nodules Ulcers Subacute bacterial endocarditis Renal emboli Glomerulonephritis Petechiae Purpura Cholesterol emboli Renal emboli Petechiae Livedo reticularis Blue toes Hepatitis C virus Glomerulonephritis Purpura Porphyria cutanea tarda Lichen planus Sclerodermatous plaques Cutaneous polyarteritis nodosa Necrolytic acral erythema Human immunodeficiency virus (HIV) HIV-associated nephropathy Eosinophilic folliculitis Oral hairy leukoplakia Bacillary angiomatosis

2014 eMedicine.com

44. Dermatologic Manifestations of Hematologic Disease (Diagnosis)

Dermatologic Manifestations of Hematologic Disease (Diagnosis) Dermatologic Manifestations of Hematologic Disease: Coagulation Disorders, Cutaneous Manifestations of Anemia, Plasma-Cell Disorders and Dysproteinemias Edition: No Results No Results Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache (...) =aHR0cHM6Ly9lbWVkaWNpbmUubWVkc2NhcGUuY29tL2FydGljbGUvMTA5NjE4My1vdmVydmlldw== processing > Dermatologic Manifestations of Hematologic Disease Updated: Jun 16, 2017 Author: Saira J George, MD; Chief Editor: William D James, MD Share Email Print Feedback Close Sections Sections Dermatologic Manifestations of Hematologic Disease Coagulation Disorders Antiphospholipid syndrome (APS) is an acquired, multisystemic disorder characterized by recurrent thromboses in the arterial system, venous system, or both. Antiphospholipid syndrome is classified into 2 groups: primary

2014 eMedicine.com

45. Dermatologic Manifestations of Gastrointestinal Disease (Diagnosis)

of the epidemic form of KS has risen dramatically in the United States over the past 20 years with the spread of AIDS. Human herpesvirus type 8 (HHV-8) has been implicated in the pathogenesis of KS in both HIV-infected and non-HIV–infected patients. [ , , , ] KS may in fact be a hyperplasia caused by infection with HHV-8, rather than a sarcoma. Supporting evidence includes lack of clonality, multifocality, symmetry, absence of metastasis, and spontaneous regression with immune reconstitution. Recent evidence (...) or familial, but, in either case, it is clear that extrinsic factors play an important role in producing a clinical manifestation of the disease. Endogenous and exogenous factors (eg, alcohol, iron, estrogen, porphyrins, chronic hepatitis C virus infection, polychlorinated biphenyls, polychlorinated cyclic hydrocarbons) produce oxidative stress on the liver, leading to inhibition or decreased production of UROD. The pathogenesis of iron in porphyria cutanea tarda also provides the link to hereditary

2014 eMedicine.com

46. Dermatologic Manifestations of Renal Disease (Diagnosis)

as it was in the past. The remaining causes of ESRD included vasculitis from an infectious or rheumatologic disease, interstitial nephritis, tumors, cholesterol emboli, and systemic amyloidosis. Infectious causes of glomerulonephritis included streptococcal infections, human immunodeficiency virus (HIV) infection, and hepatitis viral infections, both hepatitis C (HCV) and hepatitis B (HBV). [ ] Systemic lupus erythematosus (SLE) has been the most commonly reported rheumatologic cause of ESRD. Polyarteritis nodosa (...) Glomerulonephritis Vasculitis Purpura Subcutaneous nodules Ulcers Subacute bacterial endocarditis Renal emboli Glomerulonephritis Petechiae Purpura Cholesterol emboli Renal emboli Petechiae Livedo reticularis Blue toes Hepatitis C virus Glomerulonephritis Purpura Porphyria cutanea tarda Lichen planus Sclerodermatous plaques Cutaneous polyarteritis nodosa Necrolytic acral erythema Human immunodeficiency virus (HIV) HIV-associated nephropathy Eosinophilic folliculitis Oral hairy leukoplakia Bacillary angiomatosis

2014 eMedicine.com

47. Acute hypophysitis and hypopituitarism in early syphilitic meningitis in a HIV-infected patient: a case report. Full Text available with Trip Pro

Acute hypophysitis and hypopituitarism in early syphilitic meningitis in a HIV-infected patient: a case report. Sexually transmitted diseases and most notably syphilis-infections are rising amongst men who have sex with men. In HIV-co-infected patients, an accelerated clinical course of syphilis neurological involvement is known.A 46 year old HIV-positive male patient came in to our emergency department in the late evening with acute fever, rapidly progressive cephalgia and photophobia. Palmar (...) skin efflorescence was evocative of an active syphilis infection. A reactive Treponema pallidum particle agglutination (TPPA) assay with positive Treponema pallidum-specific IgG/IgM immunofluorescence as well as a highly reactive Veneral diseases research laboratory (VDRL) test confirmed the diagnosis. Liquor pleocytosis, liquor protein elevation and a highly positive VDRL test in cerebrospinal fluid (CSF) were interpreted in context of the clinical symptoms as neurosyphilitic manifestations within

2013 BMC Infectious Diseases

48. HIV Presentation

SnomedCT 111880001 English Acute HIV infection syndrome , acute HIV infection , Acute human immunodeficiency virus infection (disorder) , Acute HIV infection (disorder) , HIV infection acute , Acute HIV infection (diagnosis) , Acute HIV infection , Acute human immunodeficiency virus infection , Acute human immunodeficiency virus seroconversion illness , Acute infection with HIV , HIV seroconversion illness Italian Infezione acuta da HIV , Malattia da sieroconversione HIV , Infezione acuta con HIV Dutch (...) HIV Presentation HIV Presentation Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 HIV Presentation HIV Presentation Aka: HIV

2015 FP Notebook

49. HIV Related Rheumatologic Conditions

HIV Related Rheumatologic Conditions HIV Related Rheumatologic Conditions Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 HIV Related (...) Rheumatologic Conditions HIV Related Rheumatologic Conditions Aka: HIV Related Rheumatologic Conditions , Rheumatologic Manifestations of HIV , HIV Related Rheumatologic Complications II. Epidemiology Patients report musculoskeletal symptoms: 75% Severe is rare HIV complication III. Associated Conditions: HIV Associated Rheumatic Conditions Reduced and Increased risk by 15-50% Contributing factors include lower body weight, chronic inflammation, low s, abuse and is found in 80% of patients with therapy

2015 FP Notebook

50. Pediatric HIV

Pediatric HIV Pediatric HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Pediatric HIV Pediatric HIV Aka: Pediatric HIV , Pediatric (...) of transmission (acquisition) Transfusion (risk of 1 in 425,000 by test) Foreign adoptee Accounts for 90% of cases under age 13 years Adolescents with high risk behaviors Accounts for 50% of new HIV cases in the United States under age 18 years IV. Clinical Manifestations Lymph nodes may be size of nodes Hepatosplenomegaly Recurrent (especially over age 2 years old) or Recurrent Encephalopathy Lymphocytic Interstitial Pneumonitis (LIP) May be first indicator of perinatal Peak at age 3 to 6 months May occur

2015 FP Notebook

51. Diarrhea in HIV

Diarrhea in HIV Diarrhea in HIV Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Diarrhea in HIV Diarrhea in HIV Aka: Diarrhea in HIV (...) , HIV related Diarrhea , AIDS Associated Diarrhea From Related Chapters II. Epidemiology is most common intestinal HIV manifestation Affects 50-90% of HIV patients III. Signs Often voluminous IV. Causes: Infectious (Pathogen identified in 85% of AIDS patient) Microsporidia (MAC) (CMV) Infection accompanies (HSV) Can also cause rectal ulcers and pain V. Causes: Pathogen negative Gastrointestinal Cancer Non-hodgkin Kaposi Anal Fat malabsorption (related to pancreatic exocrine insufficiency

2015 FP Notebook

52. HIV Complications

HIV Complications HIV Complications Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 HIV Complications HIV Complications Aka: HIV (...) Complications , HIV Associated Conditions , HIV Related Conditions From Related Chapters II. Complications Eye Manifestations III. References Images: Related links to external sites (from Bing) These images are a random sampling from a Bing search on the term "HIV Complications." Click on the image (or right click) to open the source website in a new browser window. Related Studies (from Trip Database) Related Topics in Examination About FPnotebook.com is a rapid access, point-of-care medical reference

2015 FP Notebook

53. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children Full Text available with Trip Pro

the chairs, co-chairs, methodologists, and group heads, as well as within subgroups, served as an integral part of the guideline development process. Methods: The panel consisted of six subgroups: recognition and management of infection , hemodynamics and resuscitation, ventilation, endocrine and metabolic therapies, adjunctive therapies, and research priorities. We conducted a systematic review for each Population, Intervention, Control, and Outcomes question to identify the best available evidence (...) and resuscitation, 3) ventilation, 4) endocrine and metabolic therapies, and 5) adjunctive therapies. A sixth subgroup was added to review research priorities in pediatric sepsis . The co-chairs, co-vice chairs, and group heads made initial selections of the topics. We included topics addressed in the 2016 SSC adult guidelines that were relevant to children, as well as other key pediatric topics discussed in previously published guidelines ( ). The PICO format, which describes the population (P), intervention

2020 Society of Critical Care Medicine

54. Treatment of Patients with Schizophrenia

and Statistical Manual of Mental Disorders DSM-5 Diagnostic and Statistical Manual of Mental Disorders, 5th Edition ECG Electrocardiography ECT Electroconvulsive therapy ER Extended release FDA Food and Drug Administration FGA First-generation antipsychotic GAF Global Assessment of Functioning GRADE Grading of Recommendations Assessment, Development and Evaluation HIPAA Health Insurance Portability and Accountability Act HIV Human immunodeficiency virus HR Hazard ratio ICD International Classification (...) • Past or current neurological or neurocognitive disorders or symptoms • Past physical trauma, including head injuries • Past or current endocrinological disease • Past or current infectious disease, including sexually transmitted diseases, HIV, tuberculosis, hepatitis C, and locally endemic infectious diseases such as Lyme disease • Past or current sleep abnormalities, including sleep apnea • Past or current symptoms or conditions associated with significant pain and discomfort • Additional review

2020 American Psychiatric Association

55. Drug-Induced Liver Injury

in chronic liver disease. Clinical trials involving treatment of human immunode?- ciencyvirus(HIV)infectionreportahighrateofhepaticadverse reactions ranging from 2% to 18% 107 with lower incidence of DILI in larger studies. The vast majority of these events (84%) only led to either a temporary or no interruption of therapy. 108 The contribution of each particular drug to the development of hepatotoxicity in a ‘highly active antiretroviral therapy’ (HAART) regimen is dif?cult to determine; a number (...) mitochondria is predictive of the risk associated with a large proportion of the drugs known to cause idiosyncratic DILI. 3,4 The key feature of idiosyncratic DILI with most drugs is the critical role of the adaptive immune system. Many drugs which cause immune- mediatedidiosyncraticDILIexhibitnosystemicallergicfeatures such as rash and eosinophilia. Key in the development of an adaptive immune response is the role of restricted human leukocyte antigen (HLA) associations. Nevertheless, in most instances

2019 European Association for the Study of the Liver

56. Opioid Treatments for Chronic Pain

Opioid Treatments for Chronic Pain Opioid Treatments for Chronic Pain Comparative Effectiveness Review Number 229 R Comparative Effectiveness Review Number 229 Opioid Treatments for Chronic Pain Prepared for: Agency for Healthcare Research and Quality U.S. Department of Health and Human Services 5600 Fishers Lane Rockville, MD 20857 www.ahrq.gov Contract No. 290-2015-00009-I Prepared by: Pacific Northwest Evidence-based Practice Center Portland, OR Investigators: Roger Chou, M.D. Daniel Hartung (...) and mental functioning and reduced quality of life, and is the leading cause of disability in the United States. 1 Chronic pain is caused by a variety of conditions and is influenced by multiple biological, psychological, and social factors. Therefore, optimal approaches to the management of chronic pain should consider psychological and social factors as well as underlying biological mechanisms and physical manifestations of chronic pain (the “biopsychosocial” framework or perspective). 3 Opioids

2020 Effective Health Care Program (AHRQ)

57. AACE Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis

Homocystinuria due to cystathionine deficiency Marfan syndrome Osteogenesis imperfecta AIDS/HIV Ankylosing spondylitis Chronic obstructive pulmonary disease Gaucher disease Hemophilia Hypercalciuria Immobilization Major depression Myeloma and some cancers Organ transplantation Renal insufficiency/ failure Renal tubular acidosis Rheumatoid arthritis Systemic mastocytosis Thalassemia AIDS = acquired immunodeficiency syndrome; GI = gastrointestinal; HIV = human immunodeficiency virus; SGLT2 = sodium- glucose (...) AACE Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis ENDOCRINE PRACTICE Vol 26 (Suppl 1) May 2020 1 Copyright © 2020 AACE Clinical Practice Guidelines AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS/ AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS— 2020 UPDATE Pauline M. Camacho, MD, FACE 1 ; Steven M. Petak, MD, JD, FACP , FCLM, MACE, CCD 2 ; Neil Binkley, MD 3 ; Dima L

2020 American Association of Clinical Endocrinologists

58. Overview of brain tumours

non-Hodgkin's lymphoma. Risk factors include immunosuppression, especially HIV infection, where an association with EBV infection is recognised. MacMahon EM, Glass JD, Hayward SD, et al. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet. 1991;338:969-973. http://www.ncbi.nlm.nih.gov/pubmed/1681341?tool=bestpractice.com Diagnosis is based on cranial CT and clinical history, with LP and CSF analysis. The most effective treatment is methotrexate-based chemotherapy (...) . Medulloblastoma: new insights into biology and treatment. Arch Dis Child Educ Pract Ed. 2008;93:137-144. http://www.ncbi.nlm.nih.gov/pubmed/18809691?tool=bestpractice.com Symptoms, as a result of a mass effect from the tumour or due to obstructive hydrocephalus, include morning headaches, nausea, vomiting, diplopia (a manifestation of sixth nerve palsy), and ataxia. Vomiting often relieves the headaches. Cranial CT and MRI are essential diagnostic and postoperative investigations. Primary treatment

2018 BMJ Best Practice

59. Assessment of memory deficit

of these systems. When a patient presents to the neurologist with memory loss, the patient or the family is frequently concerned about a neurodegenerative process or dementia. Dementia is often defined as impairment of memory and at least one other cognitive domain that leads to a decline in ability to perform activities of daily living. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human (...) in a clinical presentation suggestive of a memory disorder. Consideration should be made regarding the patient's affective state, because depressed patients may experience diminished concentration, sleep disruption, and mild impairments on delayed recall, which may manifest as a memory disorder. Karlawish JH, Clark CM. Diagnostic evaluation of elderly patients with mild memory problems. Ann Intern Med. 2003 Mar 4;138(5):411-9. http://www.ncbi.nlm.nih.gov/pubmed/12614094?tool=bestpractice.com Patients

2018 BMJ Best Practice

60. Overview of brain tumours

non-Hodgkin's lymphoma. Risk factors include immunosuppression, especially HIV infection, where an association with EBV infection is recognised. MacMahon EM, Glass JD, Hayward SD, et al. Epstein-Barr virus in AIDS-related primary central nervous system lymphoma. Lancet. 1991;338:969-973. http://www.ncbi.nlm.nih.gov/pubmed/1681341?tool=bestpractice.com Diagnosis is based on cranial CT and clinical history, with LP and CSF analysis. The most effective treatment is methotrexate-based chemotherapy (...) . Medulloblastoma: new insights into biology and treatment. Arch Dis Child Educ Pract Ed. 2008;93:137-144. http://www.ncbi.nlm.nih.gov/pubmed/18809691?tool=bestpractice.com Symptoms, as a result of a mass effect from the tumour or due to obstructive hydrocephalus, include morning headaches, nausea, vomiting, diplopia (a manifestation of sixth nerve palsy), and ataxia. Vomiting often relieves the headaches. Cranial CT and MRI are essential diagnostic and postoperative investigations. Primary treatment

2018 BMJ Best Practice

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