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Enclosed Vehicle Excessive Heat

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21. Seebri Breezhaler - glycopyrronium bromide

bromide (metered dose), equivalent to 50 µg of glycopyrronium. The delivered dose (the dose that leaves the mouthpiece of the inhaler) is equivalent to 44 µg of glycopyrronium (55 µg of glycopyrronium bromide). The product is presented in hypromellose hard capsules containing the active substance mixed with two excipients lactose monohydrate and magnesium stearate. The powder is enclosed in hard capsules composed of hypromellose, carrageenan, potassium chloride and Sunset Yellow FCF (E110 (...) if significant changes were seen after storage in the refrigerator. The applicant has also submitted three months stability data at 25°C/60% RH and 40°C/75% RH for three production scale batches. Stability program was supplemented by a photostability study, stress testing (storage for one month at 50°C, 60°C and 80°C), forced decomposition studies (3 day heated in aqueous solution under acidic, alkaline, neutral and oxidising conditions), isomerisation study (storage for one month at 50°C exposed to acid

2012 European Medicines Agency - EPARs

22. Enurev Breezhaler - glycopyrronium bromide

bromide (metered dose), equivalent to 50 µg of glycopyrronium. The delivered dose (the dose that leaves the mouthpiece of the inhaler) is equivalent to 44 µg of glycopyrronium (55 µg of glycopyrronium bromide). The product is presented in hypromellose hard capsules containing the active substance mixed with two excipients lactose monohydrate and magnesium stearate. The powder is enclosed in hard capsules composed of hypromellose, carrageenan, potassium chloride and Sunset Yellow FCF (E110 (...) if significant changes were seen after storage in the refrigerator. The applicant has also submitted three months stability data at 25°C/60% RH and 40°C/75% RH for three production scale batches. Stability program was supplemented by a photostability study, stress testing (storage for one month at 50°C, 60°C and 80°C), forced decomposition studies (3 day heated in aqueous solution under acidic, alkaline, neutral and oxidising conditions), isomerisation study (storage for one month at 50°C exposed to acid

2012 European Medicines Agency - EPARs

23. Tepadina - thiotepa

are provided to justify the proposed manufacturing process of the finished product. ? Adventitious Agents The active substance is not of human or animal origin, therefore there is no TSE/BSE risk. This medicinal product does not contain excipients. ? Manufacture of the Product Heat sterilisation is not possible due to the thermolability of the active substance. Consequently, the drug product is manufactured by aseptic processing, including dilution of the active substance in water, sterilisation (...) product have been properly described. All non- pharmacopoeial methods were validated. Batch results for three batches of both product presentations are enclosed. Analytical results of commercial production batches are presented for the 15 mg formulation, whereas for the 100 mg formulation results are presented for validation batches. The results comply with the specification and confirm consistency of the product. Page 8 of 78 ? Stability of the Product Satisfactory accelerated and long-term stability

2010 European Medicines Agency - EPARs

24. Overview of Fractures, Dislocations, and Sprains

knowledge Overview of Heat Illness Withdrawal from which of the following substances is most likely to increase a patient’s heat input? Alcohol Cannabis Cocaine Phencyclidine NEWS & VIDEOS Fractures Have Long-Term Impact on Quality of Life for Older Adults TUESDAY, Feb. 12, 2019 (HealthDay News) -- Incident fragility fractures are associated with long-term impacts on health-related quality of life (HRQOL) in older people, according to a study... 3D Model Musculoskeletal Connective Tissues Video Wrist (...) suggests potentially severe or multiple injuries (as in a high-speed motor vehicle crash or fall from a height), patients are first evaluated from head to toe for serious injuries to all organ systems and, if needed, are resuscitated (see ). Patients, especially those with pelvic or femoral fractures, are evaluated for hemorrhagic shock due to occult blood loss. If a limb is injured, it is immediately evaluated for open wounds and symptoms or signs of neurovascular injury (numbness, paresis, poor

2013 Merck Manual (19th Edition)

25. Smoking ban

banning smoking across whole cities, including every place except residential homes. More than 20 cities in California enacted park and beach smoking restrictions. Since December 1993, in , it is illegal to smoke in any public enclosed places and any public transport vehicles (according to Law 25357 issued on 27 November 1991 and its regulations issued on 25 November 1993 by decree D.S.983-93-PCM). There is also legislation restricting publicity, and it is also illegal (Law 26957 21 May 1998) to sell (...) Clean Air Act of 1999 prohibits smoking inside a public building or an enclosed public place including public vehicles and other means of transport or in any enclosed area outside of one’s private residence, private place of work or any duly designated smoking area. has original text related to this article: The Tobacco Regulation Act also prohibits smoking in public places, like schools, public transportation terminals, malls, and places with , like gas stations. Cancer survivors support

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2012 Wikipedia

26. Mosquito

. Aedes females generally drop their eggs singly, much as Anopheles do, but not as a rule into water. Instead, they lay their eggs on damp mud or other surfaces near the water's edge. Such an oviposition site commonly is the wall of a cavity such as a hollow stump or a container such as a bucket or a discarded vehicle tire. The eggs generally do not hatch until they are flooded, and they may have to withstand considerable desiccation before that happens. They are not resistant to desiccation straight (...) . A mosquito has a variety of ways of finding its prey, including chemical, visual, and heat sensors. Both plant materials and blood are useful sources of energy in the form of sugars, and blood also supplies more concentrated nutrients, such as , but the most important function of blood meals is to obtain proteins as materials for egg production. Among humans, the feeding preferences of mosquitoes typically include those with blood, those who are heavy breathers, those with an abundance of skin bacteria

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2012 Wikipedia

27. Carbon monoxide

of -containing compounds; it forms when there is not enough oxygen to produce (CO 2 ), such as when operating a or an in an enclosed space. In the presence of oxygen, including atmospheric concentrations, carbon monoxide burns with a blue flame, producing carbon dioxide. , which was widely used before the 1960s for domestic lighting, cooking, and heating, had carbon monoxide as a significant fuel constituent. Some processes in modern technology, such as , still produce carbon monoxide as a byproduct. A large (...) was the mechanism of death. Greek physician (129–199 AD) speculated that there was a change in the composition of the air that caused harm when inhaled. In 1776, the French chemist produced CO by heating with , but mistakenly concluded that the gaseous product was , as it burned with a blue flame. The gas was identified as a compound containing and by the Scottish chemist in 1800. Its toxic properties on dogs were thoroughly investigated by around 1846. During , a gas mixture including carbon monoxide was used

2012 Wikipedia

28. Carbon monoxide poisoning

. This is enforced by municipal inspectors, and was inspired by the death of 7-year-old Nicole Garofalo in 2005 due to snow blocking a home heating vent. Other jurisdictions may have no requirement or only mandate detectors for new construction or at time of sale. Despite similar deaths in vehicles with clogged exhaust pipes (for example in the and ) and the commercial availability of the equipment, there is no legal requirement for automotive CO detectors. [ ] World Health Organization recommendations (...) ventilation, may produce excessive carbon monoxide. Carbon monoxide detection and poisoning also increases during power outages, when electric heating and cooking appliances become inoperative and residents may temporarily resort to fuel-burning space heaters, stoves, and grills (some of which are safe only for outdoor use but nonetheless are errantly burned indoors). It has been estimated that more than 40,000 people per year seek medical attention for carbon monoxide poisoning in the United States. 95

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2012 Wikipedia

29. Ultrasound Scanning - Non-obstetric

tissues or predisposes to malignant change. Unlike ionising radiation, it does not break chromosomes, at least at the power used for medical purposes. It does cause a slight heating of tissues and potentially small cavitation in tissues. There is no evidence this causes any harm but, nevertheless, it is advised that imaging which is not medically necessary be avoided and exposure limited to the minimum level required. [ ] It is non-invasive and painless. The equipment tends to be much cheaper than (...) stationary. We may recall the change in pitch from higher to lower of the whistle of a train as it speeds through a station, or the siren of an emergency vehicle as it speeds past on the road. This is the Doppler effect and the degree of change in pitch can be used to calculate the velocity of the moving source. However, the source may be static and the reflecting interface moving. This produces the same effect. Hence, it is possible to measure speed of flow. This may be displayed in the form of colour

2008 Mentor

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