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Emergency Pediatric Dosing 12-14 kilogram

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121. Exercise Standards for Testing and Training

light 10 11 Fairly light 12 13 Somewhat hard 14 15 Hard 16 17 Very hard 18 19 Very, very hard 20 Reprinted from Borg with permission of the publisher. Copyright ©1982, the American College of Sports Medicine. Angina Characteristics and Scale Levels of anginal discomfort in those with known or suspected CAD are also excellent subjective end points. Whether typical angina occurs with exercise or is the reason for termination of the test is an important observation in evaluation of the exercise test (...) equations, some of which are derived separately for men and women. For one of the commonly used equations (maximum predicted HR=220–age in years), a high degree of variability exists among subjects of identical age (±12 beats per minute [bpm]). Accordingly, the practice of using achievement of 85% of age-predicted maximal HR to define sufficient effort during exercise testing is limited and should not be used in isolation as a termination criterion. Dynamic exercise increases HR more than either

2013 American Heart Association

122. Promotion of Physical Activity for Children and Adults With Congenital Heart Disease

and sustained physical activity, as well as the risks of inactivity for people with and without heart disease, have been documented extensively. The benefits include well-described physiological improvements in skeletal muscle function, vascular health, immune system function, obesity prevention, and complex psychological, cognitive and social function. Emerging science also suggests that the health risks associated with inactivity, such as hypertension, diabetes, obesity, depression, cancer (...) Heart Association classification. Pedometers can also be used to encourage increased physical activity by having the number of steps taken displayed to the user. Current recommendations for optimal health are for adults to achieve 10 000 steps per day and for children to achieve 12 000 steps per day. Self-reports of physical activity significantly overestimate the quantity and intensity of activity performed, , with reported activity often exceeding total daily time. Therefore, use of self-reports

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2013 American Heart Association

123. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection

of new recommendations 221 11.3 Monitoring the outputs and outcomes of scaling up access to Ar V drugs 222 11.4 Other monitoring considerations 225 11.4.1 HIV drug resistance 225 11.4.2 Sentinel surveillance for Ar V toxicity monitoring 225 11.4.3 Evaluation, including impact and programme performance, and implementation research 225 11.5 r eviewing and strengthening monitoring and evaluation systems 227 12. Annexes 229 Annex 1. WHO clinical staging of HIV disease in adults, adolescents and children (...) NVP nevirapine OST opioid substitution therapy PCr polymerase chain reaction PI protease inhibitor PICO Population, Intervention, Comparison and Outcomes PCP/PJP Pneumocystis (jirovecii) pneumonia PMTCT prevention of mother-to-child transmission of HIV PrEP pre-exposure prophylaxis of HIV rAL raltegravir r BV ribavirin rIF rifampicin r NA ribonucleic acid rTV ritonavir sd-NVP single-dose nevirapine TAM thymidine analogue mutation TB tuberculosis TDF tenofovir disoproxil fumarate TPV tipranavir

2013 World Health Organisation HIV Guidelines

124. Nonnutritive Sweeteners: Current Use and Health Perspectives

bw 15 (1980) 1981 187 14, 12-oz servings 40 68 Neotame N -[ N -(3,3-dimethylbutyl)- l -α-aspartyl]- l -phenylalanine 1-methyl ester Neotame 2 mg/kg bw 52 (2004) 2002 Not in carbonated beverages … No consumer product … Saccharin 1,1-Dioxo-1,2-benzothiazol-3-one Sweet'N Low 5 mg/kg bw 32 (1993) Before 1958 8 (blended with aspartame) 42, 12-oz servings 40 8.5 Sucralose 1,6-Dichloro-1,6-dideoxy-β- d -fructofuranosyl-4-chloro-4-deoxy-α- d -galactopyranoside Splenda 15 mg/kg bw 28 (1991) 1999 68 15, 12 (...) Toxicology Monograph No. (Year) Year FDA Approved Representative Amount of Sweetener in 12-oz Soda, mg No. of Servings=to ADI for a 150 lb (68 kg) Person Amount of Sweetener in a Packet (Equivalent to 2 tsp Sugar), mg No. of Packets=to ADI for 150 lb (68 kg) Person Acesulfame-K Potassium 6-methyl-2,2-dioxo-oxathiazin-4-olate Sweet One 15 mg/kg bw 28 (1991) 1988 40 (blended with aspartame) 25, 12-oz servings 50 20 Aspartame N -( l -α-Aspartyl)- l - phenylalanine, 1-methyl ester Equal NutraSweet 40 mg/kg

2012 American Heart Association

125. Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices

-acting contraception in young women ( , ). Adolescents have high continuation rates with LARC methods. A meta-analysis of 12 studies evaluating LARC method continuation among adolescents and women younger than 25 years found a 12-month continuation rate of 84% for LARC methods ( ). The CHOICE project, a prospective cohort study of 9,256 girls and women of reproductive age (ages 14–45 years) designed to promote the use of LARC, found that 81% of adolescents aged 14–19 years continued use of a LARC (...) clinical trials. . Vickery Z, Madden T, Zhao Q, Secura GM, Allsworth JE, Peipert JF. Weight change at 12 months in users of three progestin-only contraceptive methods. . Bonny AE, Ziegler J, Harvey R, Debanne SM, Secic M, Cromer BA. Weight gain in obese and nonobese adolescent girls initiating depot medroxyprogesterone, oral contraceptive pills, or no hormonal contraceptive method. . Berlan E, Mizraji K, Bonny AE. Twelve-month discontinuation of etonogestrel implant in an outpatient pediatric setting

2012 American College of Obstetricians and Gynecologists

126. Urologic Surgery Antimicrobial Prophylaxis

of postprocedure UTI. A decision-analysis model based upon estimates from the literature and consensus suggested that prophylactic antimicrobials after urodynamic studies are beneficial once the rate of UTI without antimicrobials exceeds 10%. 69 Conversely, a RCT involving a single oral dose of ciprofloxacin versus placebo in 192 patients who had urine without growth before urodynamic study found that postprocedure UTI decreased significantly, from 14% to 1%, with prophylaxis; the authors recommended (...) ureteroscopy or ureteral stent placement. 41 Vaginal surgery (prophylaxis indicated in all patients) Level of evidence: Ia/b, IIb In one prospective study of urethropexy, comparing intravenous cefazolin in 14 women to no antimicrobials in 12 women, postoperative fever and hospital stay were significantly less in patients who received prophylactic antimicrobials. 86 Randomized controlled trials involving antimicrobial prophylaxis for vaginal urologic surgery have not been reported, but considerable evidence

2012 American Urological Association

127. Heart Disease and Stroke Statistics?2012 Update

and 17.5% of women continued to be cigarette smokers. In 2009, 19.5% of students in grades 9 through 12 reported current cigarette use. The percentage of the nonsmoking population with detectable serum cotinine (indicating exposure to secondhand smoke) declined from 52.5% in 1999 to 2000 to 40.1% in 2007 to 2008, with declines occurring, and was higher for those 3 to 11 years of age (53.6%) and those 12 to 19 years of age (46.5%) than for those 20 years of age and older (36.7%). An estimated 33 600 000 (...) adults ≥20 years of age have total serum cholesterol levels ≥240 mg/dL, with a prevalence of 15.0% (Table 14-1). In 2008, an estimated 18 300 000 Americans had diagnosed diabetes mellitus, representing 8.0% of the adult population. An additional 7 100 000 had undiagnosed diabetes mellitus, and 36.8% had prediabetes, with abnormal fasting glucose levels. African Americans, Mexican Americans, Hispanic/Latino individuals, and other ethnic minorities bear a strikingly disproportionate burden of diabetes

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2012 American Heart Association

128. Population Approaches to Improve Diet, Physical Activity, and Smoking Habits

campaigns to reduce sedentary activities. † Factors that increase effectiveness include greater duration and dose of exposure to the media campaign and use of strong negative messages about health. National, Community, and School-Based Media or Educational Campaigns to Increase Physical Activity Several media and educational campaigns have been used to promote physical activity. Examples in the United States include VERB, a national social marketing campaign coordinated by the CDC to increase

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2012 American Heart Association

129. KDIGO Clinical Practice Guideline for Acute Kidney Injury

to the stage and cause 26 Figure 6. Chronic Kidney Disease Epidemiology Collaboration cohort changes in eGFR and final eGFR corresponding to KDIGO definition and stages of AKI 34 Figure 7. GFR/SCr algorithm 34 Figure 8. Conceptual model for development and clinical course of AKI 38 Figure 9. Effect of furosemide vs. control on all-cause mortality 48 Figure 10. Effect of furosemide vs. control on need for RRT 48 Figure 11. Effect of low-dose dopamine on mortality 51 Figure 12. Effect of low-dose dopamine (...) KDIGO Clinical Practice Guideline for Acute Kidney Injury VOLUME 2 | ISSUE 1 | MARCH 2012 http://www.kidney-international.org OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF NEPHROLOGY KDIGO Clinical Practice Guideline for Acute Kidney Injury KI_SuppCover_2.1.indd 1 KI_SuppCover_2.1.indd 1 2/7/12 12:32 PM 2/7/12 12:32 PMKDIGO Clinical Practice Guideline for Acute Kidney Injury Tables and Figures iv Notice 1 Work Group Membership 2 KDIGO Board Members 3 Reference Keys 4 Abbreviations

2012 National Kidney Foundation

130. Acute Diarrhea in Adults and Children: A Global Perspective

Constituents of oral rehydration salts (ORS) 13 Table 12 Recommended daily allowance (RDA) guide for a 1-year-old child 13 Table 13 Dietary recommendations 14 Table 14 Nonspecific antidiarrheal agents 16 Table 15 Antimicrobial agents for the treatment of specific causes of diarrhea 16 Table 16 Treatment for children based on the degree of dehydration 20 List of figures Fig. 1 Therapeutic approach to acute bloody diarrhea in children 21 Fig. 2 Cascade for acute, severe, watery diarrhea—cholera-like (...) , severe dehydration leading to hypovolemic shock and death can occur within 12–18 h after the onset of the first symptom. • Stools are watery, colorless, and flecked with mucus; often referred to as “rice- watery” stools. • Vomiting is common; fever is typically absent. • There is a potential for epidemic spread; any infection should be reported promptly to the public health authorities. Pediatric details. In children, hypoglycemia can lead to convulsions and death. Salmonella: • Enteric fever

2012 World Gastroenterology Organisation

131. SNMMI Procedure Standard for Therapy of Thyroid Disease with 131I (Sodium Iodide) 3.0

SNMMI Procedure Standard for Therapy of Thyroid Disease with 131I (Sodium Iodide) 3.0 The SNM Practice Guideline for Therapy of Thyroid Disease with 131 I 3.0* Edward B.Silberstein 1 (Chair),AbassAlavi 2 ,HelenaR.Balon 3 ,SusanE.M.Clarke 4 ,ChaitanyaDivgi 5 ,MichaelJ.Gelfand 6 , StanleyJ.Goldsmith 7 ,HosseinJadvar 8 ,CarolS.Marcus 9 ,William H.Martin 10 ,J.AnthonyParker 11 ,HenryD. Royal 12 , SalilD. Sarkar 13 ,Michael Stabin 14 ,and Alan D. Waxman 15 1 UC Health University Hospital, Cincinnati (...) University Medical Center, Nashville, Tennessee; 11 Beth Israel Deaconess Medical Center, Boston, Massachusetts; 12 Mallinckrodt Institute of Radiology, St. Louis, Missouri; 13 Jacobi Medical Center, Bronx, New York; 14 Vanderbilt University, Nashville, Tennessee; and 15 Cedars-Sinai Medical Center, Los Angeles, California INDEX Preamble 1 I. Introduction: patient management, licensure 2 II. Goals 2 III. De?nitions: risk levels 2 IV. Common clinical indications 3 V. Quali?cations and responsibilities

2012 Society of Nuclear Medicine and Molecular Imaging

132. Clinical Practice Guidelines for Hypothyroidism in Adults

Subclinical Overt TSH Comment NHANES III 4.3% 0.3% 4.5 Colorado Thyroid Disease Prevalence 8.5% 0.4% 5.0 Not on thyroid hormone Framingham 10.0 Over age 60 years: 5.9% women; 2.3% men; 39% of whom had subnormal T 4 British Whickham 10.0 9.3% women; 1.2% men Sources: Hollowell et al., 2002 (11); Canaris et al., 2000 (12); Sawin et al., 1985 (13); Vanderpump et al., 1995 (14); Vanderpump and Tunbridge, 2002 (15). Abbreviations: NHANES = National Health and Nutrition Examination Survey. 997 aspiration (FNA (...) a strong impact, then recommendation grades may be adjusted up (“positive” impact) or down (“negative” impact). If a two-thirds consensus cannot be reached, then the recommendation grade is D. Source: Mechanick et al., 2010 (5). N/A, not applicable (regardless of the presence or absence of strong subjective factors, the absence of a two-thirds consensus mandates a recommendation grade D).996 age 12 between 1988 and 1994, using the upper limit of normal for TSH as 4.5 mIU/mL (11). The prevalence

2012 American Association of Clinical Endocrinologists

133. Guidelines for selection and HLA matching of related, adult unrelated donors and umbilical cord units for haematopoietic progenitor cell transplantation

donors for allogeneic progenitor cell transplantation. 14 excludes alleles that are not expressed as cell-surface proteins. Examples are typing with the following characteristics: (a) Alleles within a P group designation e.g., A*02:01P, DPB1*04:02P. The P group designation is assigned to alleles that encode for the same protein sequence in exon 2 and 3 for HLA class I and exon 2 for HLA class II. (b) Alleles within a G group designation (e.g., A*02:01:01G, DRB1*12:01:01G) with the exception (...) to the size of the patient being transplanted. A consensus has evolved that 2.5 x 10 7 nucleated cells per kilogram body weight is the minimum cell dose required to reliably achieve engraftment in unrelated cord blood transplants (40). UCB units have on average 1/10 th the number of lymphoid derived cells of an average BM collection(41). The cell dose from the cord blood unit and the degree of HLA matching affect engraftment. In general, the greater the level of mismatch the higher the cell dose needed

2012 British Society for Histocompatibility and Immunogenetics

134. Management of Patients with Infections Caused by Methicillin-Resistant Staphylococcus Aureus

or 300–450 mg twice daily (B-III) . 57. Alternatives include the following: linezolid 600 mg PO/IV twice daily (B-II) and TMP-SMX 5 mg/kg/dose IV every 8–12 h (C-III ). Pediatric considerations 58. IV vancomycin is recommended (A-II). VII. What is the role of adjunctive therapies for the treatment of MRSA infections? 59. Protein synthesis inhibitors (eg, clindamycin and linezolid) and intravenous immunoglobulin (IVIG) are not routinely recommended as adjunctive therapy for the management of invasive (...) for other works by this author on: Sheldon L. Kaplan 10Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas Search for other works by this author on: Adolf W. Karchmer 11Division of Infectious Diseases, Beth Israel Deaconess Medicine Center, Harvard Medical School, Boston, Massachusetts Search for other works by this author on: Donald P. Levine 12 Department of Medicine, Division of Infectious Diseases, Wayne State University, Detroit Receiving Hospital

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2011 Infectious Diseases Society of America

135. Diagnosis and Management of Cerebral Venous Thrombosis

recommendations are provided for the diagnosis, management, and prevention of recurrence of cerebral venous thrombosis. Recommendations on the evaluation and management of cerebral venous thrombosis during pregnancy and in the pediatric population are provided. Considerations for the management of clinical complications (seizures, hydrocephalus, intracranial hypertension, and neurological deterioration) are also summarized. An algorithm for diagnosis and management of patients with cerebral venous sinus (...) (eg, thrombophilias, inflammatory bowel disease), transient situations (eg, pregnancy, dehydration, infection), selected medications (eg, oral contraceptives, substance abuse), and unpredictable events (eg, head trauma) are some predisposing conditions. , Given the diversity of causes and presenting scenarios, CVT may commonly be encountered not only by neurologists and neurosurgeons but also by emergency physicians, internists, oncologists, hematologists, obstetricians, pediatricians, and family

2011 Congress of Neurological Surgeons

136. Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition

Provider, Investigator) Primary Purpose: Treatment Official Title: A 24-Week Double-blind, Safety, Efficacy, and Pharmacodynamic Study Investigating Two Doses of Teduglutide in Pediatric Subjects Through 17 Years of Age With Short Bowel Syndrome Who Are Dependent on Parenteral Support Actual Study Start Date : June 23, 2016 Actual Primary Completion Date : August 18, 2017 Actual Study Completion Date : August 18, 2017 Resource links provided by the National Library of Medicine available for: resources (...) ClinicalTrials.gov identifier (NCT number): NCT02682381 Sponsors and Collaborators Shire Investigators Layout table for investigator information Study Director: Shire Physician Shire Study Documents (Full-Text) Documents provided by Shire: [PDF] March 12, 2015 [PDF] June 22, 2015 [PDF] February 25, 2016 [PDF] March 15, 2016 [PDF] July 14, 2017 [PDF] October 6, 2015 More Information Go to Layout table for additonal information Responsible Party: Shire ClinicalTrials.gov Identifier: Other Study ID Numbers: TED-C14

2016 Clinical Trials

137. Aminopenicillins

. ) Conditions Infectious Enteritis ( ) VIII. Adverse effects Similar to s Maculopapular rash Onset 5-7 days after initiating medication Typically not IgE mediated (non-allergic) No immediate allergy (e.g. ), systemic symptoms or mucous membrane involvement Typically safe to use Amoxicillin in future if non-allergic rash alone Consider IgE if unclear rash etiology References Orman and Hayes in Herbert (2017) EM:Rap 17(7): 7-8 (modifications can decrease stools to 12%) Dose exactly by kilogram for children (...) Aminopenicillins Aminopenicillins Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Aminopenicillins Aminopenicillins Aka

2018 FP Notebook

138. Unfractionated Heparin

Heparin Aka: Unfractionated Heparin , Heparin From Related Chapters II. Mechanism Potentiates (AT III) See III. Dosing: Prophylactic for DVT Prevention Heparin 5000 Units SQ every 8-12 hours IV. Dosing: Therapeutic Dosing by Weight based Calculations Measure Total body weight (TBW) in kilograms Height in inches Calculate (LBW) in kilograms Male: 50 + 2.3 x (height in inches - 60) Female: 45 + 2.3 x (height in inches -60) Calculate Dosing Weight Non-Obese Dosing Weight (kg): TBW above Obese (TBW > 1.4 (...) Unfractionated Heparin Unfractionated Heparin Toggle navigation Brain Head & Neck Chest Endocrine Abdomen Musculoskeletal Skin Infectious Disease Hematology & Oncology Cohorts Diagnostics Emergency Findings Procedures Prevention & Management Pharmacy Resuscitation Trauma Emergency Procedures Ultrasound Cardiovascular Emergencies Lung Emergencies Infectious Disease Pediatrics Neurologic Emergencies Skin Exposure Miscellaneous Abuse Cancer Administration 4 Unfractionated Heparin Unfractionated

2018 FP Notebook

139. Gastrointestinal Complications (PDQ®): Health Professional Version

. Gastrointest Endosc 54 (2): 229-32, 2001. [ ] Martinez-Santos C, Lobato RF, Fradejas JM, et al.: Self-expandable stent before elective surgery vs. emergency surgery for the treatment of malignant colorectal obstructions: comparison of primary anastomosis and morbidity rates. Dis Colon Rectum 45 (3): 401-6, 2002. [ ] Ripamonti C, Bruera E: Palliative management of malignant bowel obstruction. Int J Gynecol Cancer 12 (2): 135-43, 2002 Mar-Apr. [ ] Potluri V, Zhukovsky DS: Recent advances in malignant bowel (...) chemotherapy.[ ] The large and small bowel are very sensitive to ionizing radiation. Although the probability of tumor control increases with the radiation dose, so does the damage to normal tissues. Acute side effects to the intestines occur at approximately 10 Gy. Because curative doses for many abdominal or pelvic tumors range between 50 and 75 Gy, enteritis is likely to occur.[ ] In this summary, unless otherwise stated, evidence and practice issues as they relate to adults are discussed. The evidence

2015 PDQ - NCI's Comprehensive Cancer Database

140. Management of Women with Obesity in Pregnancy

12. Care during childbirth 11 13. Postnatal care and follow-up after pregnancy 13 14. Local guidelines 15 15. Facilities and equipment 15 16. Education of health professionals 16 17. Areas for further research 17 18. Auditable standards 17 References 18 APPENDIX 1: Process for developing the consensus standards 22 APPENDIX 2: Levels and grades of evidence 26 APPENDIX 3: Maternal and fetal risks in women with a BMI =30 kg/m 2 compared to women with a healthy BMI 27 APPENDIX 4: Pre-pregnancy (...) of a number of serious adverse outcomes, including miscarriage, 6 fetal congenital anomaly, 7 thromboembolism, 8,9 gestational diabetes, 10 pre-eclampsia, 11 dysfunctional labour, 12 postpartum haemorrhage, 10 wound infections, 10 stillbirth 13,14 and neonatal death. 14-16 There is a higher caesarean section rate 17 and lower breastfeeding rate 18 in this group of women compared to women with a healthy BMI. There is also evidence to suggest that obesity may be a risk factor for maternal death

2010 Royal College of Obstetricians and Gynaecologists

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